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View Protein Complex Details

Complex Overview

From Publication: Ho Y. et al. (2002) Systematic identification of protein complexes in Saccharomyces cerevisiae by mass spectrometry. Nature. 2002 Jan 10;415(6868):180-3.
Notes: This molecular complex record represents a population of complexes co-purified by immunoprecipitation of FLAG-tagged Hap2. The topolgies of protein complexes in this experiment are unknown.
Complex Size: 34 proteins

Complex Member Proteins

Protein

GO Cellular Component GO Biological Process GO Molecular Function
AAC3
  • mitochondrion
  • mitochondrial inner membrane
  • anaerobic respiration
  • ATP:ADP antiporter activity
  • ARP4
  • nucleus
  • nuclear chromatin
  • NuA4 histone acetyltransferase complex
  • Swr1 complex
  • Ino80 complex
  • DNA repair
  • chromatin remodeling
  • regulation of transcription, DNA-dependent
  • histone acetylation
  • chromatin organization
  • regulation of transcription from RNA polymerase II promoter
  • histone acetyltransferase activity
  • ATP-dependent 5'-3' DNA helicase activity
  • chromatin binding
  • ASA1
  • cellular_component
  • biological_process
  • molecular_function
  • ATG17
  • cytoplasm
  • autophagy
  • telomere maintenance
  • kinase activator activity
  • ATG29
  • cytoplasm
  • autophagy
  • molecular_function
  • ATP3
  • mitochondrial proton-transporting ATP synthase, central stalk
  • mitochondrion
  • ATP synthesis coupled proton transport
  • hydrogen ion transporting ATP synthase activity, rotational mechanism
  • CDC33
  • nucleus
  • eukaryotic translation initiation factor 4F complex
  • cytoplasm
  • ribosome
  • nuclear-transcribed mRNA catabolic process, nonsense-mediated decay
  • translational initiation
  • translation initiation factor activity
  • CIC1
  • proteasome complex
  • nucleolus
  • protein catabolic process
  • ribosomal large subunit biogenesis
  • ribosome biogenesis
  • protein binding, bridging
  • CIS1
  • cytoplasm
  • autophagy
  • microtubule cytoskeleton organization
  • molecular_function
  • CYS4
  • cytoplasm
  • mitochondrion
  • response to drug
  • cysteine biosynthetic process
  • cystathionine beta-synthase activity
  • FOL2
  • nucleus
  • cytoplasm
  • folic acid and derivative biosynthetic process
  • GTP cyclohydrolase I activity
  • GRH1
  • cytoplasm
  • mitotic cell cycle spindle assembly checkpoint
  • Golgi organization
  • molecular_function
  • HAP2
  • nucleus
  • CCAAT-binding factor complex
  • regulation of carbohydrate metabolic process
  • transcription
  • transcription activator activity
  • HAP5
  • nucleus
  • CCAAT-binding factor complex
  • regulation of carbohydrate metabolic process
  • transcription
  • DNA binding
  • transcription activator activity
  • IPP1
  • cytosol
  • phosphate metabolic process
  • inorganic diphosphatase activity
  • LOC1
  • nucleus
  • intracellular mRNA localization
  • ribosomal large subunit biogenesis
  • mRNA binding
  • MAM33
  • mitochondrial matrix
  • mitochondrion
  • response to drug
  • aerobic respiration
  • molecular_function
  • MTQ1
  • mitochondrion
  • biological_process
  • S-adenosylmethionine-dependent methyltransferase activity
  • NAP1
  • nucleus
  • cytoplasm
  • nuclear nucleosome
  • M phase of mitotic cell cycle
  • budding cell bud growth
  • nucleosome assembly
  • histone binding
  • NMD5
  • nucleus
  • cytoplasm
  • protein import into nucleus
  • protein transmembrane transporter activity
  • NOP16
  • nucleus
  • nucleolus
  • ribosomal large subunit biogenesis
  • molecular_function
  • NSA2
  • nucleus
  • preribosome, large subunit precursor
  • ribosomal large subunit biogenesis
  • ribosome biogenesis
  • processing of 27S pre-rRNA
  • molecular_function
  • POL5
  • nucleolus
  • DNA replication
  • rRNA transcription
  • DNA-directed DNA polymerase activity
  • PSE1
  • nucleus
  • cytoplasm
  • mRNA export from nucleus
  • protein import into nucleus
  • protein transmembrane transporter activity
  • RHR2
  • nucleus
  • cytoplasm
  • response to drug
  • response to osmotic stress
  • glycerol biosynthetic process
  • glycerol-1-phosphatase activity
  • SAH1
  • cytoplasm
  • methionine metabolic process
  • selenocysteine metabolic process
  • adenosylhomocysteinase activity
  • SAP190
  • cytoplasm
  • G1/S transition of mitotic cell cycle
  • protein serine/threonine phosphatase activity
  • SPE3
  • nucleus
  • cytoplasm
  • pantothenate biosynthetic process
  • spermidine biosynthetic process
  • spermidine synthase activity
  • SSK2
  • cellular bud tip
  • cellular bud neck
  • cytosol
  • osmosensory signaling pathway
  • response to osmotic stress
  • protein amino acid phosphorylation
  • actin cytoskeleton organization
  • activation of MAPKK activity involved in osmosensory signaling pathway
  • MAP kinase kinase kinase activity
  • TIF1, TIF2
  • plasma membrane enriched fraction
  • eukaryotic translation initiation factor 4F complex
  • cytoplasm
  • ribosome
  • regulation of translation
  • translational initiation
  • regulation of translational initiation
  • translation
  • nucleotide binding
  • nucleic acid binding
  • translation initiation factor activity
  • ATP binding
  • RNA binding
  • ATP-dependent helicase activity
  • helicase activity
  • ATP-dependent RNA helicase activity
  • hydrolase activity
  • TIF6
  • nucleus
  • cytoplasm
  • nuclear outer membrane
  • nucleolus
  • ribosomal subunit export from nucleus
  • ribosomal large subunit biogenesis
  • processing of 27S pre-rRNA
  • ribosomal large subunit binding
  • YRA1
  • transcription export complex
  • mRNA export from nucleus
  • RNA binding
  • YRA2
  • nucleus
  • poly(A)+ mRNA export from nucleus
  • RNA binding
  • YTM1
  • nucleus
  • nucleolus
  • ribosomal large subunit biogenesis
  • ribosome biogenesis
  • molecular_function
  • Cellular Component Analysis

