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Protein Overview: r-PA, FBpp030914...

General Information:
Name(s) found: FBpp0309142 [FlyBase]
FBpp0309141 [FlyBase]
FBpp0309140 [FlyBase]
r-PA / FBpp0088675 [FlyBase]
Description(s) found:
Found 33 descriptions.
SHOW ALL
  • type=protein; loc=X:join(16550431..16551189,16551254..16554505,16554571..16554675,16559221..16559360,16560068..16561892,16561970..16562353,16562418..16562627); ID=FBpp0309142; name=r-PE; parent=FBgn0003189,FBtr0340156; dbxref=FlyBase:FBpp0309142,FlyBase_Annotation_IDs:CG18572-PE; MD5=477f39c508620bf5db3ce4c1b8dfd3a5; length=2224; release=r5.56; species=Dmel; [FlyBase]
  • type=protein; loc=X:join(16550431..16551189,16551254..16554505,16554571..16554675,16559221..16559360,16560068..16561892,16561970..16562353,16562418..16562627); ID=FBpp0309141; name=r-PD; parent=FBgn0003189,FBtr0340155; dbxref=FlyBase:FBpp0309141,FlyBase_Annotation_IDs:CG18572-PD; MD5=477f39c508620bf5db3ce4c1b8dfd3a5; length=2224; release=r5.56; species=Dmel; [FlyBase]
  • type=protein; loc=X:join(16550431..16551189,16551254..16554505,16554571..16554675,16559221..16559360,16560068..16561892,16561970..16562353,16562418..16562627); ID=FBpp0309140; name=r-PC; parent=FBgn0003189,FBtr0340154; dbxref=FlyBase:FBpp0309140,FlyBase_Annotation_IDs:CG18572-PC; MD5=477f39c508620bf5db3ce4c1b8dfd3a5; length=2224; release=r5.56; species=Dmel; [FlyBase]
  • The gene rudimentary is referred to in FlyBase by the symbol Dmel\r (CG18572, FBgn0003189). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is X:16549412..16563110. It has the cytological map location 14F5-15A1. There is experimental evidence that it has the molecular function</span>: dihydroorotase activity; aspartate carbamoyltransferase activity; carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity. There is experimental evidence that it is involved in the biological process</span>: 'de novo' pyrimidine base biosynthetic process; glutamine metabolic process. 268 alleles are reported. The phenotypes of these alleles are annotated with: ovary; wing margin bristle; wing vein L4; posterior wing margin; wing; wing vein. It has 2 annotated transcripts and 2 annotated polypeptides. [FlyBase]
    • Organism: Drosophila melanogaster
    Length: 2224 amino acids

    Gene Ontology:
    Cellular Component: cytoplasm [NAS]
    Biological Process: 'de novo' pyrimidine base biosynthetic process [IMP][NAS]
    glutamine metabolic process [IC][IMP]
    Molecular Function: ATP binding [IC][IEA]
    aspartate carbamoyltransferase activity [IDA][IMP][ISS]
    dihydroorotase activity [IDA][IMP][ISS]
    carbamoyl-phosphate synthase (ammonia) activity [ISS]
    carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity [IDA][IMP]
    amino acid binding [IEA]
    glutamine binding [IC]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MASTDCYLAL EDGTVLPGYS FGYVPSENES KVGFGGEVVF QTGMVGYTEA LTDRSYSGQI  60
   61 LVLTYPLIGN YGVPAPDEDE HGLPLHFEWM KGVVQATALV VGEVAEEAFH WRKWKTLPDW 120
  121 LKQHKVPGIQ DIDTRALTKK LREQGSMLGK IVYEKPPVEG LPKSSFVDPN VRNLAKECSV 180
  181 KERQVYGNPN GKGPRIAILD CGLKLNQLRC LLQRGASVTL LPWSARLEDE QFDALFLSNG 240
  241 PGNPESCDQI VQQVRKVIEE GQKPVFGICL GHQLLAKAIG CSTYKMKYGN RGHNLPCLHR 300
  301 ATGRCLMTSQ NHGYAVDLEQ LPDGWSELFV NANDGTNEGI VHASKPYFSV QFHPEHHAGP 360
  361 QDTEFLFDVF MESIQQKDLT IPQLIEQRLR PTTPAIDSAP VMPRKVLILG SGGLSIGQAG 420
  421 EFDYSGSQAI KAMRESNIQT VLINPNIATV QTSKGMADKC YFLPLTPHYV EQVIKSERPN 480
  481 GVLLTFGGQT ALNCGVQLER AGVFSKYNVR ILGTPIQSII ETEDRKLFAE RVNEIGEQVA 540
  541 PSEAVYSVAQ ALDAASRLGY PVMARAAFSL GGLGSGFANN EEELQSLAQQ ALAHSSQLIV 600
  601 DKSLKGWKEV EYEVVRDAYN NCITVCNMEN FDPLGIHTGE SIVVAPSQTL SDREYQMLRS 660
  661 TALKVIRHFG VVGECNIQYA LCPHSEQYYI IEVNARLSRS SALASKATGY PLAYVAAKLA 720
  721 LGLPLPDIKN SVTGNTTACF EPSLDYCVVK IPRWDLAKFV RVSKHIGSSM KSVGEVMAIG 780
  781 RNFEEAFQKA LRMVDSDVLG FDPDVVPLNK EQLAEQLSEP TDRRPFVIAA ALQLGMSLRE 840
  841 LHQLTNIDYW FLEKLERIIL LQSLLTRNGS RTDAALLLKA KRFGFSDKQI AKYIKSTELA 900
  901 VRHQRQEFGI RPHVKQIDTV AGEWPASTNY LYHTYNGSEH DVDFPGGHTI VVGSGVYRIG 960
  961 SSVEFDWCAV GCLRELRKLQ RPTIMINYNP ETVSTDYDMC DRLYFEEISF EVVMDIYEME1020
 1021 NSEGIILSMG GQLPNNIAMD LHRQQAKVLG TSPESIDCAE NRFKFSRMLD RKGILQPRWK1080
 1081 ELTNLQSAIE FCEEVGYPCL VRPSYVLSGA AMNVAYSNQD LETYLNAASE VSREHPVVIS1140
 1141 KFLTEAKEID VDAVASDGRI LCMAVSEHVE NAGVHSGDAT LVTPPQDLNA ETLEAIKRIT1200
 1201 CDLASVLDVT GPFNMQLIAK NNELKVIECN VRVSRSFPFV SKTLDHDFVA TATRAIVGLD1260
 1261 VEPLDVLHGV GKVGVKVPQF SFSRLAGADV QLGVEMASTG EVACFGDNRY EAYLKAMMST1320
 1321 GFQIPKNAVL LSIGSFKHKM ELLPSIRDLA KMGYKLYASM GTGDFYAEHG VNVESVQWTF1380
 1381 DKTTPDDING ELRHLAEFLA NKQFDLVINL PMSGGGARRV SSFMTHGYRT RRLAVDYSIP1440
 1441 LVTDVKCTKL LVESMRMNGG KPPMKTHTDC MTSRRIVKLP GFIDVHVHLR EPGATHKEDF1500
 1501 ASGTAAALAG GVTLVCAMPN TNPSIVDRET FTQFQELAKA GARCDYALYV GASDDNWAQV1560
 1561 NELASHACGL KMYLNDTFGT LKLSDMTSWQ RHLSHWPKRS PIVCHAERQS TAAVIMLAHL1620
 1621 LDRSVHICHV ARKEEIQLIR SAKEKGVKVT CEVCPHHLFL STKDVERLGH GMSEVRPLLC1680
 1681 SPEDQEALWE NIDYIDVFAT DHAPHTLAEK RSERPPPGFP GVETILPLLL QAVHEGRLTM1740
 1741 EDIKRKFHRN PKIIFNLPDQ AQTYVEVDLD EEWTITGNEM KSKSGWTPFE GTKVKGRVHR1800
 1801 VVLRGEVAFV DGQVLVQPGF GQNVRPKQSP LASEASQDLL PSDNDANDTF TRLLTSEGPG1860
 1861 GGVHGISTKV HFVDGANFLR PNSPSPRIRL DSASNTTLRE YLQRTTNSNP VAHSLMGKHI1920
 1921 LAVDMFNKDH LNDIFNLAQL LKLRGTKDRP VDELLPGKIM ASVFYEVSTR TQCSFAAAML1980
 1981 RLGGRVISMD NITSSVKKGE SLEDSIKVVS SYADVVVLRH PSPGAVARAA TFSRKPLINA2040
 2041 GDGVGEHPTQ ALLDIFTIRE EFGTVNGLTI TMVGDLKNGR TVHSLARLLT LYNVNLQYVA2100
 2101 PNSLQMPDEV VQFVHQRGVK QLFARDLKNV LPDTDVLYMT RIQRERFDNV EDYEKCCGHL2160
 2161 VLTPEHMMRA KKRSIVLHPL PRLNEISREI DSDPRAAYFR QAEYGMYIRM ALLAMVVGGR2220
 2221 NTAL

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..389] PSI-BLAST 125.0 Carbamoyl phosphate synthetase, small subunit N-terminal domain; Carbamoyl phosphate synthetase, small subunit C-terminal domain
    2 View Details [390..1459] PSI-BLAST 1000.0 Carbamoyl phosphate synthetase, large subunit connection domain; Carbamoyl phosphate synthetase, large subunit allosteric, C-terminal domain; Carbamoyl phosphate synthetase (CPS), large subunit PreATP-grasp domains; Carbamoyl phosphate synthetase (CPS), large subunit ATP-binding domains
    3 View Details [1460..1829] PSI-BLAST 63.69897 The Crystal Structure of a Novel, Latent Dihydroorotase from Aquifex aeolicus at 1.7 A resolution
    4 View Details [1830..1896] deduced N/A No confident structure predictions are available.
    5 View Details [1897..2224] PSI-BLAST 98.221849 Aspartate carbamoyltransferase catalytic subunit

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
    		•  11.6556846811261 bayes_pls_golite062009
  • carbamoyl-phosphate synthase activity
    		•  11.614541080865 bayes_pls_golite062009
  • carbon-nitrogen ligase activity, with glutamine as amido-N-donor
    		•  8.83104490344765 bayes_pls_golite062009
  • ligase activity, forming carbon-nitrogen bonds
    		•  6.7523653122648 bayes_pls_golite062009
  • ligase activity
    		•  2.64230127203047 bayes_pls_golite062009
  • nucleic acid binding
    		•  1.83357525248647 bayes_pls_golite062009
  • phosphotransferase activity, alcohol group as acceptor
    		•  1.68223120807504 bayes_pls_golite062009
  • kinase activity
    		•  1.67508566693087 bayes_pls_golite062009
  • transferase activity, transferring phosphorus-containing groups
    		•  1.57588199570083 bayes_pls_golite062009
  • transferase activity
    		•  1.56222597521764 bayes_pls_golite062009
  • phosphoribosylformylglycinamidine synthase activity
    		•  1.51568729563523 bayes_pls_golite062009
  • binding
    		•  1.22860407524238 bayes_pls_golite062009
  • catalytic activity
    		•  0.902495165806215 bayes_pls_golite062009
  • transferase activity, transferring glycosyl groups
    		•  0.774587372455935 bayes_pls_golite062009
  • hydrolase activity
    		•  0.488948677783382 bayes_pls_golite062009
  • imidazoleglycerol-phosphate synthase activity
    		•  0.270391651600004 bayes_pls_golite062009
  • anthranilate synthase activity
    		•  0.243205818526006 bayes_pls_golite062009
  • peptidase activity
    		•  0.0466975117232061 bayes_pls_golite062009
  • protein binding
    		•  0.0152024556625711 bayes_pls_golite062009
    2
    Term Confidence Notes
  • carbamoyl-phosphate synthase activity
    		•  10.3961907577933 bayes_pls_golite062009
  • carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
    		•  10.3817460390594 bayes_pls_golite062009
  • carbon-nitrogen ligase activity, with glutamine as amido-N-donor
    		•  7.55690629692775 bayes_pls_golite062009
  • ligase activity, forming carbon-nitrogen bonds
    		•  7.41655699341139 bayes_pls_golite062009
  • carbamoyl-phosphate synthase (ammonia) activity
    		•  5.29301695671381 bayes_pls_golite062009
  • ligase activity
    		•  4.44283992739984 bayes_pls_golite062009
  • aspartate carbamoyltransferase activity
    		•  3.38433995801364 bayes_pls_golite062009
  • dihydroorotase activity
    		•  2.87758723400434 bayes_pls_golite062009
  • succinate-CoA ligase activity
    		•  2.77725772893528 bayes_pls_golite062009
  • CoA carboxylase activity
    		•  2.53820799209252 bayes_pls_golite062009
  • catalytic activity
    		•  2.5009559386228 bayes_pls_golite062009
  • carboxyl- or carbamoyltransferase activity
    		•  2.46049425383361 bayes_pls_golite062009
  • ligase activity, forming carbon-carbon bonds
    		•  2.27702293106204 bayes_pls_golite062009
  • acetyl-CoA carboxylase activity
    		•  2.18226575117684 bayes_pls_golite062009
  • CoA-ligase activity
    		•  1.95069402824125 bayes_pls_golite062009
  • acid-thiol ligase activity
    		•  1.72672517234442 bayes_pls_golite062009
  • phosphoribosylaminoimidazole carboxylase activity
    		•  1.57708889650281 bayes_pls_golite062009
  • transferase activity, transferring phosphorus-containing groups
    		•  1.43253315277789 bayes_pls_golite062009
  • binding
    		•  1.21275677338476 bayes_pls_golite062009
  • transferase activity
    		•  1.11190599598314 bayes_pls_golite062009
  • phosphoribosylamine-glycine ligase activity
    		•  1.04915286326924 bayes_pls_golite062009
  • carbon-oxygen lyase activity, acting on phosphates
    		•  0.964679554894316 bayes_pls_golite062009
  • ligase activity, forming carbon-sulfur bonds
    		•  0.96165574211624 bayes_pls_golite062009
  • biotin carboxylase activity
    		•  0.925630424589009 bayes_pls_golite062009
  • phosphoribosylaminoimidazolecarboxamide formyltransferase activity
    		•  0.898425265043358 bayes_pls_golite062009
  • acid-amino acid ligase activity
    		•  0.823961741659657 bayes_pls_golite062009
  • succinate-CoA ligase (ADP-forming) activity
    		•  0.731047220665703 bayes_pls_golite062009
  • carbon-oxygen lyase activity
    		•  0.482425669839603 bayes_pls_golite062009
  • propionyl-CoA carboxylase activity
    		•  0.377204236873769 bayes_pls_golite062009
  • hydrolase activity
    		•  0.358639651655949 bayes_pls_golite062009
  • glutathione binding
    		•  0.20743435331623 bayes_pls_golite062009
  • succinate-CoA ligase (GDP-forming) activity
    		•  0.04189990190488 bayes_pls_golite062009
    3
    Term Confidence Notes
  • dihydroorotase activity
    		•  5.83804402298952 bayes_pls_golite062009
  • hydrolase activity
    		•  3.43682651851542 bayes_pls_golite062009
  • hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
    		•  3.03591306120652 bayes_pls_golite062009
  • allantoinase activity
    		•  2.45571277189844 bayes_pls_golite062009
  • transcription regulator activity
    		•  2.05422491012934 bayes_pls_golite062009
  • deaminase activity
    		•  1.79186203771221 bayes_pls_golite062009
  • nucleic acid binding
    		•  1.75483241027992 bayes_pls_golite062009
  • catalytic activity
    		•  1.70199291046899 bayes_pls_golite062009
  • DNA binding
    		•  1.70075498563244 bayes_pls_golite062009
  • hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds
    		•  1.60895003474033 bayes_pls_golite062009
  • binding
    		•  1.20793368650496 bayes_pls_golite062009
  • transcription factor activity
    		•  1.01581417842484 bayes_pls_golite062009
  • AMP deaminase activity
    		•  0.8498975324894 bayes_pls_golite062009
  • hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines
    		•  0.573107361273483 bayes_pls_golite062009
  • deacetylase activity
    		•  0.57075565732108 bayes_pls_golite062009
  • guanine deaminase activity
    		•  0.134430884998957 bayes_pls_golite062009
  • dihydropyrimidinase activity
    		•  0.101722148781441 bayes_pls_golite062009
    4 No functions predicted.
    5
    Term Confidence Notes
  • carboxyl- or carbamoyltransferase activity
    		•  8.44774290170513 bayes_pls_golite062009
  • carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
    		•  8.39877026738977 bayes_pls_golite062009
  • carbamoyl-phosphate synthase activity
    		•  8.35868658131065 bayes_pls_golite062009
  • aspartate carbamoyltransferase activity
    		•  7.47628089321489 bayes_pls_golite062009
  • ornithine carbamoyltransferase activity
    		•  6.08861672645671 bayes_pls_golite062009
  • carbon-nitrogen ligase activity, with glutamine as amido-N-donor
    		•  5.70428077078256 bayes_pls_golite062009
  • transferase activity
    		•  4.46011936943199 bayes_pls_golite062009
  • dihydroorotase activity
    		•  4.10312514971972 bayes_pls_golite062009
  • ligase activity, forming carbon-nitrogen bonds
    		•  4.09429261864362 bayes_pls_golite062009
  • aspartate binding
    		•  3.43574933938267 bayes_pls_golite062009
  • UTP binding
    		•  3.43574933938267 bayes_pls_golite062009
  • transferase activity, transferring one-carbon groups
    		•  2.1749430001471 bayes_pls_golite062009
  • catalytic activity
    		•  2.06069688716378 bayes_pls_golite062009
  • phosphotransferase activity, alcohol group as acceptor
    		•  1.71477949033699 bayes_pls_golite062009
  • kinase activity
    		•  1.70283432187593 bayes_pls_golite062009
  • binding
    		•  1.63251597999268 bayes_pls_golite062009
  • transferase activity, transferring phosphorus-containing groups
    		•  1.5976562586299 bayes_pls_golite062009
  • protein kinase activity
    		•  1.48895685647086 bayes_pls_golite062009
  • hydrolase activity
    		•  0.628276058923848 bayes_pls_golite062009
  • ligase activity
    		•  0.345534785035194 bayes_pls_golite062009
  • amine binding
    		•  0.33918556173094 bayes_pls_golite062009
  • protein binding
    		•  0.271043612914069 bayes_pls_golite062009
  • hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
    		•  0.254873181665999 bayes_pls_golite062009


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.95

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle