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Protein Overview: pcu4

General Information:
Name(s) found: pcu4 / SPAC3A11.08 [Sanger Pombe]
Description(s) found:
Found 20 descriptions.
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  • cullin 4 [Sanger Pombe]
    • Organism: Schizosaccharomyces pombe
    Length: 734 amino acids

    Gene Ontology:
    Cellular Component: nucleus [IDALink to PubMed articleLink to PubMed article]
    CLRC ubiquitin ligase complex [IDALink to PubMed article]
    nuclear centromeric heterochromatin [TASLink to PubMed article]
    cytosol [IDALink to PubMed article]
    signalosome [IDALink to PubMed article]
    Biological Process: regulation of histone methylation [IMPLink to PubMed article]
    positive regulation of meiosis [IGILink to PubMed article]
    regulation of protein localization [IGILink to PubMed article]
    transcription-coupled nucleotide-excision repair [IMPLink to PubMed article]
    chromosome segregation [IMPLink to PubMed article]
    negative regulation of DNA replication [IMPLink to PubMed article]
    donor selection [TASLink to PubMed article]
    response to DNA damage stimulus [IMPLink to PubMed article]
    chromatin silencing at telomere [IMPLink to PubMed article]
    protein ubiquitination during ubiquitin-dependent protein catabolic process [IGILink to PubMed article]
    chromatin silencing at centromere [IMPLink to PubMed article]
    heterochromatin formation [IMPLink to PubMed article]
    regulation of histone H3-K9 methylation [IMPLink to PubMed article]
    chromatin silencing at silent mating-type cassette [IMPLink to PubMed article]
    negative regulation of DNA endoreduplication [IMPLink to PubMed article]
    cellular protein localization [IGILink to PubMed articleLink to PubMed article]
    chromatin silencing by small RNA [IMPLink to PubMed article]
    protein ubiquitination [IDALink to PubMed article]
    Molecular Function: ubiquitin-protein ligase activity [IDALink to PubMed article]
    ubiquitin protein ligase binding [IEA]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MPPEAKRIVV KGFDPRKSRQ RQETYYVTMI DRLNMALQVV MAGLGLKTGY QELYSGVENL  60
   61 TRADQASRCF NILQHHMSSG IQLLKDSAES FIQLEGTETD TNACTVVVGC WNKWLERVEI 120
  121 VQNIFYYMDK TFLSHHPDYP TIEELSLSLF REKLMAVKNI QIPFLNSLLQ SFENLHSSKS 180
  181 TDHAYLQDAM LMLHRTEMYS SVFVPMYLVM LSRFYDTESS QKIQELPLEE YLEYAMSSLE 240
  241 REDAYVEKFD IVRDKKSIRE TVQRCLITSH LDTLTKGISQ FIEKRDAHSC KLLYALLQFN 300
  301 HETEYLIQPW SDCLVDVGFK LVNDESKDDT LVQELLSFHK FLQVVVDESF LHDETLSYAM 360
  361 RKAFETFING AKGSQREAPA RLIAKYIDYL LRVGEQASGG KPLKEVFSEI LDLFRYIASK 420
  421 DIFEAYYKLD IAKRLLLNKS ASAQNELMLL DMLKKTCGSQ FTHSLEGMFR DVNISKEFTS 480
  481 SFRHSKAAHN LHRDLYVNVL SQAYWPSYPE SHIRLPDDMQ QDLDCFEKFY LSKQVGKKIS 540
  541 WYASLGHCIV KARFPLGNKE LSISLFQACV LLQFNNCLGG EGISYQDLKK STELSDIDLT 600
  601 RTLQSLSCAR IRPLVMVPKS KKPSPDTMFY VNEKFTDKLY RVKINQIYLK EERQENSDVQ 660
  661 EQVVRDRQFE LQASIVRVMK QKEKMKHDDL VQYVINNVKD RGIPLVSDVK TAIEKLLEKE 720
  721 YLEREDNDIY TYVT

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    SHOWING SINGLE HITS. [ Hide Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..734] PSI-BLAST 1000.0 No description for 2hyeC was found.

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • ubiquitin-protein ligase activity
    		•  9.47178230940453 bayes_pls_golite062009
  • small conjugating protein ligase activity
    		•  9.15192834197166 bayes_pls_golite062009
  • acid-amino acid ligase activity
    		•  8.12051073361876 bayes_pls_golite062009
  • ligase activity, forming carbon-nitrogen bonds
    		•  6.87003086224111 bayes_pls_golite062009
  • transcription regulator activity
    		•  5.55329976718261 bayes_pls_golite062009
  • transcription factor activity
    		•  4.33152142980289 bayes_pls_golite062009
  • transcription repressor activity
    		•  3.85678231380989 bayes_pls_golite062009
  • ligase activity
    		•  3.18349288224112 bayes_pls_golite062009
  • transcription activator activity
    		•  2.37668609508629 bayes_pls_golite062009
  • binding
    		•  2.3219000606044 bayes_pls_golite062009
  • nucleic acid binding
    		•  2.21939548334548 bayes_pls_golite062009
  • protein binding
    		•  2.20237620151495 bayes_pls_golite062009
  • vasopressin activated calcium mobilizing receptor activity
    		•  2.15618962838168 bayes_pls_golite062009
  • DNA binding
    		•  2.06132216820898 bayes_pls_golite062009
  • RNA polymerase II transcription factor activity
    		•  1.70025468248325 bayes_pls_golite062009
  • structure-specific DNA binding
    		•  1.33374581364046 bayes_pls_golite062009
  • specific transcriptional repressor activity
    		•  0.96257232341735 bayes_pls_golite062009
  • transporter activity
    		•  0.891050405674973 bayes_pls_golite062009
  • transcription factor binding
    		•  0.85714789329232 bayes_pls_golite062009
  • DNA replication origin binding
    		•  0.71823621709622 bayes_pls_golite062009
  • DNA-dependent ATPase activity
    		•  0.697234220778482 bayes_pls_golite062009
  • transmembrane transporter activity
    		•  0.648150681919233 bayes_pls_golite062009
  • substrate-specific transporter activity
    		•  0.368917395770011 bayes_pls_golite062009
  • transcription corepressor activity
    		•  0.322180400748724 bayes_pls_golite062009
  • DNA helicase activity
    		•  0.300899564141452 bayes_pls_golite062009
  • double-stranded DNA binding
    		•  0.286130392009263 bayes_pls_golite062009
  • structural molecule activity
    		•  0.272316540117209 bayes_pls_golite062009
  • sequence-specific DNA binding
    		•  0.257777071965243 bayes_pls_golite062009
  • transferase activity, transferring phosphorus-containing groups
    		•  0.249771970501337 bayes_pls_golite062009
  • catalytic activity
    		•  0.201606344181603 bayes_pls_golite062009
  • hydrolase activity
    		•  0.140191206949582 bayes_pls_golite062009
  • substrate-specific transmembrane transporter activity
    		•  0.107671044044222 bayes_pls_golite062009
  • structural constituent of ribosome
    		•  0.0912115683429473 bayes_pls_golite062009
  • specific RNA polymerase II transcription factor activity
    		•  0.0856082199488197 bayes_pls_golite062009
  • transferase activity
    		•  0.064832527337659 bayes_pls_golite062009


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.91

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle