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Protein Overview: Klp98A-PA

General Information:
Name(s) found: Klp98A-PA / FBpp0084581 [FlyBase]
Description(s) found:
Found 20 descriptions.
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  • The gene Kinesin-like protein at 98A is referred to in FlyBase by the symbol Dmel\Klp98A (CG5658, FBgn0004387). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 3R:23373496..23384836. It has the cytological map location 98A4-98A6. Based on sequence similarity, it is predicted to have molecular function</span>: microtubule motor activity. Based on sequence similarity, it is predicted to be involved in the biological process</span>: microtubule-based movement. 7 alleles are reported. No phenotypic data is available. It has one annotated transcript and one annotated polypeptide. [FlyBase]
    • Organism: Drosophila melanogaster
    Length: 1265 amino acids

    Gene Ontology:
    Cellular Component: kinesin complex [ISS]
    Biological Process: cell communication [IEA]
    microtubule-based movement [ISS]
    Molecular Function: ATP binding [IEA]
    microtubule motor activity [ISS]
    protein binding [IEA]
    phosphoinositide binding [IEA]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSSLKVAVRV RPFNSREIDM DAQLIMEMEN KKTRLLKPRL QSIRDAGRDN HHDFTFDYSY  60
   61 WSFDAEDPHF ATQEQVYSDL GNDVVDCAYE GYNACVFAYG QTGSGKTFTM MGTPNNPGLI 120
  121 PRICEELFAR MRVGQESGTG YRTHASYLEI YNERVKDLLA AQSTGHGLRV REHRSLGPYV 180
  181 ENLSQHAVSD FDEIQECIAR GNAQRTTAST NMNDTSSRSH AIFTITFVQA VFMNDMPSET 240
  241 VSKIHLVDLA GSERANATGA TGQRLKEGAH INKSLVTLGS VISALAEQTG GGHNSSSSAL 300
  301 ATTPNGASKR VLYIPYRDSI LTWLLKDSLG GNSKTIMIAA LSPADCNYSE TLSTLRYANR 360
  361 AKNIINKPTV NEDTNVKLIR ELREEINKLK SMLAGDIHSL QPSLKVLADL QKKEAQEKVL 420
  421 TEEWTEKWKV AQSILQEQKS LGLRKSGVGV VLDSEMPHLI GIHNDVTTGV TLYSLKEGET 480
  481 RIGSEDADVA QDIELAGDGI RAQHCSIFLK GGVVTLHPWP LAQCWVNAHL IDEPKQISQG 540
  541 DIILLGRTNI FRFNNPAEAA KLRKDLSRSQ LDMSRLSLIT SSKENLLTCS IYSDEDGASP 600
  601 YKRPERQYYP QRPMSRDDPE LQDENRKILD TIENALKQLN VERVQMHDQY KTKVRKLTEE 660
  661 LIRLEQEEMD GLQLLNCREQ ELIARKDMLL WEKNNEKVQI DIVCRQISAF QTQLDSKKRD 720
  721 FSEYVAKELQ ELQDCGKLDE MGMKIEEGTP LNDELLLQVS DSLDLFAAQF IKDTVRRNNE 780
  781 EIRKLDEQIA EKERILNAST TKIAKVDETM LEIQAQLERL RLERAESEAE SQAMRAKKQN 840
  841 MKLQLGNKSM STSTSTNEAD DVSKSDTYET CDTFHTAQSN LSLVSSPTIT EGQQSPLSNC 900
  901 SCDAEDEAED TRKDDLSGSS EETSRTCTAG PSSGSGSGSV GIGGSGSAPS CTPSSQAIMS 960
  961 DSGVCLDSRN QAILQNGHLN NYKQAVRTSD EDTGSCSSCE LGRHSDVARP YCPLHSLRRK1020
 1021 IAAQKALIMK NLETDLNKAQ LDEHIADLQD LQRRYIQMEQ EMLQSVQDLE AHAQCCADER1080
 1081 SGMERQYELA SSIMRSSVMS PTSMEESTSQ IYSPSMTRSC PSMREFPEGE HFITIPSFVM1140
 1141 RGAGKQTHYE YEVRIALPDG KLNILRRYSR FRELHLCMKH CYGAKISALP FPRRELFASN1200
 1201 SEPVAKHRRR LLELYLRRLF VVCSKIPQCP IYEGPGGTGL TRASLVQLSS FFKKGLFENG1260
 1261 KHGTG

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..365] PSI-BLAST 104.0 Kinesin
    2 View Details [366..429] deduced N/A No confident structure predictions are available.
    3 View Details [430..592] FFAS03 3.97 No description for 2eh0A was found.
    4 View Details [593..799] deduced N/A No confident structure predictions are available.
    5 View Details [800..885] deduced N/A No confident structure predictions are available.
    6 View Details [886..1135] deduced N/A No confident structure predictions are available.
    7 View Details [1136..1265] PSI-BLAST 7.69897 No description for 2v14A was found.

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • microtubule motor activity
    		•  7.68336791348661 bayes_pls_golite062009
  • plus-end-directed microtubule motor activity
    		•  4.97507344344589 bayes_pls_golite062009
  • microfilament motor activity
    		•  4.176620576177 bayes_pls_golite062009
  • motor activity
    		•  4.04927796049806 bayes_pls_golite062009
  • nucleoside-triphosphatase activity
    		•  2.95079405147356 bayes_pls_golite062009
  • pyrophosphatase activity
    		•  2.87427509025394 bayes_pls_golite062009
  • hydrolase activity, acting on acid anhydrides
    		•  2.85499564954033 bayes_pls_golite062009
  • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides
    		•  2.85178667290149 bayes_pls_golite062009
  • actin-dependent ATPase activity
    		•  2.77140616759165 bayes_pls_golite062009
  • microtubule plus-end binding
    		•  2.71138928021716 bayes_pls_golite062009
  • tubulin binding
    		•  2.67743463093593 bayes_pls_golite062009
  • binding
    		•  2.64537357529343 bayes_pls_golite062009
  • microtubule binding
    		•  2.59155206524122 bayes_pls_golite062009
  • transporter activity
    		•  2.58140740499725 bayes_pls_golite062009
  • cytoskeletal protein binding
    		•  2.4101693596493 bayes_pls_golite062009
  • transmembrane transporter activity
    		•  2.39695871109024 bayes_pls_golite062009
  • ATPase activity
    		•  2.39535714892224 bayes_pls_golite062009
  • ATPase activity, coupled
    		•  2.18396165590908 bayes_pls_golite062009
  • ATP-dependent DNA helicase activity
    		•  2.07967285635739 bayes_pls_golite062009
  • actin binding
    		•  1.75397031486306 bayes_pls_golite062009
  • hydrolase activity
    		•  1.57549510726226 bayes_pls_golite062009
  • general RNA polymerase II transcription factor activity
    		•  1.40384549325664 bayes_pls_golite062009
  • helicase activity
    		•  1.33212695797068 bayes_pls_golite062009
  • substrate-specific transporter activity
    		•  1.29730375126024 bayes_pls_golite062009
  • protein binding
    		•  1.22129154759482 bayes_pls_golite062009
  • DNA-dependent ATPase activity
    		•  1.07479235523606 bayes_pls_golite062009
  • purine nucleotide binding
    		•  0.929901285538132 bayes_pls_golite062009
  • nucleotide binding
    		•  0.922442819194247 bayes_pls_golite062009
  • purine ribonucleotide binding
    		•  0.920987930180051 bayes_pls_golite062009
  • ribonucleotide binding
    		•  0.920926158369519 bayes_pls_golite062009
  • substrate-specific transmembrane transporter activity
    		•  0.906554174337376 bayes_pls_golite062009
  • nucleic acid binding
    		•  0.777787753097919 bayes_pls_golite062009
  • actin filament binding
    		•  0.728264616959762 bayes_pls_golite062009
  • structure-specific DNA binding
    		•  0.579644950922817 bayes_pls_golite062009
  • kinetochore binding
    		•  0.505370954958131 bayes_pls_golite062009
  • DNA binding
    		•  0.479412476059825 bayes_pls_golite062009
  • GTPase activity
    		•  0.437665353870877 bayes_pls_golite062009
  • active transmembrane transporter activity
    		•  0.434775387083003 bayes_pls_golite062009
  • ATP binding
    		•  0.41092997612902 bayes_pls_golite062009
  • guanyl nucleotide binding
    		•  0.399434758448606 bayes_pls_golite062009
  • GTP binding
    		•  0.398333597279278 bayes_pls_golite062009
  • guanyl ribonucleotide binding
    		•  0.39332178627529 bayes_pls_golite062009
  • adenyl ribonucleotide binding
    		•  0.385813421701492 bayes_pls_golite062009
  • adenyl nucleotide binding
    		•  0.377870145186619 bayes_pls_golite062009
  • ion transmembrane transporter activity
    		•  0.355466224802969 bayes_pls_golite062009
  • RNA helicase activity
    		•  0.34746349346164 bayes_pls_golite062009
  • histone acetyltransferase activity
    		•  0.328186246219424 bayes_pls_golite062009
  • lysine N-acetyltransferase activity
    		•  0.328186246219424 bayes_pls_golite062009
  • transcription regulator activity
    		•  0.312171320541728 bayes_pls_golite062009
  • ATP-dependent RNA helicase activity
    		•  0.30832907234141 bayes_pls_golite062009
  • RNA-dependent ATPase activity
    		•  0.29532978396745 bayes_pls_golite062009
  • primary active transmembrane transporter activity
    		•  0.294474570607914 bayes_pls_golite062009
  • P-P-bond-hydrolysis-driven transmembrane transporter activity
    		•  0.282352478532746 bayes_pls_golite062009
  • ATP-dependent helicase activity
    		•  0.25143870859482 bayes_pls_golite062009
  • purine NTP-dependent helicase activity
    		•  0.25143870859482 bayes_pls_golite062009
  • hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances
    		•  0.220608508617331 bayes_pls_golite062009
  • ATPase activity, coupled to transmembrane movement of substances
    		•  0.219533217661421 bayes_pls_golite062009
  • ATPase activity, coupled to movement of substances
    		•  0.219157471322311 bayes_pls_golite062009
  • protein transporter activity
    		•  0.178442534411253 bayes_pls_golite062009
  • DNA helicase activity
    		•  0.17029946873911 bayes_pls_golite062009
  • mismatched DNA binding
    		•  0.13866566261611 bayes_pls_golite062009
  • minus-end-directed microtubule motor activity
    		•  0.068779631341469 bayes_pls_golite062009
  • cation transmembrane transporter activity
    		•  0.0254369227200564 bayes_pls_golite062009
  • structural constituent of cytoskeleton
    		•  0.0111338193708552 bayes_pls_golite062009
    2 No functions predicted.
    3 No functions predicted.
    4 No functions predicted.
    5 No functions predicted.
    6 No functions predicted.
    7 No functions predicted.


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle