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View Structure Prediction Details

Protein: erg11
Organism: Schizosaccharomyces pombe
Length: 495 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for erg11.

Description E-value Query
Range		 Subject
Range
F3PH_ARATH - Flavonoid 3'-monooxygenase OS=Arabidopsis thaliana GN=CYP75B1 PE=1 SV=1
 427.0 [0..1] [494..1]
gi|115496944, gi... - gi|94574282|gb|AAI16042.1| Cytochrome P450, family 2, subfamily C, polypeptide 18 [Bos taurus], gi|1...
 425.0 [0..24] [493..20]
gi|3582021 - gi|3582021|emb|CAA70575.1| cytochrome P450 [Nepeta racemosa]
 417.0 [0..1] [495..1]
CP2CP_MESAU - Cytochrome P450 2C25 OS=Mesocricetus auratus GN=CYP2C25 PE=2 SV=1
 417.0 [0..7] [493..3]
gi|77176700 - gi|77176700|gb|ABA64468.1| flavonoid 3'-hydroxylase [Gerbera hybrid cultivar]
 415.0 [0..3] [494..1]
CP2CT_MOUSE - Cytochrome P450 2C29 OS=Mus musculus GN=Cyp2c29 PE=1 SV=2
 414.0 [0..7] [493..3]
CP2CK_MACFA - Cytochrome P450 2C20 OS=Macaca fascicularis GN=CYP2C20 PE=2 SV=1
 412.0 [0..7] [493..3]

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Predicted Domain #1
Region A:
Residues: [1-495] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MAFSLVSILL SIALAWYVGY IINQLTSRNS KRPPIVFHWI PFVGSAVAYG MDPYVFFREC  60
   61 RAKYGDVFTF VCMGRKMTAF LGVQGNDFLF NGKLADLNAE EAYSHLTTPV FGKDVVYDIP 120
  121 NHVFMEHKKF IKSGLGFSQF RSYVPLILNE MDAFLSTSPD FGPGKEGVAD LLKTMPVMTI 180
  181 YTASRTLQGA EVRKGFDAGF ADLYHDLDQG FSPVNFVFPW LPLPRNRRRD RAHKIMQKTY 240
  241 LKIIKDRRSS TENPGTDMIW TLMSCKYRDG RPLKEHEIAG MMIALLMAGQ HTSAATIVWV 300
  301 LALLGSKPEI IEMLWEEQKR VVGENLELKF DQYKDMPLLN YVIQETLRLH PPIHSHMRKV 360
  361 KRDLPVPGSK IVIPANNYLL AAPGLTATEE EYFTHATDFD PKRWNDRVNE DENAEQIDYG 420
  421 YGLVTKGAAS PYLPFGAGRH RCIGEQFAYM HLSTIISKFV HDYTWTLIGK VPNVDYSSMV 480
  481 ALPLGPVKIA WKRRN

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 67.0
Match: 1x8vA
Description: Estriol-bound and ligand-free structures of sterol 14alpha-demethylase (CYP51)
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
monooxygenase activity 5.57229509004705 bayes_pls_golite062009
steroid hydroxylase activity 5.04794778387361 bayes_pls_golite062009
oxysterol 7-alpha-hydroxylase activity 5.03099580095037 bayes_pls_golite062009
retinoic acid 4-hydroxylase activity 3.76307535769621 bayes_pls_golite062009
oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen 3.68151610133025 bayes_pls_golite062009
demethylase activity 3.40807632433846 bayes_pls_golite062009
retinoic acid binding 3.04897926497756 bayes_pls_golite062009
arachidonic acid monooxygenase activity 3.03830845324387 bayes_pls_golite062009
sterol 14-demethylase activity 2.94610675710811 bayes_pls_golite062009
retinoid binding 2.60220937953757 bayes_pls_golite062009
isoprenoid binding 2.47826119804163 bayes_pls_golite062009
steroid 7-alpha-hydroxylase activity 2.29989218606587 bayes_pls_golite062009
oxygen binding 2.16126306603565 bayes_pls_golite062009
oxidoreductase activity 2.09151585300316 bayes_pls_golite062009
oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen 1.97593187367475 bayes_pls_golite062009
flavonoid 3'-monooxygenase activity 1.71233606135238 bayes_pls_golite062009
fatty acid (omega-1)-hydroxylase activity 1.65569090470706 bayes_pls_golite062009
electron carrier activity 1.48516712188486 bayes_pls_golite062009
arachidonic acid epoxygenase activity 1.4220050618113 bayes_pls_golite062009
binding 1.2866152532988 bayes_pls_golite062009
steroid 17-alpha-monooxygenase activity 0.918503562996019 bayes_pls_golite062009
catalytic activity 0.608111453189583 bayes_pls_golite062009
oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced iron-sulfur protein as one donor, and incorporation of one atom of oxygen 0.33710488712754 bayes_pls_golite062009
transition metal ion binding 0.22562022703652 bayes_pls_golite062009
1-alpha,25-dihydroxyvitamin D3 24-hydroxylase activity 0.169431271735966 bayes_pls_golite062009
YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle