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Protein Overview: sqd-PB

General Information:
Name(s) found: sqd-PB / FBpp0082320 [FlyBase]
Description(s) found:
Found 20 descriptions.
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  • The gene squid is referred to in FlyBase by the symbol Dmel\sqd (CG16901, FBgn0086897). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 3R:9461214..9472026. It has the cytological map location 87F5-87F6. There is experimental evidence that it has the molecular function</span>: SUMO binding. There is experimental evidence for 12 unique biological process</span> terms, many of which group under: reproductive process in a multicellular organism; anatomical structure development; anterior/posterior axis specification; oocyte axis specification; regulation of metabolic process; regulation of biological process; negative regulation of nitrogen compound metabolic process; establishment or maintenance of polarity of follicular epithelium; cellular component movement; establishment or maintenance of cytoskeleton polarity; negative regulation of RNA splicing. 35 alleles are reported. The phenotypes of these alleles are annotated with: spermatogonium; chorion; egg; oocyte; egg operculum; dorsal appendage; ventral furrow. It has 4 annotated transcripts and 4 annotated polypeptides. [FlyBase]
    • Organism: Drosophila melanogaster
    Length: 344 amino acids

    Gene Ontology:
    Cellular Component: nucleus [IC][IDA][TAS]
    polytene chromosome puff [IDA]
    ribonucleoprotein complex [ISS][NAS]
    omega speckle [IDA]
    catalytic step 2 spliceosome [IDA]
    cytoplasm [TAS]
    precatalytic spliceosome [IDA]
    [NOT]nucleolus [IDA]
    chromatin [IDA]
    Biological Process: germarium-derived egg chamber formation [IMP]
    intracellular mRNA localization [NAS][TAS]
    ovarian follicle cell migration [IMP]
    dorsal/ventral axis specification, ovarian follicular epithelium [IMP]
    dorsal/ventral pattern formation [IMP][TAS]
    oocyte anterior/posterior axis specification [IMP]
    nuclear mRNA splicing, via spliceosome [IC]
    mRNA export from nucleus [NAS]
    pole plasm mRNA localization [IMP]
    RNA export from nucleus [TAS]
    nuclear-transcribed mRNA catabolic process, nonsense-mediated decay [TAS]
    oogenesis [IMP][TAS]
    regulation of alternative nuclear mRNA splicing, via spliceosome [IMP]
    pole plasm oskar mRNA localization [IEP]
    negative regulation of RNA splicing [IMP]
    negative regulation of translation [TAS]
    oocyte microtubule cytoskeleton organization [IMP]
    oocyte localization during germarium-derived egg chamber formation [IMP]
    Molecular Function: nucleic acid binding [IEA]
    nucleotide binding [IEA]
    SUMO binding [IPI]
    mRNA binding [ISS][NAS]
    mRNA 3'-UTR binding [TAS]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MAENKQVDTE INGEDFTKDV TADGPGSENG DAGAAGSTNG SSDNQSAASG QRDDDRKLFV  60
   61 GGLSWETTEK ELRDHFGKYG EIESINVKTD PQTGRSRGFA FIVFTNTEAI DKVSAADEHI 120
  121 INSKKVDPKK AKARHGKIFV GGLTTEISDE EIKTYFGQFG NIVEVEMPFD KQKSQRKGFC 180
  181 FITFDSEQVV TDLLKTPKQK IAGKEVDVKR ATPKPENQMM GGMRGGPRGG MRGGRGGYGG 240
  241 RGGYNNQWDG QGSYGGYGGG YGGYGAGGYG DYYAGGYYNG YDYGYDGYGY GGGFEGNGYG 300
  301 GGGGGNMGGG RGGPRGGGGP KGGGGFNGGK QRGGGGRQQR HQPY

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..218] PSI-BLAST 50.522879 HNRNP A1 (RBD1,2) FROM HOMO SAPIENS
    2 View Details [219..344] FFAS03 1.7 Crystal structure of the C-terminal domain of BclA, the major antigen of the exosporium of the Bacillus anthracis spore.

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • binding
    		•  0.950788308762215 bayes_pls_golite062009
  • nucleic acid binding
    		•  0.29562225149076 bayes_pls_golite062009
    2 No functions predicted.


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle