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Protein Overview: Cyp4d14-PA

General Information:
Name(s) found: Cyp4d14-PA / FBpp0070410 [FlyBase]
Description(s) found:
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  • gi|7290279|gb|AAF45740.1| Cyp4d14 [Drosophila melanogaster] [NCBI NR]
  • gi|2894112|emb|CAA15696.1| EG:152A3.2 [Drosophila melanogaster] [NCBI NR]
  • gi|21355669|ref|NP_652020.1| Cyp4d14 [Drosophila melanogaster] [NCBI NR]
  • gi|212287994|gb|ACJ23471.1| RE27104p [Drosophila melanogaster] [NCBI NR]
  • gi|11386631|sp|O46051.1|C4D14_DROME RecName: Full=Probable cytochrome P450 4d14; AltName: Full=CYPIVD14 [NCBI NR]
  • (O46051) Probable cytochrome P450 4d14 (EC 1.14.-.-) (CYPIVD14) [Swiss-Prot]
  • Probable cytochrome P450 4d14 OS=Drosophila melanogaster GN=Cyp4d14 PE=3 SV=1 [Swiss-Prot]
  • The gene Cyp4d14 is referred to in FlyBase by the symbol Dmel\Cyp4d14 (CG3540, FBgn0023541). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is X:2067530..2069346. It has the cytological map location 2E1. Based on sequence similarity, it is predicted to have molecular function</span>: electron carrier activity. An electronic pipeline based on InterPro domains suggests that it is involved in the biological process</span>: oxidation reduction. 3 alleles are reported. No phenotypic data is available. It has one annotated transcript and one annotated polypeptide. [FlyBase]
  • >CG3540-PA translation from_gene[CG3540 Cyp4d14 FBgn0023541] seq_release:3 mol_weight=57482 cds_boundaries:(X:1,930,272..1,932,008[-]) aa_length:507 transcript_info:[CG3540-RA seq_release:3] gene_info:[gene symbol:Cyp4d14 FBgn0023541 gene_boundaries:(X [hmr_yeast5_DM3-1_pombe.fasta]
  • (AE003423) Cyp4d14 gene product [Drosophila melanogaster] [yeastflysequest.fasta]
  • CG3540-PA [Drosophila melanogaster]gi|21355669|ref|NP_652020.1| CG3540-PA [Drosophila melanogaster]gi|2894112|emb|CAA15696.1| EG:152A3.2 [Drosophila melanogaster]gi|11386631|sp|O46051|C4DE_DROME Probable cytochrome P450 4d14 (CYPIVD14) [nrdb_11152004_Chlamydomonas]
  • type=protein; loc=X:complement(2067530..2068433,2068497..2068953,2069107..2069269); ID=FBpp0070410; name=Cyp4d14-PA; parent=FBgn0023541,FBtr0070426; dbxref=FlyBase:FBpp0070410,FlyBase_Annotation_IDs:CG3540-PA,GB_protein:AAF45740.1,REFSEQ:NP_652020,GB_prot [fly-100309-contam.fasta]
  • EG:152A3.2 [Drosophila melanogaster] [nr-271106-contam.fasta]
  • Probable cytochrome P450 4d14 (CYPIVD14) [nr-271106-contam.fasta]
  • Cyp4d14 CG3540-PA [Drosophila melanogaster] [nr-271106-contam.fasta]
  • CG3540-PA [Drosophila melanogaster] [nr-271106-contam.fasta]
  • type=protein; loc=X:complement(2067530..2068433,2068497..2068953,2069107..2069269); ID=FBpp0070410; name=Cyp4d14-PA; parent=FBgn0023541,FBtr0070426; dbxref=FlyBase:FBpp0070410,FlyBase_Annotation_IDs:CG3540-PA,GB_protein:AAF45740.1,REFSEQ:NP_652020,GB_protein:AAF45740; MD5=1217e22982d812771e801b6676604932; length=507; release=r5.16; species=Dmel; [fly-contam-His-TEV-Tub4complex.fasta]
  • type=protein; loc=X:complement(2067530..2068433,2068497..2068953,2069107..2069269); ID=FBpp0070410; name=Cyp4d14-PA; parent=FBgn0023541,FBtr0070426; dbxref=FlyBase:FBpp0070410,FlyBase_Annotation_IDs:CG3540-PA,GB_protein:AAF45740.1,REFSEQ:NP_652020,GB_protein:AAF45740; MD5=1217e22982d812771e801b6676604932; length=507; release=r5.21; species=Dmel; [Other_drosophila_na_09-09-2009_reversed.fasta]
  • RE27104p OS=Drosophila melanogaster GN=Cyp4d14-RA PE=2 SV=1 [UniProt_drosophila_07-01-2011_reversed.fasta]
  • type=protein; loc=X:complement(2067530..2068433,2068497..2068953,2069107..2069269); ID=FBpp0070410; name=Cyp4d14-PA; parent=FBgn0023541,FBtr0070426; dbxref=FlyBase:FBpp0070410,FlyBase_Annotation_IDs:CG3540-PA,GB_protein:AAF45740.1,REFSEQ:NP_652020,GB_protein:AAF45740,FlyMine:FBpp0070410,modMine:FBpp0070410; MD5=1217e22982d812771e801b6676604932; length=507; release=r5.46; species=Dmel; [fly-062812-sfps-sandra-contam.fasta]
  • type=protein; loc=X:complement(join(2175074..2175236,2174464..2174920,2173497..2174400)); ID=FBpp0070410; name=Cyp4d14-PA; parent=FBgn0023541,FBtr0070426; dbxref=FlyBase:FBpp0070410,FlyBase_Annotation_IDs:CG3540-PA,GB_protein:AAF45740.1,REFSEQ:NP_652020,GB_protein:AAF45740,FlyMine:FBpp0070410,modMine:FBpp0070410; MD5=1217e22982d812771e801b6676604932; length=507; release=r6.02; species=Dmel; [fly-2014-05-contam.fasta]
  • type=protein; loc=X:complement(join(2175074..2175236,2174464..2174920,2173497..2174400)); ID=FBpp0070410; name=Cyp4d14-PA; parent=FBgn0023541,FBtr0070426; dbxref=FlyBase:FBpp0070410,FlyBase_Annotation_IDs:CG3540-PA,GB_protein:AAF45740.1,REFSEQ:NP_652020,GB_protein:AAF45740,FlyMine:FBpp0070410,modMine:FBpp0070410; MD5=1217e22982d812771e801b6676604932; length=507; release=r6.07; species=Dmel; [fly-08202015-contam.fasta]
  • FBpp0070410 type=protein; loc=X:complement(join(2175074..2175236,2174464..2174920,2173497..2174400)); ID=FBpp0070410; name=Cyp4d14-PA; parent=FBgn0023541,FBtr0070426; dbxref=FlyBase:FBpp0070410,FlyBase_Annotation_IDs:CG3540-PA,GB_protein:AAF45740.1,REFSEQ:NP_652020,GB_protein:AAF45740,FlyMine:FBpp0070410,modMine:FBpp0070410; MD5=1217e22982d812771e801b6676604932; length=507; release=r6.09; species=Dmel; [dmel-all-translation-r6.09.fasta]
  • [fly-122215-dmel-6-09-contam.fasta]
  • type=protein; loc=X:complement(join(2175074..2175236,2174464..2174920,2173497..2174400)); ID=FBpp0070410; name=Cyp4d14-PA; parent=FBgn0023541,FBtr0070426; dbxref=FlyBase:FBpp0070410,FlyBase_Annotation_IDs:CG3540-PA,GB_protein:AAF45740.1,REFSEQ:NP_652020,GB_protein:AAF45740,UniProt/Swiss-Prot:O46051,FlyMine:FBpp0070410,modMine:FBpp0070410; MD5=1217e22982d812771e801b6676604932; length=507; release=r6.14; species=Dmel; [fly-dmel-jan2017-sandracontam.fasta]
    • Organism: Drosophila melanogaster
    Length: 507 amino acids

    Gene Ontology:
    Cellular Component: membrane [NAS]
    microsome [NAS]
    Biological Process: oxidation reduction [IEA]
    Molecular Function: electron carrier activity [IEA][ISS][NAS]
    monooxygenase activity [IEA]
    heme binding [IEA]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MYLELFAILL ATALAWDYMR KRRHNKMYAE AGIRGPKSYP LVGNAPLLIN ESPKTIFDMQ  60
   61 FRLIAEFGKN IKTQMLGESG FMTADSKMIE AIMSSQQTIQ KNNLYSLLVN WLGDGLLISQ 120
  121 GKKWFRRRKI ITPAFHFKIL EDFVEVFDQQ SATMVQKLYD RADGKTVINM FPVACLCAMD 180
  181 IIAETAMGVK INAQLQPQFT YVQSVTTASA MLAERFMNPL QRLDFTMKLF YPKLLDKLND 240
  241 AVKNMHDFTN SVITERRELL QKAIADGGDA DAALLNDVGQ KRRMALLDVL LKSTIDGAPL 300
  301 SNDDIREEVD TFMFEGHDTT TSSIAFTCYL LARHPEVQAR VFQEVRDVIG DDKSAPVTMK 360
  361 LLGELKYLEC VIKESLRLFP SVPIIGRYIS QDTVLDGKLI PADSNVIILI YHAQRDPDYF 420
  421 PDPEKFIPDR FSMERKGEIS PFAYTPFSAG PRNCIGQKFA MLEMKSTISK MVRHFELLPL 480
  481 GEEVQPVLNV ILRSTTGINC GLKPRVY

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    SHOWING SINGLE HITS. [ Hide Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..507] PSI-BLAST 100.0 Crystal Structure of Human Microsomal P450 3A4

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • arachidonic acid monooxygenase activity
    		•  6.76823710927794 bayes_pls_golite062009
  • fatty acid (omega-1)-hydroxylase activity
    		•  6.3313834755701 bayes_pls_golite062009
  • monooxygenase activity
    		•  5.57229509004705 bayes_pls_golite062009
  • steroid hydroxylase activity
    		•  5.04794778387361 bayes_pls_golite062009
  • arachidonic acid epoxygenase activity
    		•  4.80764258881036 bayes_pls_golite062009
  • retinoic acid 4-hydroxylase activity
    		•  3.76307535769621 bayes_pls_golite062009
  • oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen
    		•  3.68151610133025 bayes_pls_golite062009
  • demethylase activity
    		•  2.80780658333504 bayes_pls_golite062009
  • oxygen binding
    		•  2.77495508953933 bayes_pls_golite062009
  • retinoic acid binding
    		•  2.70323898361882 bayes_pls_golite062009
  • retinoid binding
    		•  2.60220937953757 bayes_pls_golite062009
  • oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen
    		•  2.56821164444595 bayes_pls_golite062009
  • isoprenoid binding
    		•  2.47826119804163 bayes_pls_golite062009
  • thromboxane-A synthase activity
    		•  2.45281910634006 bayes_pls_golite062009
  • oxysterol 7-alpha-hydroxylase activity
    		•  2.36480328243514 bayes_pls_golite062009
  • oxidoreductase activity
    		•  2.35847923992364 bayes_pls_golite062009
  • sterol 14-demethylase activity
    		•  2.33937429425924 bayes_pls_golite062009
  • steroid 7-alpha-hydroxylase activity
    		•  2.21042366294727 bayes_pls_golite062009
  • oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of one atom of oxygen
    		•  2.15105968497418 bayes_pls_golite062009
  • vitamin D 24-hydroxylase activity
    		•  1.81919676974797 bayes_pls_golite062009
  • vitamin D3 25-hydroxylase activity
    		•  1.65825585934141 bayes_pls_golite062009
  • vitamin D 25-hydroxylase activity
    		•  1.65825585934141 bayes_pls_golite062009
  • electron carrier activity
    		•  1.48516712188486 bayes_pls_golite062009
  • arachidonic acid 11,12-epoxygenase activity
    		•  1.48500938886158 bayes_pls_golite062009
  • testosterone 6-beta-hydroxylase activity
    		•  1.4661447981611 bayes_pls_golite062009
  • oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced iron-sulfur protein as one donor, and incorporation of one atom of oxygen
    		•  1.46109575978397 bayes_pls_golite062009
  • binding
    		•  1.0881336564542 bayes_pls_golite062009
  • 25-hydroxycholecalciferol-24-hydroxylase activity
    		•  1.06487564122685 bayes_pls_golite062009
  • steroid 17-alpha-monooxygenase activity
    		•  0.918503562996019 bayes_pls_golite062009
  • flavonoid 3'-monooxygenase activity
    		•  0.89030345144459 bayes_pls_golite062009
  • ecdysteroid 25-hydroxylase activity
    		•  0.89030345144459 bayes_pls_golite062009
  • catalytic activity
    		•  0.608111453189583 bayes_pls_golite062009
  • iron ion binding
    		•  0.529598228513719 bayes_pls_golite062009
  • cation binding
    		•  0.510556740388808 bayes_pls_golite062009
  • metal ion binding
    		•  0.510556740388808 bayes_pls_golite062009
  • ion binding
    		•  0.503326724714616 bayes_pls_golite062009
  • transition metal ion binding
    		•  0.450436868179747 bayes_pls_golite062009
  • cholesterol monooxygenase (side-chain-cleaving) activity
    		•  0.276594551871869 bayes_pls_golite062009
  • 1-alpha,25-dihydroxyvitamin D3 24-hydroxylase activity
    		•  0.203772707673481 bayes_pls_golite062009


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    [View Details]
    Source: Reynolds et al. 2008. Manuscript submitted Philius confidence legend
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