Protein Overview: dco-PB, dco-PA, ...

General Information:
Name(s) found:	FBpp0306615 [FlyBase] dco-PC / FBpp0085106 [FlyBase] dco-PB / FBpp0085105 [FlyBase] dco-PA / FBpp0085104 [FlyBase]
Description(s) found: Found 58 descriptions. SHOW ALL	type=protein; loc=3R:complement(26882251..26883573); ID=FBpp0306615; name=dco-PD; parent=FBgn0002413,FBtr0334548; dbxref=FlyBase:FBpp0306615,FlyBase_Annotation_IDs:CG2048-PD,REFSEQ:NP_001263132,GB_protein:AGB96511; MD5=28dd3b77392d3a39c76762301067e361; length=440; release=r5.56; species=Dmel; [FlyBase] The gene discs overgrown is referred to in FlyBase by the symbol Dmel\dco (CG2048, FBgn0002413). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 3R:26880905..26886931. It has the cytological map location 100B2. There is experimental evidence that it has the molecular function</span>: kinase activity. There is experimental evidence for 12 unique biological process</span> terms, many of which group under: regulation of biological process; anatomical structure development; cell communication; establishment of planar polarity; positive regulation of biological process; biopolymer modification; circadian rhythm; regulation of apoptosis; response to cocaine; regulation of anatomical structure size. 89 alleles are reported. The phenotypes of these alleles are annotated with 17 unique terms, many of which group under: external compound sense organ; adult segment; peripheral nervous system; organ system; thoracic segment; nervous system; adult mesothoracic segment; imaginal precursor; compound cell cluster organ; wing hair; dorsal thoracic disc; cephalopharyngeal skeleton; antennal segment. It has 3 annotated transcripts and 3 annotated polypeptides. [FlyBase] The gene discs overgrown is referred to in FlyBase by the symbol Dmel\dco (CG2048, FBgn0002413). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 3R:26880905..26886931. It has the cytological map location 100B2. There is experimental evidence that it has the molecular function</span>: kinase activity. There is experimental evidence for 12 unique biological process</span> terms, many of which group under: regulation of biological process; anatomical structure development; cell communication; establishment of planar polarity; positive regulation of biological process; biopolymer modification; circadian rhythm; regulation of apoptosis; response to cocaine; regulation of anatomical structure size. 89 alleles are reported. The phenotypes of these alleles are annotated with 17 unique terms, many of which group under: external compound sense organ; adult segment; peripheral nervous system; organ system; thoracic segment; nervous system; adult mesothoracic segment; imaginal precursor; compound cell cluster organ; wing hair; dorsal thoracic disc; cephalopharyngeal skeleton; antennal segment. It has 3 annotated transcripts and 3 annotated polypeptides. [FlyBase] The gene discs overgrown is referred to in FlyBase by the symbol Dmel\dco (CG2048, FBgn0002413). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 3R:26880905..26886931. It has the cytological map location 100B2. There is experimental evidence that it has the molecular function</span>: kinase activity. There is experimental evidence for 12 unique biological process</span> terms, many of which group under: regulation of biological process; anatomical structure development; cell communication; establishment of planar polarity; positive regulation of biological process; biopolymer modification; circadian rhythm; regulation of apoptosis; response to cocaine; regulation of anatomical structure size. 89 alleles are reported. The phenotypes of these alleles are annotated with 17 unique terms, many of which group under: external compound sense organ; adult segment; peripheral nervous system; organ system; thoracic segment; nervous system; adult mesothoracic segment; imaginal precursor; compound cell cluster organ; wing hair; dorsal thoracic disc; cephalopharyngeal skeleton; antennal segment. It has 3 annotated transcripts and 3 annotated polypeptides. [FlyBase]
Organism:	Drosophila melanogaster
Length:	440 amino acids
Gene Ontology:
Cellular Component:	nucleus [IDA][TAS] cytoplasm [IDA][TAS] plasma membrane [IDA]
Biological Process:	eclosion rhythm [TAS] regulation of protein import into nucleus [TAS] cell communication [IMP] establishment of ommatidial planar polarity [IMP] circadian rhythm [IMP][IPI][NAS][TAS] protein amino acid phosphorylation [IDA][NAS][TAS] regulation of ecdysteroid secretion [IMP] imaginal disc growth [IMP] rhythmic behavior [TAS] positive regulation of cell growth [IMP] behavioral response to cocaine [IMP][NAS] positive regulation of cell division [IMP] locomotor rhythm [NAS] negative regulation of apoptosis [IMP] establishment of imaginal disc-derived wing hair orientation [IMP] Wnt receptor signaling pathway [IMP] sleep [NAS]
Molecular Function:	ATP binding [IEA] protein serine/threonine kinase activity [IEA][ISS][NAS] kinase activity [IMP]

Sequence:

Sequence:
[PDR BLAST]
[ProtParam]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MELRVGNKYR LGRKIGSGSF GDIYLGTTIN TGEEVAIKLE CIRTKHPQLH IESKFYKTMQ  60
   61 GGIGIPRIIW CGSEGDYNVM VMELLGPSLE DLFNFCSRRF SLKTVLLLAD QMISRIDYIH 120
  121 SRDFIHRDIK PDNFLMGLGK KGNLVYIIDF GLAKKFRDAR SLKHIPYREN KNLTGTARYA 180
  181 SINTHLGIEQ SRRDDLESLG YVLMYFNLGA LPWQGLKAAN KRQKYERISE KKLSTSIVVL 240
  241 CKGFPSEFVN YLNFCRQMHF DQRPDYCHLR KLFRNLFHRL GFTYDYVFDW NLLKFGGPRN 300
  301 PQAIQQAQDG ADGQAGHDAV AAAAAVAAAA AASSHQQQQH KVNAALGGGG GSAAQQQLQG 360
  361 GQTLAMLGGN GGGNGSQLIG GNGLNMDDSM AATNSSRPPY DTPERRPSIR MRQGGGGGGG 420
  421 GVGVGGMPSG GGGGGVGNAK

Protein Complex Data

No complex found for this protein.

Mass Spectrometry Data

No mass spectrometry results found for this protein.

Yeast Two-Hybrid Data

The following interactions contain this protein:

NOT SHOWING SINGLE HITS. [ Show Single Hits ]

[View our yeast two-hybrid interpretation guidelines.]

No yeast two-hybrid interactions found for this protein.

Searching the YRC Public Image Repository, found results:

Currently showing to of results.

[View Search in the YRC Public Image Repository]

Searching the YRC Public Image Repository, found no results.

Ginzu Version Information

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

Gene Ontology predictions

Term	Confidence	Notes
phosphotransferase activity, alcohol group as acceptor	5.49988294224815	bayes_pls_golite062009
protein kinase activity	5.4586557943719	bayes_pls_golite062009
kinase activity	5.3287080791198	bayes_pls_golite062009
transferase activity, transferring phosphorus-containing groups	4.96052051118534	bayes_pls_golite062009
protein serine/threonine kinase activity	4.46381887831481	bayes_pls_golite062009
transferase activity	3.97138602499442	bayes_pls_golite062009
protein tyrosine kinase activity	2.8153155526437	bayes_pls_golite062009
binding	2.74863538127007	bayes_pls_golite062009
transmembrane receptor activity	2.59526003830791	bayes_pls_golite062009
transmembrane receptor protein kinase activity	2.54265774272269	bayes_pls_golite062009
molecular transducer activity	2.40586892801446	bayes_pls_golite062009
signal transducer activity	2.40586892801446	bayes_pls_golite062009
receptor activity	2.39311927684508	bayes_pls_golite062009
protein binding	2.276111749106	bayes_pls_golite062009
transmembrane receptor protein tyrosine kinase activity	2.16831387024372	bayes_pls_golite062009
receptor signaling protein activity	2.10379226653669	bayes_pls_golite062009
ATP binding	1.97600611746091	bayes_pls_golite062009
adenyl ribonucleotide binding	1.93596671856664	bayes_pls_golite062009
adenyl nucleotide binding	1.90928021591891	bayes_pls_golite062009
receptor signaling protein serine/threonine kinase activity	1.81249386965144	bayes_pls_golite062009
purine ribonucleotide binding	1.65732943334212	bayes_pls_golite062009
ribonucleotide binding	1.65726906484847	bayes_pls_golite062009
purine nucleotide binding	1.63763394711025	bayes_pls_golite062009
nucleotide binding	1.63195828048121	bayes_pls_golite062009
catalytic activity	1.21655087018101	bayes_pls_golite062009
transporter activity	1.11833481501707	bayes_pls_golite062009
transmembrane transporter activity	0.97575992765505	bayes_pls_golite062009
growth factor binding	0.86076618871384	bayes_pls_golite062009
nucleic acid binding	0.794058505655489	bayes_pls_golite062009
transcription regulator activity	0.775404673285876	bayes_pls_golite062009
DNA binding	0.714163549867672	bayes_pls_golite062009
transcription factor activity	0.563262875317016	bayes_pls_golite062009
peptidase activity	0.540289770145252	bayes_pls_golite062009
cyclin-dependent protein kinase activity	0.499492353295369	bayes_pls_golite062009
protein serine/threonine/tyrosine kinase activity	0.48345772948903	bayes_pls_golite062009
substrate-specific transporter activity	0.451090007290896	bayes_pls_golite062009
magnesium ion binding	0.393328812780268	bayes_pls_golite062009
MAP kinase kinase kinase activity	0.37115026509016	bayes_pls_golite062009
MAP kinase kinase activity	0.35402045013148	bayes_pls_golite062009
kinase binding	0.26752427107238	bayes_pls_golite062009
peptidase activity, acting on L-amino acid peptides	0.265003282584135	bayes_pls_golite062009
MAP kinase activity	0.26024936404169	bayes_pls_golite062009
protein complex binding	0.239339759110451	bayes_pls_golite062009
transforming growth factor beta receptor activity	0.20643152368029	bayes_pls_golite062009
transmembrane receptor protein serine/threonine kinase activity	0.20643152368029	bayes_pls_golite062009
substrate-specific transmembrane transporter activity	0.205652638854091	bayes_pls_golite062009
protein kinase C activity	0.0795689006739899	bayes_pls_golite062009
protein kinase binding	0.00674998152095019	bayes_pls_golite062009

No functions predicted.

Protein predicted to be:	GLOBULAR (No transmembrane regions or signal peptide)
Confidence of classification:	0.51

Source: Reynolds et al. (2008)

#		Region(s)	Method	Confidence	Match Description
1	View Details	[1..295]	PSI-BLAST	70.69897	Casein kinase-1, CK1
2	View Details	[296..440]	deduced	N/A	No confident structure predictions are available.

Protein Overview: dco-PB, dco-PA, ...

Protein Complex Data

Mass Spectrometry Data

Yeast Two-Hybrid Data

Microscopy / Localization Data

Protein Structure Data

Philius Transmembrane Prediction: