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Protein Overview: ddr-2

General Information:
Name(s) found: ddr-2 / CE27950 [WormBase]
Description(s) found:
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  • WBGene00017381 locus:ddr-2 status:Partially_confirmed UniProt:Q95ZV7 protein_id:CCD69233.1 [WormBase]
  • gi|17551608|ref|NP_508572.1| Discoidin Domain Receptor family member (ddr-2) [Caenorhabditis elegans] [NCBI NR]
  • gi|14574071|gb|AAK68319.1|U41532_3 Discoidin domain receptor protein 2, isoform a, partially confirmed by transcript evidence [Caenorhabditis elegans] [NCBI NR]
  • Discoidin domain-containing receptor tyrosine kinase B OS=Caenorhabditis elegans GN=ddr-2 PE=2 SV=1 [Swiss-Prot]
  • [wormpep67.fasta]
  • CE27950 WBGene00017381 tyrosine kinase status:Partially_confirmed TR:Q95ZV7 protein_id:AAK68319.1 [wormpep150.fasta]
  • 27950 WBGene00017381 tyrosine kinase status:Partially_confirmed TR:Q95ZV7 protein_id:AAK68319.1 [wormpep130-phg-ecoli-orf-rand.fasta]
  • domain (90.3 kD) (XD941) [Caenorhabditis elegans]gi|14574071|gb|AAK68319.1| Hypothetical protein F11D5.3a [Caenorhabditis elegans] [nrdb_11152004_Chlamydomonas]
  • tyrosine kinase status:Partially_confirmed TR:Q95ZV7 protein_id:AAK68319.1 [wormpep115.fasta.reversed]
  • CE27950 tyrosine kinase status:Partially_confirmed TR:Q95ZV7 protein_id:AAK68319.1 [wormpep80.hongbin]
  • CE27950 WBGene00017381 locus:ddr-2 tyrosine kinase status:Partially_confirmed UniProt:Q95ZV7_CAEEL protein_id:AAK68319.1 [WormBase_C-elegans_193_07-31-2008_con_reversed.fasta]
  • CE27950 WBGene00017381 locus:ddr-2 tyrosine kinase status:Partially_confirmed UniProt:Q95ZV7_CAEEL protein_id:AAK68319.1| [wormORF-contam.fasta]
  • Hypothetical protein F11D5.3a [Caenorhabditis elegans] [nr-271106-contam.fasta]
  • F11D5.3a [Caenorhabditis elegans] [nr-271106-contam.fasta]
  • CE27950 WBGene00017381 locus:ddr-2 tyrosine kinase status:Partially_confirmed TR:Q95ZV7 protein_id:AAK68319.1 [WormBase_C-elegans_wp180_08-19-2007_reversed.fasta]
  • CE27950 WBGene00017381 locus:ddr-2 tyrosine kinase status:Partially_confirmed UniProt:Q95ZV7 protein_id:AAK68319.1 [wormbase_c-elegans_2.11_01-10-2010_reversed.fasta]
  • [wormpep210-phg-orf-LaDeana-ecoli-contam.fasta.nr]
  • CE27950 WBGene00017381 locus:ddr-2 tyrosine kinase status:Partially_confirmed UniProt:Q95ZV7 protein_id:CCD69233.1 [wormbase_c_elegans_ws231_03-13-2012_reversed.fasta]
  • CE27950 WBGene00017381 locus:ddr-2 status:Partially_confirmed UniProt:Q95ZV7 protein_id:CCD69233.1 [wormpep246-ecoli-contam.fasta]
  • Discoidin domain-containing receptor B OS=Caenorhabditis elegans GN=ddr-2 PE=2 SV=1 [uniprot_sprot.fasta.20160308]
    • Organism: Caenorhabditis elegans
    Length: 797 amino acids

    Gene Ontology:
    Cellular Component: cytoplasm [IEALink to PubMed article]
    Biological Process: signal transduction [IEALink to PubMed article]
    cell adhesion [IEALink to PubMed article]
    protein amino acid phosphorylation [IEALink to PubMed article]
    Molecular Function: ATP binding [IEALink to PubMed article]
    protein tyrosine kinase activity [IEALink to PubMed article]
    non-membrane spanning protein tyrosine kinase activity [IEALink to PubMed article]
    protein kinase activity [IEALink to PubMed article]
    protein serine/threonine kinase activity [IEALink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MKLLLYLFGV TFHSNTVVAL ELRECSHQLG MSNRKIRDEQ ISASSSFDLQ STGPQHARAH  60
   61 QESGSGAWCP KNQINSLSKE WLQISFSVDT VITSVETQGR FDDGRGMEYA TAFKIQYWRP 120
  121 SLNAWASYKD DFELETIPAN NDTEHAIRRH LDRAIIARRI RIVPVSNSTR TVCMRVEVFG 180
  181 CPFDDSLVFY NVDQGDLQSG ISYHDFSYDG NLANSPHLTG GIGKLYDGEV GKNNVFVNHH 240
  241 KWVGWRRKRN GNVKLAFEFS ELRNISGILI HTSNEFKKSA KAFSSATVLF SINGKDFSDT 300
  301 IVHFNNPEDT ESEVPRWIRI PVNNRIAKVA KIRLNFGTDS DWLFISEVNF ESNHTNIELL 360
  361 NDDVVIPDSV SYFSVTEHDD GTSMFAFIIF FFMFLIVAVI ILTVLYRKRE YRVKASSPSP 420
  421 NAKREILLTI DGNTIKHHVS PSTYQMARDN LQNALIEKMP MSPIISDYAE PDISVCSDVT 480
  481 ANTPLLYGID GPYDTQKRSN PLSSMVKYSD YGEVYCTTLP EIARDKLICV SRIGQGEFGE 540
  541 VDLCQLENRK VAVKKLHGIS QADEFSFHRE IRVLGSLKHP NVVEVVGVCT IQKPILCIME 600
  601 YMENGDLKSY ILKNPTIQTS QCISICTQLA AGLAYLESCN FVHRDIAARN CLVDGEGNVK 660
  661 IADFGMARSL YSQEYYKVEG KFVLPIRWMA WEALLLGKFS TASDVWGFGV TMWEIFSLCS 720
  721 EKPYSDMTDD DVVENLQSMS STGSLKQVLS RPRMCPSKLY NEQILPCWNY ESSRRPSFEN 780
  781 VHLHLQSLVH TSPHIHF

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..308] PSI-BLAST 78.221849 No description for 2orxA was found.
    2 View Details [309..797] PSI-BLAST 80.39794 No description for 2h8hA was found.

    Functions predicted (by domain):

    # Gene Ontology predictions
    1 No functions predicted.
    2
    Term Confidence Notes
  • protein kinase activity
    		•  5.4586557943719 bayes_pls_golite062009
  • phosphotransferase activity, alcohol group as acceptor
    		•  5.04467222534257 bayes_pls_golite062009
  • kinase activity
    		•  4.85903980916957 bayes_pls_golite062009
  • transferase activity, transferring phosphorus-containing groups
    		•  4.63692708178478 bayes_pls_golite062009
  • protein serine/threonine kinase activity
    		•  4.46381887831481 bayes_pls_golite062009
  • transmembrane receptor protein tyrosine kinase activity
    		•  3.41480681854114 bayes_pls_golite062009
  • transmembrane receptor protein kinase activity
    		•  3.40140621607334 bayes_pls_golite062009
  • transferase activity
    		•  3.26787750561728 bayes_pls_golite062009
  • transmembrane receptor activity
    		•  3.1965684217331 bayes_pls_golite062009
  • epidermal growth factor receptor binding
    		•  2.9751846707539 bayes_pls_golite062009
  • receptor activity
    		•  2.96273889901429 bayes_pls_golite062009
  • molecular transducer activity
    		•  2.85730457922199 bayes_pls_golite062009
  • signal transducer activity
    		•  2.85730457922199 bayes_pls_golite062009
  • protein tyrosine kinase activity
    		•  2.8153155526437 bayes_pls_golite062009
  • binding
    		•  2.74863538127007 bayes_pls_golite062009
  • protein binding
    		•  2.276111749106 bayes_pls_golite062009
  • transmembrane receptor protein serine/threonine kinase activity
    		•  2.1677218320705 bayes_pls_golite062009
  • transforming growth factor beta receptor activity
    		•  2.1677218320705 bayes_pls_golite062009
  • receptor signaling protein activity
    		•  2.10379226653669 bayes_pls_golite062009
  • ATP binding
    		•  1.97600611746091 bayes_pls_golite062009
  • adenyl ribonucleotide binding
    		•  1.93596671856664 bayes_pls_golite062009
  • adenyl nucleotide binding
    		•  1.90928021591891 bayes_pls_golite062009
  • phosphoinositide 3-kinase binding
    		•  1.90879495821405 bayes_pls_golite062009
  • receptor signaling protein serine/threonine kinase activity
    		•  1.81249386965144 bayes_pls_golite062009
  • molecular adaptor activity
    		•  1.81145713371725 bayes_pls_golite062009
  • non-membrane spanning protein tyrosine kinase activity
    		•  1.66669268613198 bayes_pls_golite062009
  • purine ribonucleotide binding
    		•  1.65732943334212 bayes_pls_golite062009
  • ribonucleotide binding
    		•  1.65726906484847 bayes_pls_golite062009
  • purine nucleotide binding
    		•  1.63763394711025 bayes_pls_golite062009
  • vinculin binding
    		•  1.63216315345235 bayes_pls_golite062009
  • nucleotide binding
    		•  1.63195828048121 bayes_pls_golite062009
  • SH3/SH2 adaptor activity
    		•  1.59474164216385 bayes_pls_golite062009
  • growth factor binding
    		•  1.53863828216563 bayes_pls_golite062009
  • kinase binding
    		•  1.26086833316556 bayes_pls_golite062009
  • activin binding
    		•  1.22461306010416 bayes_pls_golite062009
  • catalytic activity
    		•  1.21655087018101 bayes_pls_golite062009
  • protein kinase binding
    		•  1.06030596516506 bayes_pls_golite062009
  • insulin receptor activity
    		•  0.974517002259609 bayes_pls_golite062009
  • insulin receptor substrate binding
    		•  0.95914323793919 bayes_pls_golite062009
  • transforming growth factor beta receptor activity, type I
    		•  0.880236579821909 bayes_pls_golite062009
  • protein binding, bridging
    		•  0.83823250804321 bayes_pls_golite062009
  • fibroblast growth factor binding
    		•  0.825379373288839 bayes_pls_golite062009
  • MAP kinase activity
    		•  0.81943579965027 bayes_pls_golite062009
  • activin receptor activity
    		•  0.811117252475389 bayes_pls_golite062009
  • fibroblast growth factor receptor activity
    		•  0.75189004129952 bayes_pls_golite062009
  • transporter activity
    		•  0.710766490066447 bayes_pls_golite062009
  • actin filament binding
    		•  0.66248865719696 bayes_pls_golite062009
  • nucleic acid binding
    		•  0.655396214040669 bayes_pls_golite062009
  • fibroblast growth factor 1 binding
    		•  0.634101338055638 bayes_pls_golite062009
  • transcription regulator activity
    		•  0.631882811427766 bayes_pls_golite062009
  • MAP kinase kinase activity
    		•  0.610230065465794 bayes_pls_golite062009
  • transmembrane transporter activity
    		•  0.60324822483033 bayes_pls_golite062009
  • DNA binding
    		•  0.599969415455862 bayes_pls_golite062009
  • cyclin-dependent protein kinase activity
    		•  0.499492353295369 bayes_pls_golite062009
  • enzyme binding
    		•  0.46284745266176 bayes_pls_golite062009
  • transcription factor activity
    		•  0.457173041568166 bayes_pls_golite062009
  • protein kinase C activity
    		•  0.41587987561486 bayes_pls_golite062009
  • magnesium ion binding
    		•  0.393328812780268 bayes_pls_golite062009
  • substrate-specific transporter activity
    		•  0.385603245903806 bayes_pls_golite062009
  • PTB domain binding
    		•  0.384625387464921 bayes_pls_golite062009
  • JUN kinase kinase kinase kinase activity
    		•  0.349343975617553 bayes_pls_golite062009
  • protein complex binding
    		•  0.239339759110451 bayes_pls_golite062009
  • substrate-specific transmembrane transporter activity
    		•  0.152203945257581 bayes_pls_golite062009
  • activin receptor activity, type I
    		•  0.117759584117941 bayes_pls_golite062009


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    [View Details]
    Source: Reynolds et al. 2008. Manuscript submitted Philius confidence legend
    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle