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Protein Overview: BYE1

General Information:
Name(s) found: BYE1 / YKL005C [SGD]
Description(s) found:
Found 24 descriptions.
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  • Negative regulator of transcription elongation, contains a TFIIS-like domain and a PHD finger, multicopy suppressor of temperature-sensitive ess1 mutations, probably binds RNA polymerase II large subunit [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 594 amino acids

    Gene Ontology:
    Cellular Component: nucleus [TASLink to PubMed article]
    Biological Process: negative regulation of transcription from RNA polymerase II promoter [IGILink to PubMed article]
    Molecular Function: transcription elongation regulator activity [IGILink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSVRTSSRSN KGQNKYIEYL LQEETEAPKK KRTKKKVDSA IEKNKKSDSS QEPRKDTENV  60
   61 RTDEVDEADE GYVRCLCGAN NENYDAAEYS HGDMVQCDGC DTWQHIKCMT DGKDTIDGLM 120
  121 SEDSKYYCEL CDPSLYAHLE TSKEAEVSED EDYHDDVYKP VNDHDDNDAD VFLDEESPRK 180
  181 RKRSPDSAKG IHIKSKQVKK SNGSKKRNKS IDAAKSDTAE NEMPTRKDFE SEKEHKLRYN 240
  241 AEKMFSTLFS KFIVPETIEA KLYELPDGKD VISISQEFAH NLEEELYKAC LNVEFGTLDK 300
  301 IYTEKVRSLY SNLKDKKNLE LKAHVVEGKL PLNKLVNMNA SELANPDLQE FKEKRDKIIL 360
  361 ENFIVEVPDK PMYVKTHKGD ELIEDIAEPQ EDILYSKDSI RLHNIDSIDS DKSKIEQTHA 420
  421 ISKEPSPSTI INEESLNCAF LYPGLGLEFT GYLNYIGASQ KLRRDIFKEA IGDGKLYVEG 480
  481 RLPTTTAAPY LKEISCSRAI LVYQLFPSND SESKTTFADV VDSLENKGRI AGIKPKTRYE 540
  541 KDFYIVPSKG GEIPEILKDI LGSHNDERSE RFSRMKSDER TLFAFVVVKQ EFIH

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Krogan NJ, et al. (2006) BYE1 MLP2 NOC4 RIF1 TIF3

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..193] ORFEUS 8.12 Nuclear corepressor KAP-1 (TIF-1beta)
    2 View Details [194..254] deduced N/A No confident structure predictions are available.
    3 View Details [255..351] PSI-BLAST 16.30103 Elongation factor TFIIS domain 2
    4 View Details [352..422] MSA 1.049995 View MSA. No confident structure predictions are available.
    5 View Details [423..594] deduced N/A No confident structure predictions are available.

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • binding
    		•  2.93415748500038 bayes_pls_golite062009
  • transcription regulator activity
    		•  2.89424169822343 bayes_pls_golite062009
  • DNA binding
    		•  2.67786232715949 bayes_pls_golite062009
  • nucleic acid binding
    		•  2.6327300364647 bayes_pls_golite062009
  • transcription repressor activity
    		•  2.13907615882531 bayes_pls_golite062009
  • transcription factor activity
    		•  1.62385700361588 bayes_pls_golite062009
  • protein binding
    		•  1.42349040268084 bayes_pls_golite062009
  • chromatin binding
    		•  1.04248905371583 bayes_pls_golite062009
  • transcription activator activity
    		•  0.739132967687069 bayes_pls_golite062009
  • histone binding
    		•  0.34407565577548 bayes_pls_golite062009
  • sequence-specific DNA binding
    		•  0.0725773086825168 bayes_pls_golite062009
  • transcription factor binding
    		•  0.0538806851320555 bayes_pls_golite062009
    2 No functions predicted.
    3
    Term Confidence Notes
  • DNA binding
    		•  3.54473441396096 bayes_pls_golite062009
  • nucleic acid binding
    		•  3.48558304847931 bayes_pls_golite062009
  • transcription regulator activity
    		•  2.99210735079034 bayes_pls_golite062009
  • binding
    		•  2.41724497205118 bayes_pls_golite062009
  • sequence-specific DNA binding
    		•  2.05998863112202 bayes_pls_golite062009
  • promoter binding
    		•  1.83726450182234 bayes_pls_golite062009
  • transcription repressor activity
    		•  1.65986761464116 bayes_pls_golite062009
  • transcription activator activity
    		•  1.38544336130022 bayes_pls_golite062009
  • transcription factor activity
    		•  1.36469181687855 bayes_pls_golite062009
  • structure-specific DNA binding
    		•  1.10125855381509 bayes_pls_golite062009
  • protein binding
    		•  1.08484616730639 bayes_pls_golite062009
  • DNA-dependent ATPase activity
    		•  0.761344747515317 bayes_pls_golite062009
  • double-stranded DNA binding
    		•  0.72942170277234 bayes_pls_golite062009
  • transcription corepressor activity
    		•  0.594929844028595 bayes_pls_golite062009
  • DNA helicase activity
    		•  0.486136971288514 bayes_pls_golite062009
  • helicase activity
    		•  0.409609667937952 bayes_pls_golite062009
  • ATP-dependent DNA helicase activity
    		•  0.364602306790165 bayes_pls_golite062009
  • telomeric DNA binding
    		•  0.323407552453846 bayes_pls_golite062009
  • purine NTP-dependent helicase activity
    		•  0.311579649994958 bayes_pls_golite062009
  • ATP-dependent helicase activity
    		•  0.311579649994958 bayes_pls_golite062009
  • catalytic activity
    		•  0.284946544609129 bayes_pls_golite062009
  • transcription factor binding
    		•  0.147270026435341 bayes_pls_golite062009
    4 No functions predicted.
    5 No functions predicted.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.96

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle