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Protein Overview: cyp-14A2

General Information:
Name(s) found: cyp-14A2 / CE03474 [WormBase]
Description(s) found:
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  • WBGene00010706 locus:cyp-14A2 status:Partially_confirmed UniProt:Q27505 protein_id:CAA90615.1 [WormBase]
  • pir||T23523 hypothetical protein K09A11.3 - Caenorhabditis elegans [NCBI NR]
  • gi|3878448|emb|CAA90615.1| C. elegans protein K09A11.3, partially confirmed by transcript evidence [Caenorhabditis elegans] [NCBI NR]
  • gi|17568777|ref|NP_510204.1| CYtochrome P450 family member (cyp-14A2) [Caenorhabditis elegans] [NCBI NR]
  • [wormpep67.fasta]
  • CE03474 WBGene00010706 locus:cyp-14A2 Cytochrome P450 status:Partially_confirmed TR:Q27505 protein_id:CAA90615.1 [wormpep150.fasta]
  • 03474 WBGene00010706 Cytochrome P450 status:Partially_confirmed TR:Q27505 protein_id:CAA90615.1 [wormpep130-phg-ecoli-orf-rand.fasta]
  • predicted CDS, cytochrome P450 2C2 family member (XN886) [Caenorhabditis elegans]gi|3878448|emb|CAA90615.1| Hypothetical protein K09A11.3 [Caenorhabditis elegans]gi|7505611|pir||T23523 hypothetical protein K09A11.3 - Caenorhabditis elegans [nrdb_11152004_Chlamydomonas]
  • CE03474 WBGene00010706 Cytochrome P450 status:Partially_confirmed TR:Q27505 protein_id:CAA90615.1 [wormpep132.fasta]
  • 03474 WBGene00010706 locus:cyp-14A2 Cytochrome P450 status:Partially_confirmed TR:Q27505 protein_id:CAA90615.1 [wormpep150-phg-orf-ecoli-rand.fasta]
  • Cytochrome P450 status:Predicted TR:Q27505 protein_id:CAA90615.1 [wormpep115.fasta.reversed]
  • CE03474 Cytochrome P450 status:Predicted TR:Q27505 protein_id:CAA90615.1 [wormpep80.hongbin]
  • CE03474 WBGene00010706 locus:cyp-14A2 Cytochrome P450 status:Partially_confirmed UniProt:Q27505_CAEEL protein_id:CAA90615.1 [WormBase_C-elegans_193_07-31-2008_con_reversed.fasta]
  • CE03474 WBGene00010706 locus:cyp-14A2 Cytochrome P450 status:Partially_confirmed UniProt:Q27505_CAEEL protein_id:CAA90615.1| [wormORF-contam.fasta]
  • Hypothetical protein K09A11.3 [Caenorhabditis elegans] [nr-271106-contam.fasta]
  • CYtochrome P450 family member (cyp-14A2) [Caenorhabditis elegans] [nr-271106-contam.fasta]
  • CE03474 WBGene00010706 locus:cyp-14A2 Cytochrome P450 status:Partially_confirmed UniProt:Q27505 protein_id:CAA90615.1 [wormbase_c-elegans_2.11_01-10-2010_reversed.fasta]
  • [wormpep210-phg-orf-LaDeana-ecoli-contam.fasta.nr]
  • CE03474 WBGene00010706 locus:cyp-14A2 status:Partially_confirmed UniProt:Q27505 protein_id:CAA90615.1 Cytochrome P450 family [wormpep246-ecoli-contam.fasta]
  • CYtochrome P450 family OS=Caenorhabditis elegans GN=cyp-14a2 PE=3 SV=1 [CAEEL.fasta.20160308]
    • Organism: Caenorhabditis elegans
    Length: 492 amino acids

    Gene Ontology:
    Cellular Component: integral to membrane [IEALink to PubMed article]
    Biological Process: electron transport [IEALink to PubMed article]
    Molecular Function: iron ion binding [IEALink to PubMed article]
    oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen [IEALink to PubMed article]
    monooxygenase activity [IEALink to PubMed article]
    heme binding [IEALink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSILIVAFLV SITVYIAYFY WKVSKYPKGP FPLPFIGNIL QIPSENIQEY LDDLSKTYGP  60
   61 CFTLWTPLPA IVLTDYEHVK EAFVTQGDAF IYRADRPPET LLQPHLNTGV LFSNGDNWRF 120
  121 QRRTALKILR DFGLGRNLME EQVMRSVHEM LAQLERIADK KNVDMFWPIQ LCVGNVINES 180
  181 LFSYHYKYED SKKFETFVKV LDKHLKTVQG KTIFLMSAFP WLKHFPVIGE LGYHRIKKNI 240
  241 QSYQEFINDE VTSQIKHYDG ESEPENFVHA YMQQMKQSGN PNLDMNNLCA SVIDFWLAGM 300
  301 ETTSNSLRWH LAFMMKYPEI QDKVRKEILD NVGTARLPSM SDKPNMPYTQ AVIHEVQRCS 360
  361 NMIPILGTHT NRDDILLKGK KIPTGTLVFA QIWSVLKNDP VFEESSKFNP DRYLMADGKT 420
  421 INKSVLERTI PFSVGKRNCV GEGLARMELF LIFSALIQKY EFIPKTNIDV KPVCGAVLTT 480
  481 KPYICELVPQ AA

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..492] PSI-BLAST 109.0 Crystal Structure of Human Drug Metabolizing Cytochrome P450 2C8

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • arachidonic acid monooxygenase activity
    		•  6.76823710927794 bayes_pls_golite062009
  • fatty acid (omega-1)-hydroxylase activity
    		•  6.3313834755701 bayes_pls_golite062009
  • monooxygenase activity
    		•  5.57229509004705 bayes_pls_golite062009
  • steroid hydroxylase activity
    		•  5.04794778387361 bayes_pls_golite062009
  • arachidonic acid epoxygenase activity
    		•  4.80764258881036 bayes_pls_golite062009
  • electron carrier activity
    		•  4.64931978461551 bayes_pls_golite062009
  • oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced iron-sulfur protein as one donor, and incorporation of one atom of oxygen
    		•  4.64322346579269 bayes_pls_golite062009
  • steroid 17-alpha-monooxygenase activity
    		•  3.99744233006162 bayes_pls_golite062009
  • retinoic acid 4-hydroxylase activity
    		•  3.76307535769621 bayes_pls_golite062009
  • oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen
    		•  3.68151610133025 bayes_pls_golite062009
  • demethylase activity
    		•  3.40807632433846 bayes_pls_golite062009
  • oxygen binding
    		•  3.29945075872446 bayes_pls_golite062009
  • flavonoid 3'-monooxygenase activity
    		•  3.16634614522939 bayes_pls_golite062009
  • sterol 14-demethylase activity
    		•  2.94610675710811 bayes_pls_golite062009
  • retinoic acid binding
    		•  2.70323898361882 bayes_pls_golite062009
  • retinoid binding
    		•  2.60220937953757 bayes_pls_golite062009
  • oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen
    		•  2.56821164444595 bayes_pls_golite062009
  • isoprenoid binding
    		•  2.47826119804163 bayes_pls_golite062009
  • oxysterol 7-alpha-hydroxylase activity
    		•  2.36480328243514 bayes_pls_golite062009
  • oxidoreductase activity
    		•  2.35847923992364 bayes_pls_golite062009
  • 1-alpha,25-dihydroxyvitamin D3 24-hydroxylase activity
    		•  2.30416050662077 bayes_pls_golite062009
  • steroid 7-alpha-hydroxylase activity
    		•  2.21042366294727 bayes_pls_golite062009
  • oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of one atom of oxygen
    		•  2.15105968497418 bayes_pls_golite062009
  • arachidonic acid 11,12-epoxygenase activity
    		•  2.0071742914584 bayes_pls_golite062009
  • ecdysteroid 25-hydroxylase activity
    		•  2.0071742914584 bayes_pls_golite062009
  • vitamin D 24-hydroxylase activity
    		•  1.81919676974797 bayes_pls_golite062009
  • vitamin D3 25-hydroxylase activity
    		•  1.65825585934141 bayes_pls_golite062009
  • vitamin D 25-hydroxylase activity
    		•  1.65825585934141 bayes_pls_golite062009
  • corticosterone 18-monooxygenase activity
    		•  1.64204907906991 bayes_pls_golite062009
  • steroid 11-beta-monooxygenase activity
    		•  1.64204907906991 bayes_pls_golite062009
  • testosterone 6-beta-hydroxylase activity
    		•  1.4661447981611 bayes_pls_golite062009
  • binding
    		•  1.2866152532988 bayes_pls_golite062009
  • 25-hydroxycholecalciferol-24-hydroxylase activity
    		•  1.06487564122685 bayes_pls_golite062009
  • protein binding
    		•  0.836411857417911 bayes_pls_golite062009
  • ecdysteroid 22-hydroxylase activity
    		•  0.7601272997427 bayes_pls_golite062009
  • catalytic activity
    		•  0.608111453189583 bayes_pls_golite062009
  • cholesterol monooxygenase (side-chain-cleaving) activity
    		•  0.276594551871869 bayes_pls_golite062009


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    [View Details]
    Source: Reynolds et al. 2008. Manuscript submitted Philius confidence legend
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