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Protein Overview: Prp19-PA

General Information:
Name(s) found: Prp19-PA / FBpp0085902 [FlyBase]
Description(s) found:
Found 22 descriptions.
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  • The gene Prp19 is referred to in FlyBase by the symbol Dmel\Prp19 (CG5519, FBgn0261119). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 2R:14334860..14338545. It has the cytological map location 55D1-55C9. An electronic pipeline based on InterPro domains suggests that it has the molecular function</span>: ubiquitin-protein ligase activity. Based on sequence similarity, it is predicted to be involved in the biological process</span>: nuclear mRNA splicing, via spliceosome. 4 alleles are reported. The phenotype of these alleles is annotated with: crystal cell. It has one annotated transcript and one annotated polypeptide. [FlyBase]
    • Organism: Drosophila melanogaster
    Length: 505 amino acids

    Gene Ontology:
    Cellular Component: ubiquitin ligase complex [IEA]
    catalytic step 2 spliceosome [IDA]
    precatalytic spliceosome [IDA]
    spliceosomal complex [ISS][TAS]
    Biological Process: nuclear mRNA splicing, via spliceosome [IC][ISS][TAS]
    protein ubiquitination [IEA]
    Molecular Function: ubiquitin-protein ligase activity [IEA]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MALVCALTNE VPETPVVSPH SGAVFEKRVI EKYLLENGCD PISGKELKPE ELIEIKTPAV  60
   61 VKPKPPSATS IPATLKTMQD EWDALMIHSF TQRQQLQTTR QELSHALYQH DAACRVIARL 120
  121 NKEVAAAREA LATLKPQAGI ANAPTAIPQP ALASEAGGAA AHPMEQAGMS AEVIQKLQDK 180
  181 ATVLTQERKK RGRTVPEDLV TTDQVKNFLT VASHPGLHSA SVPGILALDI NSADHSKILT 240
  241 GGNDKNATVF NKDTEQMVAI LKGHTKKITK VIYHPNEDTV ITGSPDMNIR IWHVPTSQTQ 300
  301 LLLRCHEGPV TGLSLHPTGD YLLSTSSDKH WAFSDIRTGR LLTKVIDTAE VGLTTAQFHP 360
  361 DGLIFGTGTV DSQVKIWDLK EQSNVANFPG HTGPISAISF SENGYYLATA ADDACVKLWD 420
  421 LRKLKNFKTI QLDDGYEVKD LCFDQSGTYL AIAGSDVRVY LCKQWQELKV FNDHTALATG 480
  481 VRFGKHAQYL ASTSMDRTLK LYAIE

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..65] PSI-BLAST 17.39794 Pre-mRNA splicing factor Prp19
    2 View Details [66..166] Pfam 38.619789 No description for PF08606.2 was found. No confident structure predictions are available.
    3 View Details [167..505] PSI-BLAST 82.154902 No description for 2gnqA was found.

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • ubiquitin-protein ligase activity
    		•  10.2497392096259 bayes_pls_golite062009
  • small conjugating protein ligase activity
    		•  10.0460587929138 bayes_pls_golite062009
  • acid-amino acid ligase activity
    		•  8.99384576623969 bayes_pls_golite062009
  • ligase activity, forming carbon-nitrogen bonds
    		•  7.6988425139962 bayes_pls_golite062009
    		• 4.77196423114965 bayes_pls_golite062009
  • ligase activity
    		•  3.92677358871643 bayes_pls_golite062009
  • RNA binding
    		•  3.04658201081989 bayes_pls_golite062009
  • binding
    		•  2.78710909602478 bayes_pls_golite062009
  • transcription regulator activity
    		•  2.72498741013971 bayes_pls_golite062009
  • protein binding
    		•  2.64803540957326 bayes_pls_golite062009
  • SUMO polymer binding
    		•  2.43472107361379 bayes_pls_golite062009
  • nucleic acid binding
    		•  2.32387297115017 bayes_pls_golite062009
  • DNA binding
    		•  2.00904221080834 bayes_pls_golite062009
  • transcription repressor activity
    		•  1.98209395225978 bayes_pls_golite062009
  • ubiquitin-ubiquitin ligase activity
    		•  1.37401357060257 bayes_pls_golite062009
  • transcription factor activity
    		•  1.22579085356684 bayes_pls_golite062009
  • small conjugating protein-specific protease activity
    		•  1.2126425713931 bayes_pls_golite062009
  • transcription factor binding
    		•  1.11842175076436 bayes_pls_golite062009
  • ubiquitin-specific protease activity
    		•  1.03469202541773 bayes_pls_golite062009
  • general RNA polymerase II transcription factor activity
    		•  1.03166235240211 bayes_pls_golite062009
  • copper ion binding
    		•  0.649716953783871 bayes_pls_golite062009
  • hydrolase activity
    		•  0.52386813728704 bayes_pls_golite062009
  • cysteine-type peptidase activity
    		•  0.50197530717959 bayes_pls_golite062009
  • transcription corepressor activity
    		•  0.384990496120483 bayes_pls_golite062009
  • metal ion binding
    		•  0.27118370366296 bayes_pls_golite062009
  • cation binding
    		•  0.27118370366296 bayes_pls_golite062009
  • ubiquitin thiolesterase activity
    		•  0.265769062717221 bayes_pls_golite062009
  • ion binding
    		•  0.265633945008889 bayes_pls_golite062009
  • transcription cofactor activity
    		•  0.233838999434784 bayes_pls_golite062009
  • transition metal ion binding
    		•  0.219773564054437 bayes_pls_golite062009
  • catalytic activity
    		•  0.14112008370434 bayes_pls_golite062009
  • transcription activator activity
    		•  0.126093965701234 bayes_pls_golite062009
  • enzyme binding
    		•  0.104373352314595 bayes_pls_golite062009
    2 No functions predicted.
    3 No functions predicted.


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle