Protein Overview: Elongin-C-PA, El...

General Information:
Name(s) found:	Elongin-C-PB / FBpp0085725 [FlyBase] Elongin-C-PA / FBpp0085724 [FlyBase]
Description(s) found: SHOW ONLY BEST	gi\|7302473\|gb\|AAF57557.1\| elongin C, isoform B [Drosophila melanogaster] [NCBI NR] gi\|24655726\|ref\|NP_725894.1\| elongin C, isoform A [Drosophila melanogaster] [NCBI NR] gi\|21645174\|gb\|AAF57558.3\| elongin C, isoform A [Drosophila melanogaster] [NCBI NR] gi\|21064811\|gb\|AAM29635.1\| RH71704p [Drosophila melanogaster] [NCBI NR] gi\|17945032\|gb\|AAL48578.1\| RE05591p [Drosophila melanogaster] [NCBI NR] gi\|17647383\|ref\|NP_523794.1\| elongin C, isoform B [Drosophila melanogaster] [NCBI NR] The gene Elongin C is referred to in FlyBase by the symbol Dmel\Elongin-C (CG9291, FBgn0023211). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 2R:15332590..15333797. It has the cytological map location 56D7. Based on sequence similarity, it is predicted to have molecular function</span>: transcription elongation regulator activity. There is experimental evidence that it is involved in the biological process</span>: dendrite morphogenesis. 6 alleles are reported. The phenotype of these alleles is annotated with: dendrite. It has 2 annotated transcripts and 2 annotated polypeptides. [FlyBase] >CG9291-PB translation from_gene[CG9291 Elongin-C FBgn0023211] seq_release:3 mol_weight=13119 cds_boundaries:(2R:14,508,961..14,509,859[-]) aa_length:117 transcript_info:[CG9291-RB seq_release:3] gene_info:[gene symbol:Elongin-C FBgn0023211 gene_bounda [hmr_yeast5_DM3-1_pombe.fasta] >CG9291-PA translation from_gene[CG9291 Elongin-C FBgn0023211] seq_release:3 mol_weight=13119 cds_boundaries:(2R:14,508,961..14,509,859[-]) aa_length:117 transcript_info:[CG9291-RA seq_release:3] gene_info:[gene symbol:Elongin-C FBgn0023211 gene_bounda [hmr_yeast5_DM3-1_pombe.fasta] (Q9V8V2) ELONGIN-C protein (RE05591p) (RH71704p) [DrosMelano7227.FASTAC.txt] (AE003796) Elongin-C gene product [alt 1] [Drosophila melanogaster] [yeastflysequest.fasta] similar to Drosophila melanogaster elongin-C [Drosophila yakuba]gi\|7302473\|gb\|AAF57557.1\| CG9291-PB, isoform B [Drosophila melanogaster]gi\|21645174\|gb\|AAF57558.3\| CG9291-PA, isoform A [Drosophila melanogaster]gi\|21064811\|gb\|AAM29635.1\| RH71704p [Drosop [nrdb_11152004_Chlamydomonas] type=protein; loc=2R:complement(15332743..15332884,15333433..15333644); ID=FBpp0085724; name=Elongin-C-PA; parent=FBgn0023211,FBtr0086540; dbxref=FlyBase:FBpp0085724,FlyBase_Annotation_IDs:CG9291-PA,GB_protein:AAF57558.3,REFSEQ:NP_725894,GB_protein:AAF575 [fly-100309-contam.fasta] type=protein; loc=2R:complement(15332743..15332884,15333433..15333644); ID=FBpp0085725; name=Elongin-C-PB; parent=FBgn0023211,FBtr0086541; dbxref=FlyBase:FBpp0085725,FlyBase_Annotation_IDs:CG9291-PB,GB_protein:AAF57557.1,REFSEQ:NP_523794,GB_protein:AAF575 [fly-100309-contam.fasta] Elongin C CG9291-PA, isoform A [Drosophila melanogaster] [nr-271106-contam.fasta] RE05591p [Drosophila melanogaster] [nr-271106-contam.fasta] Elongin C CG9291-PB, isoform B [Drosophila melanogaster] [nr-271106-contam.fasta] RH71704p [Drosophila melanogaster] [nr-271106-contam.fasta] CG9291-PA, isoform A [Drosophila melanogaster] [nr-271106-contam.fasta] CG9291-PB, isoform B [Drosophila melanogaster] [nr-271106-contam.fasta] type=protein; loc=2R:complement(15332743..15332884,15333433..15333644); ID=FBpp0085724; name=Elongin-C-PA; parent=FBgn0023211,FBtr0086540; dbxref=FlyBase:FBpp0085724,FlyBase_Annotation_IDs:CG9291-PA,GB_protein:AAF57558.3,REFSEQ:NP_725894,GB_protein:AAF57558; MD5=16c21ec4903e5ff3cdfd2e69b1ee68c2; length=117; release=r5.16; species=Dmel; [fly-contam-His-TEV-Tub4complex.fasta] type=protein; loc=2R:complement(15332743..15332884,15333433..15333644); ID=FBpp0085725; name=Elongin-C-PB; parent=FBgn0023211,FBtr0086541; dbxref=FlyBase:FBpp0085725,FlyBase_Annotation_IDs:CG9291-PB,GB_protein:AAF57557.1,REFSEQ:NP_523794,GB_protein:AAF57557; MD5=16c21ec4903e5ff3cdfd2e69b1ee68c2; length=117; release=r5.16; species=Dmel; [fly-contam-His-TEV-Tub4complex.fasta] type=protein; loc=2R:complement(15332743..15332884,15333433..15333644); ID=FBpp0085724; name=Elongin-C-PA; parent=FBgn0023211,FBtr0086540; dbxref=FlyBase:FBpp0085724,FlyBase_Annotation_IDs:CG9291-PA,GB_protein:AAF57558.3,REFSEQ:NP_725894,GB_protein:AAF57558; MD5=16c21ec4903e5ff3cdfd2e69b1ee68c2; length=117; release=r5.21; species=Dmel; [Other_drosophila_na_09-09-2009_reversed.fasta] type=protein; loc=2R:complement(15332743..15332884,15333433..15333644); ID=FBpp0085725; name=Elongin-C-PB; parent=FBgn0023211,FBtr0086541; dbxref=FlyBase:FBpp0085725,FlyBase_Annotation_IDs:CG9291-PB,GB_protein:AAF57557.1,REFSEQ:NP_523794,GB_protein:AAF57557; MD5=16c21ec4903e5ff3cdfd2e69b1ee68c2; length=117; release=r5.21; species=Dmel; [Other_drosophila_na_09-09-2009_reversed.fasta] Elongin C, isoform A OS=Drosophila melanogaster GN=Elongin-C PE=1 SV=1 [UniProt_drosophila_07-01-2011_reversed.fasta] type=protein; loc=2R:complement(15332743..15332884,15333433..15333644); ID=FBpp0085724; name=Elongin-C-PA; parent=FBgn0023211,FBtr0086540; dbxref=FlyBase:FBpp0085724,FlyBase_Annotation_IDs:CG9291-PA,GB_protein:AAF57558.3,REFSEQ:NP_725894,GB_protein:AAF57558; MD5=16c21ec4903e5ff3cdfd2e69b1ee68c2; length=117; release=r5.46; species=Dmel; [fly-062812-sfps-sandra-contam.fasta] type=protein; loc=2R:complement(15332743..15332884,15333433..15333644); ID=FBpp0085725; name=Elongin-C-PB; parent=FBgn0023211,FBtr0086541; dbxref=FlyBase:FBpp0085725,FlyBase_Annotation_IDs:CG9291-PB,GB_protein:AAF57557.1,REFSEQ:NP_523794,GB_protein:AAF57557,FlyMine:FBpp0085725,modMine:FBpp0085725; MD5=16c21ec4903e5ff3cdfd2e69b1ee68c2; length=117; release=r5.46; species=Dmel; [fly-062812-sfps-sandra-contam.fasta] Elongin C, isoform A OS=Drosophila melanogaster GN=Elongin-C PE=2 SV=1 [UniProt_D_Melanogaster_07132012_07-13-2012_reversed.fasta] type=protein; loc=2R:complement(join(19445928..19446139,19445238..19445379)); ID=FBpp0085724; name=EloC-PA; parent=FBgn0266711,FBtr0086540; dbxref=FlyBase:FBpp0085724,FlyBase_Annotation_IDs:CG9291-PA,GB_protein:AAF57558.3,REFSEQ:NP_725894,GB_protein:AAF57558; MD5=16c21ec4903e5ff3cdfd2e69b1ee68c2; length=117; release=r6.02; species=Dmel; [fly-2014-05-contam.fasta] type=protein; loc=2R:complement(join(19445928..19446139,19445238..19445379)); ID=FBpp0085725; name=EloC-PB; parent=FBgn0266711,FBtr0086541; dbxref=FlyBase:FBpp0085725,FlyBase_Annotation_IDs:CG9291-PB,GB_protein:AAF57557.1,REFSEQ:NP_523794,GB_protein:AAF57557,FlyMine:FBpp0085725,modMine:FBpp0085725; MD5=16c21ec4903e5ff3cdfd2e69b1ee68c2; length=117; release=r6.02; species=Dmel; [fly-2014-05-contam.fasta] type=protein; loc=2R:complement(join(19445928..19446139,19445238..19445379)); ID=FBpp0085724; name=EloC-PA; parent=FBgn0266711,FBtr0086540; dbxref=FlyBase:FBpp0085724,FlyBase_Annotation_IDs:CG9291-PA,GB_protein:AAF57558.3,REFSEQ:NP_725894,GB_protein:AAF57558; MD5=16c21ec4903e5ff3cdfd2e69b1ee68c2; length=117; release=r6.07; species=Dmel; [fly-08202015-contam.fasta] type=protein; loc=2R:complement(join(19445928..19446139,19445238..19445379)); ID=FBpp0085725; name=EloC-PB; parent=FBgn0266711,FBtr0086541; dbxref=FlyBase:FBpp0085725,FlyBase_Annotation_IDs:CG9291-PB,GB_protein:AAF57557.1,REFSEQ:NP_523794,GB_protein:AAF57557,FlyMine:FBpp0085725,modMine:FBpp0085725; MD5=16c21ec4903e5ff3cdfd2e69b1ee68c2; length=117; release=r6.07; species=Dmel; [fly-08202015-contam.fasta] Elongin C, isoform A OS=Drosophila melanogaster GN=EloC PE=1 SV=1 [DROME.fasta.20160308] FBpp0085724 type=protein; loc=2R:complement(join(19445928..19446139,19445238..19445379)); ID=FBpp0085724; name=EloC-PA; parent=FBgn0266711,FBtr0086540; dbxref=FlyBase:FBpp0085724,FlyBase_Annotation_IDs:CG9291-PA,GB_protein:AAF57558.3,REFSEQ:NP_725894,GB_protein:AAF57558; MD5=16c21ec4903e5ff3cdfd2e69b1ee68c2; length=117; release=r6.09; species=Dmel; [dmel-all-translation-r6.09.fasta] FBpp0085725 type=protein; loc=2R:complement(join(19445928..19446139,19445238..19445379)); ID=FBpp0085725; name=EloC-PB; parent=FBgn0266711,FBtr0086541; dbxref=FlyBase:FBpp0085725,FlyBase_Annotation_IDs:CG9291-PB,GB_protein:AAF57557.1,REFSEQ:NP_523794,GB_protein:AAF57557,FlyMine:FBpp0085725,modMine:FBpp0085725; MD5=16c21ec4903e5ff3cdfd2e69b1ee68c2; length=117; release=r6.09; species=Dmel; [dmel-all-translation-r6.09.fasta] [fly-122215-dmel-6-09-contam.fasta] type=protein; loc=2R:complement(join(19445928..19446139,19445238..19445379)); ID=FBpp0085724; name=EloC-PA; parent=FBgn0266711,FBtr0086540; dbxref=FlyBase:FBpp0085724,FlyBase_Annotation_IDs:CG9291-PA,GB_protein:AAF57558.3,REFSEQ:NP_725894,GB_protein:AAF57558,UniProt/TrEMBL:Q7JWD6; MD5=16c21ec4903e5ff3cdfd2e69b1ee68c2; length=117; release=r6.14; species=Dmel; [fly-dmel-jan2017-sandracontam.fasta] type=protein; loc=2R:complement(join(19445928..19446139,19445238..19445379)); ID=FBpp0085725; name=EloC-PB; parent=FBgn0266711,FBtr0086541; dbxref=FlyBase:FBpp0085725,FlyBase_Annotation_IDs:CG9291-PB,GB_protein:AAF57557.1,REFSEQ:NP_523794,GB_protein:AAF57557,UniProt/TrEMBL:Q7JWD6,FlyMine:FBpp0085725,modMine:FBpp0085725; MD5=16c21ec4903e5ff3cdfd2e69b1ee68c2; length=117; release=r6.14; species=Dmel; [fly-dmel-jan2017-sandracontam.fasta]
Organism:	Drosophila melanogaster
Length:	117 amino acids
Gene Ontology:
Cellular Component:	transcription elongation factor complex [ISS]
Biological Process:	ubiquitin-dependent protein catabolic process [IEA] dendrite morphogenesis [IMP]
Molecular Function:	transcription elongation regulator activity [ISS] protein binding [IEA]

Sequence:
Sequence: [PDR BLAST] [ProtParam]	1 11 21 31 41 51 \| \| \| \| \| \| 1 MIAMDEQRGD KIYGGCEGPD AMYVKLISSD GHEFVVKREH ALTSGTIRAM LSGPGQFAEN 60 61 EANEVHFREI PSHVLQKVCM YFTYKVRYTN SSTEIPEFPI APEIALELLM AANFLDC

Protein Complex Data

No complex found for this protein.

Mass Spectrometry Data

No mass spectrometry results found for this protein.

Yeast Two-Hybrid Data

The following interactions contain this protein:

NOT SHOWING SINGLE HITS. [ Show Single Hits ]

[View our yeast two-hybrid interpretation guidelines.]

No yeast two-hybrid interactions found for this protein.

Microscopy / Localization Data

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No microscopy data found in the PDR for this protein.

Protein Structure Data

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[View Top Sequence Alignments] [Show Ginzu Version Information]

Domains predicted:

#		Region(s)	Method	Confidence	Match Description
1	View Details	[1..117]	PSI-BLAST	38.154902	Elongin C

Functions predicted (by domain):

#

Gene Ontology predictions

1

Term	Confidence	Notes
transcription elongation regulator activity	7.53002625989446	bayes_pls_golite062009
ubiquitin-protein ligase activity	6.78934422958647	bayes_pls_golite062009
small conjugating protein ligase activity	6.52079977531395	bayes_pls_golite062009
acid-amino acid ligase activity	5.78412146341235	bayes_pls_golite062009
ligase activity, forming carbon-nitrogen bonds	4.95822114853319	bayes_pls_golite062009
transcription regulator activity	4.03732153795237	bayes_pls_golite062009
DNA binding	3.50992893425527	bayes_pls_golite062009
nucleic acid binding	3.39650042677839	bayes_pls_golite062009
transcription factor activity	2.77967244868934	bayes_pls_golite062009
voltage-gated cation channel activity	2.75167015020269	bayes_pls_golite062009
binding	2.73171412378045	bayes_pls_golite062009
cation channel activity	2.69496177380647	bayes_pls_golite062009
transporter activity	2.69283272202719	bayes_pls_golite062009
voltage-gated potassium channel activity	2.6326729238119	bayes_pls_golite062009
voltage-gated ion channel activity	2.62698068681382	bayes_pls_golite062009
voltage-gated channel activity	2.62598337348177	bayes_pls_golite062009
potassium channel activity	2.60418200634863	bayes_pls_golite062009
transmembrane transporter activity	2.57638436739741	bayes_pls_golite062009
gated channel activity	2.55327516550249	bayes_pls_golite062009
substrate-specific transporter activity	2.55217077864016	bayes_pls_golite062009
ion channel activity	2.55187860471911	bayes_pls_golite062009
cation transmembrane transporter activity	2.52366517282235	bayes_pls_golite062009
substrate-specific channel activity	2.49612586394403	bayes_pls_golite062009
channel activity	2.47974023065334	bayes_pls_golite062009
passive transmembrane transporter activity	2.47974023065334	bayes_pls_golite062009
ion transmembrane transporter activity	2.47370185025265	bayes_pls_golite062009
substrate-specific transmembrane transporter activity	2.46166567746833	bayes_pls_golite062009
metal ion transmembrane transporter activity	2.36236066628439	bayes_pls_golite062009
ligase activity	1.75579073151181	bayes_pls_golite062009
transcription repressor activity	1.71028791830657	bayes_pls_golite062009
protein binding	1.38558174459188	bayes_pls_golite062009
RNA polymerase II transcription factor activity	0.933012980583336	bayes_pls_golite062009
structure-specific DNA binding	0.784594789263781	bayes_pls_golite062009
delayed rectifier potassium channel activity	0.72427436100801	bayes_pls_golite062009
sequence-specific DNA binding	0.278232864316812	bayes_pls_golite062009
catalytic activity	0.112500532859479	bayes_pls_golite062009
chromatin binding	0.0908724449159477	bayes_pls_golite062009
double-stranded DNA binding	0.033499769837058	bayes_pls_golite062009

Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

Philius Transmembrane Prediction:

Protein predicted to be:	GLOBULAR (No transmembrane regions or signal peptide)
Confidence of classification:	0.99

Source: Reynolds et al. (2008)

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