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Protein Overview: eat-16

General Information:
Name(s) found: eat-16 / CE30491 [WormBase]
Description(s) found:
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  • WBGene00001145 locus:eat-16 status:Confirmed UniProt:Q8T3F0 protein_id:CAD30433.1 [WormBase]
  • gi|25145850|ref|NP_740905.1| EATing: abnormal pharyngeal pumping family member (eat-16) [Caenorhabditis elegans] [NCBI NR]
  • gi|20338936|emb|CAD30433.1| C. elegans protein C16C2.2b, confirmed by transcript evidence [Caenorhabditis elegans] [NCBI NR]
  • [wormpep79.fasta]
  • CE30491 WBGene00001145 locus:eat-16 regulator of G-protein signalling status:Confirmed TR:Q8T3F0 protein_id:CAD30433.1 [wormpep150.fasta]
  • 30491 WBGene00001145 locus:eat-16 regulator of G-protein signalling status:Confirmed TR:Q8T3F0 protein_id:CAD30433.1 [wormpep130-phg-ecoli-orf-rand.fasta]
  • EATing: abnormal pharyngeal pumping EAT-16, regulator of g-protein signaling 7 (50.4 kD) (eat-16) [Caenorhabditis elegans]gi|20338936|emb|CAD30433.1| Hypothetical protein C16C2.2b [Caenorhabditis elegans] [nrdb_11152004_Chlamydomonas]
  • locus:eat-16 regulator of G-protein signalling status:Confirmed TR:Q8T3F0 protein_id:CAD30433.1 [wormpep115.fasta.reversed]
  • CE30491 regulator of G-protein signalling status:Confirmed protein_id:CAD30433.1 [wormpep80.hongbin]
  • CE30491 WBGene00001145 locus:eat-16 regulator of G-protein signalling status:Confirmed UniProt:Q8T3F0_CAEEL protein_id:CAD30433.1 [WormBase_C-elegans_193_07-31-2008_con_reversed.fasta]
  • CE30491 WBGene00001145 locus:eat-16 regulator of G-protein signalling status:Confirmed UniProt:Q8T3F0_CAEEL protein_id:CAD30433.1| [wormORF-contam.fasta]
  • Hypothetical protein C16C2.2b [Caenorhabditis elegans] [nr-271106-contam.fasta]
  • EATing: abnormal pharyngeal pumping family member (eat-16) [Caenorhabditis elegans] [nr-271106-contam.fasta]
  • CE30491 WBGene00001145 locus:eat-16 regulator of G-protein signalling status:Confirmed UniProt:Q8T3F0 protein_id:CAD30433.1 [wormbase_c-elegans_2.11_01-10-2010_reversed.fasta]
  • [wormpep210-phg-orf-LaDeana-ecoli-contam.fasta.nr]
  • CE30491 WBGene00001145 locus:eat-16 status:Confirmed UniProt:Q8T3F0 protein_id:CAD30433.1 [wormpep246-ecoli-contam.fasta]
  • Isoform of O17589, Uncharacterized protein OS=Caenorhabditis elegans GN=eat-16 PE=1 SV=1 [CAEEL.fasta.20160308]
    • Organism: Caenorhabditis elegans
    Length: 431 amino acids

    Gene Ontology:
    Cellular Component: heterotrimeric G-protein complex [IEALink to PubMed article]
    cytoplasm [IDALink to PubMed article]
    neuron projection [IDALink to PubMed article]
    Biological Process: response to food [IMPLink to PubMed article]
    negative regulation of locomotion [IMPLink to PubMed article]
    regulation of locomotion [IMPLink to PubMed article]
    G-protein coupled receptor protein signaling pathway [IEALink to PubMed article]
    dopamine receptor signaling pathway [IMPLink to PubMed article]
    regulation of G-protein coupled receptor protein signaling pathway [IDALink to PubMed article][IGILink to PubMed article]
    reproduction [IMPLink to PubMed article]
    regulation of pharyngeal pumping [IMPLink to PubMed article]
    inhibition of phospholipase C activity involved in G-protein coupled receptor signaling pathway [IDALink to PubMed article]
    regulation of oviposition [IMPLink to PubMed article]
    nematode larval development [IGILink to PubMed article]
    regulation of GTPase activity [IGILink to PubMed article]
    regulation of synaptic transmission [IGILink to PubMed article]
    Molecular Function: GTPase activator activity [IGILink to PubMed article]
    regulator of G-protein signaling activity [IDALink to PubMed article][IGILink to PubMed article]
    signal transducer activity [IEALink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MMPPLTKIEV LAKRVMEGAQ LKTHKYFRIA VPHAITGQQL IALVLERGAP DDEAEASHLA  60
   61 SLLLHHGYMF PVIEHGQPFK DDGTLYRLQR PYFWPSQAEL VPDVEYAIYL NKRLLRNEQK 120
  121 HGLEEDEVES FNRLADVLAH MWAFIVQQSE LQLKQQKEKK KVDKVVFDSE ERAFWKIRKP 180
  181 SRGGPNFLED PYMKIEKKIR RQNAQGYRCL MDRLRFAIKT KPWLKALKAS DTMVTWVDQR 240
  241 AEFDPFLHPP QPSNPWISDE ASFWNQPTDT SSAEIPTEKR VKRWGLSVQE LVKDPIGRQV 300
  301 LETFLESEFS SENIRFWIAI QDLKYAPNEQ IYQKAERIRE EFLAQGAPAQ VNVDNRTLDQ 360
  361 TLECISKAKD ASQMRFAFYH SEEHVFTLMA KDSYPRFVRS QIYKAVLTAA QQHGTKRLGW 420
  421 RNFVFNMGNY V

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..194] PSI-BLAST 17.69897 Solution structure of the DEP domain of human pleckstrin
    2 View Details [195..266] FFAS03 2.89 The Crystal Structure of a Biologically Active Peptide (SIGK) Bound to a G Protein Beta:Gamma Heterodimer
    3 View Details [267..431] PSI-BLAST 36.69897 RGS9, RGS domain

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • transcription regulator activity
    		•  3.77201910025409 bayes_pls_golite062009
  • binding
    		•  3.52874320222492 bayes_pls_golite062009
  • DNA binding
    		•  3.44642410378325 bayes_pls_golite062009
  • nucleic acid binding
    		•  3.25777282180864 bayes_pls_golite062009
  • transcription factor activity
    		•  2.83460075788873 bayes_pls_golite062009
  • transcription repressor activity
    		•  2.26839643623044 bayes_pls_golite062009
  • sequence-specific DNA binding
    		•  1.4788427609721 bayes_pls_golite062009
  • transcription activator activity
    		•  1.28486271107855 bayes_pls_golite062009
  • signal transducer activity
    		•  0.968719315363638 bayes_pls_golite062009
  • molecular transducer activity
    		•  0.968719315363638 bayes_pls_golite062009
  • protein binding
    		•  0.753698599635855 bayes_pls_golite062009
  • transcription factor binding
    		•  0.63938506997853 bayes_pls_golite062009
  • RNA polymerase II transcription factor activity
    		•  0.49916895549368 bayes_pls_golite062009
  • receptor binding
    		•  0.0995086620605325 bayes_pls_golite062009
    2
    Term Confidence Notes
  • binding
    		•  1.90500749049821 bayes_pls_golite062009
  • signal transducer activity
    		•  1.70315911322844 bayes_pls_golite062009
  • molecular transducer activity
    		•  1.70315911322844 bayes_pls_golite062009
  • GTPase activity
    		•  0.944482131496004 bayes_pls_golite062009
  • protein binding
    		•  0.40736300061233 bayes_pls_golite062009
  • receptor binding
    		•  0.363468238376214 bayes_pls_golite062009
    3
    Term Confidence Notes
  • binding
    		•  2.35238988967981 bayes_pls_golite062009
  • GTPase regulator activity
    		•  1.92987277493861 bayes_pls_golite062009
  • nucleoside-triphosphatase regulator activity
    		•  1.90800479999702 bayes_pls_golite062009
  • GTPase activator activity
    		•  1.87534424848905 bayes_pls_golite062009
  • enzyme activator activity
    		•  1.62073651679221 bayes_pls_golite062009
  • enzyme regulator activity
    		•  1.49796137854909 bayes_pls_golite062009
  • protein binding
    		•  1.34804002381061 bayes_pls_golite062009
  • signal transducer activity
    		•  1.14361809679544 bayes_pls_golite062009
  • molecular transducer activity
    		•  1.14361809679544 bayes_pls_golite062009
  • beta-catenin binding
    		•  0.59248827140739 bayes_pls_golite062009


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle