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View Protein Complex Details

Complex Overview

Complex Member Proteins

Protein

GO Cellular Component GO Biological Process GO Molecular Function
BUD31
  • nucleus
  • RNA splicing
  • cellular bud site selection
  • molecular_function
  • CDC40
  • spliceosomal complex
  • nuclear mRNA branch site recognition
  • nuclear mRNA 3'-splice site recognition
  • second spliceosomal transesterification activity
  • CEF1
  • spliceosomal complex
  • nuclear mRNA splicing, via spliceosome
  • DNA binding
  • first spliceosomal transesterification activity
  • CLF1
  • chromatin
  • DNA replication
  • cell cycle
  • cis assembly of pre-catalytic spliceosome
  • nuclear mRNA splicing, via spliceosome
  • protein binding
  • CWC2
  • spliceosomal complex
  • nuclear mRNA splicing, via spliceosome
  • molecular_function
  • CWC22
  • spliceosomal complex
  • nuclear mRNA splicing, via spliceosome
  • molecular_function
  • CWC23
  • spliceosomal complex
  • biological_process
  • molecular_function
  • ECM2
  • nucleus
  • cellular cell wall organization
  • nuclear mRNA splicing, via spliceosome
  • molecular_function
  • HSH155
  • U2 snRNP
  • spliceosome assembly
  • mRNA binding
  • ISY1
  • spliceosomal complex
  • nuclear mRNA splicing, via spliceosome
  • second spliceosomal transesterification activity
  • first spliceosomal transesterification activity
  • LEA1
  • cytoplasm
  • U2 snRNP
  • telomere maintenance
  • nuclear mRNA splicing, via spliceosome
  • RNA binding
  • molecular_function
  • PRP19
  • nucleus
  • cytoplasm
  • mitochondrion
  • spliceosomal complex
  • nuclear mRNA splicing, via spliceosome
  • ubiquitin-dependent protein catabolic process
  • ubiquitin-protein ligase activity
  • first spliceosomal transesterification activity
  • RNA binding
  • PRP2
  • nucleus
  • spliceosomal complex
  • RNA splicing
  • generation of catalytic spliceosome for first transesterification step
  • mRNA processing
  • ATP-dependent RNA helicase activity
  • PRP21
  • U2 snRNP
  • nuclear mRNA splicing, via spliceosome
  • RNA binding
  • PRP22
  • spliceosomal complex
  • generation of catalytic spliceosome for second transesterification step
  • second spliceosomal transesterification activity
  • ATP-dependent RNA helicase activity
  • PRP43
  • mitochondrion
  • spliceosomal complex
  • nuclear outer membrane
  • maturation of SSU-rRNA
  • ribosomal large subunit biogenesis
  • ribosome biogenesis
  • rRNA processing
  • processing of 27S pre-rRNA
  • ATP-dependent RNA helicase activity
  • PRP45
  • nucleus
  • spliceosomal complex
  • positive regulation of transcription from RNA polymerase II promoter
  • nuclear mRNA splicing, via spliceosome
  • transcription activator activity
  • PRP46
  • spliceosomal complex
  • nuclear mRNA splicing, via spliceosome
  • molecular_function
  • RSE1
  • U2 snRNP
  • spliceosome assembly
  • nuclear mRNA splicing, via spliceosome
  • U2 snRNA binding
  • SMD2
  • U4/U6 x U5 tri-snRNP complex
  • U5 snRNP
  • U1 snRNP
  • nuclear mRNA splicing, via spliceosome
  • RNA binding
  • molecular_function
  • SNT309
  • spliceosomal complex
  • nuclear mRNA splicing, via spliceosome
  • protein binding
  • SNU114
  • U4/U6 x U5 tri-snRNP complex
  • U5 snRNP
  • generation of catalytic spliceosome for first transesterification step
  • nuclear mRNA splicing, via spliceosome
  • GTP binding
  • U5 snRNA binding
  • GTPase activity
  • SPP382
  • nucleus
  • cytoplasm
  • mitochondrion
  • spliceosomal complex
  • nuclear mRNA splicing, via spliceosome
  • RNA binding
  • STO1
  • commitment complex
  • nuclear cap binding complex
  • nuclear-transcribed mRNA catabolic process, nonsense-mediated decay
  • telomere maintenance
  • nuclear mRNA splicing, via spliceosome
  • mRNA binding
  • SYF1
  • spliceosomal complex
  • cell cycle
  • nuclear mRNA splicing, via spliceosome
  • molecular_function
  • Cellular Component Analysis

    Given the number of proteins in the complex (A), total proteins annotated with a given GO term (B), and the total number of annotated proteins (T); the p-value represents the chances of randomly having the number of proteins in the complex annotated with a specific GO term (I).

    Only showing terms with a p-value less than or equal to 0.01.

    GO Term

    P-value

    A

    B

    I

    T

    spliceosomal complex 4.4891E-30 25 45 16 6292
    ribonucleoprotein complex 1.3993E-21 25 514 22 6292
    nuclear part 2.5984E-14 25 1103 22 6292
    nucleus 2.9033E-11 25 2041 24 6292
    macromolecular complex 1.1811E-10 25 1635 22 6292
    organelle part 8.8641E-9 25 2282 23 6292
    intracellular organelle part 8.8641E-9 25 2282 23 6292
    small nuclear ribonucleoprotein complex 1.2068E-7 25 63 6 6292
    U2 snRNP 1.3533E-7 25 13 4 6292
    intracellular organelle 1.8147E-5 25 4070 25 6292
    organelle 1.8259E-5 25 4071 25 6292
    membrane-bounded organelle 4.7722E-5 25 3771 24 6292
    intracellular membrane-bounded organelle 4.7722E-5 25 3771 24 6292
    U5 snRNP 1.3396E-3 25 14 2 6292
    intracellular part 2.3087E-3 25 4938 25 6292
    intracellular 2.7836E-3 25 4975 25 6292
    U4/U6 x U5 tri-snRNP complex 6.989E-3 25 32 2 6292

    Biological Process Analysis

    Given the number of proteins in the complex (A), total proteins annotated with a given GO term (B), and the total number of annotated proteins (T); the p-value represents the chances of randomly having the number of proteins in the complex annotated with a specific GO term (I).

    Only showing terms with a p-value less than or equal to 0.01.

    GO Term

    P-value

    A

    B

    I

    T

    nuclear mRNA splicing, via spliceosome 3.9539E-38 25 99 22 6292
    RNA splicing, via transesterification reactions with bulged adenosine as nucleophile 5.0668E-38 25 100 22 6292
    RNA splicing 9.9285E-38 25 132 23 6292
    RNA splicing, via transesterification reactions 2.6681E-37 25 107 22 6292
    mRNA processing 2.2455E-33 25 156 22 6292
    mRNA metabolic process 3.1803E-30 25 213 22 6292
    RNA processing 6.5222E-29 25 380 24 6292
    RNA metabolic process 3.646E-19 25 954 24 6292
    gene expression 4.5341E-16 25 1283 24 6292
    nucleic acid metabolic process 4.7316E-15 25 1415 24 6292
    nucleobase, nucleoside, nucleotide and nucleic acid metabolic process 5.3353E-14 25 1566 24 6292
    cellular nitrogen compound metabolic process 9.8691E-13 25 1770 24 6292
    nitrogen compound metabolic process 1.3065E-12 25 1791 24 6292
    cellular macromolecule metabolic process 4.1889E-10 25 2285 24 6292
    macromolecule metabolic process 8.0334E-10 25 2349 24 6292
    ribonucleoprotein complex assembly 4.403E-8 25 92 7 6292
    primary metabolic process 1.0865E-7 25 2896 24 6292
    cellular metabolic process 3.185E-7 25 3033 24 6292
    spliceosome assembly 5.715E-7 25 18 4 6292
    metabolic process 8.0676E-7 25 3157 24 6292
    spliceosomal conformational changes to generate catalytic conformation 4.5831E-6 25 9 3 6292
    cellular macromolecular complex assembly 4.6689E-6 25 182 7 6292
    generation of catalytic spliceosome for first transesterification step 4.5363E-5 25 3 2 6292
    cellular macromolecular complex subunit organization 4.6915E-5 25 259 7 6292
    ribonucleoprotein complex biogenesis 6.3869E-5 25 374 8 6292
    macromolecular complex assembly 7.8951E-5 25 281 7 6292
    macromolecular complex subunit organization 3.5213E-4 25 357 7 6292
    cellular component assembly 5.5785E-4 25 385 7 6292
    cellular process 1.7226E-3 25 4426 24 6292
    cellular component biogenesis 4.1095E-3 25 694 8 6292
    nuclear mRNA 3'-splice site recognition 7.9314E-3 25 2 1 6292
    cis assembly of pre-catalytic spliceosome 7.9314E-3 25 2 1 6292

    Molecular Function Analysis

    Given the number of proteins in the complex (A), total proteins annotated with a given GO term (B), and the total number of annotated proteins (T); the p-value represents the chances of randomly having the number of proteins in the complex annotated with a specific GO term (I).

    Only showing terms with a p-value less than or equal to 0.01.

    GO Term

    P-value

    A

    B

    I

    T

    first spliceosomal transesterification activity 1.0998E-6 25 6 3 6292
    second spliceosomal transesterification activity 1.9197E-6 25 7 3 6292
    RNA binding 6.2822E-6 25 367 9 6292
    nucleic acid binding 1.227E-4 25 666 10 6292
    snRNA binding 1.5047E-4 25 5 2 6292
    ATP-dependent RNA helicase activity 1.7004E-4 25 28 3 6292
    RNA-dependent ATPase activity 1.8917E-4 25 29 3 6292
    RNA helicase activity 5.7439E-4 25 42 3 6292
    ATP-dependent helicase activity 8.5189E-4 25 48 3 6292
    purine NTP-dependent helicase activity 8.5189E-4 25 48 3 6292
    binding 1.9421E-3 25 1294 12 6292
    U2 snRNA binding 3.9733E-3 25 1 1 6292
    helicase activity 4.1292E-3 25 83 3 6292
    U5 snRNA binding 7.9314E-3 25 2 1 6292
    mRNA binding 8.3231E-3 25 35 2 6292

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle