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Protein Overview: trxr-1

General Information:
Name(s) found: trxr-1 / CE34250 [WormBase]
Description(s) found:
Found 12 descriptions.
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  • WBGene00015553 locus:trxr-1 Thioredoxin reductase 1 status:Confirmed UniProt:Q17745 protein_id:CCD83555.1 [WormBase]
    • Organism: Caenorhabditis elegans
    Length: 667 amino acids

    Gene Ontology:
    Cellular Component: cytoplasm [IEALink to PubMed article]
    Biological Process: electron transport [IEALink to PubMed article]
    removal of superoxide radicals [IEALink to PubMed article]
    glutathione metabolic process [IEALink to PubMed article]
    cell redox homeostasis [IEALink to PubMed article]
    detoxification of mercury ion [IEALink to PubMed article]
    Molecular Function: disulfide oxidoreductase activity [IEALink to PubMed article]
    NADP or NADPH binding [IEALink to PubMed article]
    oxidoreductase activity [IEALink to PubMed article]
    FAD binding [IEALink to PubMed article]
    mercury ion binding [IEALink to PubMed article]
    mercury (II) reductase activity [IEALink to PubMed article]
    thioredoxin-disulfide reductase activity [IEALink to PubMed article]
    glutathione-disulfide reductase activity [IEALink to PubMed article]
    dihydrolipoyl dehydrogenase activity [IEALink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MKSLTELFGC FKRQPSQQEA SSPANPHVSD TLSMGVAASG MPPPKRPAPA ESPTLPGETL  60
   61 VDAPGIPLKE ALKEAANSKI VIFYNSSDEE KQLVEFETYL NSLKEPADAE KPLEIPEMKK 120
  121 LQVSRASQKV IQYLTLHTSW PLMYIKGNAV GGLKELKALK QDYLKEWLRD HTYDLIVIGG 180
  181 GSGGLAAAKE ASRLGKKVAC LDFVKPSPQG TSWGLGGTCV NVGCIPKKLM HQASLLGHSI 240
  241 HDAKKYGWKL PEGKVEHQWN HLRDSVQDHI ASLNWGYRVQ LSEKTVTYIN SYGEFTGPFE 300
  301 ISATNKKKKV EKLTADRFLI STGLRPKYPE IPGVKEYTMT SDDLFQLPYS PGKTLCVGAS 360
  361 YVSLECAGFL HGFGFDVTVM VRSILLRGFD QDMAERIRKH MIAYGMKFEA GVPTSIEQID 420
  421 EKTDEKAGKY RVFWPKKNEE TGEMQEVSEE YNTILMAIGS EAVTDDVGLT TIGVESAKSK 480
  481 KVLGSREQST TIPWVYAIGD VLEGTPELTP VAIQAGSVLM SRIFDGANEL TEYDQIPTTV 540
  541 FTPLEYGCCG LSEEDAMMKY GKDNIMIYHN VFNPLEYTIS ESMDKDHCYL KMICLSNEEE 600
  601 KVVGFHILTP NAGEVTQGFG IALKLAAKKA DFDRLIGIHP TVAENFTTLT LEKKEGDEEL 660
  661 QASGCUG

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..530] PSI-BLAST 55.522879 Alkyl hydroperoxide reductase subunit F (AhpF), C-terminal domains; Alkyl hydroperoxide reductase subunit F (AhpF), N-terminal domain
    2 View Details [531..584] PSI-BLAST 29.522879 NADH oxidase /nitrite reductase from Pyrococcus furiosus Pfu-1140779-001
    3 View Details [585..667] PSI-BLAST 92.30103 Mammalian thioredoxin reductase

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • pyruvate dehydrogenase activity
    		•  6.59152030973708 bayes_pls_golite062009
  • dihydrolipoyl dehydrogenase activity
    		•  5.38255966064925 bayes_pls_golite062009
  • NADH dehydrogenase activity
    		•  5.14449241561104 bayes_pls_golite062009
  • NADH dehydrogenase (ubiquinone) activity
    		•  4.95529028672498 bayes_pls_golite062009
  • NADH dehydrogenase (quinone) activity
    		•  4.82876826921965 bayes_pls_golite062009
  • oxidoreductase activity, acting on NADH or NADPH
    		•  4.2228247129925 bayes_pls_golite062009
  • oxidoreductase activity, acting on NADH or NADPH, quinone or similar compound as acceptor
    		•  4.20950024259132 bayes_pls_golite062009
  • selenium binding
    		•  3.88074839847028 bayes_pls_golite062009
  • antioxidant activity
    		•  3.8464796631544 bayes_pls_golite062009
  • oxidoreductase activity, acting on peroxide as acceptor
    		•  3.43831566988273 bayes_pls_golite062009
  • peroxidase activity
    		•  3.43831566988273 bayes_pls_golite062009
  • oxidoreductase activity, acting on the CH-NH2 group of donors
    		•  3.35142373392777 bayes_pls_golite062009
  • glutathione binding
    		•  3.12157603958172 bayes_pls_golite062009
  • oxidoreductase activity, acting on sulfur group of donors, NAD or NADP as acceptor
    		•  2.87947896544827 bayes_pls_golite062009
  • hydrogen ion transmembrane transporter activity
    		•  2.57282017498189 bayes_pls_golite062009
  • glutathione peroxidase activity
    		•  2.56524997297011 bayes_pls_golite062009
  • monovalent inorganic cation transmembrane transporter activity
    		•  2.50603438449246 bayes_pls_golite062009
  • inorganic cation transmembrane transporter activity
    		•  2.28982462439281 bayes_pls_golite062009
  • oxidoreductase activity, acting on sulfur group of donors
    		•  2.23310780102446 bayes_pls_golite062009
  • peroxiredoxin activity
    		•  2.12777217096121 bayes_pls_golite062009
  • oxidoreductase activity, acting on the aldehyde or oxo group of donors
    		•  2.12515648558024 bayes_pls_golite062009
  • thioredoxin peroxidase activity
    		•  1.96134566495756 bayes_pls_golite062009
  • glutathione transferase activity
    		•  1.85683051472829 bayes_pls_golite062009
  • proteasome inhibitor activity
    		•  1.80247749812127 bayes_pls_golite062009
  • oxidoreductase activity
    		•  1.71351657881838 bayes_pls_golite062009
  • hydrolase activity
    		•  1.59638719668687 bayes_pls_golite062009
  • protein disulfide oxidoreductase activity
    		•  1.47769936616412 bayes_pls_golite062009
  • oxygen-dependent protoporphyrinogen oxidase activity
    		•  1.42994468012845 bayes_pls_golite062009
  • peptidase activity
    		•  1.42472072343891 bayes_pls_golite062009
  • disulfide oxidoreductase activity
    		•  1.32811008894503 bayes_pls_golite062009
  • binding
    		•  1.25802922431343 bayes_pls_golite062009
  • protein binding
    		•  1.18479617596618 bayes_pls_golite062009
  • signal transducer activity
    		•  1.03696928411308 bayes_pls_golite062009
  • molecular transducer activity
    		•  1.03696928411308 bayes_pls_golite062009
  • peptidase activity, acting on L-amino acid peptides
    		•  1.03363648652755 bayes_pls_golite062009
  • electron carrier activity
    		•  0.930374417686729 bayes_pls_golite062009
  • transporter activity
    		•  0.890824576391732 bayes_pls_golite062009
  • phospholipid-hydroperoxide glutathione peroxidase activity
    		•  0.874146425427531 bayes_pls_golite062009
  • transmembrane transporter activity
    		•  0.706117386114413 bayes_pls_golite062009
  • NADPH-adrenodoxin reductase activity
    		•  0.684108511779641 bayes_pls_golite062009
  • catalytic activity
    		•  0.672192331361968 bayes_pls_golite062009
  • transferase activity
    		•  0.570364999445227 bayes_pls_golite062009
  • transcription regulator activity
    		•  0.52671047749426 bayes_pls_golite062009
  • substrate-specific transporter activity
    		•  0.491481205015383 bayes_pls_golite062009
  • substrate-specific transmembrane transporter activity
    		•  0.26114823844682 bayes_pls_golite062009
  • intramolecular oxidoreductase activity
    		•  0.13913802190798 bayes_pls_golite062009
  • succinate dehydrogenase activity
    		•  0.110826254138262 bayes_pls_golite062009
    2 No functions predicted.
    3 No functions predicted.


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.97

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle