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Protein Overview: aux-PA, aux-PB

General Information:
Name(s) found: aux-PB / FBpp0078605 [FlyBase]
aux-PA / FBpp0078604 [FlyBase]
Description(s) found:
Found 35 descriptions.
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  • The gene auxillin is referred to in FlyBase by the symbol Dmel\aux (CG1107, FBgn0037218). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 3R:37505..53244. It has the cytological map location 82A1. It is reported to have molecular function</span>: protein kinase activity. There is experimental evidence that it is involved in the biological process</span>: Notch signaling pathway; compound eye morphogenesis. 45 alleles are reported. The phenotypes of these alleles are annotated with: epidermis; posterior crossvein; eye; vibrissae; wing blade; eye photoreceptor cell; wing; ommatidium; wing vein; embryo. It has 2 annotated transcripts and 2 annotated polypeptides. [FlyBase]
  • The gene auxillin is referred to in FlyBase by the symbol Dmel\aux (CG1107, FBgn0037218). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 3R:37505..53244. It has the cytological map location 82A1. It is reported to have molecular function</span>: protein kinase activity. There is experimental evidence that it is involved in the biological process</span>: Notch signaling pathway; compound eye morphogenesis. 45 alleles are reported. The phenotypes of these alleles are annotated with: epidermis; posterior crossvein; eye; vibrissae; wing blade; eye photoreceptor cell; wing; ommatidium; wing vein; embryo. It has 2 annotated transcripts and 2 annotated polypeptides. [FlyBase]
    • Organism: Drosophila melanogaster
    Length: 1165 amino acids

    Gene Ontology:
    Cellular Component: NONE FOUND
    Biological Process: synaptic vesicle uncoating [TAS]
    Notch signaling pathway [IMP]
    compound eye morphogenesis [IMP]
    protein amino acid phosphorylation [IEA][NAS]
    Molecular Function: heat shock protein binding [IEA]
    ATP binding [IEA]
    protein kinase activity [NAS]
    protein serine/threonine kinase activity [IEA]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MGEFFKSLNL NYFSSSEVNG AAGNGAPEAL GGRLDNDFVG QVVEVAGHRL RIKCVIAEGG  60
   61 YAFVYVAQDV QTGTEYALKR LIGADMQAST AIINEINIHK QLSGHENIVA FVGSSYTAPS 120
  121 TQLGAQYLLL TELCKGGSLV DCFRTNNAPF NPTCVLRIFY QMARAVASLH SQSPPIAHRD 180
  181 IKIENFLIGN DKQIKLCDFG SASTEVLSPT FEWSANQRSM LEDQLNTVTT PMYRSPEMLD 240
  241 TWSNNPIGPK VDIWALGCIL YFLCYRKHPY EDGGKLRIIN ANYMLPPDPQ YQCFSDIIRG 300
  301 CLKVNPFERL DITMVLEGLA ALAETHNWSL KGPLDLHIMP IESLPAESPL KSSAYSEVYT 360
  361 EPLSAAIPSS YNGHGSLLSS LRGGAGTLLK NIKDTSTKVM QTMQQSLARN DLDISHITSR 420
  421 ILVMPCPSDG FESTYKTNNI EDVRLSLESR FVPQKLSIYN FGQRTEPRLP PPVRTVEAGS 480
  481 VYGCPQAHAP NLQGLFTVSA DMYNFLNADP KSVVIVQTGD SGGCTAATVI CALLMYADLL 540
  541 REPEDAVQVF AVKRHTINLR PSEFRYLYYF GDILRPTPLL PHYKNTTLVS LSCQPVPRMT 600
  601 KARDGCRIYM EVYCNGNLLL STLQDYEKMR LYQAGPGKIV LPINLTACGD VTVVLFHARK 660
  661 GMVRPQGLKI CQFQFNTGFI PEPETLITFT NQDLDDLPDP EQVTPRFCVS LSLAVTDSES 720
  721 PPSHKPPWMP AKPKRSPAAL FSSDLEYAEM LDNFVTKPST RSSPPPGARK SDRVSSPLVL 780
  781 PDVTETAHEL PSPMPEPSPP IDLLNLNQQP SDVPAADPLT SAKPSTDASF DLLGAFGDDD 840
  841 STGIGSAPIP DILPPPPLQQ PQPKINNDPF DIFGSVDQGG VPSMKPSGFP PFVGSLPTFV 900
  901 AQPAATTNPS PTHPARASAD PFANIADLAT GLNLNFNRST LSGKSPVNTS PQPTQFSSPT 960
  961 HKPSPSSQPQ ATFMHTPPTP QTLPSTSSIR TPTQPQAVPA QSRPDYSRLH FDSQKAAQQP1020
 1021 GTGGSKNSDI FADILGQQGY SFGSKMNQCP RSINEMRKED LFKDMDPKKV RIMEWTDGKK1080
 1081 NNIRALLCSM HTVLWDNAKW QRCEMSTMVT PTEVKKAYRR ACLAVHPDKH NGTENEEIAK1140
 1141 LIFMELNNAW TDFENDATQQ NMFNA

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..388] PSI-BLAST 83.154902 Crystal Structure of PKC-theta complexed with Staurosporine at 2A resolution
    2 View Details [389..694] PSI-BLAST 76.69897 Pten tumor suppressor (Phoshphoinositide phosphatase), C-terminal domain; Phoshphoinositide phosphatase Pten (Pten tumor suppressor), N-terminal domain
    3 View Details [695..1078] PSI-BLAST 6.69897 No description for 1y0fB was found.
    4 View Details [1079..1165] PSI-BLAST 50.39794 NMR Structure of the J-Domain and Clathrin Substrate Binding Domain of Bovine Auxilin

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • phosphotransferase activity, alcohol group as acceptor
    		•  5.49988294224815 bayes_pls_golite062009
  • protein kinase activity
    		•  5.4586557943719 bayes_pls_golite062009
  • kinase activity
    		•  5.3287080791198 bayes_pls_golite062009
  • transferase activity, transferring phosphorus-containing groups
    		•  4.96052051118534 bayes_pls_golite062009
  • protein serine/threonine kinase activity
    		•  4.46381887831481 bayes_pls_golite062009
  • transferase activity
    		•  3.97138602499442 bayes_pls_golite062009
  • binding
    		•  2.74863538127007 bayes_pls_golite062009
  • protein binding
    		•  2.276111749106 bayes_pls_golite062009
  • ATP binding
    		•  1.97600611746091 bayes_pls_golite062009
  • adenyl ribonucleotide binding
    		•  1.93596671856664 bayes_pls_golite062009
  • adenyl nucleotide binding
    		•  1.90928021591891 bayes_pls_golite062009
  • purine ribonucleotide binding
    		•  1.65732943334212 bayes_pls_golite062009
  • ribonucleotide binding
    		•  1.65726906484847 bayes_pls_golite062009
  • purine nucleotide binding
    		•  1.63763394711025 bayes_pls_golite062009
  • nucleotide binding
    		•  1.63195828048121 bayes_pls_golite062009
  • transcription regulator activity
    		•  1.56748951434625 bayes_pls_golite062009
  • nucleic acid binding
    		•  1.46547714006072 bayes_pls_golite062009
  • protein tyrosine kinase activity
    		•  1.3898059094397 bayes_pls_golite062009
  • receptor signaling protein serine/threonine kinase activity
    		•  1.38496328649031 bayes_pls_golite062009
  • DNA binding
    		•  1.35333135345112 bayes_pls_golite062009
  • receptor signaling protein activity
    		•  1.27291233344322 bayes_pls_golite062009
  • catalytic activity
    		•  1.21655087018101 bayes_pls_golite062009
  • transcription factor activity
    		•  1.10928254946881 bayes_pls_golite062009
  • transcription activator activity
    		•  0.997272622653026 bayes_pls_golite062009
  • transmembrane receptor activity
    		•  0.913893847407112 bayes_pls_golite062009
  • transmembrane receptor protein kinase activity
    		•  0.821371946077904 bayes_pls_golite062009
  • receptor activity
    		•  0.775180603313375 bayes_pls_golite062009
  • cyclin-dependent protein kinase activity
    		•  0.499492353295369 bayes_pls_golite062009
  • protein serine/threonine/tyrosine kinase activity
    		•  0.48345772948903 bayes_pls_golite062009
  • transmembrane receptor protein tyrosine kinase activity
    		•  0.461392047923247 bayes_pls_golite062009
  • RNA polymerase II transcription factor activity
    		•  0.401250804041384 bayes_pls_golite062009
  • magnesium ion binding
    		•  0.393328812780268 bayes_pls_golite062009
  • MAP kinase kinase kinase activity
    		•  0.37115026509016 bayes_pls_golite062009
  • MAP kinase kinase activity
    		•  0.35402045013148 bayes_pls_golite062009
  • signal transducer activity
    		•  0.270054246024761 bayes_pls_golite062009
  • molecular transducer activity
    		•  0.270054246024761 bayes_pls_golite062009
  • MAP kinase activity
    		•  0.26024936404169 bayes_pls_golite062009
    2
    Term Confidence Notes
  • phosphatase activity
    		•  3.46044873655892 bayes_pls_golite062009
  • phosphoprotein phosphatase activity
    		•  3.31810516049102 bayes_pls_golite062009
  • phosphoric ester hydrolase activity
    		•  3.27287246441913 bayes_pls_golite062009
  • protein tyrosine phosphatase activity
    		•  2.72498052648516 bayes_pls_golite062009
  • hydrolase activity, acting on ester bonds
    		•  2.31514936029825 bayes_pls_golite062009
  • protein binding
    		•  2.12487185456363 bayes_pls_golite062009
  • binding
    		•  2.06015698112379 bayes_pls_golite062009
  • nucleic acid binding
    		•  2.05424732017237 bayes_pls_golite062009
  • DNA binding
    		•  1.95001230878269 bayes_pls_golite062009
  • phosphotransferase activity, alcohol group as acceptor
    		•  1.56455764981613 bayes_pls_golite062009
  • hydrolase activity
    		•  1.5596484415033 bayes_pls_golite062009
  • kinase activity
    		•  1.54798529194457 bayes_pls_golite062009
  • transferase activity, transferring phosphorus-containing groups
    		•  1.36326098454926 bayes_pls_golite062009
  • protein kinase activity
    		•  1.3466747511896 bayes_pls_golite062009
  • transmembrane receptor activity
    		•  1.19889854601141 bayes_pls_golite062009
  • calcium-dependent phospholipid binding
    		•  1.06635493706319 bayes_pls_golite062009
  • catalytic activity
    		•  1.06283028154109 bayes_pls_golite062009
  • transferase activity
    		•  1.05480035577492 bayes_pls_golite062009
  • receptor activity
    		•  1.01393772058468 bayes_pls_golite062009
  • transmembrane receptor protein tyrosine phosphatase activity
    		•  0.743245088266464 bayes_pls_golite062009
  • transmembrane receptor protein phosphatase activity
    		•  0.743245088266464 bayes_pls_golite062009
  • protein tyrosine/serine/threonine phosphatase activity
    		•  0.631313032497835 bayes_pls_golite062009
  • SNARE binding
    		•  0.501334097212321 bayes_pls_golite062009
  • neurexin binding
    		•  0.27749877320051 bayes_pls_golite062009
    3 No functions predicted.
    4 No functions predicted.


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.98

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle