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Protein Overview: FBpp0309258, nod-PA

General Information:
Name(s) found: FBpp0309258 [FlyBase]
nod-PA / FBpp0073363 [FlyBase]
Description(s) found:
Found 33 descriptions.
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  • type=protein; loc=X:join(11474957..11475073,11475138..11475332,11475403..11475937,11476072..11476217,11478339..11478529,11478593..11479303,11479382..11479487); ID=FBpp0309258; name=nod-PB; parent=FBgn0002948,FBtr0340297; dbxref=FlyBase:FBpp0309258,FlyBase_Annotation_IDs:CG1763-PB; MD5=0329865f97265fe516b50760eb9c1d65; length=666; release=r5.56; species=Dmel; [FlyBase]
  • The gene no distributive disjunction is referred to in FlyBase by the symbol Dmel\nod (CG1763, FBgn0002948). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is X:11474851..11479787. It has the cytological map location 10C7-10C8. There is experimental evidence that it has the molecular function</span>: microtubule plus-end binding; microtubule motor activity. There is experimental evidence that it is involved in the biological process</span>: meiotic chromosome segregation; spindle assembly involved in female meiosis I; distributive segregation; establishment of meiotic spindle orientation; mitotic spindle organization; positive regulation of microtubule polymerization. 35 alleles are reported. The phenotype of these alleles is annotated with: polytene chromosome chromocenter. It has one annotated transcript and one annotated polypeptide. [FlyBase]
    • Organism: Drosophila melanogaster
    Length: 666 amino acids

    Gene Ontology:
    Cellular Component: kinesin complex [ISS]
    Biological Process: distributive segregation [IMP]
    DNA repair [IEA]
    mitotic spindle organization [IMP]
    meiotic chromosome segregation [IMP]
    establishment of meiotic spindle orientation [IMP]
    spindle assembly involved in female meiosis I [IMP]
    microtubule-based movement [IEA][ISS]
    positive regulation of microtubule polymerization [IDA]
    Molecular Function: DNA binding [IEA]
    ATP binding [IEA]
    microtubule motor activity [IMP][ISS]
    microtubule plus-end binding [IDA]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MEGAKLSAVR IAVREAPYRQ FLGRREPSVV QFPPWSDGKS LIVDQNEFHF DHAFPATISQ  60
   61 DEMYQALILP LVDKLLEGFQ CTALAYGQTG TGKSYSMGMT PPGEILPEHL GILPRALGDI 120
  121 FERVTARQEN NKDAIQVYAS FIEIYNEKPF DLLGSTPHMP MVAARCQRCT CLPLHSQADL 180
  181 HHILELGTRN RRVRPTNMNS NSSRSHAIVT IHVKSKTHHS RMNIVDLAGS EGVRRTGHEG 240
  241 VARQEGVNIN LGLLSINKVV MSMAAGHTVI PYRDSVLTTV LQASLTAQSY LTFLACISPH 300
  301 QCDLSETLST LRFGTSAKKL RLNPMQVARQ KQSLAARTTH VFRQALCTST AIKSNAANHN 360
  361 SIVVPKSKYS TTKPLSAVLH RTRSELGMTP KAKKRARELL ELEETTLELS SIHIQDSSLS 420
  421 LLGFHSDSDK DRHLMPPPTG QEPRQASSQN STLMGIVEET EPKESSKVQQ SMVAPTVPTT 480
  481 VRCQLFNTTI SPISLRASSS QRELSGIQPM EETVVASPQQ PCLRRSVRLA SSMRSQNYGA 540
  541 IPKVMNLRRS TRLAGIREHA TSVVVKNETD AIPHLRSTVQ KKRTRNVKPA PKAWMANNTK 600
  601 CFLDLLNNGN VKQLQEIPGI GPKSAFSLAL HRSRLGCFEN LFQVKSLPIW SGNKWERFCQ 660
  661 INCLDT

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..227] PSI-BLAST 87.0 Kinesin
    2 View Details [228..666] PSI-BLAST 13.69897 Heavy meromyosin subfragment

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • microtubule motor activity
    		•  7.68336791348661 bayes_pls_golite062009
  • plus-end-directed microtubule motor activity
    		•  4.97507344344589 bayes_pls_golite062009
  • microfilament motor activity
    		•  4.176620576177 bayes_pls_golite062009
  • motor activity
    		•  4.04927796049806 bayes_pls_golite062009
  • nucleoside-triphosphatase activity
    		•  2.95079405147356 bayes_pls_golite062009
  • pyrophosphatase activity
    		•  2.87427509025394 bayes_pls_golite062009
  • hydrolase activity, acting on acid anhydrides
    		•  2.85499564954033 bayes_pls_golite062009
  • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides
    		•  2.85178667290149 bayes_pls_golite062009
  • actin-dependent ATPase activity
    		•  2.77140616759165 bayes_pls_golite062009
  • microtubule plus-end binding
    		•  2.71138928021716 bayes_pls_golite062009
  • tubulin binding
    		•  2.67743463093593 bayes_pls_golite062009
  • binding
    		•  2.64537357529343 bayes_pls_golite062009
  • microtubule binding
    		•  2.59155206524122 bayes_pls_golite062009
  • transporter activity
    		•  2.58140740499725 bayes_pls_golite062009
  • cytoskeletal protein binding
    		•  2.4101693596493 bayes_pls_golite062009
  • transmembrane transporter activity
    		•  2.39695871109024 bayes_pls_golite062009
  • ATPase activity
    		•  2.39535714892224 bayes_pls_golite062009
  • ATPase activity, coupled
    		•  2.18396165590908 bayes_pls_golite062009
  • nucleic acid binding
    		•  1.84541587592638 bayes_pls_golite062009
  • actin binding
    		•  1.75397031486306 bayes_pls_golite062009
  • hydrolase activity
    		•  1.57549510726226 bayes_pls_golite062009
  • DNA binding
    		•  1.48341220422804 bayes_pls_golite062009
  • general RNA polymerase II transcription factor activity
    		•  1.40384549325664 bayes_pls_golite062009
  • transcription regulator activity
    		•  1.30136714640988 bayes_pls_golite062009
  • substrate-specific transporter activity
    		•  1.29730375126024 bayes_pls_golite062009
  • protein binding
    		•  1.22129154759482 bayes_pls_golite062009
  • catalytic activity
    		•  1.00104173493322 bayes_pls_golite062009
  • purine nucleotide binding
    		•  0.929901285538132 bayes_pls_golite062009
  • nucleotide binding
    		•  0.922442819194247 bayes_pls_golite062009
  • purine ribonucleotide binding
    		•  0.920987930180051 bayes_pls_golite062009
  • ribonucleotide binding
    		•  0.920926158369519 bayes_pls_golite062009
  • substrate-specific transmembrane transporter activity
    		•  0.906554174337376 bayes_pls_golite062009
  • actin filament binding
    		•  0.728264616959762 bayes_pls_golite062009
  • ATP-dependent DNA helicase activity
    		•  0.67561287336355 bayes_pls_golite062009
  • kinetochore binding
    		•  0.505370954958131 bayes_pls_golite062009
  • GTPase activity
    		•  0.437665353870877 bayes_pls_golite062009
  • active transmembrane transporter activity
    		•  0.434775387083003 bayes_pls_golite062009
  • ATP binding
    		•  0.41092997612902 bayes_pls_golite062009
  • guanyl nucleotide binding
    		•  0.399434758448606 bayes_pls_golite062009
  • GTP binding
    		•  0.398333597279278 bayes_pls_golite062009
  • guanyl ribonucleotide binding
    		•  0.39332178627529 bayes_pls_golite062009
  • adenyl ribonucleotide binding
    		•  0.385813421701492 bayes_pls_golite062009
  • adenyl nucleotide binding
    		•  0.377870145186619 bayes_pls_golite062009
  • transcription activator activity
    		•  0.374651542607188 bayes_pls_golite062009
  • ion transmembrane transporter activity
    		•  0.355466224802969 bayes_pls_golite062009
  • RNA helicase activity
    		•  0.34746349346164 bayes_pls_golite062009
  • transcription factor activity
    		•  0.341088753451767 bayes_pls_golite062009
  • helicase activity
    		•  0.33971254173831 bayes_pls_golite062009
  • histone acetyltransferase activity
    		•  0.328186246219424 bayes_pls_golite062009
  • lysine N-acetyltransferase activity
    		•  0.328186246219424 bayes_pls_golite062009
  • ATP-dependent RNA helicase activity
    		•  0.30832907234141 bayes_pls_golite062009
  • RNA-dependent ATPase activity
    		•  0.29532978396745 bayes_pls_golite062009
  • primary active transmembrane transporter activity
    		•  0.294474570607914 bayes_pls_golite062009
  • P-P-bond-hydrolysis-driven transmembrane transporter activity
    		•  0.282352478532746 bayes_pls_golite062009
  • hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances
    		•  0.220608508617331 bayes_pls_golite062009
  • ATPase activity, coupled to transmembrane movement of substances
    		•  0.219533217661421 bayes_pls_golite062009
  • ATPase activity, coupled to movement of substances
    		•  0.219157471322311 bayes_pls_golite062009
  • structural constituent of ribosome
    		•  0.208665086324262 bayes_pls_golite062009
  • protein transporter activity
    		•  0.178442534411253 bayes_pls_golite062009
  • mismatched DNA binding
    		•  0.13866566261611 bayes_pls_golite062009
  • sequence-specific DNA binding
    		•  0.106147926780353 bayes_pls_golite062009
  • minus-end-directed microtubule motor activity
    		•  0.068779631341469 bayes_pls_golite062009
  • cation transmembrane transporter activity
    		•  0.0254369227200564 bayes_pls_golite062009
  • ATP-dependent helicase activity
    		•  0.0136700590511267 bayes_pls_golite062009
  • purine NTP-dependent helicase activity
    		•  0.0136700590511267 bayes_pls_golite062009
  • structural constituent of cytoskeleton
    		•  0.0111338193708552 bayes_pls_golite062009
    2 No functions predicted.


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle