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Protein Overview: HACL_ARATH

General Information:
Name(s) found: HACL_ARATH [Swiss-Prot]
Description(s) found:
Found 14 descriptions.
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  • 2-hydroxyacyl-CoA lyase OS=Arabidopsis thaliana GN=HACL PE=1 SV=1 [Swiss-Prot]
    • Organism: Arabidopsis thaliana
    Length: 572 amino acids

    Gene Ontology:
    Cellular Component: cellular_component [ND]
    Biological Process: NONE FOUND
    Molecular Function: thiamin pyrophosphate binding [IEA]
    magnesium ion binding [IEA]
    pyruvate decarboxylase activity [ISS]
    catalytic activity [IEA]
    transferase activity [IEA]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MADKSETTPP SIDGNVLVAK SLSHLGVTHM FGVVGIPVTS LASRAMALGI RFIAFHNEQS  60
   61 AGYAASAYGY LTGKPGILLT VSGPGCVHGL AGLSNAWVNT WPMVMISGSC DQRDVGRGDF 120
  121 QELDQIEAVK AFSKLSEKAK DVREIPDCVS RVLDRAVSGR PGGCYLDIPT DVLRQKISES 180
  181 EADKLVDEVE RSRKEEPIRG SLRSEIESAV SLLRKAERPL IVFGKGAAYS RAEDELKKLV 240
  241 EITGIPFLPT PMGKGLLPDT HEFSATAARS LAIGKCDVAL VVGARLNWLL HFGESPKWDK 300
  301 DVKFILVDVS EEEIELRKPH LGIVGDAKTV IGLLNREIKD DPFCLGKSNS WVESISKKAK 360
  361 ENGEKMEIQL AKDVVPFNFL TPMRIIRDAI LAVEGPSPVV VSEGANTMDV GRSVLVQKEP 420
  421 RTRLDAGTWG TMGVGLGYCI AAAVASPDRL VVAVEGDSGF GFSAMEVETL VRYNLAVVII 480
  481 VFNNGGVYGG DRRGPEEISG PHKEDPAPTS FVPNAGYHKL IEAFGGKGYI VETPDELKSA 540
  541 LAESFAARKP AVVNVIIDPF AGAESGRLQH KN

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    SHOWING SINGLE HITS. [ Hide Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..572] PSI-BLAST 98.0 CRYSTAL STRUCTURE OF OXALYL-COA DECARBOXYLASE IN COMPLEX WITH THE COFACTOR DERIVATIVE THIAMIN-2-THIAZOLONE DIPHOSPHATE AND ADENOSINE DIPHOSPHATE

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • acetolactate synthase activity
    		•  12.903449876837 bayes_pls_golite062009
  • transferase activity, transferring aldehyde or ketonic groups
    		•  12.3239025230705 bayes_pls_golite062009
  • pyruvate dehydrogenase activity
    		•  5.28857071459273 bayes_pls_golite062009
  • oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
    		•  5.21233670052586 bayes_pls_golite062009
  • pyruvate dehydrogenase (acetyl-transferring) activity
    		•  5.08663245333808 bayes_pls_golite062009
  • transketolase activity
    		•  2.50501741089295 bayes_pls_golite062009
  • catalytic activity
    		•  2.25537597692103 bayes_pls_golite062009
  • oxidoreductase activity, acting on the aldehyde or oxo group of donors
    		•  2.15444163802756 bayes_pls_golite062009
  • hydrogen ion transmembrane transporter activity
    		•  1.98546381612935 bayes_pls_golite062009
  • thiamin pyrophosphate binding
    		•  1.87247313698582 bayes_pls_golite062009
  • oxidoreductase activity
    		•  1.85833680148029 bayes_pls_golite062009
  • monovalent inorganic cation transmembrane transporter activity
    		•  1.82969293063325 bayes_pls_golite062009
  • 3-methyl-2-oxobutanoate dehydrogenase (2-methylpropanoyl-transferring) activity
    		•  1.65348126142808 bayes_pls_golite062009
  • deoxyhypusine synthase activity
    		•  1.46517585302326 bayes_pls_golite062009
  • alpha-ketoacid dehydrogenase activity
    		•  1.20517690263403 bayes_pls_golite062009
  • inorganic cation transmembrane transporter activity
    		•  1.0611726850452 bayes_pls_golite062009
  • oxidoreductase activity, acting on NADH or NADPH
    		•  0.982646671777 bayes_pls_golite062009
  • binding
    		•  0.980920092099572 bayes_pls_golite062009
  • histone deacetylase activity
    		•  0.9493052849746 bayes_pls_golite062009
  • protein deacetylase activity
    		•  0.942714095508542 bayes_pls_golite062009
  • transcription regulator activity
    		•  0.872247149132548 bayes_pls_golite062009
  • NAD-dependent histone deacetylase activity
    		•  0.86895852396873 bayes_pls_golite062009
  • NAD-dependent protein deacetylase activity
    		•  0.86895852396873 bayes_pls_golite062009
  • cation transmembrane transporter activity
    		•  0.78591260444574 bayes_pls_golite062009
  • nucleic acid binding
    		•  0.625412573920025 bayes_pls_golite062009
  • DNA binding
    		•  0.56819169389651 bayes_pls_golite062009
  • hydrolase activity
    		•  0.536729211484905 bayes_pls_golite062009
  • ion transmembrane transporter activity
    		•  0.51426028502998 bayes_pls_golite062009
  • transferase activity
    		•  0.413024577830522 bayes_pls_golite062009
  • deacetylase activity
    		•  0.34210759801484 bayes_pls_golite062009
  • pyruvate decarboxylase activity
    		•  0.198062360371269 bayes_pls_golite062009
  • hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds
    		•  0.114062221123972 bayes_pls_golite062009
  • transcription factor binding
    		•  0.0144694403853303 bayes_pls_golite062009


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    [View Details]
    Source: Reynolds et al. 2008. Manuscript submitted Philius confidence legend
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