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Protein Overview: erg11

General Information:
Name(s) found: erg11 / SPAC13A11.02c [Sanger Pombe]
Description(s) found:
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  • gi|984223|emb|CAA90803.1| sterol 14-demethylase [Schizosaccharomyces pombe] [NCBI NR]
  • pir||T37609 probable cytochrome p450 51 - fission yeast (Schizosaccharomyces pombe) [NCBI NR]
  • gi|19113902|ref|NP_592990.1| sterol 14-demethylase [Schizosaccharomyces pombe] [NCBI NR]
  • gi|1169074|sp|Q09736.1|CP51_SCHPO RecName: Full=Lanosterol 14-alpha demethylase erg11; AltName: Full=Cytochrome P450 51; AltName: Full=CYPLI; AltName: Full=P450-LIA1; AltName: Full=Sterol 14-alpha demethylase erg11; AltName: Full=P450-14DM; Flags: Precurs [NCBI NR]
  • sterol 14-demethylase [Sanger Pombe]
  • Lanosterol 14-alpha demethylase erg11 OS=Schizosaccharomyces pombe GN=erg11 PE=1 SV=1 [Swiss-Prot]
  • PUTATIVE CYTOCHROME P450 51: Q09736; [pompepVF.fasta]
  • PROBABLE CYTOCHROME P450 51: Q09736; [pompepV13]
  • Probable cytochrome P450 51 (EC 1.14.13.70) (CYPLI) (P450-LIA1) (Sterol 14-alpha demethylase) (Lanosterol 14-alpha demethylase) (P450-14DM) [pompep4896]
  • |cyp51||putative cytochrome p450 51 [pompepnew.fasta]
  • |cyp51||cytochrome p450 51 (predicted)|Schizosaccharomyces pombe|chr 1|||Manual [pombe041504.fasta]
  • probable cytochrome p450 51 [Schizosaccharomyces pombe]gi|984223|emb|CAA90803.1| cyp51 [Schizosaccharomyces pombe]gi|1169074|sp|Q09736|CP51_SCHPO Probable cytochrome P450 51 (CYPLI) (P450-LIA1) (Sterol 14-alpha demethylase) (Lanosterol 14-alpha demethyl [nrdb_11152004_Chlamydomonas]
  • |erg11||cytochrome p450 family |Schizosaccharomyces pombe|chr 1|||Manual [pompep2242005.fasta]
  • (Q09736) Probable cytochrome P450 51 (EC 1.14.13.70) (CYPLI) (P450-LIA1) (Sterol 14-alpha demethylase) (Lanosterol 14-alpha demethylase) (P450-14DM) [pompep4896_normal_reversed]
  • |erg11||sterol 14-demethylase|Schizosaccharomyces pombe|chr 1|||Manual [SGD_S-Pombe_na_10-23-2009_con_reversed.fasta]
  • Probable cytochrome P450 51 (CYPLI) (P450-LIA1) (Sterol 14-alpha demethylase) (Lanosterol 14-alpha demethylase) (P450-14DM) [nr-271106-contam.fasta]
  • SPAC13A11.02c [Schizosaccharomyces pombe] [nr-271106-contam.fasta]
  • hypothetical protein SPAC13A11.02c [Schizosaccharomyces pombe 972h-] [nr-271106-contam.fasta]
  • |erg11||sterol 14-demethylase |Schizosaccharomyces pombe|chr 1|||Manual [Other_S_Pombe_12-15-2011_reversed.fasta]
  • Lanosterol 14-alpha demethylase erg11 OS=Schizosaccharomyces pombe (strain 972 / ATCC 24843) GN=erg11 PE=1 SV=1 [uniprot_sprot.fasta.20160308]
    • Organism: Schizosaccharomyces pombe
    Length: 495 amino acids

    Gene Ontology:
    Cellular Component: endoplasmic reticulum membrane [ISSLink to PubMed article]
    integral to membrane [IEA]
    endoplasmic reticulum [IDALink to PubMed article]
    Biological Process: ergosterol biosynthetic process [IEPLink to PubMed article]
    Molecular Function: protein binding [IPILink to PubMed article]
    iron ion binding [IEA]
    sterol 14-demethylase activity [ISSLink to PubMed article]
    heme binding [IEA]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MAFSLVSILL SIALAWYVGY IINQLTSRNS KRPPIVFHWI PFVGSAVAYG MDPYVFFREC  60
   61 RAKYGDVFTF VCMGRKMTAF LGVQGNDFLF NGKLADLNAE EAYSHLTTPV FGKDVVYDIP 120
  121 NHVFMEHKKF IKSGLGFSQF RSYVPLILNE MDAFLSTSPD FGPGKEGVAD LLKTMPVMTI 180
  181 YTASRTLQGA EVRKGFDAGF ADLYHDLDQG FSPVNFVFPW LPLPRNRRRD RAHKIMQKTY 240
  241 LKIIKDRRSS TENPGTDMIW TLMSCKYRDG RPLKEHEIAG MMIALLMAGQ HTSAATIVWV 300
  301 LALLGSKPEI IEMLWEEQKR VVGENLELKF DQYKDMPLLN YVIQETLRLH PPIHSHMRKV 360
  361 KRDLPVPGSK IVIPANNYLL AAPGLTATEE EYFTHATDFD PKRWNDRVNE DENAEQIDYG 420
  421 YGLVTKGAAS PYLPFGAGRH RCIGEQFAYM HLSTIISKFV HDYTWTLIGK VPNVDYSSMV 480
  481 ALPLGPVKIA WKRRN

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..495] PSI-BLAST 67.0 Estriol-bound and ligand-free structures of sterol 14alpha-demethylase (CYP51)

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • monooxygenase activity
    		•  5.57229509004705 bayes_pls_golite062009
  • steroid hydroxylase activity
    		•  5.04794778387361 bayes_pls_golite062009
  • oxysterol 7-alpha-hydroxylase activity
    		•  5.03099580095037 bayes_pls_golite062009
  • retinoic acid 4-hydroxylase activity
    		•  3.76307535769621 bayes_pls_golite062009
  • oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen
    		•  3.68151610133025 bayes_pls_golite062009
  • demethylase activity
    		•  3.40807632433846 bayes_pls_golite062009
  • retinoic acid binding
    		•  3.04897926497756 bayes_pls_golite062009
  • arachidonic acid monooxygenase activity
    		•  3.03830845324387 bayes_pls_golite062009
  • sterol 14-demethylase activity
    		•  2.94610675710811 bayes_pls_golite062009
  • retinoid binding
    		•  2.60220937953757 bayes_pls_golite062009
  • isoprenoid binding
    		•  2.47826119804163 bayes_pls_golite062009
  • steroid 7-alpha-hydroxylase activity
    		•  2.29989218606587 bayes_pls_golite062009
  • oxygen binding
    		•  2.16126306603565 bayes_pls_golite062009
  • oxidoreductase activity
    		•  2.09151585300316 bayes_pls_golite062009
  • oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen
    		•  1.97593187367475 bayes_pls_golite062009
  • flavonoid 3'-monooxygenase activity
    		•  1.71233606135238 bayes_pls_golite062009
  • fatty acid (omega-1)-hydroxylase activity
    		•  1.65569090470706 bayes_pls_golite062009
  • electron carrier activity
    		•  1.48516712188486 bayes_pls_golite062009
  • arachidonic acid epoxygenase activity
    		•  1.4220050618113 bayes_pls_golite062009
  • binding
    		•  1.2866152532988 bayes_pls_golite062009
  • steroid 17-alpha-monooxygenase activity
    		•  0.918503562996019 bayes_pls_golite062009
  • catalytic activity
    		•  0.608111453189583 bayes_pls_golite062009
  • oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced iron-sulfur protein as one donor, and incorporation of one atom of oxygen
    		•  0.33710488712754 bayes_pls_golite062009
  • transition metal ion binding
    		•  0.22562022703652 bayes_pls_golite062009
  • 1-alpha,25-dihydroxyvitamin D3 24-hydroxylase activity
    		•  0.169431271735966 bayes_pls_golite062009


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    [View Details]
    Source: Reynolds et al. 2008. Manuscript submitted Philius confidence legend
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