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View Structure Prediction Details

Protein: DHBF_BACSU
Organism: Bacillus subtilis
Length: 2378 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for DHBF_BACSU.

Description E-value Query
Range		 Subject
Range
gi|27817222 - gi|27817222|gb|AAO23333.1| NcpA [Nostoc sp. ATCC 53789]
 2256.0 [0..10] [2372..1134]

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Predicted Domain #1
Region A:
Residues: [1-436] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MPDTKDLQYS LTGAQTGIWF AQQLDPDNPI YNTAEYIEIN GPVNIALFEE ALRHVIKEAE  60
   61 SLHVRFGENM DGPWQMINPS PDVQLHVIDV SSEPDPEKTA LNWMKADLAK PVDLGYAPLF 120
  121 NEALFIAGPD RFFWYQRIHH IAIDGFGFSL IAQRVASTYT ALIKGQTAKS RSFGSLQAIL 180
  181 EEDTDYRGSE QYEKDRQFWL DRFADAPEVV SLADRAPRTS NSFLRHTAYL PPSDVNALKE 240
  241 AARYFSGSWH EVMIAVSAVY VHRMTGSEDV VLGLPMMGRI GSASLNVPAM VMNLLPLRLT 300
  301 VSSSMSFSEL IQQISREIRS IRRHHKYRHE ELRRDLKLIG ENHRLFGPQI NLMPFDYGLD 360
  361 FAGVRGTTHN LSAGPVDDLS INVYDRTDGS GLRIDVDANP EVYSESDIKL HQQRILQLLQ 420
  421 TASAGEDMLI GQMELL

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 41.522879
Match: 1l5aA
Description: VibH
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
carnitine O-acyltransferase activity 7.54616819269984 bayes_pls_golite062009
dihydrolipoamide S-acyltransferase activity 4.95288540231937 bayes_pls_golite062009
dihydrolipoyllysine-residue succinyltransferase activity 4.93204395646918 bayes_pls_golite062009
S-succinyltransferase activity 4.93204395646918 bayes_pls_golite062009
carnitine O-palmitoyltransferase activity 4.85941155291453 bayes_pls_golite062009
O-palmitoyltransferase activity 4.85941155291453 bayes_pls_golite062009
dihydrolipoyllysine-residue acetyltransferase activity 4.825154128623 bayes_pls_golite062009
S-acetyltransferase activity 4.79325739487657 bayes_pls_golite062009
transferase activity, transferring acyl groups 4.60481199262496 bayes_pls_golite062009
octanoyltransferase activity 4.52268776339565 bayes_pls_golite062009
carnitine O-octanoyltransferase activity 4.52268776339565 bayes_pls_golite062009
O-octanoyltransferase activity 4.52268776339565 bayes_pls_golite062009
S-acyltransferase activity 4.44987112475286 bayes_pls_golite062009
acetyltransferase activity 3.75254207032091 bayes_pls_golite062009
carnitine O-acetyltransferase activity 3.14424917442399 bayes_pls_golite062009
acyltransferase activity 3.08588280042054 bayes_pls_golite062009
O-acyltransferase activity 3.04191754934811 bayes_pls_golite062009
transferase activity, transferring acyl groups other than amino-acyl groups 3.027770031317 bayes_pls_golite062009
pyruvate dehydrogenase activity 2.43159394927614 bayes_pls_golite062009
O-acetyltransferase activity 2.37098434941789 bayes_pls_golite062009
succinyltransferase activity 2.08404693277798 bayes_pls_golite062009
transferase activity 1.78692523095641 bayes_pls_golite062009
catalytic activity 1.51562638409295 bayes_pls_golite062009
binding 1.42888906064321 bayes_pls_golite062009
pyruvate dehydrogenase (acetyl-transferring) activity 0.797801402758281 bayes_pls_golite062009
oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor 0.651721897180987 bayes_pls_golite062009
palmitoyltransferase activity 0.200750596708501 bayes_pls_golite062009
protein binding 0.104367069798378 bayes_pls_golite062009

Predicted Domain #2
Region A:
Residues: [437-961] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 LPEEKEKVIS KWNETAKSEK LVSLQDMFEK QAVLTPERIA LMCDDIQVNY RKLNEEANRL  60
   61 ARLLIEKGIG PEQFVALALP RSPEMVASML GVLKTGAAYL PLDPEFPADR ISYMLEDAKP 120
  121 SCIITTEEIA ASLPDDLAVP ELVLDQAVTQ EIIKRYSPEN QDVSVSLDHP AYIIYTSGST 180
  181 GRPKGVVVTQ KSLSNFLLSM QEAFSLGEED RLLAVTTVAF DISALELYLP LISGAQIVIA 240
  241 KKETIREPQA LAQMIENFDI NIMQATPTLW HALVTSEPEK LRGLRVLVGG EALPSGLLQE 300
  301 LQDLHCSVTN LYGPTETTIW SAAAFLEEGL KGVPPIGKPI WNTQVYVLDN GLQPVPPGVV 360
  361 GELYIAGTGL ARGYFHRPDL TAERFVADPY GPPGTRMYRT GDQARWRADG SLDYIGRADH 420
  421 QIKIRGFRIE LGEIDAVLAN HPHIEQAAVV VREDQPGDKR LAAYVVADAA IDTAELRRYM 480
  481 GASLPDYMVP SAFVEMDELP LTPNGKLDRK ALPAPDFSTS VSDRA

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 143.0
Match: 1amuA
Description: Phenylalanine activating domain of gramicidin synthetase 1
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
ligase activity, forming carbon-sulfur bonds 5.10123876514454 bayes_pls_golite062009
fatty acid ligase activity 4.83067429373059 bayes_pls_golite062009
long-chain fatty acid transporter activity 4.82574147628486 bayes_pls_golite062009
fatty acid transporter activity 4.78347692728947 bayes_pls_golite062009
long-chain fatty acid-CoA ligase activity 4.72692389032116 bayes_pls_golite062009
acetate-CoA ligase activity 4.48129067128523 bayes_pls_golite062009
acid-thiol ligase activity 4.28278725989432 bayes_pls_golite062009
CoA-ligase activity 4.12850865352867 bayes_pls_golite062009
Photinus-luciferin 4-monooxygenase (ATP-hydrolyzing) activity 2.74744781333102 bayes_pls_golite062009
oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of one atom of oxygen (internal monooxygenases or internal mixed function oxidases) 2.74744781333102 bayes_pls_golite062009
luciferin monooxygenase activity 2.67396462766343 bayes_pls_golite062009
lipid transporter activity 2.59608399999188 bayes_pls_golite062009
ligase activity 2.49556073715112 bayes_pls_golite062009
transcription regulator activity 2.31193176808353 bayes_pls_golite062009
catalytic activity 1.83545185797733 bayes_pls_golite062009
binding 1.5312519256537 bayes_pls_golite062009
transporter activity 1.29780964436121 bayes_pls_golite062009
transcription repressor activity 1.2638869228049 bayes_pls_golite062009
transmembrane transporter activity 1.07143339827205 bayes_pls_golite062009
substrate-specific transporter activity 1.03753946113449 bayes_pls_golite062009
substrate-specific transmembrane transporter activity 0.54797726647835 bayes_pls_golite062009
transferase activity, transferring acyl groups 0.464663038956639 bayes_pls_golite062009
active transmembrane transporter activity 0.251681382273558 bayes_pls_golite062009
primary active transmembrane transporter activity 0.225448500718996 bayes_pls_golite062009
P-P-bond-hydrolysis-driven transmembrane transporter activity 0.216579620878492 bayes_pls_golite062009
hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances 0.177812048124158 bayes_pls_golite062009
ATPase activity, coupled to movement of substances 0.174283007890308 bayes_pls_golite062009
ATPase activity, coupled to transmembrane movement of substances 0.173963339749644 bayes_pls_golite062009
nucleoside-triphosphatase activity 0.0401881910649647 bayes_pls_golite062009
pyrophosphatase activity 0.0047964784091391 bayes_pls_golite062009

Predicted Domain #3
Region A:
Residues: [962-1039] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 PRTPQEEILC DLFAEVLGLA RVGIDDSFFE LGGHSLLAAR LMSRIREVMG AELGIAKLFD  60
   61 EPTVAGLAAH LDLAQSAC

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 16.69897
Match: 2gdwA
Description: No description for 2gdwA was found.

Predicted functions:

Term Confidence Notes
transporter activity 4.03941350762579 bayes_pls_golite062009
acyl carrier activity 4.03850102890301 bayes_pls_golite062009
substrate-specific transporter activity 3.97641853842184 bayes_pls_golite062009
NADH dehydrogenase (ubiquinone) activity 2.40839604112739 bayes_pls_golite062009
binding 1.7733835528189 bayes_pls_golite062009
NADH dehydrogenase activity 1.74316763802854 bayes_pls_golite062009
NADH dehydrogenase (quinone) activity 1.57766881621296 bayes_pls_golite062009
oxidoreductase activity, acting on NADH or NADPH, quinone or similar compound as acceptor 0.97133085560662 bayes_pls_golite062009
catalytic activity 0.037428828577411 bayes_pls_golite062009
transferase activity, transferring acyl groups 0.0236479874354676 bayes_pls_golite062009

Predicted Domain #4
Region A:
Residues: [1040-1472] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 PALQRAERPE KIPLSFAQRR LWFLHCLEGP SPTYNIPVAV RLSGELDQGL LKAALYDLVC  60
   61 RHESLRTIFP ESQGTSYQHI LDADRACPEL HVTEIAEKEL SDRLAEAVRY SFDLAAEPAF 120
  121 RAELFVIGPD EYVLLLLVHH IVGDGWSLTP LTRDLGTAYA ARCHGRSPEW APLAVQYADY 180
  181 ALWQQELLGN EDDPNSLIAG QLAFWKETLK NLPDQLELPT DYSRPAEPSH DGDTIHFRIE 240
  241 PEFHKRLQEL ARANRVSLFM VLQSGLAALL TRLGAGTDIP IGSPIAGRND DALGDLVGLF 300
  301 INTLVLRTDT SGDPSFRELL DRVREVNLAA YDNQDLPFER LVEVLNPARS RATHPLFQIM 360
  361 LAFQNTPDAE LHLPDMESSL RINSVGSAKF DLTLEISEDR LADGTPNGME GLLEYSTDLF 420
  421 KRETAQALAD RLM

[Run NCBI BLAST on this sequence.]

Detection Method: FFAS03
Confidence: 8.28
Match: 1l5aA
Description: VibH
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
carnitine O-acyltransferase activity 6.94543084853311 bayes_pls_golite062009
dihydrolipoamide S-acyltransferase activity 4.37531303342735 bayes_pls_golite062009
dihydrolipoyllysine-residue succinyltransferase activity 4.3417940554845 bayes_pls_golite062009
S-succinyltransferase activity 4.3417940554845 bayes_pls_golite062009
carnitine O-palmitoyltransferase activity 4.31070138018542 bayes_pls_golite062009
O-palmitoyltransferase activity 4.31070138018542 bayes_pls_golite062009
dihydrolipoyllysine-residue acetyltransferase activity 4.26232148033634 bayes_pls_golite062009
S-acetyltransferase activity 4.23811204298386 bayes_pls_golite062009
transferase activity, transferring acyl groups 4.13554796912857 bayes_pls_golite062009
octanoyltransferase activity 4.02755094205265 bayes_pls_golite062009
carnitine O-octanoyltransferase activity 4.02755094205265 bayes_pls_golite062009
O-octanoyltransferase activity 4.02755094205265 bayes_pls_golite062009
S-acyltransferase activity 3.85480722379245 bayes_pls_golite062009
acetyltransferase activity 3.36849854572625 bayes_pls_golite062009
acyltransferase activity 2.59651247599228 bayes_pls_golite062009
carnitine O-acetyltransferase activity 2.58935883214714 bayes_pls_golite062009
transferase activity, transferring acyl groups other than amino-acyl groups 2.54185972075515 bayes_pls_golite062009
O-acyltransferase activity 2.53596585358445 bayes_pls_golite062009
pyruvate dehydrogenase activity 2.22567298945806 bayes_pls_golite062009
O-acetyltransferase activity 1.89721072292762 bayes_pls_golite062009
succinyltransferase activity 1.61025577060034 bayes_pls_golite062009
transferase activity 1.53549002805559 bayes_pls_golite062009
binding 1.4867313109103 bayes_pls_golite062009
catalytic activity 1.4057670600405 bayes_pls_golite062009
pyruvate dehydrogenase (acetyl-transferring) activity 0.726272561392908 bayes_pls_golite062009
oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor 0.59605028437578 bayes_pls_golite062009
protein binding 0.142046790608097 bayes_pls_golite062009

Predicted Domain #5
Region A:
Residues: [1473-2036] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 RLLEAAESDP DEQIGNLDIL APEEHSSMVT DWQSVSEKIP HACLPEQFEK QAALRPDAIA  60
   61 VVYENQELSY AELNERANRL ARMMISEGVG PEQFVALALP RSLEMAVGLL AVLKAGAAYL 120
  121 PLDPDYPADR IAFMLKDAQP AFIMTNTKAA NHIPPVENVP KIVLDDPELA EKLNTYPAGN 180
  181 PKNKDRTQPL SPLNTAYVIY TSGSTGVPKG VMIPHQNVTR LFAATEHWFR FSSGDIWTMF 240
  241 HSYAFDFSVW EIWGPLLHGG RLVIVPHHVS RSPEAFLRLL VKEGVTVLNQ TPSAFYQFMQ 300
  301 AEREQPDLGQ ALSLRYVIFG GEALELSRLE DWYNRHPENR PQLINMYGIT ETTVHVSYIE 360
  361 LDRSMAALRA NSLIGCGIPD LGVYVLDERL QPVPPGVAGE LYVSGAGLAR GYLGRPGLTS 420
  421 ERFIADPFGP PGTRMYRTGD VARLRADGSL DYVGRADHQV KIRGFRIELG EIEAALVQHP 480
  481 QLEDAAVIVR EDQPGDKRLA AYVIPSEETF DTAELRRYAA ERLPDYMVPA AFVTMKELPL 540
  541 TPNGKLDRKA LPAPDFAAAV TGRG

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 112.0
Match: 2p2bA
Description: No description for 2p2bA was found.

Predicted Domain #6
Region A:
Residues: [2037-2378] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 PRTPQEEILC DLFMEVLHLP RVGIDDRFFD LGGHSLLAVQ LMSRIREALG VELSIGNLFE  60
   61 APTVAGLAER LEMGSSQSAL DVLLPLRTSG DKPPLFCVHP AGGLGWCYAG LMTNIGTDYP 120
  121 IYGLQARGIG QREELPKTLD DMAADYIKQI RTVQPKGPYH LLGWSLGGNV VQAMATQLQN 180
  181 QGEEVSLLVM LDAYPNHFLP IKEAPDDEEA LIALLALGGY DPDSLGEKPL DFEAAIEILR 240
  241 RDGSALASLD ETVILNLKNT YVNSVGILGS YKPKTFRGNV LFFRSTIIPE WFDPIEPDSW 300
  301 KPYINGQIEQ IDIDCRHKDL CQPEPLAQIG KVLAVKLEEL NK

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 7.522879
Match: 1kezA
Description: Erythromycin polyketide synthase
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
hydrolase activity 1.95306186248921 bayes_pls_golite062009
oxidoreductase activity, acting on the CH-CH group of donors 1.54887505564745 bayes_pls_golite062009
catalytic activity 1.39629727416851 bayes_pls_golite062009
binding 0.978846093152455 bayes_pls_golite062009
S-acetyltransferase activity 0.95833435467289 bayes_pls_golite062009
lipase activity 0.849473630399459 bayes_pls_golite062009
acetyltransferase activity 0.800718137078229 bayes_pls_golite062009
hydrolase activity, acting on ester bonds 0.736960094719075 bayes_pls_golite062009
sterol esterase activity 0.567583875046532 bayes_pls_golite062009
transferase activity, transferring acyl groups 0.477772921150343 bayes_pls_golite062009
carboxylesterase activity 0.424330502936163 bayes_pls_golite062009
palmitoyl-(protein) hydrolase activity 0.277033874372149 bayes_pls_golite062009
acyl-CoA thioesterase activity 0.22764257388982 bayes_pls_golite062009
structural molecule activity 0.186735936424827 bayes_pls_golite062009
dihydrolipoyllysine-residue acetyltransferase activity 0.0548489492445434 bayes_pls_golite062009
pyrophosphatase activity 0.00117419779800387 bayes_pls_golite062009
YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle