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Protein Overview: egl-4

General Information:
Name(s) found: egl-4 / CE19897 [WormBase]
Description(s) found:
Found 19 descriptions.
SHOW ALL
  • WBGene00001173 locus:egl-4 cGMP-dependent protein kinase egl-4 status:Confirmed UniProt:O76360 protein_id:CCD71859.1 [WormBase]
    • Organism: Caenorhabditis elegans
    Length: 780 amino acids

    Gene Ontology:
    Cellular Component: cytoplasm [IEALink to PubMed article]
    cAMP-dependent protein kinase complex [IEALink to PubMed article]
    Biological Process: signal transduction [IEALink to PubMed article]
    protein amino acid phosphorylation [IEALink to PubMed article]
    Molecular Function: ATP binding [IEALink to PubMed article]
    protein tyrosine kinase activity [IEALink to PubMed article]
    zinc ion binding [IEALink to PubMed article]
    non-membrane spanning protein tyrosine kinase activity [IEALink to PubMed article]
    protein kinase activity [IEALink to PubMed article]
    protein serine/threonine kinase activity [IEALink to PubMed article]
    cAMP-dependent protein kinase regulator activity [IEALink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSSGSRPSSG GGGGGGGASG GAGGGAPGGG GGGIRGFFSK LRKPSDQPNG NQVQVGTRTF  60
   61 EAHELQKLIP QLEEAISRKD AQLRQQQTIV EGHIKRISEL EGEVTTLQRE CDKLRSVLEQ 120
  121 KAQSAASPGG QPPSPSPRTD QLGNDLQQKA VLPADGVQRA KKIAVSAEPT NFENKPATLQ 180
  181 HYNKTVGAKQ MIRDAVQKND FLKQLAKEQI IELVNCMYEM RARAGQWVIQ EGEPGDRLFV 240
  241 VAEGELQVSR EGALLGKMRA GTVMGELAIL YNCTRTASVQ ALTDVQLWVL DRSVFQMITQ 300
  301 RLGMERHSQL MNFLTKVSIF QNLSEDRISK MADVMDQDYY DGGHYIIRQG EKGDAFFVIN 360
  361 SGQVKVTQQI EGETEPREIR VLNQGDFFGE RALLGEEVRT ANIIAQAPGV EVLTLDRESF 420
  421 GKLIGDLESL KKDYGDKERL AQVVREPPSP VKIVDDFREE FAQVTLKNVK RLATLGVGGF 480
  481 GRVELVCVNG DKAKTFALKA LKKKHIVDTR QQEHIFAERN IMMETSTDWI VKLYKTFRDQ 540
  541 KFVYMLLEVC LGGELWTTLR DRGHFDDYTA RFYVACVLEG LEYLHRKNIV YRDLKPENCL 600
  601 LANTGYLKLV DFGFAKKLAS GRKTWTFCGT PEYVSPEIIL NKGHDQAADY WALGIYICEL 660
  661 MLGRPPFQAS DPMKTYTLIL KGVDALEIPN RRIGKTATAL VKKLCRDNPG ERLGSGSGGV 720
  721 NDIRKHRWFM GFDWEGLRSR TLKPPILPKV SNPADVTNFD NYPPDNDVPP DEFSGWDEGF 780
  781

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run hcp-1 hcp1 IP from december2004 Cheeseman, I.M., et al. (2005)
    View Run hcp-2 hcp2 ip from december Cheeseman, I.M., et al. (2005)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..163] PSI-BLAST 3.69897 No description for 2i1jA was found.
    2 View Details [164..351] PSI-BLAST 42.69897 REGULATORY SUBUNIT OF CAMP DEPENDENT PROTEIN KINASE
    3 View Details [352..741] PSI-BLAST 44.30103 Carboxyl-terminal src kinase (csk)
    4 View Details [742..780] PSI-BLAST 87.09691 cAMP-dependent PK, catalytic subunit

    Functions predicted (by domain):

    # Gene Ontology predictions
    1 No functions predicted.
    2 No functions predicted.
    3
    Term Confidence Notes
  • cyclic nucleotide-dependent protein kinase activity
    		•  4.97855712164511 bayes_pls_golite062009
  • cAMP-dependent protein kinase activity
    		•  4.66277812893755 bayes_pls_golite062009
  • protein serine/threonine kinase activity
    		•  4.46381887831481 bayes_pls_golite062009
  • protein binding
    		•  3.19631993182765 bayes_pls_golite062009
  • molecular transducer activity
    		•  3.13508395312263 bayes_pls_golite062009
  • signal transducer activity
    		•  3.13508395312263 bayes_pls_golite062009
  • binding
    		•  3.12724619324809 bayes_pls_golite062009
  • transmembrane receptor activity
    		•  2.59526003830791 bayes_pls_golite062009
  • transmembrane receptor protein kinase activity
    		•  2.54265774272269 bayes_pls_golite062009
  • receptor activity
    		•  2.39311927684508 bayes_pls_golite062009
  • transcription regulator activity
    		•  2.32209932468336 bayes_pls_golite062009
  • tubulin binding
    		•  2.18641675163967 bayes_pls_golite062009
  • transmembrane receptor protein tyrosine kinase activity
    		•  2.16831387024372 bayes_pls_golite062009
  • cytoskeletal protein binding
    		•  2.12615078788254 bayes_pls_golite062009
  • insulin receptor binding
    		•  2.1238568876176 bayes_pls_golite062009
  • ATP binding
    		•  1.97600611746091 bayes_pls_golite062009
  • adenyl ribonucleotide binding
    		•  1.93596671856664 bayes_pls_golite062009
  • DNA binding
    		•  1.92481088182068 bayes_pls_golite062009
  • adenyl nucleotide binding
    		•  1.90928021591891 bayes_pls_golite062009
  • microtubule binding
    		•  1.88110801192607 bayes_pls_golite062009
  • actin binding
    		•  1.87817875565699 bayes_pls_golite062009
  • phosphotransferase activity, alcohol group as acceptor
    		•  1.85015570449703 bayes_pls_golite062009
  • receptor signaling protein serine/threonine kinase activity
    		•  1.81249386965144 bayes_pls_golite062009
  • molecular adaptor activity
    		•  1.81145713371725 bayes_pls_golite062009
  • nucleic acid binding
    		•  1.78648274233597 bayes_pls_golite062009
  • kinase activity
    		•  1.78069536883109 bayes_pls_golite062009
  • purine ribonucleotide binding
    		•  1.65732943334212 bayes_pls_golite062009
  • ribonucleotide binding
    		•  1.65726906484847 bayes_pls_golite062009
  • purine nucleotide binding
    		•  1.63763394711025 bayes_pls_golite062009
  • nucleotide binding
    		•  1.63195828048121 bayes_pls_golite062009
  • transferase activity, transferring phosphorus-containing groups
    		•  1.59739467025045 bayes_pls_golite062009
  • SH3/SH2 adaptor activity
    		•  1.59474164216385 bayes_pls_golite062009
  • receptor binding
    		•  1.52843393025918 bayes_pls_golite062009
  • protein kinase activity
    		•  1.4654611643382 bayes_pls_golite062009
  • ErbB-3 class receptor binding
    		•  1.25765701903393 bayes_pls_golite062009
  • transcription factor activity
    		•  1.22542472051838 bayes_pls_golite062009
  • transferase activity
    		•  1.19152443245584 bayes_pls_golite062009
  • transporter activity
    		•  1.11833481501707 bayes_pls_golite062009
  • ErbB-2 class receptor binding
    		•  1.02996109010965 bayes_pls_golite062009
  • transmembrane transporter activity
    		•  0.97575992765505 bayes_pls_golite062009
  • insulin-like growth factor receptor binding
    		•  0.950445630788802 bayes_pls_golite062009
  • phosphoinositide 3-kinase binding
    		•  0.87390239070604 bayes_pls_golite062009
  • growth factor binding
    		•  0.86076618871384 bayes_pls_golite062009
  • transcription activator activity
    		•  0.846644791435606 bayes_pls_golite062009
  • protein binding, bridging
    		•  0.83823250804321 bayes_pls_golite062009
  • MAP kinase activity
    		•  0.81943579965027 bayes_pls_golite062009
  • actin filament binding
    		•  0.794152600084 bayes_pls_golite062009
  • substrate-specific transporter activity
    		•  0.705905455086486 bayes_pls_golite062009
  • phosphoinositide 3-kinase regulator activity
    		•  0.688047400629641 bayes_pls_golite062009
  • protein complex binding
    		•  0.65988681496356 bayes_pls_golite062009
  • protein phosphorylated amino acid binding
    		•  0.649814096718101 bayes_pls_golite062009
  • structural constituent of cytoskeleton
    		•  0.612883428421652 bayes_pls_golite062009
  • cyclin-dependent protein kinase activity
    		•  0.499492353295369 bayes_pls_golite062009
  • protein serine/threonine/tyrosine kinase activity
    		•  0.48345772948903 bayes_pls_golite062009
  • substrate-specific transmembrane transporter activity
    		•  0.450699332958421 bayes_pls_golite062009
  • magnesium ion binding
    		•  0.393328812780268 bayes_pls_golite062009
  • MAP kinase kinase kinase activity
    		•  0.37115026509016 bayes_pls_golite062009
  • MAP kinase kinase activity
    		•  0.35402045013148 bayes_pls_golite062009
  • phosphotyrosine binding
    		•  0.311079584914389 bayes_pls_golite062009
  • insulin receptor substrate binding
    		•  0.29798436765753 bayes_pls_golite062009
  • insulin receptor activity
    		•  0.237134032032089 bayes_pls_golite062009
  • protein tyrosine kinase activity
    		•  0.206747304356052 bayes_pls_golite062009
  • transforming growth factor beta receptor activity
    		•  0.20643152368029 bayes_pls_golite062009
  • transmembrane receptor protein serine/threonine kinase activity
    		•  0.20643152368029 bayes_pls_golite062009
  • phosphoprotein binding
    		•  0.16798254471727 bayes_pls_golite062009
  • cytokine receptor binding
    		•  0.16478124520484 bayes_pls_golite062009
  • ion transmembrane transporter activity
    		•  0.148194101970458 bayes_pls_golite062009
  • kinase binding
    		•  0.131981353175621 bayes_pls_golite062009
  • kinase regulator activity
    		•  0.10704587503284 bayes_pls_golite062009
  • transforming growth factor beta receptor activity, type I
    		•  0.0506751594607393 bayes_pls_golite062009
  • receptor signaling protein activity
    		•  0.0443241110585009 bayes_pls_golite062009
  • nucleoside-triphosphatase activity
    		•  0.0040394359628233 bayes_pls_golite062009
    4 No functions predicted.


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.37

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle