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Protein Overview: DHBF_BACSU

General Information:
Name(s) found: DHBF_BACSU [Swiss-Prot]
Description(s) found:
Found 7 descriptions.
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  • Dimodular nonribosomal peptide synthetase OS=Bacillus subtilis GN=dhbF PE=1 SV=3 [Swiss-Prot]
    • Organism: Bacillus subtilis
    Length: 2378 amino acids

    Gene Ontology:
    Cellular Component: NONE FOUND
    Biological Process: NONE FOUND
    Molecular Function: NONE FOUND


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MPDTKDLQYS LTGAQTGIWF AQQLDPDNPI YNTAEYIEIN GPVNIALFEE ALRHVIKEAE  60
   61 SLHVRFGENM DGPWQMINPS PDVQLHVIDV SSEPDPEKTA LNWMKADLAK PVDLGYAPLF 120
  121 NEALFIAGPD RFFWYQRIHH IAIDGFGFSL IAQRVASTYT ALIKGQTAKS RSFGSLQAIL 180
  181 EEDTDYRGSE QYEKDRQFWL DRFADAPEVV SLADRAPRTS NSFLRHTAYL PPSDVNALKE 240
  241 AARYFSGSWH EVMIAVSAVY VHRMTGSEDV VLGLPMMGRI GSASLNVPAM VMNLLPLRLT 300
  301 VSSSMSFSEL IQQISREIRS IRRHHKYRHE ELRRDLKLIG ENHRLFGPQI NLMPFDYGLD 360
  361 FAGVRGTTHN LSAGPVDDLS INVYDRTDGS GLRIDVDANP EVYSESDIKL HQQRILQLLQ 420
  421 TASAGEDMLI GQMELLLPEE KEKVISKWNE TAKSEKLVSL QDMFEKQAVL TPERIALMCD 480
  481 DIQVNYRKLN EEANRLARLL IEKGIGPEQF VALALPRSPE MVASMLGVLK TGAAYLPLDP 540
  541 EFPADRISYM LEDAKPSCII TTEEIAASLP DDLAVPELVL DQAVTQEIIK RYSPENQDVS 600
  601 VSLDHPAYII YTSGSTGRPK GVVVTQKSLS NFLLSMQEAF SLGEEDRLLA VTTVAFDISA 660
  661 LELYLPLISG AQIVIAKKET IREPQALAQM IENFDINIMQ ATPTLWHALV TSEPEKLRGL 720
  721 RVLVGGEALP SGLLQELQDL HCSVTNLYGP TETTIWSAAA FLEEGLKGVP PIGKPIWNTQ 780
  781 VYVLDNGLQP VPPGVVGELY IAGTGLARGY FHRPDLTAER FVADPYGPPG TRMYRTGDQA 840
  841 RWRADGSLDY IGRADHQIKI RGFRIELGEI DAVLANHPHI EQAAVVVRED QPGDKRLAAY 900
  901 VVADAAIDTA ELRRYMGASL PDYMVPSAFV EMDELPLTPN GKLDRKALPA PDFSTSVSDR 960
  961 APRTPQEEIL CDLFAEVLGL ARVGIDDSFF ELGGHSLLAA RLMSRIREVM GAELGIAKLF1020
 1021 DEPTVAGLAA HLDLAQSACP ALQRAERPEK IPLSFAQRRL WFLHCLEGPS PTYNIPVAVR1080
 1081 LSGELDQGLL KAALYDLVCR HESLRTIFPE SQGTSYQHIL DADRACPELH VTEIAEKELS1140
 1141 DRLAEAVRYS FDLAAEPAFR AELFVIGPDE YVLLLLVHHI VGDGWSLTPL TRDLGTAYAA1200
 1201 RCHGRSPEWA PLAVQYADYA LWQQELLGNE DDPNSLIAGQ LAFWKETLKN LPDQLELPTD1260
 1261 YSRPAEPSHD GDTIHFRIEP EFHKRLQELA RANRVSLFMV LQSGLAALLT RLGAGTDIPI1320
 1321 GSPIAGRNDD ALGDLVGLFI NTLVLRTDTS GDPSFRELLD RVREVNLAAY DNQDLPFERL1380
 1381 VEVLNPARSR ATHPLFQIML AFQNTPDAEL HLPDMESSLR INSVGSAKFD LTLEISEDRL1440
 1441 ADGTPNGMEG LLEYSTDLFK RETAQALADR LMRLLEAAES DPDEQIGNLD ILAPEEHSSM1500
 1501 VTDWQSVSEK IPHACLPEQF EKQAALRPDA IAVVYENQEL SYAELNERAN RLARMMISEG1560
 1561 VGPEQFVALA LPRSLEMAVG LLAVLKAGAA YLPLDPDYPA DRIAFMLKDA QPAFIMTNTK1620
 1621 AANHIPPVEN VPKIVLDDPE LAEKLNTYPA GNPKNKDRTQ PLSPLNTAYV IYTSGSTGVP1680
 1681 KGVMIPHQNV TRLFAATEHW FRFSSGDIWT MFHSYAFDFS VWEIWGPLLH GGRLVIVPHH1740
 1741 VSRSPEAFLR LLVKEGVTVL NQTPSAFYQF MQAEREQPDL GQALSLRYVI FGGEALELSR1800
 1801 LEDWYNRHPE NRPQLINMYG ITETTVHVSY IELDRSMAAL RANSLIGCGI PDLGVYVLDE1860
 1861 RLQPVPPGVA GELYVSGAGL ARGYLGRPGL TSERFIADPF GPPGTRMYRT GDVARLRADG1920
 1921 SLDYVGRADH QVKIRGFRIE LGEIEAALVQ HPQLEDAAVI VREDQPGDKR LAAYVIPSEE1980
 1981 TFDTAELRRY AAERLPDYMV PAAFVTMKEL PLTPNGKLDR KALPAPDFAA AVTGRGPRTP2040
 2041 QEEILCDLFM EVLHLPRVGI DDRFFDLGGH SLLAVQLMSR IREALGVELS IGNLFEAPTV2100
 2101 AGLAERLEMG SSQSALDVLL PLRTSGDKPP LFCVHPAGGL GWCYAGLMTN IGTDYPIYGL2160
 2161 QARGIGQREE LPKTLDDMAA DYIKQIRTVQ PKGPYHLLGW SLGGNVVQAM ATQLQNQGEE2220
 2221 VSLLVMLDAY PNHFLPIKEA PDDEEALIAL LALGGYDPDS LGEKPLDFEA AIEILRRDGS2280
 2281 ALASLDETVI LNLKNTYVNS VGILGSYKPK TFRGNVLFFR STIIPEWFDP IEPDSWKPYI2340
 2341 NGQIEQIDID CRHKDLCQPE PLAQIGKVLA VKLEELNK

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..436] PSI-BLAST 41.522879 VibH
    2 View Details [437..961] PSI-BLAST 143.0 Phenylalanine activating domain of gramicidin synthetase 1
    3 View Details [962..1039] PSI-BLAST 16.69897 No description for 2gdwA was found.
    4 View Details [1040..1472] FFAS03 8.28 VibH
    5 View Details [1473..2036] PSI-BLAST 112.0 No description for 2p2bA was found.
    6 View Details [2037..2378] PSI-BLAST 7.522879 Erythromycin polyketide synthase

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • carnitine O-acyltransferase activity
    		•  7.54616819269984 bayes_pls_golite062009
  • dihydrolipoamide S-acyltransferase activity
    		•  4.95288540231937 bayes_pls_golite062009
  • dihydrolipoyllysine-residue succinyltransferase activity
    		•  4.93204395646918 bayes_pls_golite062009
  • S-succinyltransferase activity
    		•  4.93204395646918 bayes_pls_golite062009
  • carnitine O-palmitoyltransferase activity
    		•  4.85941155291453 bayes_pls_golite062009
  • O-palmitoyltransferase activity
    		•  4.85941155291453 bayes_pls_golite062009
  • dihydrolipoyllysine-residue acetyltransferase activity
    		•  4.825154128623 bayes_pls_golite062009
  • S-acetyltransferase activity
    		•  4.79325739487657 bayes_pls_golite062009
  • transferase activity, transferring acyl groups
    		•  4.60481199262496 bayes_pls_golite062009
  • octanoyltransferase activity
    		•  4.52268776339565 bayes_pls_golite062009
  • carnitine O-octanoyltransferase activity
    		•  4.52268776339565 bayes_pls_golite062009
  • O-octanoyltransferase activity
    		•  4.52268776339565 bayes_pls_golite062009
  • S-acyltransferase activity
    		•  4.44987112475286 bayes_pls_golite062009
  • acetyltransferase activity
    		•  3.75254207032091 bayes_pls_golite062009
  • carnitine O-acetyltransferase activity
    		•  3.14424917442399 bayes_pls_golite062009
  • acyltransferase activity
    		•  3.08588280042054 bayes_pls_golite062009
  • O-acyltransferase activity
    		•  3.04191754934811 bayes_pls_golite062009
  • transferase activity, transferring acyl groups other than amino-acyl groups
    		•  3.027770031317 bayes_pls_golite062009
  • pyruvate dehydrogenase activity
    		•  2.43159394927614 bayes_pls_golite062009
  • O-acetyltransferase activity
    		•  2.37098434941789 bayes_pls_golite062009
  • succinyltransferase activity
    		•  2.08404693277798 bayes_pls_golite062009
  • transferase activity
    		•  1.78692523095641 bayes_pls_golite062009
  • catalytic activity
    		•  1.51562638409295 bayes_pls_golite062009
  • binding
    		•  1.42888906064321 bayes_pls_golite062009
  • pyruvate dehydrogenase (acetyl-transferring) activity
    		•  0.797801402758281 bayes_pls_golite062009
  • oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
    		•  0.651721897180987 bayes_pls_golite062009
  • palmitoyltransferase activity
    		•  0.200750596708501 bayes_pls_golite062009
  • protein binding
    		•  0.104367069798378 bayes_pls_golite062009
    2
    Term Confidence Notes
  • ligase activity, forming carbon-sulfur bonds
    		•  5.10123876514454 bayes_pls_golite062009
  • fatty acid ligase activity
    		•  4.83067429373059 bayes_pls_golite062009
  • long-chain fatty acid transporter activity
    		•  4.82574147628486 bayes_pls_golite062009
  • fatty acid transporter activity
    		•  4.78347692728947 bayes_pls_golite062009
  • long-chain fatty acid-CoA ligase activity
    		•  4.72692389032116 bayes_pls_golite062009
  • acetate-CoA ligase activity
    		•  4.48129067128523 bayes_pls_golite062009
  • acid-thiol ligase activity
    		•  4.28278725989432 bayes_pls_golite062009
  • CoA-ligase activity
    		•  4.12850865352867 bayes_pls_golite062009
  • Photinus-luciferin 4-monooxygenase (ATP-hydrolyzing) activity
    		•  2.74744781333102 bayes_pls_golite062009
  • oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of one atom of oxygen (internal monooxygenases or internal mixed function oxidases)
    		•  2.74744781333102 bayes_pls_golite062009
  • luciferin monooxygenase activity
    		•  2.67396462766343 bayes_pls_golite062009
  • lipid transporter activity
    		•  2.59608399999188 bayes_pls_golite062009
  • ligase activity
    		•  2.49556073715112 bayes_pls_golite062009
  • transcription regulator activity
    		•  2.31193176808353 bayes_pls_golite062009
  • catalytic activity
    		•  1.83545185797733 bayes_pls_golite062009
  • binding
    		•  1.5312519256537 bayes_pls_golite062009
  • transporter activity
    		•  1.29780964436121 bayes_pls_golite062009
  • transcription repressor activity
    		•  1.2638869228049 bayes_pls_golite062009
  • transmembrane transporter activity
    		•  1.07143339827205 bayes_pls_golite062009
  • substrate-specific transporter activity
    		•  1.03753946113449 bayes_pls_golite062009
  • substrate-specific transmembrane transporter activity
    		•  0.54797726647835 bayes_pls_golite062009
  • transferase activity, transferring acyl groups
    		•  0.464663038956639 bayes_pls_golite062009
  • active transmembrane transporter activity
    		•  0.251681382273558 bayes_pls_golite062009
  • primary active transmembrane transporter activity
    		•  0.225448500718996 bayes_pls_golite062009
  • P-P-bond-hydrolysis-driven transmembrane transporter activity
    		•  0.216579620878492 bayes_pls_golite062009
  • hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances
    		•  0.177812048124158 bayes_pls_golite062009
  • ATPase activity, coupled to movement of substances
    		•  0.174283007890308 bayes_pls_golite062009
  • ATPase activity, coupled to transmembrane movement of substances
    		•  0.173963339749644 bayes_pls_golite062009
  • nucleoside-triphosphatase activity
    		•  0.0401881910649647 bayes_pls_golite062009
  • pyrophosphatase activity
    		•  0.0047964784091391 bayes_pls_golite062009
    3
    Term Confidence Notes
  • transporter activity
    		•  4.03941350762579 bayes_pls_golite062009
  • acyl carrier activity
    		•  4.03850102890301 bayes_pls_golite062009
  • substrate-specific transporter activity
    		•  3.97641853842184 bayes_pls_golite062009
  • NADH dehydrogenase (ubiquinone) activity
    		•  2.40839604112739 bayes_pls_golite062009
  • binding
    		•  1.7733835528189 bayes_pls_golite062009
  • NADH dehydrogenase activity
    		•  1.74316763802854 bayes_pls_golite062009
  • NADH dehydrogenase (quinone) activity
    		•  1.57766881621296 bayes_pls_golite062009
  • oxidoreductase activity, acting on NADH or NADPH, quinone or similar compound as acceptor
    		•  0.97133085560662 bayes_pls_golite062009
  • catalytic activity
    		•  0.037428828577411 bayes_pls_golite062009
  • transferase activity, transferring acyl groups
    		•  0.0236479874354676 bayes_pls_golite062009
    4
    Term Confidence Notes
  • carnitine O-acyltransferase activity
    		•  6.94543084853311 bayes_pls_golite062009
  • dihydrolipoamide S-acyltransferase activity
    		•  4.37531303342735 bayes_pls_golite062009
  • dihydrolipoyllysine-residue succinyltransferase activity
    		•  4.3417940554845 bayes_pls_golite062009
  • S-succinyltransferase activity
    		•  4.3417940554845 bayes_pls_golite062009
  • carnitine O-palmitoyltransferase activity
    		•  4.31070138018542 bayes_pls_golite062009
  • O-palmitoyltransferase activity
    		•  4.31070138018542 bayes_pls_golite062009
  • dihydrolipoyllysine-residue acetyltransferase activity
    		•  4.26232148033634 bayes_pls_golite062009
  • S-acetyltransferase activity
    		•  4.23811204298386 bayes_pls_golite062009
  • transferase activity, transferring acyl groups
    		•  4.13554796912857 bayes_pls_golite062009
  • octanoyltransferase activity
    		•  4.02755094205265 bayes_pls_golite062009
  • carnitine O-octanoyltransferase activity
    		•  4.02755094205265 bayes_pls_golite062009
  • O-octanoyltransferase activity
    		•  4.02755094205265 bayes_pls_golite062009
  • S-acyltransferase activity
    		•  3.85480722379245 bayes_pls_golite062009
  • acetyltransferase activity
    		•  3.36849854572625 bayes_pls_golite062009
  • acyltransferase activity
    		•  2.59651247599228 bayes_pls_golite062009
  • carnitine O-acetyltransferase activity
    		•  2.58935883214714 bayes_pls_golite062009
  • transferase activity, transferring acyl groups other than amino-acyl groups
    		•  2.54185972075515 bayes_pls_golite062009
  • O-acyltransferase activity
    		•  2.53596585358445 bayes_pls_golite062009
  • pyruvate dehydrogenase activity
    		•  2.22567298945806 bayes_pls_golite062009
  • O-acetyltransferase activity
    		•  1.89721072292762 bayes_pls_golite062009
  • succinyltransferase activity
    		•  1.61025577060034 bayes_pls_golite062009
  • transferase activity
    		•  1.53549002805559 bayes_pls_golite062009
  • binding
    		•  1.4867313109103 bayes_pls_golite062009
  • catalytic activity
    		•  1.4057670600405 bayes_pls_golite062009
  • pyruvate dehydrogenase (acetyl-transferring) activity
    		•  0.726272561392908 bayes_pls_golite062009
  • oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
    		•  0.59605028437578 bayes_pls_golite062009
  • protein binding
    		•  0.142046790608097 bayes_pls_golite062009
    5 No functions predicted.
    6
    Term Confidence Notes
  • hydrolase activity
    		•  1.95306186248921 bayes_pls_golite062009
  • oxidoreductase activity, acting on the CH-CH group of donors
    		•  1.54887505564745 bayes_pls_golite062009
  • catalytic activity
    		•  1.39629727416851 bayes_pls_golite062009
  • binding
    		•  0.978846093152455 bayes_pls_golite062009
  • S-acetyltransferase activity
    		•  0.95833435467289 bayes_pls_golite062009
  • lipase activity
    		•  0.849473630399459 bayes_pls_golite062009
  • acetyltransferase activity
    		•  0.800718137078229 bayes_pls_golite062009
  • hydrolase activity, acting on ester bonds
    		•  0.736960094719075 bayes_pls_golite062009
  • sterol esterase activity
    		•  0.567583875046532 bayes_pls_golite062009
  • transferase activity, transferring acyl groups
    		•  0.477772921150343 bayes_pls_golite062009
  • carboxylesterase activity
    		•  0.424330502936163 bayes_pls_golite062009
  • palmitoyl-(protein) hydrolase activity
    		•  0.277033874372149 bayes_pls_golite062009
  • acyl-CoA thioesterase activity
    		•  0.22764257388982 bayes_pls_golite062009
  • structural molecule activity
    		•  0.186735936424827 bayes_pls_golite062009
  • dihydrolipoyllysine-residue acetyltransferase activity
    		•  0.0548489492445434 bayes_pls_golite062009
  • pyrophosphatase activity
    		•  0.00117419779800387 bayes_pls_golite062009


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.83

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle