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View Structure Prediction Details

Protein: phm-PA, FBpp0309669
Organism: Drosophila melanogaster
Length: 574 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for phm-PA, FBpp0309669.

Description E-value Query
Range
Subject
Range
gi|116174726, gi... - gi|55824550|gb|AAV66395.1| cytochrome P450 isoform 2J [Ovis aries], gi|116174726|ref|NP_001070678.1|...
381.0 [0..1] [558..1]

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Predicted Domain #1
Region A:
Residues: [1-574]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSADIVDIGH TGWMPSVQSL SILLVPGALV LVILYLCERQ CNDLMGAPPP GPWGLPFLGY  60
   61 LPFLDARAPH KSLQKLAKRY GGIFELKMGR VPTVVLSDAA LVRDFFRRDV MTGRAPLYLT 120
  121 HGIMGGFGII CAQEDIWRHA RRETIDWLKA LGMTRRPGEL RARLERRIAR GVDECVRLFD 180
  181 TEAKKSCASE VNPLPALHHS LGNIINDLVF GITYKRDDPD WLYLQRLQEE GVKLIGVSGV 240
  241 VNFLPWLRHL PANVRNIRFL LEGKAKTHAI YDRIVEACGQ RLKEKQKVFK ELQEQKRLQR 300
  301 QLEKEQLRQS KEADPSQEQS EADEDDEESD EEDTYEPECI LEHFLAVRDT DSQLYCDDQL 360
  361 RHLLADLFGA GVDTSLATLR WFLLYLAREQ RCQRRLHELL LPLGPSPTLE ELEPLAYLRA 420
  421 CISETMRIRS VVPLGIPHGC KENFVVGDYF IKGGSMIVCS EWAIHMDPVA FPEPEEFRPE 480
  481 RFLTADGAYQ APPQFIPFSS GYRMCPGEEM ARMILTLFTG RILRRFHLEL PSGTEVDMAG 540
  541 ESGITLTPTP HMLRFTKLPA VEMRHAPDGA VVQD

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 98.39794
Match: 1pq2A
Description: Crystal Structure of Human Drug Metabolizing Cytochrome P450 2C8
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
arachidonic acid monooxygenase activity 6.76823710927794 bayes_pls_golite062009
monooxygenase activity 5.57229509004705 bayes_pls_golite062009
steroid hydroxylase activity 5.04794778387361 bayes_pls_golite062009
arachidonic acid epoxygenase activity 4.80764258881036 bayes_pls_golite062009
demethylase activity 3.40807632433846 bayes_pls_golite062009
oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen 3.24344797738248 bayes_pls_golite062009
sterol 14-demethylase activity 2.94610675710811 bayes_pls_golite062009
oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen 2.56821164444595 bayes_pls_golite062009
oxysterol 7-alpha-hydroxylase activity 2.36480328243514 bayes_pls_golite062009
oxidoreductase activity 2.35847923992364 bayes_pls_golite062009
retinoic acid 4-hydroxylase activity 2.27465774301343 bayes_pls_golite062009
steroid 17-alpha-monooxygenase activity 2.036553099796 bayes_pls_golite062009
ecdysteroid 25-hydroxylase activity 2.0071742914584 bayes_pls_golite062009
oxygen binding 1.66120675703571 bayes_pls_golite062009
fatty acid (omega-1)-hydroxylase activity 1.65569090470706 bayes_pls_golite062009
retinoid binding 1.55427837836259 bayes_pls_golite062009
electron carrier activity 1.48516712188486 bayes_pls_golite062009
oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced iron-sulfur protein as one donor, and incorporation of one atom of oxygen 1.46109575978397 bayes_pls_golite062009
isoprenoid binding 1.43053384013166 bayes_pls_golite062009
retinoic acid binding 1.21667685596765 bayes_pls_golite062009
oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of one atom of oxygen 1.20113920678403 bayes_pls_golite062009
binding 1.0881336564542 bayes_pls_golite062009
flavonoid 3'-monooxygenase activity 0.89030345144459 bayes_pls_golite062009
ecdysteroid 22-hydroxylase activity 0.7601272997427 bayes_pls_golite062009
catalytic activity 0.608111453189583 bayes_pls_golite062009
cholesterol monooxygenase (side-chain-cleaving) activity 0.276594551871869 bayes_pls_golite062009
arachidonic acid 11,12-epoxygenase activity 0.0888154993183798 bayes_pls_golite062009

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle