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Protein Overview: FBpp0309614, para-PA

General Information:
Name(s) found: FBpp0309614 [FlyBase]
para-PA / FBpp0074073 [FlyBase]
Description(s) found:
Found 24 descriptions.
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  • type=protein; loc=X:complement(16357821..16358825,16360528..16360832,16365247..16365517,16367615..16367860,16368480..16368674,16369661..16369783,16371482..16371604,16375359..16375532,16376659..16377066,16377711..16377922,16380374..16380617,16380751..16380938,16381916..16382078,16383376..16383549,16383633..16383910,16386480..16386548,16392303..16392402,16392478..16392689,16392749..16392929,16394540..16394602,16398023..16398331,16399540..16399849,16400004..16400280,16400381..16400472,16403609..16403737,16407748..16407953,16408062..16408217,16412838..16412870,16415656..16415805); ID=FBpp0309614; name=para-PBG; parent=FBgn0264255,FBtr0342746; dbxref=FlyBase:FBpp0309614,FlyBase_Annotation_IDs:CG9907-PBG; MD5=84db0f1cc5e7c38403beb01122d10a92; length=2131; release=r5.56; species=Dmel; [FlyBase]
  • The gene paralytic is referred to in FlyBase by the symbol Dmel\para (CG9907, FBgn0260993). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is X:16357638..16421448. It has the cytological map location 14D1-16A2. There is experimental evidence that it has the molecular function</span>: voltage-gated sodium channel activity. There is experimental evidence that it is involved in the biological process</span>: male courtship behavior, veined wing generated song production; response to pyrethroid; sodium ion transport; response to DDT. 68 alleles are reported. The phenotypes of these alleles are annotated with: central nervous system; neuromuscular junction; synapse; adult brain. It has 4 annotated transcripts and 4 annotated polypeptides. [FlyBase]
    • Organism: Drosophila melanogaster
    Length: 2131 amino acids

    Gene Ontology:
    Cellular Component: integral to plasma membrane [IDA][NAS]
    voltage-gated sodium channel complex [ISS]
    plasma membrane [NAS]
    Biological Process: response to DDT [IDA][IMP][NAS]
    sodium ion transport [IDA][NAS]
    transmembrane transport [IEA]
    response to pyrethroid [IMP][NAS]
    male courtship behavior, veined wing generated song production [IMP][NAS]
    Molecular Function: voltage-gated sodium channel activity [IDA][ISS][NAS]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MTEDSDSISE EERSLFRPFT RESLVQIEQR IAAEHEKQKE LERKRAEGEV PQYGRKKKQK  60
   61 EIRYDDEDED EGPQPDPTLE QGVPIPVRLQ GSFPPELAST PLEDIDPYYS NVLTFVVVSK 120
  121 GKDIFRFSAS KAMWMLDPFN PIRRVAIYIL VHPLFSLFII TTILVNCILM IMPTTPTVES 180
  181 TEVIFTGIYT FESAVKVMAR GFILCPFTYL RDAWNWLDFV VIALAYVTMG IDLGNLAALR 240
  241 TFRVLRALKT VAIVPGLKTI VGAVIESVKN LRDVIILTMF SLSVFALMGL QIYMGVLTQK 300
  301 CIKKFPLDGS WGNLTDENWD YHNRNSSNWY SEDEGISFPL CGNISGAGQC DDDYVCLQGF 360
  361 GPNPNYGYTS FDSFGWAFLS AFRLMTQDFW EDLYQLVLRA AGPWHMLFFI VIIFLGSFYL 420
  421 VNLILAIVAM SYDELQKKAE EEEAAEEEAI REAEEAAAAK AAKLEERANA QAQAAADAAA 480
  481 AEEAALHPEM AKSPTYSCIS YELFVGGEKG NDDNNKEKMS IRSVEVESES VSVIQRQPAP 540
  541 TTAHQATKVR KVSTTSLSLP GSPFNIRRGS RSSHKYTIRN GRGRFGIPGS DRKPLVLSTY 600
  601 QDAQQHLPYA DDSNAVTPMS EENGAIIVPV YYGNLGSRHS SYTSHQSRIS YTSHGDLLGG 660
  661 MAVMGVSTMT KESKLRNRNT RNQSVGATNG GTTCLDTNHK LDHRDYEIGL ECTDEAGKIK 720
  721 HHDNPFIEPV QTQTVVDMKD VMVLNDIIEQ AAGRHSRASD RGVSVYYFPT EDDDEDGPTF 780
  781 KDKALEVILK GIDVFCVWDC CWVWLKFQEW VSLIVFDPFV ELFITLCIVV NTMFMAMDHH 840
  841 DMNKEMERVL KSGNYFFTAT FAIEATMKLM AMSPKYYFQE GWNIFDFIIV ALSLLELGLE 900
  901 GVQGLSVLRS FRLLRVFKLA KSWPTLNLLI SIMGRTMGAL GNLTFVLCII IFIFAVMGMQ 960
  961 LFGKNYHDHK DRFPDGDLPR WNFTDFMHSF MIVFRVLCGE WIESMWDCMY VGDVSCIPFF1020
 1021 LATVVIGNLV VLNLFLALLL SNFGSSSLSA PTADNDTNKI AEAFNRIGRF KSWVKRNIAD1080
 1081 CFKLIRNKLT NQISDQPSGE RTNQISWIWS EGKGVCRCIS AEHGDNELEL GHDEILADGL1140
 1141 IKKGIKEQTQ LEVAIGDGME FTIHGDMKNN KPKKSKYLNN ATDDDTASIN SYGSHKNRPF1200
 1201 KDESHKGSAE TMEGEEKRDA SKEDLGLDEE LDEEGECEEG PLDGDIIIHA HDEDILDEYP1260
 1261 ADCCPDSYYK KFPILAGDDD SPFWQGWGNL RLKTFQLIEN KYFETAVITM ILMSSLALAL1320
 1321 EDVHLPQRPI LQDILYYMDR IFTVIFFLEM LIKWLALGFK VYFTNAWCWL DFVIVMVSLI1380
 1381 NFVASLVGAG GIQAFKTMRT LRALRPLRAM SRMQGMRVVV NALVQAIPSI FNVLLVCLIF1440
 1441 WLIFAIMGVQ LFAGKYFKCE DMNGTKLSHE IIPNRNACES ENYTWVNSAM NFDHVGNAYL1500
 1501 CLFQVATFKG WIQIMNDAID SREVDKQPIR ETNIYMYLYF VFFIIFGSFF TLNLFIGVII1560
 1561 DNFNEQKKKA GGSLEMFMTE DQKKYYNAMK KMGSKKPLKA IPRPRWRPQA IVFEIVTDKK1620
 1621 FDIIIMLFIG LNMFTMTLDR YDASDTYNAV LDYLNAIFVV IFSSECLLKI FALRYHYFIE1680
 1681 PWNLFDVVVV ILSILGLVLS DIIEKYFVSP TLLRVVRVAK VGRVLRLVKG AKGIRTLLFA1740
 1741 LAMSLPALFN ICLLLFLVMF IFAIFGMSFF MHVKEKSGIN DVYNFKTFGQ SMILLFQMST1800
 1801 SAGWDGVLDA IINEEACDPP DNDKGYPGNC GSATVGITFL LSYLVISFLI VINMYIAVIL1860
 1861 ENYSQATEDV QEGLTDDDYD MYYEIWQQFD PEGTQYIRYD QLSEFLDVLE PPLQIHKPNK1920
 1921 YKIISMDIPI CRGDLMYCVD ILDALTKDFF ARKGNPIEET GEIGEIAARP DTEGYEPVSS1980
 1981 TLWRQREEYC ARLIQHAWRK HKARGEGGGS FEPDTDHGDG GDPDAGDPAP DEATDGDAPA2040
 2041 GGDGSVNGTA EGAADADESN VNSPGEDAAA AAAAAAAAAA AGTTTAGSPG AGSAGRQTAV2100
 2101 LVESDGFVTK NGHKVVIHSR SPSITSRTAD V

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..151] FFAS03 1.98 Crystal structure of the editing domain of threonyl-tRNA synthetase
    2 View Details [152..349] PSI-BLAST 4.69897 Crystal structure of KvAP-33H1 Fv complex
    3 View Details [350..592] deduced N/A No confident structure predictions are available.
    4 View Details [593..1162] FFAS03 4.21 Mammalian Shaker Kv1.2 potassium channel- beta subunit complex
    5 View Details [1163..1284] deduced N/A No confident structure predictions are available.
    6 View Details [1285..1467] MSA 1.295985 View MSA. No confident structure predictions are available.
    7 View Details [1468..1542] deduced N/A No confident structure predictions are available.
    8 View Details [1543..1871] PSI-BLAST 37.69897 Mammalian Shaker Kv1.2 potassium channel- beta subunit complex
    9 View Details [1872..2040] FFAS03 1.0 Myosin Light Chain Mlc1p
    10 View Details [2041..2131] deduced N/A No confident structure predictions are available.

    Functions predicted (by domain):

    # Gene Ontology predictions
    1 No functions predicted.
    2
    Term Confidence Notes
  • metal ion transmembrane transporter activity
    		•  9.85051068330727 bayes_pls_golite062009
  • voltage-gated potassium channel activity
    		•  9.81160995334402 bayes_pls_golite062009
  • voltage-gated cation channel activity
    		•  9.68106228022033 bayes_pls_golite062009
  • potassium channel activity
    		•  9.663779798406 bayes_pls_golite062009
  • cation channel activity
    		•  9.62064031772276 bayes_pls_golite062009
  • voltage-gated ion channel activity
    		•  9.44972890633534 bayes_pls_golite062009
  • voltage-gated channel activity
    		•  9.42561802306797 bayes_pls_golite062009
  • ion channel activity
    		•  8.91395130684665 bayes_pls_golite062009
  • gated channel activity
    		•  8.84587381436962 bayes_pls_golite062009
  • channel activity
    		•  8.68489845295557 bayes_pls_golite062009
  • passive transmembrane transporter activity
    		•  8.68489845295557 bayes_pls_golite062009
  • substrate-specific channel activity
    		•  8.67927944890782 bayes_pls_golite062009
  • ligand-gated ion channel activity
    		•  5.74511802205447 bayes_pls_golite062009
  • ligand-gated channel activity
    		•  5.74511802205447 bayes_pls_golite062009
  • cation transmembrane transporter activity
    		•  5.13805155650973 bayes_pls_golite062009
  • ion transmembrane transporter activity
    		•  5.04374327766634 bayes_pls_golite062009
  • substrate-specific transmembrane transporter activity
    		•  4.64120459994573 bayes_pls_golite062009
  • inward rectifier potassium channel activity
    		•  4.10787296124574 bayes_pls_golite062009
  • transporter activity
    		•  2.93091397928047 bayes_pls_golite062009
  • transmembrane transporter activity
    		•  2.82224868778929 bayes_pls_golite062009
  • substrate-specific transporter activity
    		•  2.79688978937497 bayes_pls_golite062009
    3 No functions predicted.
    4 No functions predicted.
    5 No functions predicted.
    6 No functions predicted.
    7 No functions predicted.
    8 No functions predicted.
    9
    Term Confidence Notes
  • metal ion transmembrane transporter activity
    		•  6.54328429516612 bayes_pls_golite062009
  • cation channel activity
    		•  5.62208255919933 bayes_pls_golite062009
  • ion channel activity
    		•  5.0664469565818 bayes_pls_golite062009
  • channel activity
    		•  5.00141647830212 bayes_pls_golite062009
  • passive transmembrane transporter activity
    		•  5.00141647830212 bayes_pls_golite062009
  • substrate-specific channel activity
    		•  4.95065330354844 bayes_pls_golite062009
  • potassium channel activity
    		•  4.91572875132629 bayes_pls_golite062009
  • voltage-gated potassium channel activity
    		•  4.89487102647079 bayes_pls_golite062009
  • voltage-gated cation channel activity
    		•  4.88770625681129 bayes_pls_golite062009
  • gated channel activity
    		•  4.82664289611237 bayes_pls_golite062009
  • voltage-gated ion channel activity
    		•  4.7555088124105 bayes_pls_golite062009
  • voltage-gated channel activity
    		•  4.74181737598988 bayes_pls_golite062009
  • binding
    		•  3.05873877511752 bayes_pls_golite062009
  • ion transmembrane transporter activity
    		•  2.58331384033974 bayes_pls_golite062009
  • cation transmembrane transporter activity
    		•  2.56450760908401 bayes_pls_golite062009
  • substrate-specific transmembrane transporter activity
    		•  2.39219065596758 bayes_pls_golite062009
  • metal ion binding
    		•  2.2959528243596 bayes_pls_golite062009
  • cation binding
    		•  2.2959528243596 bayes_pls_golite062009
  • ion binding
    		•  2.28923116241522 bayes_pls_golite062009
  • outward rectifier potassium channel activity
    		•  2.01104796684049 bayes_pls_golite062009
  • structural constituent of muscle
    		•  1.8065079408882 bayes_pls_golite062009
  • molecular transducer activity
    		•  1.57685201816793 bayes_pls_golite062009
  • signal transducer activity
    		•  1.57685201816793 bayes_pls_golite062009
  • myosin heavy chain binding
    		•  1.55270989227878 bayes_pls_golite062009
  • transporter activity
    		•  1.18173318787461 bayes_pls_golite062009
  • protein binding
    		•  1.09433047543741 bayes_pls_golite062009
  • transmembrane transporter activity
    		•  0.967232199555998 bayes_pls_golite062009
  • calcium ion binding
    		•  0.96333115642547 bayes_pls_golite062009
  • substrate-specific transporter activity
    		•  0.713088884599039 bayes_pls_golite062009
  • A-type (transient outward) potassium channel activity
    		•  0.553372634071692 bayes_pls_golite062009
  • transcription regulator activity
    		•  0.467743512816825 bayes_pls_golite062009
  • peptide binding
    		•  0.390501353810487 bayes_pls_golite062009
  • active transmembrane transporter activity
    		•  0.255162242356474 bayes_pls_golite062009
    		• 0.184502455796377 bayes_pls_golite062009
  • channel regulator activity
    		•  0.165732133218208 bayes_pls_golite062009
  • nucleic acid binding
    		•  0.137921428032586 bayes_pls_golite062009
  • DNA binding
    		•  0.126696463568471 bayes_pls_golite062009
  • receptor binding
    		•  0.0768449444338068 bayes_pls_golite062009
  • nucleoside-triphosphatase activity
    		•  0.014511553141427 bayes_pls_golite062009
    10 No functions predicted.


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    [View Details]
    Source: Reynolds et al. 2008. Manuscript submitted Philius confidence legend
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