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View Structure Prediction Details

Protein: BYE1
Organism: Saccharomyces cerevisiae
Length: 594 amino acids
Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for BYE1.

Description E-value Query
Range
Subject
Range
BYE1_YEAST - Transcription factor BYE1 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=BYE1 PE=1 SV=1
BYE1 - Negative regulator of transcription elongation, contains a TFIIS-like domain and a PHD finger, multi...
0.0 [1..594] [1..594]
gi|147904545, gi... - gi|147904545|ref|NP_001090166.1| transcription elongation factor XSII-K1 [Xenopus laevis], gi|108017...
5.0E-61 [5..390] [221..629]
gi|168278551 - gi|168278551|dbj|BAG11155.1| PHD finger protein 3 [synthetic construct]
PHF3 - PHD finger protein 3
4.0E-60 [15..439] [659..1119]
TCEA2_MOUSE - Transcription elongation factor A protein 2 OS=Mus musculus GN=Tcea2 PE=2 SV=2
3.0E-57 [141..390] [16..283]
gi|7507776 - gi|7507776|pir||T16867 probable cytochrome P450 T13C5.1 [similarity] - Caenorhabditis elegans
5.0E-57 [137..390] [13..287]
TCEA2_RAT - Transcription elongation factor A protein 2 OS=Rattus norvegicus GN=Tcea2 PE=2 SV=1
gi|712842 - gi|712842|dbj|BAA02310.1| transcription elongation factor S-II [Rattus sp.]
8.0E-57 [141..390] [16..283]

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Predicted Domain #1
Region A:
Residues: [1-193]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSVRTSSRSN KGQNKYIEYL LQEETEAPKK KRTKKKVDSA IEKNKKSDSS QEPRKDTENV  60
   61 RTDEVDEADE GYVRCLCGAN NENYDAAEYS HGDMVQCDGC DTWQHIKCMT DGKDTIDGLM 120
  121 SEDSKYYCEL CDPSLYAHLE TSKEAEVSED EDYHDDVYKP VNDHDDNDAD VFLDEESPRK 180
  181 RKRSPDSAKG IHI

[Run NCBI BLAST on this sequence.]

Detection Method: ORFEUS
Confidence: 8.12
Match: 1fp0A
Description: Nuclear corepressor KAP-1 (TIF-1beta)
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
binding 2.93415748500038 bayes_pls_golite062009
transcription regulator activity 2.89424169822343 bayes_pls_golite062009
DNA binding 2.67786232715949 bayes_pls_golite062009
nucleic acid binding 2.6327300364647 bayes_pls_golite062009
transcription repressor activity 2.13907615882531 bayes_pls_golite062009
transcription factor activity 1.62385700361588 bayes_pls_golite062009
protein binding 1.42349040268084 bayes_pls_golite062009
chromatin binding 1.04248905371583 bayes_pls_golite062009
transcription activator activity 0.739132967687069 bayes_pls_golite062009
histone binding 0.34407565577548 bayes_pls_golite062009
sequence-specific DNA binding 0.0725773086825168 bayes_pls_golite062009
transcription factor binding 0.0538806851320555 bayes_pls_golite062009

Predicted Domain #2
Region A:
Residues: [194-254]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 KSKQVKKSNG SKKRNKSIDA AKSDTAENEM PTRKDFESEK EHKLRYNAEK MFSTLFSKFI  60
   61 V

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #3
Region A:
Residues: [255-351]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 PETIEAKLYE LPDGKDVISI SQEFAHNLEE ELYKACLNVE FGTLDKIYTE KVRSLYSNLK  60
   61 DKKNLELKAH VVEGKLPLNK LVNMNASELA NPDLQEF

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 16.30103
Match: 1enwA_
Description: Elongation factor TFIIS domain 2
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
DNA binding 3.54473441396096 bayes_pls_golite062009
nucleic acid binding 3.48558304847931 bayes_pls_golite062009
transcription regulator activity 2.99210735079034 bayes_pls_golite062009
binding 2.41724497205118 bayes_pls_golite062009
sequence-specific DNA binding 2.05998863112202 bayes_pls_golite062009
promoter binding 1.83726450182234 bayes_pls_golite062009
transcription repressor activity 1.65986761464116 bayes_pls_golite062009
transcription activator activity 1.38544336130022 bayes_pls_golite062009
transcription factor activity 1.36469181687855 bayes_pls_golite062009
structure-specific DNA binding 1.10125855381509 bayes_pls_golite062009
protein binding 1.08484616730639 bayes_pls_golite062009
DNA-dependent ATPase activity 0.761344747515317 bayes_pls_golite062009
double-stranded DNA binding 0.72942170277234 bayes_pls_golite062009
transcription corepressor activity 0.594929844028595 bayes_pls_golite062009
DNA helicase activity 0.486136971288514 bayes_pls_golite062009
helicase activity 0.409609667937952 bayes_pls_golite062009
ATP-dependent DNA helicase activity 0.364602306790165 bayes_pls_golite062009
telomeric DNA binding 0.323407552453846 bayes_pls_golite062009
purine NTP-dependent helicase activity 0.311579649994958 bayes_pls_golite062009
ATP-dependent helicase activity 0.311579649994958 bayes_pls_golite062009
catalytic activity 0.284946544609129 bayes_pls_golite062009
transcription factor binding 0.147270026435341 bayes_pls_golite062009

Predicted Domain #4
Region A:
Residues: [352-422]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 KEKRDKIILE NFIVEVPDKP MYVKTHKGDE LIEDIAEPQE DILYSKDSIR LHNIDSIDSD  60
   61 KSKIEQTHAI S

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #5
Region A:
Residues: [423-594]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 KEPSPSTIIN EESLNCAFLY PGLGLEFTGY LNYIGASQKL RRDIFKEAIG DGKLYVEGRL  60
   61 PTTTAAPYLK EISCSRAILV YQLFPSNDSE SKTTFADVVD SLENKGRIAG IKPKTRYEKD 120
  121 FYIVPSKGGE IPEILKDILG SHNDERSERF SRMKSDERTL FAFVVVKQEF IH

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.


YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle