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Protein Overview: SAL1

General Information:
Name(s) found: SAL1 / YNL083W [SGD]
Description(s) found:
Found 18 descriptions.
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  • ADP/ATP transporter; member of the Ca2+-binding subfamily of mitochondrial carriers, with two EF-hand motifs; transport activity of either Sal1p or Pet9p is critical for viability; polymorphic in different S. cerevisiae strains [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 545 amino acids

    Gene Ontology:
    Cellular Component: mitochondrion [IDALink to PubMed article]
    mitochondrial inner membrane [ISSLink to PubMed article]
    Biological Process: transport [ISSLink to PubMed article]
    Molecular Function: calcium ion binding [IDALink to PubMed article]
    transporter activity [ISSLink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MLLKNCETDK QRDIRYACLF KELDVKGNGQ VTLDNLISAF EKNDHPLKGN DEAIKMLFTA  60
   61 MDVNKDSVVD LSDFKKYASN AESQIWNGFQ RIDLDHDGKI GINEINRYLS DLDNQSICNN 120
  121 ELNHELSNEK MNKFSRFFEW AFPKRKANIA LRGQASHKKN TDNDRSKKTT DSDLYVTYDQ 180
  181 WRDFLLLVPR KQGSRLHTAY SYFYLFNEDV DLSSEGDVTL INDFIRGFGF FIAGGISGVI 240
  241 SRTCTAPFDR LKVFLIARTD LSSILLNSKT DLLAKNPNAD INKISSPLAK AVKSLYRQGG 300
  301 IKAFYVGNGL NVIKVFPESS IKFGSFEVTK KIMTKLEGCR DTKDLSKFST YIAGGLAGMA 360
  361 AQFSVYPIDT LKFRVQCAPL DTKLKGNNLL FQTAKDMFRE GGLRLFYRGV TVGIVGIFPY 420
  421 AALDLGTFSA LKKWYIAKQA KTLNLPQDQV TLSNLVVLPM GAFSGTVGAS VVYPINLLRT 480
  481 RLQAQGTYAH PYVYNGFKDV LLKTLEREGY QGLFKGLVPT LAKVCPAVSI SYLCYENLKK 540
  541 FMNLE

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run MLP2 #24 Asynchronous Prep3-TiO2 Phosphopeptide enrichment Keck JM, et al. (2011)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

      PROTEIN(S) PUBLICATION
    View Data SAL1 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..156] PSI-BLAST 29.0 Calmodulin
    2 View Details [157..219] FFAS03 0.992 Structure of calmodulin bound to a calcineurin peptide: a new way of making an old binding mode
    3 View Details [220..545] PSI-BLAST 78.221849 structure of mitochondrial ADP/ATP carrier in complex with carboxyatractyloside

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • binding
    		•  2.74623080162785 bayes_pls_golite062009
  • metal ion transmembrane transporter activity
    		•  2.61874575467092 bayes_pls_golite062009
  • ion transmembrane transporter activity
    		•  2.57032504567157 bayes_pls_golite062009
  • cation transmembrane transporter activity
    		•  2.55650624542181 bayes_pls_golite062009
  • substrate-specific transmembrane transporter activity
    		•  2.37465721152046 bayes_pls_golite062009
  • cation channel activity
    		•  1.49312394054212 bayes_pls_golite062009
  • calcium ion binding
    		•  1.40919295397643 bayes_pls_golite062009
  • molecular transducer activity
    		•  1.38521870126745 bayes_pls_golite062009
  • signal transducer activity
    		•  1.38521870126745 bayes_pls_golite062009
  • potassium channel activity
    		•  1.3851218799514 bayes_pls_golite062009
  • ion binding
    		•  1.36376383271837 bayes_pls_golite062009
  • metal ion binding
    		•  1.34827363853601 bayes_pls_golite062009
  • cation binding
    		•  1.34827363853601 bayes_pls_golite062009
  • voltage-gated potassium channel activity
    		•  1.30851580400009 bayes_pls_golite062009
  • structural molecule activity
    		•  1.26857768455914 bayes_pls_golite062009
  • transcription regulator activity
    		•  1.22886396511326 bayes_pls_golite062009
  • protein binding
    		•  1.16246005294206 bayes_pls_golite062009
  • transporter activity
    		•  1.15928534291452 bayes_pls_golite062009
  • channel activity
    		•  1.05847414989139 bayes_pls_golite062009
  • passive transmembrane transporter activity
    		•  1.05847414989139 bayes_pls_golite062009
  • ion channel activity
    		•  1.0369591011376 bayes_pls_golite062009
  • substrate-specific channel activity
    		•  1.03529144716694 bayes_pls_golite062009
  • voltage-gated cation channel activity
    		•  0.986621437232479 bayes_pls_golite062009
  • transmembrane transporter activity
    		•  0.945691505472547 bayes_pls_golite062009
  • voltage-gated ion channel activity
    		•  0.910148857310729 bayes_pls_golite062009
  • voltage-gated channel activity
    		•  0.896351900356978 bayes_pls_golite062009
  • gated channel activity
    		•  0.855502499003241 bayes_pls_golite062009
  • nucleic acid binding
    		•  0.849623084382492 bayes_pls_golite062009
  • DNA binding
    		•  0.81633153359201 bayes_pls_golite062009
  • cytoskeletal protein binding
    		•  0.75057755360417 bayes_pls_golite062009
  • amine transmembrane transporter activity
    		•  0.717054504236607 bayes_pls_golite062009
  • substrate-specific transporter activity
    		•  0.693724160233023 bayes_pls_golite062009
    		• 0.34446792626966 bayes_pls_golite062009
  • channel regulator activity
    		•  0.32809521759917 bayes_pls_golite062009
  • protein complex binding
    		•  0.278602833762221 bayes_pls_golite062009
  • active transmembrane transporter activity
    		•  0.246383459363256 bayes_pls_golite062009
  • structural constituent of muscle
    		•  0.23313435855689 bayes_pls_golite062009
  • motor activity
    		•  0.0886596083402598 bayes_pls_golite062009
  • transcription factor binding
    		•  0.02456682442567 bayes_pls_golite062009
    2 No functions predicted.
    3 No functions predicted.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    [View Details]
    Source: Reynolds et al. 2008. Manuscript submitted Philius confidence legend
    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle