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View Structure Prediction Details

Protein: ilv1
Organism: Schizosaccharomyces pombe
Length: 669 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for ilv1.

Description E-value Query
Range
Subject
Range
gi|481665, gi|406192 - pir||S39111 acetolactate synthase (EC 4.1.3.18) precursor - fission yeast (Schizosaccharomyces pombe...
589.0 [0..1] [669..1]
gi|7436698 - pir||C70341 acetolactate synthase (EC 4.1.3.18) large chain - Aquifex aeolicus
gi|15605942, gi|... - gi|2983101|gb|AAC06706.1| acetolactate synthase large subunit [Aquifex aeolicus VF5], gi|15605942|re...
557.0 [0..84] [666..1]
orf19.9180 - ILV2 CGDID:CAL0006335 Assembly 19, Contig19-20123 (18878, 16827) CDS, reverse complemented, translat...
gi|46443492, gi|... - gi|68468504|ref|XP_721571.1| hypothetical protein CaO19.9180 [Candida albicans SC5314], gi|46443492|...
gi|238880654 - gi|238880654|gb|EEQ44292.1| acetolactate synthase, mitochondrial precursor [Candida albicans WO-1]
554.0 [0..5] [667..1]
gi|219993234, gi... - gi|89210057|ref|ZP_01188450.1| Acetolactate synthase, large subunit, biosynthetic type [Halothermoth...
550.0 [0..84] [663..1]
gi|222054607, gi... - gi|222054607|ref|YP_002536969.1| acetolactate synthase, large subunit, biosynthetic type [Geobacter ...
547.0 [0..85] [664..1]
gi|146399240, gi... - gi|88936939|ref|ZP_01142531.1| Acetolactate synthase, large subunit, biosynthetic type [Geobacter ur...
547.0 [0..85] [664..1]
gi|77958248 - gi|77958248|ref|ZP_00822285.1| COG0028: Thiamine pyrophosphate-requiring enzymes [acetolactate synth...
545.0 [0..68] [667..1]
gi|77996676, gi|... - gi|78044561|ref|YP_359375.1| acetolactate synthase, large subunit, biosynthetic type [Carboxydotherm...
545.0 [0..85] [663..1]
gi|75908969, gi|... - gi|75908969|ref|YP_323265.1| acetolactate synthase 3 catalytic subunit [Anabaena variabilis ATCC 294...
545.0 [0..56] [663..1]

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Predicted Domain #1
Region A:
Residues: [1-669]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MTVLAPLRRL HTRAAFSSYG REIALQKRFL NLNSCSAVRR YGTGFSNNLR IKKLKNAFGV  60
   61 VRANSTKSTS TVTTASPIKY DSSFVGKTGG EIFHDMMLKH NVKHVFGYPG GAILPVFDAI 120
  121 YRSPHFEFIL PRHEQAAGHA AQAYSRVTKK PGVVLVTSGP GATNVITPIA DALADGTPLV 180
  181 VFSGQVATSA IGSDAFQEAD MVGISRSCTK WNVMVKDVAD LPRRIDEAFE IATSGRPGPV 240
  241 LVDLPKDVTA SVLKEPIPIL SSVPSMNRRM KEVLEEGSKN VTAKIDRVAN LLKLAKKPVI 300
  301 FCGHGVLANP ECPTLLRKFS ERLQIPVTTS LLGLGAVDER SDLSLHMLGM HGSGYANMAM 360
  361 QEADLILALG VRFDDRVTGN VSLFAPQARL AAAEERGGII HFDISPKNIG KVVQPTEAIE 420
  421 GDVYESLKLL DSATKNIKIP SRFDWLSQIQ TWKERFPFTF TRSAPGELVK PQEVIQELDK 480
  481 QTSDIKDKVT ITTGVGAHQM WAATFYRWTK PSSLVTSGGL GTMGFGLPAA IGASVAAPKD 540
  541 IVIDIDGDAS FSMTGMELAT VRQFDIPVKI LILNNEEQGM VTQWQNLFYE KRYSHTHQKN 600
  601 PNFVKLADAM GIKALRVEKR EDLAKKMKEF LSTKGPVLME VLVAQKEHVY PFVPGGKALH 660
  661 QFILHESLS

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 151.0
Match: 1n0hA
Description: Acetohydroxyacid synthase catalytic subunit
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
acetolactate synthase activity 12.903449876837 bayes_pls_golite062009
transferase activity, transferring aldehyde or ketonic groups 12.3239025230705 bayes_pls_golite062009
pyruvate dehydrogenase activity 5.28857071459273 bayes_pls_golite062009
oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor 5.21233670052586 bayes_pls_golite062009
pyruvate dehydrogenase (acetyl-transferring) activity 5.08663245333808 bayes_pls_golite062009
transcription regulator activity 2.51117258094456 bayes_pls_golite062009
transketolase activity 2.50501741089295 bayes_pls_golite062009
oxidoreductase activity, acting on the aldehyde or oxo group of donors 2.15444163802756 bayes_pls_golite062009
DNA binding 2.09930834951157 bayes_pls_golite062009
binding 2.06552694538163 bayes_pls_golite062009
deoxyhypusine synthase activity 2.04735838056767 bayes_pls_golite062009
nucleic acid binding 2.00972611627502 bayes_pls_golite062009
hydrogen ion transmembrane transporter activity 1.98546381612935 bayes_pls_golite062009
NAD-dependent histone deacetylase activity 1.93141177609772 bayes_pls_golite062009
NAD-dependent protein deacetylase activity 1.93141177609772 bayes_pls_golite062009
histone deacetylase activity 1.91254869751164 bayes_pls_golite062009
protein deacetylase activity 1.90521776801103 bayes_pls_golite062009
thiamin pyrophosphate binding 1.87247313698582 bayes_pls_golite062009
monovalent inorganic cation transmembrane transporter activity 1.82969293063325 bayes_pls_golite062009
electron carrier activity 1.6597783195591 bayes_pls_golite062009
3-methyl-2-oxobutanoate dehydrogenase (2-methylpropanoyl-transferring) activity 1.65348126142808 bayes_pls_golite062009
alpha-ketoacid dehydrogenase activity 1.20517690263403 bayes_pls_golite062009
transcription factor binding 1.07103864164531 bayes_pls_golite062009
inorganic cation transmembrane transporter activity 1.0611726850452 bayes_pls_golite062009
transcription factor activity 1.0180828203704 bayes_pls_golite062009
NAD or NADH binding 0.98460927780383 bayes_pls_golite062009
oxidoreductase activity, acting on NADH or NADPH 0.982646671777 bayes_pls_golite062009
deacetylase activity 0.977680867213479 bayes_pls_golite062009
cation transmembrane transporter activity 0.78591260444574 bayes_pls_golite062009
coenzyme binding 0.78091040721014 bayes_pls_golite062009
catalytic activity 0.739210399081789 bayes_pls_golite062009
hydrolase activity 0.536729211484905 bayes_pls_golite062009
transcription repressor activity 0.516307124442946 bayes_pls_golite062009
ion transmembrane transporter activity 0.51426028502998 bayes_pls_golite062009
protein binding 0.475479132768057 bayes_pls_golite062009
transcription cofactor activity 0.42635585193838 bayes_pls_golite062009
oxidoreductase activity 0.343338509910926 bayes_pls_golite062009
transcription corepressor activity 0.23414654967509 bayes_pls_golite062009
pyruvate decarboxylase activity 0.198062360371269 bayes_pls_golite062009
hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds 0.114062221123972 bayes_pls_golite062009

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