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Protein Overview: gi|149043899, gi...

General Information:
Name(s) found: gi|157820927 [NCBI NR]
gi|149043899 [NCBI NR]
Description(s) found:
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  • gi|157820927|ref|NP_001101097.1| sirtuin 1 [Rattus norvegicus] [NCBI NR]
  • gi|149043899|gb|EDL97350.1| sirtuin 1 ((silent mating type information regulation 2, homolog) 1 (S. cerevisiae) (predicted), isoform CRA_a [Rattus norvegicus] [NCBI NR]
  • sirtuin 1 ((silent mating type information regulation 2, homolog) 1 [Rattus norvegicus] [NCBI-RefSeq_multi-organisms_na_08-12-2008_con_reversed.fasta]
  • sirtuin 1 ((silent mating type information regulation 2, homolog) 1 (S. cerevisiae) (predicted), isoform CRA_a [Rattus norvegicus] [NCBI-RefSeq_multi-organisms_na_08-12-2008_con_reversed.fasta]
  • sirtuin 1 [Rattus norvegicus] [NCBI-RefSeq_human-rat_na_04-07-2009_con_reversed.fasta]
  • Tax_Id=10116 Gene_Symbol=Sirt1 sirtuin 1 [rat-ipi-250309-contam.fasta]
  • Sirtuin 1 ((Silent mating type information regulation 2, homolog) 1 (S. cerevisiae) (Predicted), isoform CRA_a) OS=Rattus norvegicus GN=Sirt1 [011711_HMR.fasta]
  • Sirtuin 1 ((Silent mating type information regulation 2, homolog) 1 (S. cerevisiae) (Predicted), isoform CRA_a) OS=Rattus norvegicus GN=Sirt1_predicted PE=4 SV=1 [UNIPROT_RAT_07-21-2011_reversed.fasta]
  • Sirtuin 1 ((Silent mating type information regulation 2, homolog) 1 (S. cerevisiae) (Predicted), isoform CRA_a) OS=Rattus norvegicus GN=Sirt1_predicted [120808_122_R_norvegicus.fasta]
    • Organism: Rattus norvegicus
    Length: 126 amino acids

    Gene Ontology:
    Cellular Component: nuclear envelope [UNKNOWN]
    nucleus [UNKNOWN][IDA]
    PML body [UNKNOWN]
    [NOT]cytoplasm [UNKNOWN]
    rDNA heterochromatin [UNKNOWN]
    nucleolus [UNKNOWN]
    cellular_component [ND]
    chromatin silencing complex [UNKNOWN]
    nucleoplasm [UNKNOWN]
    Biological Process: biological_process [ND]
    negative regulation of DNA damage response, signal transduction by p53 class mediator [UNKNOWN]
    spermatogenesis [UNKNOWN]
    establishment of chromatin silencing [UNKNOWN]
    maintenance of chromatin silencing [UNKNOWN]
    protein amino acid deacetylation [UNKNOWN][IDA][IEA]
    negative regulation of transcription factor activity [UNKNOWN]
    chromatin silencing [IEA]
    response to DNA damage stimulus [UNKNOWN]
    regulation of transcription [IEA]
    regulation of cell proliferation [UNKNOWN]
    ovulation from ovarian follicle [UNKNOWN]
    chromatin silencing at rDNA [UNKNOWN]
    negative regulation of transcription [UNKNOWN]
    negative regulation of helicase activity [UNKNOWN]
    positive regulation of chromatin silencing [UNKNOWN]
    regulation of protein import into nucleus, translocation [UNKNOWN]
    peptidyl-lysine deacetylation [UNKNOWN]
    histone deacetylation [UNKNOWN]
    response to nutrient levels [IEP]
    histone H3 deacetylation [IDA]
    Molecular Function: hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides [IEA]
    zinc ion binding [IEA]
    identical protein binding [UNKNOWN]
    protein C-terminus binding [UNKNOWN]
    molecular_function [ND]
    p53 binding [UNKNOWN]
    protein binding [UNKNOWN]
    NAD-dependent protein deacetylase activity [UNKNOWN]
    histone binding [UNKNOWN]
    deacetylase activity [UNKNOWN]
    transcription repressor activity [UNKNOWN]
    NAD-dependent histone deacetylase activity [UNKNOWN][IDA]
    NAD binding [IEA]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MIGTDPRTIL KDLLPETIPP PELDDMTLWQ IVINILSEPP KRKKRKDINT IEDAVKLLQE  60
   61 CKKIIVLTGA GVSVSCGIPD FRSRDGIYAR LAVDFPDLPD PQAMFDIEYF RKDPRPFFKF 120
  121 AKKKQH

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    SHOWING SINGLE HITS. [ Hide Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data



    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.98

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle