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Protein Overview: Dcr-1-PA

General Information:
Name(s) found: Dcr-1-PA / FBpp0083717 [FlyBase]
Description(s) found:
Found 21 descriptions.
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  • The gene Dicer-1 is referred to in FlyBase by the symbol Dmel\Dcr-1 (CG4792, FBgn0039016). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 3R:18559727..18566752. It has the cytological map location 94C4. There is experimental evidence that it has the molecular function</span>: protein binding; bidentate ribonuclease III activity. There is experimental evidence that it is involved in the biological process</span>: siRNA loading onto RISC involved in RNA interference; RNA interference; dsRNA transport; mitotic cell cycle, embryonic; production of miRNAs involved in gene silencing by miRNA; production of siRNA involved in RNA interference; pole cell formation; pre-microRNA processing; segment polarity determination; germ-line stem cell division. 19 alleles are reported. The phenotypes of these alleles are annotated with: oocyte; larval neuromuscular junction. It has one annotated transcript and one annotated polypeptide. [FlyBase]
    • Organism: Drosophila melanogaster
    Length: 2249 amino acids

    Gene Ontology:
    Cellular Component: nucleus [IDA]
    cytoplasm [IDA]
    RNA-induced silencing complex [IDA]
    Biological Process: pre-microRNA processing [IDA][IMP][TAS]
    gene silencing by miRNA [TAS]
    production of miRNAs involved in gene silencing by miRNA [IMP][TAS]
    siRNA loading onto RISC involved in RNA interference [IMP]
    germ-line stem cell division [IMP]
    pole cell formation [IMP]
    segment polarity determination [IGI]
    production of siRNA involved in RNA interference [IDA]
    RNA interference [IDA][IMP][TAS]
    dsRNA transport [IMP]
    mitotic cell cycle, embryonic [IMP]
    dendrite morphogenesis [IMP]
    Molecular Function: ATP binding [IEA]
    protein binding [IPI]
    double-stranded RNA binding [IEA][ISS]
    helicase activity [IEA]
    bidentate ribonuclease III activity [IDA]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MAFHWCDNNL HTTVFTPRDF QVELLATAYE RNTIICLGHR SSKEFIALKL LQELSRRARR  60
   61 HGRVSVYLSC EVGTSTEPCS IYTMLTHLTD LRVWQEQPDM QIPFDHCWTD YHVSILRPEG 120
  121 FLYLLETREL LLSSVELIVL EDCHDSAVYQ RIRPLFENHI MPAPPADRPR ILGLAGPLHS 180
  181 AGCELQQLSA MLATLEQSVL CQIETASDIV TVLRYCSRPH EYIVQCAPFE MDELSLVLAD 240
  241 VLNTHKSFLL DHRYDPYEIY GTDQFMDELK DIPDPKVDPL NVINSLLVVL HEMGPWCTQR 300
  301 AAHHFYQCNE KLKVKTPHER HYLLYCLVST ALIQLYSLCE HAFHRHLGSG SDSRQTIERY 360
  361 SSPKVRRLLQ TLRCFKPEEV HTQADGLRRM RHQVDQADFN RLSHTLESKC RMVDQMDQPP 420
  421 TETRALVATL EQILHTTEDR QTNRSAARVT PTPTPAHAKP KPSSGANTAQ PRTRRRVYTR 480
  481 RHHRDHNDGS DTLCALIYCN QNHTARVLFE LLAEISRRDP DLKFLRCQYT TDRVADPTTE 540
  541 PKEAELEHRR QEEVLKRFRM HDCNVLIGTS VLEEGIDVPK CNLVVRWDPP TTYRSYVQCK 600
  601 GRARAAPAYH VILVAPSYKS PTVGSVQLTD RSHRYICATG DTTEADSDSD DSAMPNSSGS 660
  661 DPYTFGTARG TVKILNPEVF SKQPPTACDI KLQEIQDELP AAAQLDTSNS SDEAVSMSNT 720
  721 SPSESSTEQK SRRFQCELSS LTEPEDTSDT TAEIDTAHSL ASTTKDLVHQ MAQYREIEQM 780
  781 LLSKCANTEP PEQEQSEAER FSACLAAYRP KPHLLTGASV DLGSAIALVN KYCARLPSDT 840
  841 FTKLTALWRC TRNERAGVTL FQYTLRLPIN SPLKHDIVGL PMPTQTLARR LAALQACVEL 900
  901 HRIGELDDQL QPIGKEGFRA LEPDWECFEL EPEDEQIVQL SDEPRPGTTK RRQYYYKRIA 960
  961 SEFCDCRPVA GAPCYLYFIQ LTLQCPIPEE QNTRGRKIYP PEDAQQGFGI LTTKRIPKLS1020
 1021 AFSIFTRSGE VKVSLELAKE RVILTSEQIV CINGFLNYTF TNVLRLQKFL MLFDPDSTEN1080
 1081 CVFIVPTVKA PAGGKHIDWQ FLELIQANGN TMPRAVPDEE RQAQPFDPQR FQDAVVMPWY1140
 1141 RNQDQPQYFY VAEICPHLSP LSCFPGDNYR TFKHYYLVKY GLTIQNTSQP LLDVDHTSAR1200
 1201 LNFLTPRYVN RKGVALPTSS EETKRAKREN LEQKQILVPE LCTVHPFPAS LWRTAVCLPC1260
 1261 ILYRINGLLL ADDIRKQVSA DLGLGRQQIE DEDFEWPMLD FGWSLSEVLK KSRESKQKES1320
 1321 LKDDTINGKD LADVEKKPTS EETQLDKDSK DDKVEKSAIE LIIEGEEKLQ EADDFIEIGT1380
 1381 WSNDMADDIA SFNQEDDDED DAFHLPVLPA NVKFCDQQTR YGSPTFWDVS NGESGFKGPK1440
 1441 SSQNKQGGKG KAKGPAKPTF NYYDSDNSLG SSYDDDDNAG PLNYMHHNYS SDDDDVADDI1500
 1501 DAGRIAFTSK NEAETIETAQ EVEKRQKQLS IIQATNANER QYQQTKNLLI GFNFKHEDQK1560
 1561 EPATIRYEES IAKLKTEIES GGMLVPHDQQ LVLKRSDAAE AQVAKVSMME LLKQLLPYVN1620
 1621 EDVLAKKLGD RRELLLSDLV ELNADWVARH EQETYNVMGC GDSFDNYNDH HRLNLDEKQL1680
 1681 KLQYERIEIE PPTSTKAITS AILPAGFSFD RQPDLVGHPG PSPSIILQAL TMSNANDGIN1740
 1741 LERLETIGDS FLKYAITTYL YITYENVHEG KLSHLRSKQV ANLNLYRLGR RKRLGEYMIA1800
 1801 TKFEPHDNWL PPCYYVPKEL EKALIEAKIP THHWKLADLL DIKNLSSVQI CEMVREKADA1860
 1861 LGLEQNGGAQ NGQLDDSNDS CNDFSCFIPY NLVSQHSIPD KSIADCVEAL IGAYLIECGP1920
 1921 RGALLFMAWL GVRVLPITRQ LDGGNQEQRI PGSTKPNAEN VVTVYGAWPT PRSPLLHFAP1980
 1981 NATEELDQLL SGFEEFEESL GYKFRDRSYL LQAMTHASYT PNRLTDCYQR LEFLGDAVLD2040
 2041 YLITRHLYED PRQHSPGALT DLRSALVNNT IFASLAVRHG FHKFFRHLSP GLNDVIDRFV2100
 2101 RIQQENGHCI SEEYYLLSEE ECDDAEDVEV PKALGDVFES IAGAIFLDSN MSLDVVWHVY2160
 2161 SNMMSPEIEQ FSNSVPKSPI RELLELEPET AKFGKPEKLA DGRRVRVTVD VFCKGTFRGI2220
 2221 GRNYRIAKCT AAKCALRQLK KQGLIAKKD

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    SHOWING SINGLE HITS. [ Hide Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..375] PSI-BLAST 69.39794 No description for 2j0qA was found.
    2 View Details [376..458] deduced N/A No confident structure predictions are available.
    3 View Details [459..814] PSI-BLAST 14.69897 Nucleotide excision repair enzyme UvrB
    4 View Details [815..983] deduced N/A No confident structure predictions are available.
    5 View Details [984..1706] FFAS03 2.1 Crystal Structure of Dicer from Giardia intestinalis
    6 View Details [1707..1935] PSI-BLAST 57.69897 RNase III endonuclease catalytic domain; RNase III, C-terminal domain
    7 View Details [1936..2168] PSI-BLAST 31.39794 RNase III endonuclease catalytic domain
    8 View Details [2169..2249] PSI-BLAST 6.045757 No description for 2yt4A was found.

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • nucleoside-triphosphatase activity
    		•  2.85628130885095 bayes_pls_golite062009
  • pyrophosphatase activity
    		•  2.78950165917982 bayes_pls_golite062009
  • hydrolase activity, acting on acid anhydrides
    		•  2.76996223962376 bayes_pls_golite062009
  • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides
    		•  2.7670079419026 bayes_pls_golite062009
  • binding
    		•  2.64537357529343 bayes_pls_golite062009
  • transporter activity
    		•  2.36978240084485 bayes_pls_golite062009
  • ATPase activity
    		•  2.26864012421561 bayes_pls_golite062009
  • transmembrane transporter activity
    		•  2.18065576425044 bayes_pls_golite062009
  • nucleic acid binding
    		•  2.11222585187695 bayes_pls_golite062009
  • ATPase activity, coupled
    		•  2.07184330056272 bayes_pls_golite062009
  • RNA helicase activity
    		•  1.8459294302596 bayes_pls_golite062009
  • DNA binding
    		•  1.72568209621547 bayes_pls_golite062009
  • transcription regulator activity
    		•  1.63193306273479 bayes_pls_golite062009
  • RNA binding
    		•  1.60613159109369 bayes_pls_golite062009
  • structural constituent of ribosome
    		•  1.57653963868443 bayes_pls_golite062009
  • hydrolase activity
    		•  1.44476395406467 bayes_pls_golite062009
    		• 1.44426272235796 bayes_pls_golite062009
  • substrate-specific transporter activity
    		•  1.09373202836575 bayes_pls_golite062009
  • catalytic activity
    		•  1.00104173493322 bayes_pls_golite062009
  • purine nucleotide binding
    		•  0.929901285538132 bayes_pls_golite062009
  • nucleotide binding
    		•  0.922442819194247 bayes_pls_golite062009
  • purine ribonucleotide binding
    		•  0.920987930180051 bayes_pls_golite062009
  • ribonucleotide binding
    		•  0.920926158369519 bayes_pls_golite062009
  • RNA-dependent ATPase activity
    		•  0.74918137191219 bayes_pls_golite062009
  • transcription repressor activity
    		•  0.720765886383727 bayes_pls_golite062009
  • substrate-specific transmembrane transporter activity
    		•  0.696000326143746 bayes_pls_golite062009
  • ATP-dependent RNA helicase activity
    		•  0.69117331267457 bayes_pls_golite062009
  • microtubule motor activity
    		•  0.61802593501 bayes_pls_golite062009
  • structural molecule activity
    		•  0.596382945962261 bayes_pls_golite062009
  • transcription factor activity
    		•  0.567932466447757 bayes_pls_golite062009
  • GTPase activity
    		•  0.564061217246417 bayes_pls_golite062009
  • active transmembrane transporter activity
    		•  0.434775387083003 bayes_pls_golite062009
  • ATP binding
    		•  0.41092997612902 bayes_pls_golite062009
  • adenyl ribonucleotide binding
    		•  0.385813421701492 bayes_pls_golite062009
  • adenyl nucleotide binding
    		•  0.377870145186619 bayes_pls_golite062009
  • guanyl nucleotide binding
    		•  0.296406132096546 bayes_pls_golite062009
  • GTP binding
    		•  0.295705904888768 bayes_pls_golite062009
  • primary active transmembrane transporter activity
    		•  0.294474570607914 bayes_pls_golite062009
  • guanyl ribonucleotide binding
    		•  0.29028316917561 bayes_pls_golite062009
  • P-P-bond-hydrolysis-driven transmembrane transporter activity
    		•  0.282352478532746 bayes_pls_golite062009
  • hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances
    		•  0.220608508617331 bayes_pls_golite062009
  • ATPase activity, coupled to transmembrane movement of substances
    		•  0.219533217661421 bayes_pls_golite062009
  • ATPase activity, coupled to movement of substances
    		•  0.219157471322311 bayes_pls_golite062009
  • protein binding
    		•  0.170837278876362 bayes_pls_golite062009
  • ion transmembrane transporter activity
    		•  0.140475613064199 bayes_pls_golite062009
  • structure-specific DNA binding
    		•  0.0869561319004262 bayes_pls_golite062009
  • helicase activity
    		•  0.0775311459068899 bayes_pls_golite062009
  • signal sequence binding
    		•  6.53725193420218E-4 bayes_pls_golite062009
    2 No functions predicted.
    3
    Term Confidence Notes
  • nucleoside-triphosphatase activity
    		•  2.85628130885095 bayes_pls_golite062009
  • pyrophosphatase activity
    		•  2.78950165917982 bayes_pls_golite062009
  • hydrolase activity, acting on acid anhydrides
    		•  2.76996223962376 bayes_pls_golite062009
  • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides
    		•  2.7670079419026 bayes_pls_golite062009
  • binding
    		•  2.64537357529343 bayes_pls_golite062009
  • transporter activity
    		•  2.36978240084485 bayes_pls_golite062009
  • ATPase activity
    		•  2.26864012421561 bayes_pls_golite062009
  • transmembrane transporter activity
    		•  2.18065576425044 bayes_pls_golite062009
  • nucleic acid binding
    		•  2.11222585187695 bayes_pls_golite062009
  • ATPase activity, coupled
    		•  2.07184330056272 bayes_pls_golite062009
  • RNA helicase activity
    		•  1.8459294302596 bayes_pls_golite062009
  • DNA binding
    		•  1.72568209621547 bayes_pls_golite062009
  • transcription regulator activity
    		•  1.63193306273479 bayes_pls_golite062009
  • RNA binding
    		•  1.60613159109369 bayes_pls_golite062009
  • structural constituent of ribosome
    		•  1.57653963868443 bayes_pls_golite062009
  • hydrolase activity
    		•  1.44476395406467 bayes_pls_golite062009
    		• 1.44426272235796 bayes_pls_golite062009
  • substrate-specific transporter activity
    		•  1.09373202836575 bayes_pls_golite062009
  • catalytic activity
    		•  1.00104173493322 bayes_pls_golite062009
  • purine nucleotide binding
    		•  0.929901285538132 bayes_pls_golite062009
  • nucleotide binding
    		•  0.922442819194247 bayes_pls_golite062009
  • purine ribonucleotide binding
    		•  0.920987930180051 bayes_pls_golite062009
  • ribonucleotide binding
    		•  0.920926158369519 bayes_pls_golite062009
  • RNA-dependent ATPase activity
    		•  0.74918137191219 bayes_pls_golite062009
  • transcription repressor activity
    		•  0.720765886383727 bayes_pls_golite062009
  • substrate-specific transmembrane transporter activity
    		•  0.696000326143746 bayes_pls_golite062009
  • ATP-dependent RNA helicase activity
    		•  0.69117331267457 bayes_pls_golite062009
  • microtubule motor activity
    		•  0.61802593501 bayes_pls_golite062009
  • structural molecule activity
    		•  0.596382945962261 bayes_pls_golite062009
  • transcription factor activity
    		•  0.567932466447757 bayes_pls_golite062009
  • GTPase activity
    		•  0.564061217246417 bayes_pls_golite062009
  • active transmembrane transporter activity
    		•  0.434775387083003 bayes_pls_golite062009
  • ATP binding
    		•  0.41092997612902 bayes_pls_golite062009
  • adenyl ribonucleotide binding
    		•  0.385813421701492 bayes_pls_golite062009
  • adenyl nucleotide binding
    		•  0.377870145186619 bayes_pls_golite062009
  • guanyl nucleotide binding
    		•  0.296406132096546 bayes_pls_golite062009
  • GTP binding
    		•  0.295705904888768 bayes_pls_golite062009
  • primary active transmembrane transporter activity
    		•  0.294474570607914 bayes_pls_golite062009
  • guanyl ribonucleotide binding
    		•  0.29028316917561 bayes_pls_golite062009
  • P-P-bond-hydrolysis-driven transmembrane transporter activity
    		•  0.282352478532746 bayes_pls_golite062009
  • hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances
    		•  0.220608508617331 bayes_pls_golite062009
  • ATPase activity, coupled to transmembrane movement of substances
    		•  0.219533217661421 bayes_pls_golite062009
  • ATPase activity, coupled to movement of substances
    		•  0.219157471322311 bayes_pls_golite062009
  • protein binding
    		•  0.170837278876362 bayes_pls_golite062009
  • ion transmembrane transporter activity
    		•  0.140475613064199 bayes_pls_golite062009
  • structure-specific DNA binding
    		•  0.0869561319004262 bayes_pls_golite062009
  • helicase activity
    		•  0.0775311459068899 bayes_pls_golite062009
  • signal sequence binding
    		•  6.53725193420218E-4 bayes_pls_golite062009
    4 No functions predicted.
    5 No functions predicted.
    6
    Term Confidence Notes
  • bidentate ribonuclease III activity
    		•  7.43273509253496 bayes_pls_golite062009
  • RNA binding
    		•  5.07736605479017 bayes_pls_golite062009
  • nucleic acid binding
    		•  3.65107032334139 bayes_pls_golite062009
  • binding
    		•  3.29553298371996 bayes_pls_golite062009
  • siRNA binding
    		•  2.97216972787792 bayes_pls_golite062009
  • structural constituent of ribosome
    		•  2.92231310035944 bayes_pls_golite062009
  • structural molecule activity
    		•  2.39325095233158 bayes_pls_golite062009
  • ribonuclease III activity
    		•  2.17541496872253 bayes_pls_golite062009
  • DNA binding
    		•  2.1200214740272 bayes_pls_golite062009
  • transcription regulator activity
    		•  1.90221544752436 bayes_pls_golite062009
  • transcription repressor activity
    		•  1.67466835456592 bayes_pls_golite062009
  • endoribonuclease activity
    		•  1.62086478301433 bayes_pls_golite062009
  • protein binding
    		•  1.43319050998069 bayes_pls_golite062009
  • double-stranded RNA binding
    		•  0.967560318725736 bayes_pls_golite062009
  • transcription factor activity
    		•  0.94870998048449 bayes_pls_golite062009
  • mRNA binding
    		•  0.404665180963566 bayes_pls_golite062009
  • single-stranded RNA binding
    		•  0.35650576095599 bayes_pls_golite062009
  • transcription activator activity
    		•  0.270384165279764 bayes_pls_golite062009
  • nucleoside-triphosphatase activity
    		•  0.0407924801791524 bayes_pls_golite062009
  • pyrophosphatase activity
    		•  0.0126548515995795 bayes_pls_golite062009
  • RNA helicase activity
    		•  0.0112094156505713 bayes_pls_golite062009
  • hydrolase activity, acting on acid anhydrides
    		•  0.00332337214730594 bayes_pls_golite062009
  • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides
    		•  9.75560608640569E-4 bayes_pls_golite062009
    7
    Term Confidence Notes
  • ribonuclease III activity
    		•  7.98215035226939 bayes_pls_golite062009
  • bidentate ribonuclease III activity
    		•  7.43273509253496 bayes_pls_golite062009
  • endoribonuclease activity, producing 5'-phosphomonoesters
    		•  3.62034457906124 bayes_pls_golite062009
  • endonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters
    		•  3.472019089204 bayes_pls_golite062009
  • RNA binding
    		•  3.13107297902467 bayes_pls_golite062009
  • ribonuclease activity
    		•  2.98742815985809 bayes_pls_golite062009
  • nuclease activity
    		•  2.45414735688985 bayes_pls_golite062009
  • endonuclease activity
    		•  2.36392815890913 bayes_pls_golite062009
  • nucleic acid binding
    		•  2.01588157313998 bayes_pls_golite062009
  • binding
    		•  1.78270819466471 bayes_pls_golite062009
  • endoribonuclease activity
    		•  1.62086478301433 bayes_pls_golite062009
  • hydrolase activity
    		•  1.55049982171696 bayes_pls_golite062009
  • catalytic activity
    		•  1.11705147289713 bayes_pls_golite062009
  • hydrolase activity, acting on ester bonds
    		•  0.956576570132238 bayes_pls_golite062009
  • protein binding
    		•  0.411168252280077 bayes_pls_golite062009
    8 No functions predicted.


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.92

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle