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Protein Overview: M3K3_ARATH

General Information:
Name(s) found: M3K3_ARATH [Swiss-Prot]
Description(s) found:
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  • gi|7658341|gb|AAF66131.1| NPK1-related protein kinase 3; 8286-4476 [Arabidopsis thaliana] [NCBI NR]
  • gi|46576859|sp|O22042.1|M3K3_ARATH RecName: Full=Mitogen-activated protein kinase kinase kinase 3; AltName: Full=Arabidopsis NPK1-related protein kinase 3 [NCBI NR]
  • gi|24111309|gb|AAN46778.1| At3g06030/F24F17_1 [Arabidopsis thaliana] [NCBI NR]
  • gi|2342427|dbj|BAA21857.1| NPK1-related protein kinase 3 [Arabidopsis thaliana] [NCBI NR]
  • gi|17979012|gb|AAL47465.1| AT3g06030/F24F17_1 [Arabidopsis thaliana] [NCBI NR]
  • gi|15230612|ref|NP_187254.1| ANP3 (ARABIDOPSIS NPK1-RELATED PROTEIN KINASE 3); ATP binding / kinase/ protein kinase/ protein serine/threonine kinase [Arabidopsis thaliana] [NCBI NR]
  • Mitogen-activated protein kinase kinase kinase 3 OS=Arabidopsis thaliana GN=ANP3 PE=1 SV=1 [Swiss-Prot]
  • (O22042) NPK1-related protein kinase 3 (AT3g06030/F24F17_1) [athaliana3702.FASTAC.txt]
  • At3g06030/F24F17_1 [Arabidopsis thaliana]gi|2342427|dbj|BAA21857.1| NPK1-related protein kinase 3 [Arabidopsis thaliana]gi|17979012|gb|AAL47465.1| AT3g06030/F24F17_1 [Arabidopsis thaliana]gi|46576859|sp|O22042|M3K3_ARATH Mitogen-activated protein kinas [nrdb_11152004_Chlamydomonas]
  • Tax_Id=3702 Mitogen-activated protein kinase kinase kinase 3 [EBI-IPI_Arabidopsis_3.11_12-06-2005_reversed.fasta]
  • | Symbols: MAPKKK12, ANP3 | ANP3 (Arabidopsis NPK1-related protein kinase 3); kinase | chr3:1818901-1822711 REVERSE [TAIR_Arabidopsis_na_04-12-2008_con_reversed.fasta]
  • Mitogen-activated protein kinase kinase kinase 3 (Arabidopsis NPK1-related protein kinase 3) [nr-271106-contam.fasta]
  • At3g06030/F24F17_1 [Arabidopsis thaliana] [nr-271106-contam.fasta]
  • AT3g06030/F24F17_1 [Arabidopsis thaliana] [nr-271106-contam.fasta]
  • ANP3; ATP binding / kinase/ protein kinase/ protein serine/threonine kinase/ protein-tyrosine kinase [Arabidopsis thaliana] [nr-271106-contam.fasta]
  • NPK1-related protein kinase 3 [Arabidopsis thaliana] [nr-271106-contam.fasta]
  • NPK1-related protein kinase 3; 8286-4476 [Arabidopsis thaliana] [nr-271106-contam.fasta]
  • | Symbols: ANP3, MAPKKK12, NP3 | NPK1-related protein kinase 3 | chr3:1818895-1822705 REVERSE LENGTH=651 [TAIR_A_Thaliana_10_12-14-2010_reversed.fasta]
    • Organism: Arabidopsis thaliana
    Length: 651 amino acids

    Gene Ontology:
    Cellular Component: apoplast [IDA]
    Biological Process: cortical microtubule organization [IMP]
    Molecular Function: ATP binding [IEA]
    protein kinase activity [IEA]
    protein serine/threonine kinase activity [IEA]
    kinase activity [ISS]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MQDILGSVRR SLVFRSSLAG DDGTSGGGLS GFVGKINSSI RSSRIGLFSK PPPGLPAPRK  60
   61 EEAPSIRWRK GELIGCGAFG RVYMGMNLDS GELLAIKQVL IAPSSASKEK TQGHIRELEE 120
  121 EVQLLKNLSH PNIVRYLGTV RESDSLNILM EFVPGGSISS LLEKFGSFPE PVIIMYTKQL 180
  181 LLGLEYLHNN GIMHRDIKGA NILVDNKGCI RLADFGASKK VVELATVNGA KSMKGTPYWM 240
  241 APEVILQTGH SFSADIWSVG CTVIEMATGK PPWSEQYQQF AAVLHIGRTK AHPPIPEDLS 300
  301 PEAKDFLMKC LHKEPSLRLS ATELLQHPFV TGKRQEPYPA YRNSLTECGN PITTQGMNVR 360
  361 SSINSLIRRS TCSGLKDVCE LGSLRSSIIY PQKSNNSGFG WRDGDSDDLC QTDMDDLCNI 420
  421 ESVRNNVLSQ STDLNKSFNP MCDSTDNWSC KFDESPKVMK SKSNLLSYQA SQLQTGVPCD 480
  481 EETSLTFAGG SSVAEDDYKG TELKIKSFLD EKAQDLKRLQ TPLLEEFHNA MNPGIPQGAL 540
  541 GDTNIYNLPN LPSISKTPKR LPSRRLSAIS DAMPSPLKSS KRTLNTSRVM QSGTEPTQVN 600
  601 ESTKKGVNNS RCFSEIRRKW EEELYEELER HRENLRHAGA GGKTPLSGHK G

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..344] PSI-BLAST 61.39794 No description for 2j51A was found.
    2 View Details [345..445] deduced N/A No confident structure predictions are available.
    3 View Details [446..491] deduced N/A No confident structure predictions are available.
    4 View Details [492..651] deduced N/A No confident structure predictions are available.

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • phosphotransferase activity, alcohol group as acceptor
    		•  5.49988294224815 bayes_pls_golite062009
  • protein kinase activity
    		•  5.4586557943719 bayes_pls_golite062009
  • kinase activity
    		•  5.3287080791198 bayes_pls_golite062009
  • transferase activity, transferring phosphorus-containing groups
    		•  4.96052051118534 bayes_pls_golite062009
  • cyclin-dependent protein kinase activity
    		•  4.62392503670521 bayes_pls_golite062009
  • protein serine/threonine kinase activity
    		•  4.46381887831481 bayes_pls_golite062009
  • transferase activity
    		•  3.97138602499442 bayes_pls_golite062009
  • phosphoinositide 3-kinase binding
    		•  2.79505438761262 bayes_pls_golite062009
  • binding
    		•  2.74863538127007 bayes_pls_golite062009
  • protein binding
    		•  2.276111749106 bayes_pls_golite062009
  • ATP binding
    		•  1.97600611746091 bayes_pls_golite062009
  • adenyl ribonucleotide binding
    		•  1.93596671856664 bayes_pls_golite062009
  • cation transmembrane transporter activity
    		•  1.93176092222748 bayes_pls_golite062009
  • adenyl nucleotide binding
    		•  1.90928021591891 bayes_pls_golite062009
  • ion transmembrane transporter activity
    		•  1.90354666768303 bayes_pls_golite062009
  • telethonin binding
    		•  1.75733591474207 bayes_pls_golite062009
  • substrate-specific transmembrane transporter activity
    		•  1.71452519680794 bayes_pls_golite062009
  • purine ribonucleotide binding
    		•  1.65732943334212 bayes_pls_golite062009
  • ribonucleotide binding
    		•  1.65726906484847 bayes_pls_golite062009
  • purine nucleotide binding
    		•  1.63763394711025 bayes_pls_golite062009
  • nucleotide binding
    		•  1.63195828048121 bayes_pls_golite062009
  • insulin receptor substrate binding
    		•  1.62657794525303 bayes_pls_golite062009
  • general RNA polymerase II transcription factor activity
    		•  1.6084489855403 bayes_pls_golite062009
  • transcription regulator activity
    		•  1.56748951434625 bayes_pls_golite062009
  • protein tyrosine kinase activity
    		•  1.3898059094397 bayes_pls_golite062009
  • receptor signaling protein serine/threonine kinase activity
    		•  1.38496328649031 bayes_pls_golite062009
  • DNA binding
    		•  1.35333135345112 bayes_pls_golite062009
  • receptor signaling protein activity
    		•  1.27291233344322 bayes_pls_golite062009
  • metal ion transmembrane transporter activity
    		•  1.27184436658773 bayes_pls_golite062009
  • insulin receptor activity
    		•  1.22442673174261 bayes_pls_golite062009
  • catalytic activity
    		•  1.21655087018101 bayes_pls_golite062009
  • nucleic acid binding
    		•  1.16049201286103 bayes_pls_golite062009
  • cytoskeletal protein binding
    		•  1.1208666000428 bayes_pls_golite062009
  • transcription factor activity
    		•  1.10928254946881 bayes_pls_golite062009
  • transcription activator activity
    		•  0.997272622653026 bayes_pls_golite062009
  • PTB domain binding
    		•  0.9900774724568 bayes_pls_golite062009
  • alpha-actinin binding
    		•  0.877087652539674 bayes_pls_golite062009
  • insulin-like growth factor receptor binding
    		•  0.872782211382796 bayes_pls_golite062009
  • insulin binding
    		•  0.614254468447749 bayes_pls_golite062009
  • transporter activity
    		•  0.595111702412257 bayes_pls_golite062009
  • tubulin binding
    		•  0.488928950975855 bayes_pls_golite062009
  • protein serine/threonine/tyrosine kinase activity
    		•  0.48345772948903 bayes_pls_golite062009
  • actin binding
    		•  0.464111806616899 bayes_pls_golite062009
  • protein kinase C activity
    		•  0.41587987561486 bayes_pls_golite062009
  • transmembrane transporter activity
    		•  0.41384976209545 bayes_pls_golite062009
  • magnesium ion binding
    		•  0.393328812780268 bayes_pls_golite062009
  • MAP kinase kinase kinase activity
    		•  0.37115026509016 bayes_pls_golite062009
  • MAP kinase kinase activity
    		•  0.35402045013148 bayes_pls_golite062009
  • protein complex binding
    		•  0.343240719858581 bayes_pls_golite062009
  • signal transducer activity
    		•  0.270054246024761 bayes_pls_golite062009
  • molecular transducer activity
    		•  0.270054246024761 bayes_pls_golite062009
  • insulin receptor binding
    		•  0.266450215230107 bayes_pls_golite062009
  • cation channel activity
    		•  0.245400615103891 bayes_pls_golite062009
  • SH2 domain binding
    		•  0.226760162354251 bayes_pls_golite062009
  • microtubule binding
    		•  0.196718452862042 bayes_pls_golite062009
  • substrate-specific transporter activity
    		•  0.0922946791401962 bayes_pls_golite062009
  • MAP kinase activity
    		•  0.08504542461349 bayes_pls_golite062009
  • transmembrane receptor protein kinase activity
    		•  0.0556163711947139 bayes_pls_golite062009
  • transmembrane receptor activity
    		•  0.00652065412910241 bayes_pls_golite062009
  • nucleoside-triphosphatase activity
    		•  0.0040394359628233 bayes_pls_golite062009
    2 No functions predicted.
    3 No functions predicted.
    4 No functions predicted.


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.89

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle