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View Structure Prediction Details

Protein: trxr-1
Organism: Caenorhabditis elegans
Length: 667 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for trxr-1.

Description E-value Query
Range		 Subject
Range
gi|71982272, gi|... - gi|71982272|ref|NP_501085.2| ThioRedoXin Reductase family member (trxr-1) [Caenorhabditis elegans], ...
 458.0 [0..1] [667..1]

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Predicted Domain #1
Region A:
Residues: [1-530] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MKSLTELFGC FKRQPSQQEA SSPANPHVSD TLSMGVAASG MPPPKRPAPA ESPTLPGETL  60
   61 VDAPGIPLKE ALKEAANSKI VIFYNSSDEE KQLVEFETYL NSLKEPADAE KPLEIPEMKK 120
  121 LQVSRASQKV IQYLTLHTSW PLMYIKGNAV GGLKELKALK QDYLKEWLRD HTYDLIVIGG 180
  181 GSGGLAAAKE ASRLGKKVAC LDFVKPSPQG TSWGLGGTCV NVGCIPKKLM HQASLLGHSI 240
  241 HDAKKYGWKL PEGKVEHQWN HLRDSVQDHI ASLNWGYRVQ LSEKTVTYIN SYGEFTGPFE 300
  301 ISATNKKKKV EKLTADRFLI STGLRPKYPE IPGVKEYTMT SDDLFQLPYS PGKTLCVGAS 360
  361 YVSLECAGFL HGFGFDVTVM VRSILLRGFD QDMAERIRKH MIAYGMKFEA GVPTSIEQID 420
  421 EKTDEKAGKY RVFWPKKNEE TGEMQEVSEE YNTILMAIGS EAVTDDVGLT TIGVESAKSK 480
  481 KVLGSREQST TIPWVYAIGD VLEGTPELTP VAIQAGSVLM SRIFDGANEL

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 55.522879
Match: 1hyuA
Description: Alkyl hydroperoxide reductase subunit F (AhpF), C-terminal domains; Alkyl hydroperoxide reductase subunit F (AhpF), N-terminal domain
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
pyruvate dehydrogenase activity 6.59152030973708 bayes_pls_golite062009
dihydrolipoyl dehydrogenase activity 5.38255966064925 bayes_pls_golite062009
NADH dehydrogenase activity 5.14449241561104 bayes_pls_golite062009
NADH dehydrogenase (ubiquinone) activity 4.95529028672498 bayes_pls_golite062009
NADH dehydrogenase (quinone) activity 4.82876826921965 bayes_pls_golite062009
oxidoreductase activity, acting on NADH or NADPH 4.2228247129925 bayes_pls_golite062009
oxidoreductase activity, acting on NADH or NADPH, quinone or similar compound as acceptor 4.20950024259132 bayes_pls_golite062009
selenium binding 3.88074839847028 bayes_pls_golite062009
antioxidant activity 3.8464796631544 bayes_pls_golite062009
oxidoreductase activity, acting on peroxide as acceptor 3.43831566988273 bayes_pls_golite062009
peroxidase activity 3.43831566988273 bayes_pls_golite062009
oxidoreductase activity, acting on the CH-NH2 group of donors 3.35142373392777 bayes_pls_golite062009
glutathione binding 3.12157603958172 bayes_pls_golite062009
oxidoreductase activity, acting on sulfur group of donors, NAD or NADP as acceptor 2.87947896544827 bayes_pls_golite062009
hydrogen ion transmembrane transporter activity 2.57282017498189 bayes_pls_golite062009
glutathione peroxidase activity 2.56524997297011 bayes_pls_golite062009
monovalent inorganic cation transmembrane transporter activity 2.50603438449246 bayes_pls_golite062009
inorganic cation transmembrane transporter activity 2.28982462439281 bayes_pls_golite062009
oxidoreductase activity, acting on sulfur group of donors 2.23310780102446 bayes_pls_golite062009
peroxiredoxin activity 2.12777217096121 bayes_pls_golite062009
oxidoreductase activity, acting on the aldehyde or oxo group of donors 2.12515648558024 bayes_pls_golite062009
thioredoxin peroxidase activity 1.96134566495756 bayes_pls_golite062009
glutathione transferase activity 1.85683051472829 bayes_pls_golite062009
proteasome inhibitor activity 1.80247749812127 bayes_pls_golite062009
oxidoreductase activity 1.71351657881838 bayes_pls_golite062009
hydrolase activity 1.59638719668687 bayes_pls_golite062009
protein disulfide oxidoreductase activity 1.47769936616412 bayes_pls_golite062009
oxygen-dependent protoporphyrinogen oxidase activity 1.42994468012845 bayes_pls_golite062009
peptidase activity 1.42472072343891 bayes_pls_golite062009
disulfide oxidoreductase activity 1.32811008894503 bayes_pls_golite062009
binding 1.25802922431343 bayes_pls_golite062009
protein binding 1.18479617596618 bayes_pls_golite062009
signal transducer activity 1.03696928411308 bayes_pls_golite062009
molecular transducer activity 1.03696928411308 bayes_pls_golite062009
peptidase activity, acting on L-amino acid peptides 1.03363648652755 bayes_pls_golite062009
electron carrier activity 0.930374417686729 bayes_pls_golite062009
transporter activity 0.890824576391732 bayes_pls_golite062009
phospholipid-hydroperoxide glutathione peroxidase activity 0.874146425427531 bayes_pls_golite062009
transmembrane transporter activity 0.706117386114413 bayes_pls_golite062009
NADPH-adrenodoxin reductase activity 0.684108511779641 bayes_pls_golite062009
catalytic activity 0.672192331361968 bayes_pls_golite062009
transferase activity 0.570364999445227 bayes_pls_golite062009
transcription regulator activity 0.52671047749426 bayes_pls_golite062009
substrate-specific transporter activity 0.491481205015383 bayes_pls_golite062009
substrate-specific transmembrane transporter activity 0.26114823844682 bayes_pls_golite062009
intramolecular oxidoreductase activity 0.13913802190798 bayes_pls_golite062009
succinate dehydrogenase activity 0.110826254138262 bayes_pls_golite062009

Predicted Domain #2
Region A:
Residues: [531-584] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 TEYDQIPTTV FTPLEYGCCG LSEEDAMMKY GKDNIMIYHN VFNPLEYTIS ESMD

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 29.522879
Match: 1xhcA
Description: NADH oxidase /nitrite reductase from Pyrococcus furiosus Pfu-1140779-001
Matching Structure (courtesy of the PDB):

Predicted Domain #3
Region A:
Residues: [585-667] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 KDHCYLKMIC LSNEEEKVVG FHILTPNAGE VTQGFGIALK LAAKKADFDR LIGIHPTVAE  60
   61 NFTTLTLEKK EGDEELQASG CUG

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 92.30103
Match: 1h6vA
Description: Mammalian thioredoxin reductase
Matching Structure (courtesy of the PDB):
YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle