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Protein Overview: robo-PB

General Information:
Name(s) found: robo-PB / FBpp0071834 [FlyBase]
Description(s) found:
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  • gi|45551150|ref|NP_726224.2| roundabout, isoform B [Drosophila melanogaster] [NCBI NR]
  • gi|45445365|gb|AAM71113.2| roundabout, isoform B [Drosophila melanogaster] [NCBI NR]
  • The gene roundabout is referred to in FlyBase by the symbol Dmel\robo (CG13521, FBgn0005631). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 2R:18580029..18588467. It has the cytological map location 59A2-59A3. There is experimental evidence that it has the molecular function</span>: heparin binding; protein binding. There is experimental evidence for 11 unique biological process</span> terms, many of which group under: anatomical structure development; cellular component movement; cell projection organization; regulation of biological process; organ morphogenesis; organ development; neuron differentiation; neuromuscular process; locomotory behavior; response to external stimulus; entrainment of circadian clock. 41 alleles are reported. The phenotypes of these alleles are annotated with 44 unique terms, many of which group under: embryonic nervous system; multi-cell-component structure; nervous system; embryonic neuron; organ system; commissure; abdominal transverse muscle; peripheral nervous system; organ system subdivision; antennal segment. It has 2 annotated transcripts and 2 annotated polypeptides. [FlyBase]
  • (AAM71113) CG13521-PB [DrosMelano7227.FASTAC.txt]
  • CG13521-PB, isoform B [Drosophila melanogaster]gi|45551150|ref|NP_726224.2| CG13521-PB [Drosophila melanogaster] [nrdb_11152004_Chlamydomonas]
  • type=protein; loc=2R:complement(18582058..18582817,18582893..18583224,18583282..18583514,18583577..18583868,18583924..18584198,18584257..18584455,18584520..18584612,18584671..18584841,18584907..18584988,18585050..18585210,18585277..18585359,18585417..1858 [fly-100309-contam.fasta]
  • CG13521-PB, isoform B [Drosophila melanogaster] [nr-271106-contam.fasta]
  • roundabout CG13521-PB, isoform B [Drosophila melanogaster] [nr-271106-contam.fasta]
  • type=protein; loc=2R:complement(18582058..18582817,18582893..18583224,18583282..18583514,18583577..18583868,18583924..18584198,18584257..18584455,18584520..18584612,18584671..18584841,18584907..18584988,18585050..18585210,18585277..18585359,18585417..18585896,18585957..18586410,18586471..18586589,18586701..18586881,18587118..18587239,18587307..18587539,18587596..18587615); ID=FBpp0071834; name=robo-PB; parent=FBgn0005631,FBtr0071923; dbxref=GB_protein:AAM71113.1,FlyBase:FBpp0071834,FlyBase_Annotation_IDs:CG13521-PB,GB_protein:AAM71113.2,REFSEQ:NP_726224,GB_protein:AAM71113; MD5=c17b483a68d606625060df198aa450b8; length=1429; release=r5.16; species=Dmel; [fly-contam-His-TEV-Tub4complex.fasta]