    Given the number of proteins in the complex (A), total proteins annotated with a given GO term (B), and the total number of annotated proteins (T); the p-value represents the chances of randomly having the number of proteins in the complex annotated with a specific GO term (I).

    Only showing terms with a p-value less than or equal to 0.01.

    GO Term

    P-value

    A

    B

    I

    T

    CCAAT-binding factor complex 1.6892E-4 34 4 2 6292
    eukaryotic translation initiation factor 4F complex 1.6892E-4 34 4 2 6292
    nuclear lumen 2.3211E-3 34 453 8 6292
    intracellular part 2.6772E-3 34 4938 33 6292
    intracellular 3.3457E-3 34 4975 33 6292
    nucleus 3.9425E-3 34 2041 19 6292
    nucleolus 5.0901E-3 34 211 5 6292
    plasma membrane enriched fraction 5.4037E-3 34 1 1 6292
    organelle lumen 6.8592E-3 34 660 9 6292
    intracellular organelle lumen 6.8592E-3 34 660 9 6292

    Biological Process Analysis

    Given the number of proteins in the complex (A), total proteins annotated with a given GO term (B), and the total number of annotated proteins (T); the p-value represents the chances of randomly having the number of proteins in the complex annotated with a specific GO term (I).

    Only showing terms with a p-value less than or equal to 0.01.

    GO Term

    P-value

    A

    B

    I

    T

    ribosomal large subunit biogenesis 1.0307E-6 34 65 6 6292
    nuclear transport 5.9947E-4 34 130 5 6292
    nucleocytoplasmic transport 5.9947E-4 34 130 5 6292
    cellular process 7.1749E-4 34 4426 32 6292
    RNA localization 1.4193E-3 34 92 4 6292
    autophagy 1.4333E-3 34 42 3 6292
    nuclear export 2.1536E-3 34 103 4 6292
    processing of 27S pre-rRNA 3.2438E-3 34 16 2 6292
    selenocysteine metabolic process 5.4037E-3 34 1 1 6292
    selenium metabolic process 5.4037E-3 34 1 1 6292
    mRNA export from nucleus 5.6863E-3 34 68 3 6292
    mRNA transport 5.6863E-3 34 68 3 6292
    group transfer coenzyme metabolic process 7.8666E-3 34 25 2 6292
    RNA export from nucleus 8.9206E-3 34 80 3 6292
    serine family amino acid metabolic process 9.142E-3 34 27 2 6292
    RNA transport 9.2298E-3 34 81 3 6292
    nucleic acid transport 9.2298E-3 34 81 3 6292
    establishment of RNA localization 9.2298E-3 34 81 3 6292
    ribosome biogenesis 9.6152E-3 34 346 6 6292

    Molecular Function Analysis

    Given the number of proteins in the complex (A), total proteins annotated with a given GO term (B), and the total number of annotated proteins (T); the p-value represents the chances of randomly having the number of proteins in the complex annotated with a specific GO term (I).

    Only showing terms with a p-value less than or equal to 0.01.

    GO Term

    P-value

    A

    B

    I

    T

    macromolecule transmembrane transporter activity 9.9648E-4 34 9 2 6292
    protein transmembrane transporter activity 9.9648E-4 34 9 2 6292
    trialkylsulfonium hydrolase activity 5.4037E-3 34 1 1 6292
    cystathionine beta-synthase activity 5.4037E-3 34 1 1 6292
    adenosylhomocysteinase activity 5.4037E-3 34 1 1 6292
    spermidine synthase activity 5.4037E-3 34 1 1 6292
    ribosomal large subunit binding 5.4037E-3 34 1 1 6292
    GTP cyclohydrolase activity 5.4037E-3 34 1 1 6292
    GTP cyclohydrolase I activity 5.4037E-3 34 1 1 6292
    translation initiation factor activity 9.142E-3 34 27 2 6292

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle