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Protein Overview: CG8142-PA

General Information:
Name(s) found: CG8142-PA / FBpp0074246 [FlyBase]
Description(s) found:
Found 20 descriptions.
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  • This gene is referred to in FlyBase by the symbol Dmel\CG8142 (CG8142, FBgn0030871). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is X:17737376..17738703. It has the cytological map location 16E1. There is experimental evidence that it has the molecular function</span>: SUMO binding. Based on sequence similarity, it is predicted to be involved in the biological process</span>: DNA replication. 3 alleles are reported. No phenotypic data is available. It has one annotated transcript and one annotated polypeptide. [FlyBase]
    • Organism: Drosophila melanogaster
    Length: 353 amino acids

    Gene Ontology:
    Cellular Component: DNA replication factor C complex [ISS]
    Biological Process: DNA replication [IEA][ISS]
    Molecular Function: DNA binding [ISS]
    ATP binding [IEA]
    SUMO binding [IPI]
    DNA clamp loader activity [IEA]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MQAFLKTGKS TAGSGDKSQG TPAARRKPPA PWVEKYRPRN VDDVVEQSEV VAVLRKCVEG  60
   61 GDLPNMLLYG PPGTGKTSTI LAASRQIFGD MFKDRILELN ASDERGINVV RTKIKNFSQL 120
  121 SASSVRPDGK PCPPFKIIIL DEADSMTHAA QSALRRTMEK ESRSTRFCLI CNYVSRIIVP 180
  181 ITSRCSKFRF KALGEDKVID RLKYICEMEG VKIEDDAYKS IVKISGGDLR RAITTLQSCY 240
  241 RLKGPEHIIN TADLFEMSGV IPEYYLEDYL EVCRSGNYER LEQFVREIGF SAYSVGQMME 300
  301 QFVEFIVHHP GLNDPQKATI CDKLGECCFR LQDGGSEYLQ IMDLGCCIIL ALK

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    SHOWING SINGLE HITS. [ Hide Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..353] PSI-BLAST 54.0 Crystal Structure of the Eukaryotic Clamp Loader (Replication Factor C, RFC) Bound to the DNA Sliding Clamp (Proliferating Cell Nuclear Antigen, PCNA)

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • DNA clamp loader activity
    		•  6.51495346697904 bayes_pls_golite062009
  • protein-DNA loading ATPase activity
    		•  6.40748863504898 bayes_pls_golite062009
  • DNA-dependent ATPase activity
    		•  2.72462789867829 bayes_pls_golite062009
  • binding
    		•  2.64537357529343 bayes_pls_golite062009
  • mismatched DNA binding
    		•  2.51625633651862 bayes_pls_golite062009
  • DNA helicase activity
    		•  2.2817164193758 bayes_pls_golite062009
  • nucleic acid binding
    		•  2.21184938313192 bayes_pls_golite062009
  • pyrophosphatase activity
    		•  2.13284212711072 bayes_pls_golite062009
  • DNA binding
    		•  1.94055378599526 bayes_pls_golite062009
  • ATP-dependent DNA helicase activity
    		•  1.88455339138556 bayes_pls_golite062009
    		• 1.85506769032946 bayes_pls_golite062009
  • transcription regulator activity
    		•  1.83584389083042 bayes_pls_golite062009
  • helicase activity
    		•  1.70242731830224 bayes_pls_golite062009
  • guanine/thymine mispair binding
    		•  1.69026972999845 bayes_pls_golite062009
  • DNA insertion or deletion binding
    		•  1.68890613599528 bayes_pls_golite062009
  • RNA helicase activity
    		•  1.63960194106079 bayes_pls_golite062009
  • DNA replication origin binding
    		•  1.62491387774159 bayes_pls_golite062009
  • ATP-dependent RNA helicase activity
    		•  1.61735400124552 bayes_pls_golite062009
  • RNA-dependent ATPase activity
    		•  1.60404584546501 bayes_pls_golite062009
  • structure-specific DNA binding
    		•  1.2539059700735 bayes_pls_golite062009
  • purine ribonucleotide binding
    		•  1.21658213854831 bayes_pls_golite062009
  • ribonucleotide binding
    		•  1.21652144153182 bayes_pls_golite062009
  • purine nucleotide binding
    		•  1.21571071905795 bayes_pls_golite062009
  • nucleotide binding
    		•  1.20347573865566 bayes_pls_golite062009
  • ATP-dependent helicase activity
    		•  1.19311444180077 bayes_pls_golite062009
  • purine NTP-dependent helicase activity
    		•  1.19311444180077 bayes_pls_golite062009
  • motor activity
    		•  1.14667913749579 bayes_pls_golite062009
  • microtubule motor activity
    		•  1.1277447806079 bayes_pls_golite062009
  • double-stranded DNA binding
    		•  1.117585097627 bayes_pls_golite062009
  • catalytic activity
    		•  1.00104173493322 bayes_pls_golite062009
  • DNA-directed DNA polymerase activity
    		•  0.971476020912368 bayes_pls_golite062009
  • DNA polymerase activity
    		•  0.928091843881235 bayes_pls_golite062009
  • transcription factor activity
    		•  0.697256579145077 bayes_pls_golite062009
  • transcription repressor activity
    		•  0.677612020025357 bayes_pls_golite062009
  • guanyl nucleotide binding
    		•  0.656009904481476 bayes_pls_golite062009
  • guanyl ribonucleotide binding
    		•  0.64416740142962 bayes_pls_golite062009
  • GTP binding
    		•  0.643084645864898 bayes_pls_golite062009
  • single base insertion or deletion binding
    		•  0.629563765934841 bayes_pls_golite062009
  • single-stranded DNA binding
    		•  0.568457189190858 bayes_pls_golite062009
  • cytoskeletal protein binding
    		•  0.500462538667228 bayes_pls_golite062009
  • GTPase activity
    		•  0.406399103964327 bayes_pls_golite062009
  • DNA strand annealing activity
    		•  0.283577486331079 bayes_pls_golite062009
  • protein binding
    		•  0.170837278876362 bayes_pls_golite062009
  • nucleoside-triphosphatase activity
    		•  0.147579541298736 bayes_pls_golite062009
  • hydrolase activity, acting on acid anhydrides
    		•  0.113504049290503 bayes_pls_golite062009
  • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides
    		•  0.111293884322157 bayes_pls_golite062009
  • structural constituent of ribosome
    		•  0.089234257580272 bayes_pls_golite062009
  • 3'-5' DNA helicase activity
    		•  0.0769112340058804 bayes_pls_golite062009
  • lysine N-acetyltransferase activity
    		•  0.0320943071400439 bayes_pls_golite062009
  • histone acetyltransferase activity
    		•  0.0320943071400439 bayes_pls_golite062009
  • double-strand/single-strand DNA junction binding
    		•  0.0136229525922795 bayes_pls_golite062009
  • actin binding
    		•  0.00482938540552702 bayes_pls_golite062009


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.98

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle