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Protein Overview: phm-PA, FBpp0309669

General Information:
Name(s) found: FBpp0309669 [FlyBase]
phm-PA / FBpp0074374 [FlyBase]
Description(s) found:
Found 42 descriptions.
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  • type=protein; loc=X:join(18579995..18580376,18580463..18580611,18580991..18582184); ID=FBpp0309669; name=phm-PB; parent=FBgn0004959,FBtr0342846; dbxref=FlyBase:FBpp0309669,FlyBase_Annotation_IDs:CG6578-PB; MD5=806a06f47e9d0679d0ecf8c26e0d675b; length=574; release=r5.56; species=Dmel; [FlyBase]
  • The gene phantom is referred to in FlyBase by the symbol Dmel\phm (CG6578, FBgn0004959). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is X:18579802..18582257. It has the cytological map location 17D1. There is experimental evidence that it has the molecular function</span>: ecdysteroid 25-hydroxylase activity. There is experimental evidence that it is involved in the biological process</span>: embryonic development via the syncytial blastoderm; oogenesis; ecdysone biosynthetic process. 19 alleles are reported. The phenotypes of these alleles are annotated with 12 unique terms, many of which group under: anatomical structure; organ system; embryonic nervous system; organism; nervous system; integumentary system; embryonic head; primordium; commissure; cuticle; embryonic peripheral nervous system; embryonic tagma; multi-cell-component structure; portion of tissue. It has one annotated transcript and one annotated polypeptide. [FlyBase]
    • Organism: Drosophila melanogaster
    Length: 574 amino acids

    Gene Ontology:
    Cellular Component: membrane [NAS]
    microsome [NAS]
    endoplasmic reticulum [IDA]
    Biological Process: embryonic development via the syncytial blastoderm [IMP]
    oogenesis [IMP]
    insecticide metabolic process [NAS]
    oxidation reduction [IEA]
    ecdysone biosynthetic process [IDA]
    Molecular Function: electron carrier activity [IEA][ISS][NAS]
    ecdysteroid 25-hydroxylase activity [IDA]
    heme binding [IEA]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSADIVDIGH TGWMPSVQSL SILLVPGALV LVILYLCERQ CNDLMGAPPP GPWGLPFLGY  60
   61 LPFLDARAPH KSLQKLAKRY GGIFELKMGR VPTVVLSDAA LVRDFFRRDV MTGRAPLYLT 120
  121 HGIMGGFGII CAQEDIWRHA RRETIDWLKA LGMTRRPGEL RARLERRIAR GVDECVRLFD 180
  181 TEAKKSCASE VNPLPALHHS LGNIINDLVF GITYKRDDPD WLYLQRLQEE GVKLIGVSGV 240
  241 VNFLPWLRHL PANVRNIRFL LEGKAKTHAI YDRIVEACGQ RLKEKQKVFK ELQEQKRLQR 300
  301 QLEKEQLRQS KEADPSQEQS EADEDDEESD EEDTYEPECI LEHFLAVRDT DSQLYCDDQL 360
  361 RHLLADLFGA GVDTSLATLR WFLLYLAREQ RCQRRLHELL LPLGPSPTLE ELEPLAYLRA 420
  421 CISETMRIRS VVPLGIPHGC KENFVVGDYF IKGGSMIVCS EWAIHMDPVA FPEPEEFRPE 480
  481 RFLTADGAYQ APPQFIPFSS GYRMCPGEEM ARMILTLFTG RILRRFHLEL PSGTEVDMAG 540
  541 ESGITLTPTP HMLRFTKLPA VEMRHAPDGA VVQD

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..574] PSI-BLAST 98.39794 Crystal Structure of Human Drug Metabolizing Cytochrome P450 2C8

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • arachidonic acid monooxygenase activity
    		•  6.76823710927794 bayes_pls_golite062009
  • monooxygenase activity
    		•  5.57229509004705 bayes_pls_golite062009
  • steroid hydroxylase activity
    		•  5.04794778387361 bayes_pls_golite062009
  • arachidonic acid epoxygenase activity
    		•  4.80764258881036 bayes_pls_golite062009
  • demethylase activity
    		•  3.40807632433846 bayes_pls_golite062009
  • oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen
    		•  3.24344797738248 bayes_pls_golite062009
  • sterol 14-demethylase activity
    		•  2.94610675710811 bayes_pls_golite062009
  • oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen
    		•  2.56821164444595 bayes_pls_golite062009
  • oxysterol 7-alpha-hydroxylase activity
    		•  2.36480328243514 bayes_pls_golite062009
  • oxidoreductase activity
    		•  2.35847923992364 bayes_pls_golite062009
  • retinoic acid 4-hydroxylase activity
    		•  2.27465774301343 bayes_pls_golite062009
  • steroid 17-alpha-monooxygenase activity
    		•  2.036553099796 bayes_pls_golite062009
  • ecdysteroid 25-hydroxylase activity
    		•  2.0071742914584 bayes_pls_golite062009
  • oxygen binding
    		•  1.66120675703571 bayes_pls_golite062009
  • fatty acid (omega-1)-hydroxylase activity
    		•  1.65569090470706 bayes_pls_golite062009
  • retinoid binding
    		•  1.55427837836259 bayes_pls_golite062009
  • electron carrier activity
    		•  1.48516712188486 bayes_pls_golite062009
  • oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced iron-sulfur protein as one donor, and incorporation of one atom of oxygen
    		•  1.46109575978397 bayes_pls_golite062009
  • isoprenoid binding
    		•  1.43053384013166 bayes_pls_golite062009
  • retinoic acid binding
    		•  1.21667685596765 bayes_pls_golite062009
  • oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of one atom of oxygen
    		•  1.20113920678403 bayes_pls_golite062009
  • binding
    		•  1.0881336564542 bayes_pls_golite062009
  • flavonoid 3'-monooxygenase activity
    		•  0.89030345144459 bayes_pls_golite062009
  • ecdysteroid 22-hydroxylase activity
    		•  0.7601272997427 bayes_pls_golite062009
  • catalytic activity
    		•  0.608111453189583 bayes_pls_golite062009
  • cholesterol monooxygenase (side-chain-cleaving) activity
    		•  0.276594551871869 bayes_pls_golite062009
  • arachidonic acid 11,12-epoxygenase activity
    		•  0.0888154993183798 bayes_pls_golite062009


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    [View Details]
    Source: Reynolds et al. 2008. Manuscript submitted Philius confidence legend
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