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Protein Overview: FBpp0311070, svr-PB

General Information:
Name(s) found: FBpp0311070 [FlyBase]
svr-PB / FBpp0070080 [FlyBase]
Description(s) found:
Found 31 descriptions.
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  • type=protein; loc=X:join(394186..394641,396018..396253,396320..396799,396869..396969,398701..398818,398949..400275,400341..400564,400632..401910); ID=FBpp0311070; name=svr-PM; parent=FBgn0004648,FBtr0344738; dbxref=FlyBase:FBpp0311070,FlyBase_Annotation_IDs:CG4122-PM; MD5=d8fd45bd00e9e5f169e95987dc8d1d06; length=1406; release=r5.56; species=Dmel; [FlyBase]
  • The gene silver is referred to in FlyBase by the symbol Dmel\svr (CG4122, FBgn0004648). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is X:390504..403113. It has the cytological map location 1B5-1B7. There is experimental evidence that it has the molecular function</span>: carboxypeptidase activity; metallocarboxypeptidase activity. There is experimental evidence that it is involved in the biological process</span>: imaginal disc-derived wing morphogenesis; phagocytosis, engulfment. 62 alleles are reported. The phenotypes of these alleles are annotated with 11 unique terms, many of which group under: adult segment; adult mesothoracic segment; organ system; thoracic segment; adult; region of integument; peripheral nervous system; nervous system; sensillum; wing vein L1; sense organ. It has 8 annotated transcripts and 8 annotated polypeptides. [FlyBase]
    • Organism: Drosophila melanogaster
    Length: 1406 amino acids

    Gene Ontology:
    Cellular Component: NONE FOUND
    Biological Process: chitin-based cuticle development [NAS]
    phagocytosis, engulfment [IMP]
    proteolysis [IEA]
    imaginal disc-derived wing morphogenesis [IMP]
    Molecular Function: zinc ion binding [IEA]
    carboxypeptidase activity [IDA]
    metallocarboxypeptidase activity [IDA][NAS]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MPTLGLLFAS IGIAVLAMGV PHCRGYTIKE DESFLQQPHY ASQEQLEDLF AGLEKAYPNQ  60
   61 AKVHFLGRSL EGRNLLALQI SRNTRSRNLL TPPVKYIANM HGDETVGRQL LVYMAQYLLG 120
  121 NHERISDLGQ LVNSTDIYLV PTMNPDGYAL SQEGNCESLP NYVGRGNAAN IDLNRDFPDR 180
  181 LEQSHVHQLR AQSRQPETAA LVNWIVSKPF VLSANFHGGA VVASYPYDNS LAHNECCEES 240
  241 LTPDDRVFKQ LAHTYSDNHP IMRKGNNCND SFSGGITNGA HWYELSGGMQ DFNYAFSNCF 300
  301 ELTIELSCCK YPAASTLPQE WQRNKASLLQ LLRQAHIGIK GLVTDASGFP IADANVYVAG 360
  361 LEEKPMRTSK RGEYWRLLTP GLYSVHASAF GYQTSAPQQV RVTNDNQEAL RLDFKLAPVE 420
  421 TNFDGNFRKV KVERSEPPQK LKKQFNGFLT PTKYEHHNFT AMESYLRAIS SSYPSLTRLY 480
  481 SIGKSVQGRD LWVLEIFATP GSHVPGVPEF KYVANMHGNE VVGKELLLIL TKYMLERYGN 540
  541 DDRITKLVNG TRMHFLYSMN PDGYEISIEG DRTGGVGRAN AHGIDLNRNF PDQYGTDRFN 600
  601 KVTEPEVAAV MNWTLSLPFV LSANLHGGSL VANYPFDDNE NDFNDPFMRL RNSSINGRKP 660
  661 NPTEDNALFK HLAGIYSNAH PTMYLGQPCE LFQNEFFPDG ITNGAQWYSV TGGMQDWNYV 720
  721 RAGCLELTIE MGCDKFPKAA ELSRYWEDHR EPLLQFIEQV HCGIHGFVHS TIGTPIAGAV 780
  781 VRLDGANHST YSQVFGDYWK LALPGRHNLT VLGDNYAPLR MEVEVPDVHP FEMRMDITLM 840
  841 PDDPQHWASA NDFRIIENVV NTRYHTNPQV RARLAELENQ NGQIASFGYA DSEFGTIFNY 900
  901 LKMTSDIGEP EEHKYKLLVV SSLYDTTAPL GREILLNLIR HLVEGFKLQD TSVVELLKRS 960
  961 VIYFLPQTSK FQNVFDMYNS NTSICDPVLG DELAERILGP ETDQAKDVFL QFLRSERFDL1020
 1021 MLTFGAGNSD LNYPKGDSVL VKFAHRMQRT EFNYSPLQCP PSATRQLHRE TTERLTNMMY1080
 1081 RIYNLPVYTL GISCCRMPHQ KKIASVWRKN IDKIKNFLAL VKTGVSGLVQ NDKGQPLREA1140
 1141 YVRLLEHDRI INVTKNVARF QLMLPHGLYG LEVTAPNYES QMIKVDVEDG RVTELGIIRM1200
 1201 HPFTLIRGVV LELPNNDNRA TTSIAGVVLD ESNHPVRNAK VSVVGQTQLR NFTGSMGQYR1260
 1261 ISAVPLGTIT LKVEAPRHLE ATRQMHLIQG GLATENVVFH LKVNEHVFGL PRFLFILCAS1320
 1321 VLIIVGVIVC VLCAQFWFYR RHRGDKPYYN FSLLPQRGKE QFGLEDDDGG DDGETELFRS1380
 1381 PIKRELSQRA HLVNNQTNYS FIIQAA

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..447] PSI-BLAST 87.0 No description for 2nsmA was found.
    2 View Details [448..827] PSI-BLAST 85.0 Carboxypeptidase D, a regulatory domain; Carboxypeptidase D, catalytic domain
    3 View Details [828..1213] FFAS03 8.5 No description for 2nsmA was found.
    4 View Details [1214..1308] PSI-BLAST 3.39794 The type II cohesin dockerin complex
    5 View Details [1309..1406] deduced N/A No confident structure predictions are available.

    Functions predicted (by domain):

    # Gene Ontology predictions
    1 No functions predicted.
    2
    Term Confidence Notes
  • peptidase activity
    		•  4.786910294594 bayes_pls_golite062009
  • peptidase activity, acting on L-amino acid peptides
    		•  4.40766568731738 bayes_pls_golite062009
  • exopeptidase activity
    		•  3.28577934113028 bayes_pls_golite062009
  • hydrolase activity
    		•  2.98013991489506 bayes_pls_golite062009
  • metallopeptidase activity
    		•  2.76103081380105 bayes_pls_golite062009
  • carboxypeptidase activity
    		•  2.63658263814587 bayes_pls_golite062009
  • metalloexopeptidase activity
    		•  1.76058821499096 bayes_pls_golite062009
  • metallocarboxypeptidase activity
    		•  1.56827526553175 bayes_pls_golite062009
  • catalytic activity
    		•  1.3989281287879 bayes_pls_golite062009
  • binding
    		•  1.13031326446259 bayes_pls_golite062009
  • nucleic acid binding
    		•  0.968016926667625 bayes_pls_golite062009
  • endopeptidase activity
    		•  0.910234727191613 bayes_pls_golite062009
  • transcription regulator activity
    		•  0.738552659762097 bayes_pls_golite062009
  • serine hydrolase activity
    		•  0.596149133958797 bayes_pls_golite062009
  • serine-type peptidase activity
    		•  0.578572340123331 bayes_pls_golite062009
  • DNA binding
    		•  0.508098629093675 bayes_pls_golite062009
  • cobalt ion binding
    		•  0.373334141253719 bayes_pls_golite062009
  • aminopeptidase activity
    		•  0.0966237570696103 bayes_pls_golite062009
    3 No functions predicted.
    4 No functions predicted.
    5 No functions predicted.


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    [View Details]
    Source: Reynolds et al. 2008. Manuscript submitted Philius confidence legend
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