  • type=protein; loc=2R:complement(18582058..18582817,18582893..18583224,18583282..18583514,18583577..18583868,18583924..18584198,18584257..18584455,18584520..18584612,18584671..18584841,18584907..18584988,18585050..18585210,18585277..18585359,18585417..18585896,18585957..18586410,18586471..18586589,18586701..18586881,18587118..18587239,18587307..18587539,18587596..18587615); ID=FBpp0071834; name=robo-PB; parent=FBgn0005631,FBtr0071923; dbxref=GB_protein:AAM71113.1,FlyBase:FBpp0071834,FlyBase_Annotation_IDs:CG13521-PB,GB_protein:AAM71113.2,REFSEQ:NP_726224,GB_protein:AAM71113; MD5=c17b483a68d606625060df198aa450b8; length=1429; release=r5.21; species=Dmel; [Other_drosophila_na_09-09-2009_reversed.fasta]
  • Roundabout, isoform B OS=Drosophila melanogaster GN=robo PE=2 SV=2 [UniProt_drosophila_07-01-2011_reversed.fasta]
  • type=protein; loc=2R:complement(18582058..18582817,18582893..18583224,18583282..18583514,18583577..18583868,18583924..18584198,18584257..18584455,18584520..18584612,18584671..18584841,18584907..18584988,18585050..18585210,18585277..18585359,18585417..18585896,18585957..18586410,18586471..18586589,18586701..18586881,18587118..18587239,18587307..18587539,18587596..18587615); ID=FBpp0071834; name=robo-PB; parent=FBgn0005631,FBtr0071923; dbxref=GB_protein:AAM71113.1,FlyBase:FBpp0071834,FlyBase_Annotation_IDs:CG13521-PB,GB_protein:AAM71113.2,REFSEQ:NP_726224,GB_protein:AAM71113,FlyMine:FBpp0071834,modMine:FBpp0071834; MD5=c17b483a68d606625060df198aa450b8; length=1429; release=r5.46; species=Dmel; [fly-062812-sfps-sandra-contam.fasta]
    • Organism: Drosophila melanogaster
    Length: 1429 amino acids

    Gene Ontology:
    Cellular Component: integral to plasma membrane [ISS]
    dendrite [IDA]
    vesicle [IDA]
    neuronal cell body [IDA]
    protein complex [IPI]
    plasma membrane [IDA]
    axon [IDA]
    Biological Process: positive regulation of cell-cell adhesion [IMP]
    neuron recognition [IMP]
    salivary gland boundary specification [IMP]
    axon guidance [IMP][TAS]
    brain morphogenesis [IGI]
    embryonic heart tube development [IMP]
    dendrite morphogenesis [TAS]
    epithelial cell migration, open tracheal system [TAS]
    locomotion involved in locomotory behavior [IMP]
    entrainment of circadian clock [IDA]
    startle response [IMP]
    axon midline choice point recognition [IMP][TAS]
    dendrite guidance [IMP]
    Molecular Function: protein binding [IPI]
    heparin binding [IDA]
    receptor activity [TAS]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MPPRLHMTQK QRQNDRRCIG SSVESSLQQH QHHKMHPMHP ENHAIARSTS TTNNPSRSRS  60
   61 SRMWLLPAWL LLVLVASNGL PAVRGQYQSP RIIEHPTDLV VKKNEPATLN CKVEGKPEPT 120
  121 IEWFKDGEPV STNEKKSHRV QFKDGALFFY RTMQGKKEQD GGEYWCVAKN RVGQAVSRHA 180
  181 SLQIAVLRDD FRVEPKDTRV AKGETALLEC GPPKGIPEPT LIWIKDGVPL DDLKAMSFGA 240
  241 SSRVRIVDGG NLLISNVEPI DEGNYKCIAQ NLVGTRESSY AKLIVQVKPY FMKEPKDQVM 300
  301 LYGQTATFHC SVGGDPPPKV LWKKEEGNIP VSRARILHDE KSLEISNITP TDEGTYVCEA 360
  361 HNNVGQISAR ASLIVHAPPN FTKRPSNKKV GLNGVVQLPC MASGNPPPSV FWTKEGVSTL 420
  421 MFPNSSHGRQ HVAADGTLQI TDVRQEDEGY YVCSAFSVVD SSTVRVFLQV SSLDERPPPI 480
  481 IQIGPANQTL PKGSVATLPC RATGNPSPRI KWFHDGHAVQ AGNRYSIIQG SSLRVDDLQL 540
  541 SDSGTYTCTA SGERGETSWA ATLTVEKPGS TSLHRAADPS TYPAPPGTPK VLNVSRTSIS 600
  601 LRWAKSQEKP GAVGPIIGYT VEYFSPDLQT GWIVAAQRVG DTQVTISGLT PGTSYVFLVR 660
  661 AENTQGISVP SGLSNTIKTI EADFDAASAN DLSAARTLLT GKSVELIDAS AINASAVRLE 720
  721 WMLHVSADEK YVEGLRIHYK DASVPSAQYH SITVMDASAE SFVVGNLKKY TKYEFFLTPF 780
  781 FETIEGQPSN SKTALTYEDV PSAPPDNIQI GMYNQTAGWV RWTPPPSQHH NGNLYGYKIE 840
  841 VSAGNTMKVL ANMTLNATTT SVLLNNLTTG AVYSVRLNSF TKAGDGPYSK PISLFMDPTH 900
  901 HVHPPRAHPS GTHDGRHEGQ DLTYHNNGNI PPGDINPTTH KKTTDYLSGP WLMVLVCIVL 960
  961 LVLVISAAIS MVYFKRKHQM TKELGHLSVV SDNEITALNI NSKESLWIDH HRGWRTADTD1020
 1021 KDSGLSESKL LSHVNSSQSN YNNSDGGTDY AEVDTRNLTT FYNCRKSPDN PTPYATTMII1080
 1081 GTSSSETCTK TTSISADKDS GTHSPYSDAF AGQVPAVPVV KSNYLQYPVE PINWSEFLPP1140
 1141 PPEHPPPSST YGYAQGSPES SRKSSKSAGS GISTNQSILN ASIHSSSSGG FSAWGVSPQY1200
 1201 AVACPPENVY SNPLSAVAGG TQNRYQITPT NQHPPQLPAY FATTGPGGAV PPNHLPFATQ1260
 1261 RHAASEYQAG LNAARCAQSR ACNSCDALAT PSPMQPPPPV PVPEGWYQPV HPNSHPMHPT1320
 1321 SSNHQIYQCS SECSDHSRSS QSHKRQLQLE EHGSSAKQRG GHHRRRAPVV QPCMESENEN1380
 1381 MLAEYEQRQY TSDCCNSSRE GDTCSCSEGS CLYAEAGEPA PRQMTAKNT

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..88] PSI-BLAST 61.39794 Axonin-1
    2 View Details [89..187] PSI-BLAST 43.522879 No description for 2v9qA was found.
    3 View Details [188..583] PSI-BLAST 41.39794 Hemolin
    4 View Details [584..647] PSI-BLAST 44.154902 No description for 2nziA was found.
    5 View Details [648..691] FFAS03 2.82 Solution Structure of the First Fibronectin Type III domain of human KIAA1568 Protein
    6 View Details [692..798] PSI-BLAST 10.522879 No description for 2edxA was found.
    7 View Details [799..993] PSI-BLAST 20.0 The solution structure of the third fibronectin type III domain of human Neogenin
    8 View Details [994..1157] deduced N/A No confident structure predictions are available.
    9 View Details [1158..1429] MSA 2.211984 View MSA. No confident structure predictions are available.

    Functions predicted (by domain):

    # Gene Ontology predictions
    1 No functions predicted.
    2 No functions predicted.
    3
    Term Confidence Notes
  • telethonin binding
    		•  6.64811984458494 bayes_pls_golite062009
  • alpha-actinin binding
    		•  5.77350124471385 bayes_pls_golite062009
  • actinin binding
    		•  5.69539760434923 bayes_pls_golite062009
  • structural constituent of muscle
    		•  4.93896503565413 bayes_pls_golite062009
  • binding
    		•  3.17641566810715 bayes_pls_golite062009
  • receptor activity
    		•  2.6260148704617 bayes_pls_golite062009
  • transmembrane receptor activity
    		•  2.26083981067854 bayes_pls_golite062009
  • molecular transducer activity
    		•  2.26075587783872 bayes_pls_golite062009
  • signal transducer activity
    		•  2.26075587783872 bayes_pls_golite062009
  • protein binding
    		•  2.22855404705168 bayes_pls_golite062009
  • fibroblast growth factor receptor activity
    		•  1.8360014271135 bayes_pls_golite062009
  • fibroblast growth factor 1 binding
    		•  1.70428381075539 bayes_pls_golite062009
  • antigen binding
    		•  1.63189745559168 bayes_pls_golite062009
  • cytoskeletal protein binding
    		•  1.58610597245454 bayes_pls_golite062009
  • actin binding
    		•  1.42681407553255 bayes_pls_golite062009
  • cell adhesion molecule binding
    		•  1.36789541796983 bayes_pls_golite062009
  • protein kinase activity
    		•  1.36635494500222 bayes_pls_golite062009
  • nucleic acid binding
    		•  1.32330470851159 bayes_pls_golite062009
  • DNA binding
    		•  1.19412627500732 bayes_pls_golite062009
  • myosin light chain kinase activity
    		•  1.17845072849922 bayes_pls_golite062009
  • transcription regulator activity
    		•  1.16252234499274 bayes_pls_golite062009
  • phosphotransferase activity, alcohol group as acceptor
    		•  1.02286631988334 bayes_pls_golite062009
  • fibroblast growth factor binding
    		•  0.955166176899348 bayes_pls_golite062009
  • kinase activity
    		•  0.929878054374821 bayes_pls_golite062009
  • transferase activity, transferring phosphorus-containing groups
    		•  0.878595022643164 bayes_pls_golite062009
  • olfactory receptor activity
    		•  0.76374091031142 bayes_pls_golite062009
  • actin filament binding
    		•  0.760856470721016 bayes_pls_golite062009
  • peptide antigen binding
    		•  0.75156669330877 bayes_pls_golite062009
  • IgG binding
    		•  0.68435857661103 bayes_pls_golite062009
  • myosin heavy chain binding
    		•  0.66378995104464 bayes_pls_golite062009
  • receptor binding
    		•  0.632627479346393 bayes_pls_golite062009
  • titin binding
    		•  0.599892148302011 bayes_pls_golite062009
  • integrin binding
    		•  0.599569390248921 bayes_pls_golite062009
  • structural molecule activity
    		•  0.567620977360967 bayes_pls_golite062009
  • protein serine/threonine kinase activity
    		•  0.564762108830441 bayes_pls_golite062009
  • transcription factor activity
    		•  0.54549168007511 bayes_pls_golite062009
  • G-protein coupled receptor activity
    		•  0.51084773288725 bayes_pls_golite062009
  • protein complex binding
    		•  0.43131084085213 bayes_pls_golite062009
  • protein tyrosine kinase activity
    		•  0.318890055375093 bayes_pls_golite062009
  • transmembrane receptor protein kinase activity
    		•  0.310661919610704 bayes_pls_golite062009
  • structural constituent of cytoskeleton
    		•  0.0579247757286607 bayes_pls_golite062009
  • transferase activity
    		•  0.053007146193305 bayes_pls_golite062009
  • transmembrane receptor protein tyrosine kinase activity
    		•  0.0182656128082201 bayes_pls_golite062009
    4 No functions predicted.
    5 No functions predicted.
    6 No functions predicted.
    7
    Term Confidence Notes
  • telethonin binding
    		•  5.81747667416248 bayes_pls_golite062009
  • structural constituent of muscle
    		•  5.71979489668015 bayes_pls_golite062009
  • alpha-actinin binding
    		•  4.57951951779666 bayes_pls_golite062009
  • actinin binding
    		•  4.57900103206288 bayes_pls_golite062009
  • receptor activity
    		•  3.28625508322269 bayes_pls_golite062009
  • transmembrane receptor activity
    		•  3.25570370343123 bayes_pls_golite062009
  • protein binding
    		•  3.24522318184038 bayes_pls_golite062009
  • binding
    		•  3.12471204223368 bayes_pls_golite062009
  • signal transducer activity
    		•  2.84396290475308 bayes_pls_golite062009
  • molecular transducer activity
    		•  2.84396290475308 bayes_pls_golite062009
  • cell adhesion molecule binding
    		•  2.32179186005318 bayes_pls_golite062009
  • cytokine binding
    		•  2.06262704705789 bayes_pls_golite062009
  • axon guidance receptor activity
    		•  2.01367445237355 bayes_pls_golite062009
  • cytoskeletal protein binding
    		•  1.85720106085239 bayes_pls_golite062009
  • growth factor binding
    		•  1.74816715186275 bayes_pls_golite062009
  • cytokine receptor activity
    		•  1.56546704499749 bayes_pls_golite062009
  • interleukin-6 binding
    		•  1.53073516901486 bayes_pls_golite062009
  • interleukin-6 receptor activity
    		•  1.53073516901486 bayes_pls_golite062009
  • myosin light chain kinase activity
    		•  1.49217960276915 bayes_pls_golite062009
  • protein kinase activity
    		•  1.42856560840953 bayes_pls_golite062009
  • nucleic acid binding
    		•  1.32813363771214 bayes_pls_golite062009
  • receptor binding
    		•  1.31676259534833 bayes_pls_golite062009
  • transcription regulator activity
    		•  1.31663344632755 bayes_pls_golite062009
  • actin binding
    		•  1.21472460452555 bayes_pls_golite062009
  • DNA binding
    		•  1.2006039770643 bayes_pls_golite062009
  • phosphotransferase activity, alcohol group as acceptor
    		•  1.15899955607967 bayes_pls_golite062009
  • transferase activity, transferring phosphorus-containing groups
    		•  1.12142142875217 bayes_pls_golite062009
  • kinase activity
    		•  1.11027658115625 bayes_pls_golite062009
  • structural molecule activity
    		•  0.94240190391222 bayes_pls_golite062009
  • protein dimerization activity
    		•  0.86564366658585 bayes_pls_golite062009
  • growth hormone receptor activity
    		•  0.840187286074179 bayes_pls_golite062009
  • ciliary neurotrophic factor receptor activity
    		•  0.71036287694215 bayes_pls_golite062009
  • protein serine/threonine kinase activity
    		•  0.703490254739121 bayes_pls_golite062009
  • kinase binding
    		•  0.65927255037265 bayes_pls_golite062009
  • enzyme binding
    		•  0.60195860585095 bayes_pls_golite062009
  • ankyrin binding
    		•  0.56921114104552 bayes_pls_golite062009
  • identical protein binding
    		•  0.564711394496051 bayes_pls_golite062009
  • transcription factor activity
    		•  0.557290274937694 bayes_pls_golite062009
  • transferase activity
    		•  0.432850266451294 bayes_pls_golite062009
  • structural constituent of cytoskeleton
    		•  0.40600177052491 bayes_pls_golite062009
  • protein kinase binding
    		•  0.405060010394646 bayes_pls_golite062009
  • peptide hormone binding
    		•  0.31580518221542 bayes_pls_golite062009
  • heparin binding
    		•  0.20390437111575 bayes_pls_golite062009
  • protein heterodimerization activity
    		•  0.1430595594485 bayes_pls_golite062009
  • transcription activator activity
    		•  0.135753557343301 bayes_pls_golite062009
  • actin filament binding
    		•  0.135484838710405 bayes_pls_golite062009
  • protein homodimerization activity
    		•  0.116391819218123 bayes_pls_golite062009
  • protease binding
    		•  0.10146157270108 bayes_pls_golite062009
  • integrin binding
    		•  0.0873424694168858 bayes_pls_golite062009
  • transcription factor binding
    		•  0.075900818564989 bayes_pls_golite062009
  • glycosaminoglycan binding
    		•  0.0645383199290401 bayes_pls_golite062009
  • oncostatin-M receptor activity
    		•  0.00424319283373897 bayes_pls_golite062009
  • leukemia inhibitory factor receptor activity
    		•  0.00424319283373897 bayes_pls_golite062009
    8 No functions predicted.
    9 No functions predicted.


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    [View Details]
    Source: Reynolds et al. 2008. Manuscript submitted Philius confidence legend
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