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Protein Overview: ilv1

General Information:
Name(s) found: ilv1 / SPBP35G2.07 [Sanger Pombe]
Description(s) found:
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  • gi|7573200|emb|CAB87369.1| acetolactate synthase catalytic subunit [Schizosaccharomyces pombe] [NCBI NR]
  • gi|19112174|ref|NP_595382.1| acetolactate synthase catalytic subunit [Schizosaccharomyces pombe 972h-] [NCBI NR]
  • gi|13124747|sp|P36620.2|ILVB_SCHPO RecName: Full=Acetolactate synthase, mitochondrial; AltName: Full=Acetohydroxy-acid synthase; AltName: Full=ALS; AltName: Full=AHAS; Flags: Precursor [NCBI NR]
  • acetolactate synthase catalytic subunit [Sanger Pombe]
  • Acetolactate synthase, mitochondrial OS=Schizosaccharomyces pombe GN=ilv1 PE=2 SV=2 [Swiss-Prot]
  • ACETOLACTATE SYNTHASE (ACETOHYDROXYACID SYNTHASE); FIRST STEP IN VALINE AND ISOLEUCINE BIOSYNTHESIS PATHWAY; SIMILAR TO S. CEREVISIAE ILV2: P36620;Q9P796; [pompepVF.fasta]
  • Acetolactate synthase, mitochondrial precursor (EC 2.2.1.6) (Acetohydroxy-acid synthase) (ALS) (AHAS) [pompep4896]
  • |ilv1||acetolactate synthase subunit (PMID 8299177) [pompepnew.fasta]
  • |ilv1||acetolactate synthase subunit (PMID 8299177)|Schizosaccharomyces pombe|chr 2|||Manual [pombe041504.fasta]
  • acetolactate synthase precursor [Schizosaccharomyces pombe]gi|7573200|emb|CAB87369.1| ilv1 [Schizosaccharomyces pombe]gi|13124747|sp|P36620|ILVB_SCHPO Acetolactate synthase, mitochondrial precursor (Acetohydroxy-acid synthase) (ALS) (AHAS) [nrdb_11152004_Chlamydomonas]
  • |ilv1||acetolactate synthase subunit|Schizosaccharomyces pombe|chr 2|||Manual [pompep2242005.fasta]
  • (P36620) Acetolactate synthase, mitochondrial precursor (EC 2.2.1.6) (Acetohydroxy-acid synthase) (ALS) (AHAS) [pompep4896_normal_reversed]
  • |ilv1||acetolactate synthase catalytic subunit|Schizosaccharomyces pombe|chr 2|||Manual [SGD_S-Pombe_na_10-23-2009_con_reversed.fasta]
  • SPBP35G2.07 [Schizosaccharomyces pombe] [nr-271106-contam.fasta]
  • Acetolactate synthase, mitochondrial precursor (Acetohydroxy-acid synthase) (ALS) (AHAS) [nr-271106-contam.fasta]
  • acetolactate synthase [Schizosaccharomyces pombe 972h-] [nr-271106-contam.fasta]
  • Acetolactate synthase, mitochondrial OS=Schizosaccharomyces pombe (strain 972 / ATCC 24843) GN=ilv1 PE=3 SV=2 [uniprot_sprot.fasta.20160308]
    • Organism: Schizosaccharomyces pombe
    Length: 669 amino acids

    Gene Ontology:
    Cellular Component: mitochondrion [IDALink to PubMed article][ISSLink to PubMed article]
    acetolactate synthase complex [ISSLink to PubMed article]
    Biological Process: isoleucine biosynthetic process [IGILink to PubMed article]
    valine metabolic process [RCALink to PubMed article]
    Molecular Function: acetolactate synthase activity [IGILink to PubMed article]
    magnesium ion binding [IEA]
    thiamin pyrophosphate binding [IEA]
    FAD binding [IEA]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MTVLAPLRRL HTRAAFSSYG REIALQKRFL NLNSCSAVRR YGTGFSNNLR IKKLKNAFGV  60
   61 VRANSTKSTS TVTTASPIKY DSSFVGKTGG EIFHDMMLKH NVKHVFGYPG GAILPVFDAI 120
  121 YRSPHFEFIL PRHEQAAGHA AQAYSRVTKK PGVVLVTSGP GATNVITPIA DALADGTPLV 180
  181 VFSGQVATSA IGSDAFQEAD MVGISRSCTK WNVMVKDVAD LPRRIDEAFE IATSGRPGPV 240
  241 LVDLPKDVTA SVLKEPIPIL SSVPSMNRRM KEVLEEGSKN VTAKIDRVAN LLKLAKKPVI 300
  301 FCGHGVLANP ECPTLLRKFS ERLQIPVTTS LLGLGAVDER SDLSLHMLGM HGSGYANMAM 360
  361 QEADLILALG VRFDDRVTGN VSLFAPQARL AAAEERGGII HFDISPKNIG KVVQPTEAIE 420
  421 GDVYESLKLL DSATKNIKIP SRFDWLSQIQ TWKERFPFTF TRSAPGELVK PQEVIQELDK 480
  481 QTSDIKDKVT ITTGVGAHQM WAATFYRWTK PSSLVTSGGL GTMGFGLPAA IGASVAAPKD 540
  541 IVIDIDGDAS FSMTGMELAT VRQFDIPVKI LILNNEEQGM VTQWQNLFYE KRYSHTHQKN 600
  601 PNFVKLADAM GIKALRVEKR EDLAKKMKEF LSTKGPVLME VLVAQKEHVY PFVPGGKALH 660
  661 QFILHESLS

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..669] PSI-BLAST 151.0 Acetohydroxyacid synthase catalytic subunit

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • acetolactate synthase activity
    		•  12.903449876837 bayes_pls_golite062009
  • transferase activity, transferring aldehyde or ketonic groups
    		•  12.3239025230705 bayes_pls_golite062009
  • pyruvate dehydrogenase activity
    		•  5.28857071459273 bayes_pls_golite062009
  • oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
    		•  5.21233670052586 bayes_pls_golite062009
  • pyruvate dehydrogenase (acetyl-transferring) activity
    		•  5.08663245333808 bayes_pls_golite062009
  • transcription regulator activity
    		•  2.51117258094456 bayes_pls_golite062009
  • transketolase activity
    		•  2.50501741089295 bayes_pls_golite062009
  • oxidoreductase activity, acting on the aldehyde or oxo group of donors
    		•  2.15444163802756 bayes_pls_golite062009
  • DNA binding
    		•  2.09930834951157 bayes_pls_golite062009
  • binding
    		•  2.06552694538163 bayes_pls_golite062009
  • deoxyhypusine synthase activity
    		•  2.04735838056767 bayes_pls_golite062009
  • nucleic acid binding
    		•  2.00972611627502 bayes_pls_golite062009
  • hydrogen ion transmembrane transporter activity
    		•  1.98546381612935 bayes_pls_golite062009
  • NAD-dependent histone deacetylase activity
    		•  1.93141177609772 bayes_pls_golite062009
  • NAD-dependent protein deacetylase activity
    		•  1.93141177609772 bayes_pls_golite062009
  • histone deacetylase activity
    		•  1.91254869751164 bayes_pls_golite062009
  • protein deacetylase activity
    		•  1.90521776801103 bayes_pls_golite062009
  • thiamin pyrophosphate binding
    		•  1.87247313698582 bayes_pls_golite062009
  • monovalent inorganic cation transmembrane transporter activity
    		•  1.82969293063325 bayes_pls_golite062009
  • electron carrier activity
    		•  1.6597783195591 bayes_pls_golite062009
  • 3-methyl-2-oxobutanoate dehydrogenase (2-methylpropanoyl-transferring) activity
    		•  1.65348126142808 bayes_pls_golite062009
  • alpha-ketoacid dehydrogenase activity
    		•  1.20517690263403 bayes_pls_golite062009
  • transcription factor binding
    		•  1.07103864164531 bayes_pls_golite062009
  • inorganic cation transmembrane transporter activity
    		•  1.0611726850452 bayes_pls_golite062009
  • transcription factor activity
    		•  1.0180828203704 bayes_pls_golite062009
  • NAD or NADH binding
    		•  0.98460927780383 bayes_pls_golite062009
  • oxidoreductase activity, acting on NADH or NADPH
    		•  0.982646671777 bayes_pls_golite062009
  • deacetylase activity
    		•  0.977680867213479 bayes_pls_golite062009
  • cation transmembrane transporter activity
    		•  0.78591260444574 bayes_pls_golite062009
  • coenzyme binding
    		•  0.78091040721014 bayes_pls_golite062009
  • catalytic activity
    		•  0.739210399081789 bayes_pls_golite062009
  • hydrolase activity
    		•  0.536729211484905 bayes_pls_golite062009
  • transcription repressor activity
    		•  0.516307124442946 bayes_pls_golite062009
  • ion transmembrane transporter activity
    		•  0.51426028502998 bayes_pls_golite062009
  • protein binding
    		•  0.475479132768057 bayes_pls_golite062009
  • transcription cofactor activity
    		•  0.42635585193838 bayes_pls_golite062009
  • oxidoreductase activity
    		•  0.343338509910926 bayes_pls_golite062009
  • transcription corepressor activity
    		•  0.23414654967509 bayes_pls_golite062009
  • pyruvate decarboxylase activity
    		•  0.198062360371269 bayes_pls_golite062009
  • hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds
    		•  0.114062221123972 bayes_pls_golite062009


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.79

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle