Protein Overview: htl-PB, htl-PA, ...

General Information:
Name(s) found:	htl-PC / FBpp0082972 [FlyBase] htl-PA / FBpp0082971 [FlyBase] htl-PB / FBpp0082970 [FlyBase]
Description(s) found: Found 49 descriptions. SHOW ALL	The gene heartless is referred to in FlyBase by the symbol Dmel\htl (CG7223, FBgn0010389). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 3R:13870936..13878706. It has the cytological map location 90E2. Based on sequence similarity, it is predicted to have molecular function</span>: protein tyrosine kinase activity; fibroblast growth factor receptor activity. There is experimental evidence for 20 unique biological process</span> terms, many of which group under: anatomical structure development; organ development; cellular component movement; muscle organ development; organ morphogenesis; mesoderm morphogenesis; gliogenesis; central nervous system development; gonadal mesoderm development; regulation of developmental process; reproductive process in a multicellular organism. 37 alleles are reported. The phenotypes of these alleles are annotated with 38 unique terms, many of which group under: organ system; primordium; hypodermal muscle of larval abdomen; late extended germ band embryo; germ layer; adult segment; larval abdominal segment; myoblast; nervous system; adult mesothoracic segment. It has 3 annotated transcripts and 3 annotated polypeptides. [FlyBase] The gene heartless is referred to in FlyBase by the symbol Dmel\htl (CG7223, FBgn0010389). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 3R:13870936..13878706. It has the cytological map location 90E2. Based on sequence similarity, it is predicted to have molecular function</span>: protein tyrosine kinase activity; fibroblast growth factor receptor activity. There is experimental evidence for 20 unique biological process</span> terms, many of which group under: anatomical structure development; organ development; cellular component movement; muscle organ development; organ morphogenesis; mesoderm morphogenesis; gliogenesis; central nervous system development; gonadal mesoderm development; regulation of developmental process; reproductive process in a multicellular organism. 37 alleles are reported. The phenotypes of these alleles are annotated with 38 unique terms, many of which group under: organ system; primordium; hypodermal muscle of larval abdomen; late extended germ band embryo; germ layer; adult segment; larval abdominal segment; myoblast; nervous system; adult mesothoracic segment. It has 3 annotated transcripts and 3 annotated polypeptides. [FlyBase] The gene heartless is referred to in FlyBase by the symbol Dmel\htl (CG7223, FBgn0010389). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 3R:13870936..13878706. It has the cytological map location 90E2. Based on sequence similarity, it is predicted to have molecular function</span>: protein tyrosine kinase activity; fibroblast growth factor receptor activity. There is experimental evidence for 20 unique biological process</span> terms, many of which group under: anatomical structure development; organ development; cellular component movement; muscle organ development; organ morphogenesis; mesoderm morphogenesis; gliogenesis; central nervous system development; gonadal mesoderm development; regulation of developmental process; reproductive process in a multicellular organism. 37 alleles are reported. The phenotypes of these alleles are annotated with 38 unique terms, many of which group under: organ system; primordium; hypodermal muscle of larval abdomen; late extended germ band embryo; germ layer; adult segment; larval abdominal segment; myoblast; nervous system; adult mesothoracic segment. It has 3 annotated transcripts and 3 annotated polypeptides. [FlyBase]
Organism:	Drosophila melanogaster
Length:	729 amino acids
Gene Ontology:
Cellular Component:	integral to membrane [ISS][NAS] plasma membrane [ISS]
Biological Process:	regulation of cell shape [IMP] endoderm development [NAS] endodermal cell fate determination [IEP] positive regulation of cell proliferation [IEA] mesoderm development [NAS] fibroblast growth factor receptor signaling pathway [ISS][TAS] salivary gland development [TAS] protein amino acid phosphorylation [ISS][NAS] pericardial cell differentiation [IMP] glial cell migration [IMP] gonadal mesoderm development [IMP] heart development [IEP][IMP][NAS][TAS] lymph gland development [IMP] mesoderm migration [IMP][NAS][TAS] cell migration [TAS] pole cell migration [TAS] mesodermal cell migration [IMP][TAS] germ cell migration [IMP][TAS] somatic muscle development [IMP] mesodermal cell fate determination [IEP] visceral muscle development [IMP] gastrulation [NAS] larval visceral muscle development [IMP] muscle fiber development [IMP] muscle organ development [NAS] ventral cord development [IMP] central nervous system development [IEP][IMP][NAS] mesodermal cell fate commitment [IGI][IMP] gonad development [TAS] cardioblast differentiation [IMP] glial cell differentiation [IMP]
Molecular Function:	fibroblast growth factor receptor activity [ISS][NAS][TAS] ATP binding [IEA] protein tyrosine kinase activity [ISS][NAS] protein binding [IEA]

Sequence:

Sequence:
[PDR BLAST]
[ProtParam]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MAAAWSWRAS HSTITMTSGS LVVLFLLLSI WQPAVQVEGR RQMANSQEMI KDHLGARSQN  60
   61 KTPAITNNAN QSSTSSADLD DGAADDDDNK ADLPVNVSSK PYWRNPKKMS FLQTRPSGSL 120
  121 LTLNCHALGN PEPNITWYRN GTVDWTRGYG SLKRNRWTLT MEDLVPGDCG NYTCKVCNSL 180
  181 GCIRHDTQVI VSDRVNHKPI LMTGPLNLTL VVNSTGSMHC KYLSDLTSKK AWIFVPCHGM 240
  241 TNCSNNRSII AEDKDQLDFV NVRMEQEGWY TCVESNSLGQ SNSTAYLRVV RSLHVLEAGV 300
  301 ASGSLHSTSF VYIFVFGGLI FIFMTTLFVF YAIRKMKHEK VLKQRIETVH QWTKKVIIFK 360
  361 PEGGGDSSGS MDTMIMPVVR IQKQRTTVLQ NGNEPAPFNE YEFPLDSNWE LPRSHLVLGA 420
  421 TLGEGAFGRV VMAEVNNAIV AVKMVKEGHT DDDIASLVRE MEVMKIIGRH INIINLLGCC 480
  481 SQNGPLYVIV EYAPHGNLKD FLYKNRPFGR DQDRDSSQPP PSPPAHVITE KDLIKFAHQI 540
  541 ARGMDYLASR RCIHRDLAAR NVLVSDDYVL KIADFGLARD IQSTDYYRKN TNGRLPIKWM 600
  601 APESLQEKFY DSKSDVWSYG ILLWEIMTYG QQPYPTIMSA EELYTYLMSG QRMEKPAKCS 660
  661 MNIYILMRQC WHFNADDRPP FTEIVEYMDK LLQTKEDYLD VDIANLDTPP STSDEEEDET 720
  721 DNLQKWCNY

Protein Complex Data

No complex found for this protein.

Mass Spectrometry Data

No mass spectrometry results found for this protein.

Yeast Two-Hybrid Data

The following interactions contain this protein:

NOT SHOWING SINGLE HITS. [ Show Single Hits ]

[View our yeast two-hybrid interpretation guidelines.]

No yeast two-hybrid interactions found for this protein.

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

#		Region(s)	Method	Confidence	Match Description
1	View Details	[1..274]	PSI-BLAST	36.522879	Crystal Structure of the 3 Ig form of FGFR3c in complex with FGF1
2	View Details	[275..392]	PSI-BLAST	15.69897	No description for 2nziA was found.
3	View Details	[393..729]	PSI-BLAST	74.09691	No description for 2pvfA was found.

Protein Overview: htl-PB, htl-PA, ...

Protein Complex Data

Mass Spectrometry Data

Yeast Two-Hybrid Data

Microscopy / Localization Data

Protein Structure Data

Philius Transmembrane Prediction: