Protein Overview: eat-16

General Information:
Name(s) found:	eat-16 / CE30491 [WormBase]
Description(s) found: Found 17 descriptions. SHOW ALL	WBGene00001145 locus:eat-16 status:Confirmed UniProt:Q8T3F0 protein_id:CAD30433.1 [WormBase]
Organism:	Caenorhabditis elegans
Length:	431 amino acids
Gene Ontology:
Cellular Component:	heterotrimeric G-protein complex [IEA] cytoplasm [IDA] neuron projection [IDA]
Biological Process:	response to food [IMP] negative regulation of locomotion [IMP] regulation of locomotion [IMP] G-protein coupled receptor protein signaling pathway [IEA] dopamine receptor signaling pathway [IMP] regulation of G-protein coupled receptor protein signaling pathway [IDA][IGI] reproduction [IMP] regulation of pharyngeal pumping [IMP] inhibition of phospholipase C activity involved in G-protein coupled receptor signaling pathway [IDA] regulation of oviposition [IMP] nematode larval development [IGI] regulation of GTPase activity [IGI] regulation of synaptic transmission [IGI]
Molecular Function:	GTPase activator activity [IGI] regulator of G-protein signaling activity [IDA][IGI] signal transducer activity [IEA]

Sequence:

Sequence:
[PDR BLAST]
[ProtParam]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MMPPLTKIEV LAKRVMEGAQ LKTHKYFRIA VPHAITGQQL IALVLERGAP DDEAEASHLA  60
   61 SLLLHHGYMF PVIEHGQPFK DDGTLYRLQR PYFWPSQAEL VPDVEYAIYL NKRLLRNEQK 120
  121 HGLEEDEVES FNRLADVLAH MWAFIVQQSE LQLKQQKEKK KVDKVVFDSE ERAFWKIRKP 180
  181 SRGGPNFLED PYMKIEKKIR RQNAQGYRCL MDRLRFAIKT KPWLKALKAS DTMVTWVDQR 240
  241 AEFDPFLHPP QPSNPWISDE ASFWNQPTDT SSAEIPTEKR VKRWGLSVQE LVKDPIGRQV 300
  301 LETFLESEFS SENIRFWIAI QDLKYAPNEQ IYQKAERIRE EFLAQGAPAQ VNVDNRTLDQ 360
  361 TLECISKAKD ASQMRFAFYH SEEHVFTLMA KDSYPRFVRS QIYKAVLTAA QQHGTKRLGW 420
  421 RNFVFNMGNY V

Protein Complex Data

No complex found for this protein.

Mass Spectrometry Data

No mass spectrometry results found for this protein.

Yeast Two-Hybrid Data

The following interactions contain this protein:

NOT SHOWING SINGLE HITS. [ Show Single Hits ]

[View our yeast two-hybrid interpretation guidelines.]

No yeast two-hybrid interactions found for this protein.

Microscopy / Localization Data

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No microscopy data found in the PDR for this protein.

Protein Structure Data

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[View Top Sequence Alignments] [Show Ginzu Version Information]

Domains predicted:

#		Region(s)	Method	Confidence	Match Description
1	View Details	[1..194]	PSI-BLAST	17.69897	Solution structure of the DEP domain of human pleckstrin
2	View Details	[195..266]	FFAS03	2.89	The Crystal Structure of a Biologically Active Peptide (SIGK) Bound to a G Protein Beta:Gamma Heterodimer
3	View Details	[267..431]	PSI-BLAST	36.69897	RGS9, RGS domain

Functions predicted (by domain):

#

Gene Ontology predictions

1

Term	Confidence	Notes
transcription regulator activity	3.77201910025409	bayes_pls_golite062009
binding	3.52874320222492	bayes_pls_golite062009
DNA binding	3.44642410378325	bayes_pls_golite062009
nucleic acid binding	3.25777282180864	bayes_pls_golite062009
transcription factor activity	2.83460075788873	bayes_pls_golite062009
transcription repressor activity	2.26839643623044	bayes_pls_golite062009
sequence-specific DNA binding	1.4788427609721	bayes_pls_golite062009
transcription activator activity	1.28486271107855	bayes_pls_golite062009
signal transducer activity	0.968719315363638	bayes_pls_golite062009
molecular transducer activity	0.968719315363638	bayes_pls_golite062009
protein binding	0.753698599635855	bayes_pls_golite062009
transcription factor binding	0.63938506997853	bayes_pls_golite062009
RNA polymerase II transcription factor activity	0.49916895549368	bayes_pls_golite062009
receptor binding	0.0995086620605325	bayes_pls_golite062009

2

Term	Confidence	Notes
binding	1.90500749049821	bayes_pls_golite062009
signal transducer activity	1.70315911322844	bayes_pls_golite062009
molecular transducer activity	1.70315911322844	bayes_pls_golite062009
GTPase activity	0.944482131496004	bayes_pls_golite062009
protein binding	0.40736300061233	bayes_pls_golite062009
receptor binding	0.363468238376214	bayes_pls_golite062009

3

Term	Confidence	Notes
binding	2.35238988967981	bayes_pls_golite062009
GTPase regulator activity	1.92987277493861	bayes_pls_golite062009
nucleoside-triphosphatase regulator activity	1.90800479999702	bayes_pls_golite062009
GTPase activator activity	1.87534424848905	bayes_pls_golite062009
enzyme activator activity	1.62073651679221	bayes_pls_golite062009
enzyme regulator activity	1.49796137854909	bayes_pls_golite062009
protein binding	1.34804002381061	bayes_pls_golite062009
signal transducer activity	1.14361809679544	bayes_pls_golite062009
molecular transducer activity	1.14361809679544	bayes_pls_golite062009
beta-catenin binding	0.59248827140739	bayes_pls_golite062009

Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

Philius Transmembrane Prediction:

Protein predicted to be:	GLOBULAR (No transmembrane regions or signal peptide)
Confidence of classification:	0.99

Source: Reynolds et al. (2008)

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle