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Protein Overview: ksg1

General Information:
Name(s) found: ksg1 / SPCC576.15c [Sanger Pombe]
Description(s) found:
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  • gi|46396282|sp|Q12701.2|KSG1_SCHPO RecName: Full=Serine/threonine-protein kinase ksg1 [NCBI NR]
  • gi|3687470|emb|CAA21194.1| serine/threonine protein kinase Ksg1 [Schizosaccharomyces pombe] [NCBI NR]
  • gi|3341488|emb|CAA67672.1| protein kinase [Schizosaccharomyces pombe] [NCBI NR]
  • gi|19075942|ref|NP_588442.1| serine/threonine protein kinase Ksg1 [Schizosaccharomyces pombe 972h-] [NCBI NR]
  • pir||T43402 probable protein kinase (EC 2.7.1.-) - fission yeast (Schizosaccharomyces pombe) [NCBI NR]
  • serine/threonine protein kinase Ksg1 [Sanger Pombe]
  • Serine/threonine-protein kinase ksg1 OS=Schizosaccharomyces pombe GN=ksg1 PE=1 SV=2 [Swiss-Prot]
  • PROTEIN KINASE; REQUIRED FOR GROWTH; PROTEIN FOR MATING; REQUIRED FOR SPORULATION; NULL LETHAL: Q12701; [pompepVF.fasta]
  • PROTEIN KINASE; REQUIRED FOR GROWTH; REQUIRED FOR MATING; REQUIRED FOR SPORULATION; NULL LETHAL: Q12701; [pompepV13]
  • Protein kinase (EC 2.7.1.37) [pompep4896]
  • |ksg1||serine/threonine protein kinase [pompepnew.fasta]
  • Serine/threonine-protein kinase ksg1 (EC 2.7.1.37) [4896.FASTAC]
  • |ksg1||serine/threonine protein kinase|Schizosaccharomyces pombe|chr 3|||Manual [pombe041504.fasta]
  • |ksg1||phosphoinositide-dependent kinase 1 family|Schizosaccharomyces pombe|chr 3|||Manual [pompep2242005.fasta]
  • protein kinase [Schizosaccharomyces pombe]gi|3341488|emb|CAA67672.1| protein kinase [Schizosaccharomyces pombe]gi|3687470|emb|CAA21194.1| ksg1 [Schizosaccharomyces pombe]gi|46396282|sp|Q12701|KSG1_SCHPO Serine/threonine-protein kinase ksg1gi|11359263| [nrdb_11152004_Chlamydomonas]
  • (Q12701) Protein kinase (EC 2.7.1.37) [pompep4896_normal_reversed]
  • |ksg1||serine/threonine protein kinase Ksg1|Schizosaccharomyces pombe|chr 3|||Manual [SGD_S-Pombe_na_10-23-2009_con_reversed.fasta]
  • Serine/threonine-protein kinase ksg1 [nr-271106-contam.fasta]
  • protein kinase [Schizosaccharomyces pombe] [nr-271106-contam.fasta]
  • hypothetical protein SPCC576.15c [Schizosaccharomyces pombe 972h-] [nr-271106-contam.fasta]
  • SPCC576.15c [Schizosaccharomyces pombe] [nr-271106-contam.fasta]
  • Serine/threonine-protein kinase ksg1 OS=Schizosaccharomyces pombe (strain 972 / ATCC 24843) GN=ksg1 PE=1 SV=2 [uniprot_sprot.fasta.20160308]
    • Organism: Schizosaccharomyces pombe
    Length: 592 amino acids

    Gene Ontology:
    Cellular Component: cytoplasm [IDALink to PubMed article]
    Biological Process: ascospore formation [IMPLink to PubMed article]
    signal transduction [IC]
    cellular cell wall organization [IMPLink to PubMed article]
    protein amino acid phosphorylation [IEA]
    regulation of conjugation with cellular fusion [IMPLink to PubMed article]
    Molecular Function: ATP binding [IEA]
    protein binding [IPILink to PubMed article]
    3-phosphoinositide-dependent protein kinase activity [ISSLink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MRNTHNPNET EASEDAENDT QSESDLSFDH GSSEKLNRAS LPKTQNSAIP QSNALNTTPN  60
   61 ESTSQIDSSP KIPSAVPHIS TPNPSSGAST PNIKRVSDFK FGEILGEGSY STVLTATENS 120
  121 TKREYAIKVL DKRHIIKEKK EKYVNIEKEA LCILSKHPGF IKLFYTFQDA HNLYFVLSLA 180
  181 RNGELLDYIN KLGRFNEICA QYYAALIVDS IDYMHGRGVI HRDLKPENIL LDDNMRTKIT 240
  241 DFGSAKILNS SHGSHEEDTH HADKPQAHSR SFVGTARYVS PEVLSDKIAG TASDIWAFGC 300
  301 ILFQMLAGKP PFVAGNEYLT FQSILHLSYE IPPDISDVAS DLIKKLLVLD PKDRLTVDEI 360
  361 HQHPFFNGIK FDNTLWELPP PRLKPFGHTS VLSLSVPNAS NKHENGDLTS PLGVPSMVSA 420
  421 STNAAPSPVG TFNRGTLLPC QSNLEEENKE WSSILQDDEK ISKIGTLNVY SMSGINGNDA 480
  481 FRFFSSLFRK RKPRTFILTN FGRYLCVASD GEGRKTVKEE IPIKSVGMRC RMVKNNEHGW 540
  541 VVETPTKSWS FEDPNGPASA WVELLDKASS ISLPFGNHSV TSFSRSIARS AV

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..378] PSI-BLAST 65.522879 Structure of human PDK1 kinase domain in complex with staurosporine
    2 View Details [379..592] PSI-BLAST 15.69897 Regulatory apparatus of Calcium Dependent protein kinase from Arabidopsis thaliana

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • phosphotransferase activity, alcohol group as acceptor
    		•  5.49988294224815 bayes_pls_golite062009
  • protein kinase activity
    		•  5.4586557943719 bayes_pls_golite062009
  • kinase activity
    		•  5.3287080791198 bayes_pls_golite062009
  • cyclic nucleotide-dependent protein kinase activity
    		•  4.97855712164511 bayes_pls_golite062009
  • transferase activity, transferring phosphorus-containing groups
    		•  4.96052051118534 bayes_pls_golite062009
  • cAMP-dependent protein kinase activity
    		•  4.66277812893755 bayes_pls_golite062009
  • protein serine/threonine kinase activity
    		•  4.46381887831481 bayes_pls_golite062009
  • calmodulin-dependent protein kinase activity
    		•  4.31938467136214 bayes_pls_golite062009
  • transferase activity
    		•  3.97138602499442 bayes_pls_golite062009
  • protein tyrosine kinase activity
    		•  2.8153155526437 bayes_pls_golite062009
  • binding
    		•  2.74863538127007 bayes_pls_golite062009
  • molecular transducer activity
    		•  2.40586892801446 bayes_pls_golite062009
  • signal transducer activity
    		•  2.40586892801446 bayes_pls_golite062009
  • telethonin binding
    		•  2.27062712605521 bayes_pls_golite062009
  • tubulin binding
    		•  2.18641675163967 bayes_pls_golite062009
  • cytoskeletal protein binding
    		•  2.12615078788254 bayes_pls_golite062009
  • receptor signaling protein activity
    		•  2.10379226653669 bayes_pls_golite062009
  • ATP binding
    		•  1.97600611746091 bayes_pls_golite062009
  • adenyl ribonucleotide binding
    		•  1.93596671856664 bayes_pls_golite062009
  • adenyl nucleotide binding
    		•  1.90928021591891 bayes_pls_golite062009
  • microtubule binding
    		•  1.88110801192607 bayes_pls_golite062009
  • actin binding
    		•  1.87817875565699 bayes_pls_golite062009
  • receptor signaling protein serine/threonine kinase activity
    		•  1.81249386965144 bayes_pls_golite062009
  • transmembrane receptor protein kinase activity
    		•  1.7769021678395 bayes_pls_golite062009
  • transmembrane receptor activity
    		•  1.6878868450299 bayes_pls_golite062009
  • purine ribonucleotide binding
    		•  1.65732943334212 bayes_pls_golite062009
  • ribonucleotide binding
    		•  1.65726906484847 bayes_pls_golite062009
  • purine nucleotide binding
    		•  1.63763394711025 bayes_pls_golite062009
  • nucleotide binding
    		•  1.63195828048121 bayes_pls_golite062009
  • insulin receptor substrate binding
    		•  1.62657794525303 bayes_pls_golite062009
  • receptor activity
    		•  1.57112777506542 bayes_pls_golite062009
  • transmembrane receptor protein tyrosine kinase activity
    		•  1.4571078357189 bayes_pls_golite062009
  • JUN kinase kinase kinase activity
    		•  1.41172362253967 bayes_pls_golite062009
  • alpha-actinin binding
    		•  1.38861866085902 bayes_pls_golite062009
  • gamma-tubulin binding
    		•  1.28511591054866 bayes_pls_golite062009
  • phosphoinositide 3-kinase binding
    		•  1.25285260301349 bayes_pls_golite062009
  • protein binding
    		•  1.22565748038754 bayes_pls_golite062009
  • catalytic activity
    		•  1.21655087018101 bayes_pls_golite062009
  • transporter activity
    		•  1.11833481501707 bayes_pls_golite062009
  • transmembrane transporter activity
    		•  0.97575992765505 bayes_pls_golite062009
  • cyclin-dependent protein kinase activity
    		•  0.959360414036299 bayes_pls_golite062009
  • MAP kinase activity
    		•  0.81943579965027 bayes_pls_golite062009
  • actin filament binding
    		•  0.794152600084 bayes_pls_golite062009
  • substrate-specific transporter activity
    		•  0.705905455086486 bayes_pls_golite062009
  • structural constituent of cytoskeleton
    		•  0.612883428421652 bayes_pls_golite062009
  • protein complex binding
    		•  0.599713385230491 bayes_pls_golite062009
  • general RNA polymerase II transcription factor activity
    		•  0.51726292539973 bayes_pls_golite062009
  • protein serine/threonine/tyrosine kinase activity
    		•  0.48345772948903 bayes_pls_golite062009
  • substrate-specific transmembrane transporter activity
    		•  0.450699332958421 bayes_pls_golite062009
  • nucleic acid binding
    		•  0.444972929276369 bayes_pls_golite062009
  • magnesium ion binding
    		•  0.393328812780268 bayes_pls_golite062009
  • MAP kinase kinase kinase activity
    		•  0.37115026509016 bayes_pls_golite062009
  • MAP kinase kinase activity
    		•  0.35402045013148 bayes_pls_golite062009
  • kinase binding
    		•  0.26752427107238 bayes_pls_golite062009
  • transmembrane receptor protein serine/threonine kinase activity
    		•  0.26602283402868 bayes_pls_golite062009
  • transforming growth factor beta receptor activity
    		•  0.26602283402868 bayes_pls_golite062009
  • insulin receptor activity
    		•  0.237134032032089 bayes_pls_golite062009
  • SH2 domain binding
    		•  0.226760162354251 bayes_pls_golite062009
  • transcription regulator activity
    		•  0.222474717779546 bayes_pls_golite062009
  • DNA binding
    		•  0.198054762876122 bayes_pls_golite062009
  • ion transmembrane transporter activity
    		•  0.148194101970458 bayes_pls_golite062009
  • growth factor binding
    		•  0.0526340287295695 bayes_pls_golite062009
  • transforming growth factor beta receptor activity, type I
    		•  0.0506751594607393 bayes_pls_golite062009
  • transcription factor activity
    		•  0.026050048647416 bayes_pls_golite062009
  • protein kinase binding
    		•  0.00674998152095019 bayes_pls_golite062009
  • nucleoside-triphosphatase activity
    		•  0.0040394359628233 bayes_pls_golite062009
    2 No functions predicted.


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.98

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle