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A protein complex that possesses histone acetyltransferase activity. A complex having histone acetylase activity on chromatin, as well as ATPase, DNA helicase and structural DNA binding activities. The complex is thought to be involved in double-strand DNA break repair. Subunits of the human complex include HTATIP/TIP60, TRRAP, RUVBL1, BUVBL2, beta-actin and BAF53/ACTL6A. In yeast, the complex has 13 subunits, including the catalytic subunit Esa1 (homologous to human Tip60). A multisubunit complex that catalyzes the acetylation of histones H4 and H2A.

View Gene Ontology (GO) Term

GO TERM SUMMARY
Name: NuA4 histone acetyltransferase complex
Acc: GO:0035267
Aspect: Cellular Component
Desc: A complex having histone acetylase activity on chromatin, as well as ATPase, DNA helicase and structural DNA binding activities. The complex is thought to be involved in double-strand DNA break repair. Subunits of the human complex include HTATIP/TIP60, TRRAP, RUVBL1, BUVBL2, beta-actin and BAF53/ACTL6A. In yeast, the complex has 13 subunits, including the catalytic subunit Esa1 (homologous to human Tip60).
Synonyms:
  • TIP60 histone acetylase complex
  • TIP60 histone acetyltransferase complex
Proteins in PDR annotated with:
   This term: 59 [Search]
   Term or descendants: 59 [Search]


[geneontology.org]
INTERACTIVE GO GRAPH

GO:0035267 - NuA4 histone acetyltransferase complex (interactive image map)
YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle