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View Structure Prediction Details

Protein: Prp19-PA
Organism: Drosophila melanogaster
Length: 505 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for Prp19-PA.

Description E-value Query
Range
Subject
Range
gi|186464325, gi... - gi|23128981|ref|ZP_00110817.1| COG2319: FOG: WD40 repeat [Nostoc punctiforme PCC 73102], gi|18668187...
499.0 [0..26] [504..1159]

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Predicted Domain #1
Region A:
Residues: [1-65]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MALVCALTNE VPETPVVSPH SGAVFEKRVI EKYLLENGCD PISGKELKPE ELIEIKTPAV  60
   61 VKPKP

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 17.39794
Match: 1n87A
Description: Pre-mRNA splicing factor Prp19
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
ubiquitin-protein ligase activity 10.2497392096259 bayes_pls_golite062009
small conjugating protein ligase activity 10.0460587929138 bayes_pls_golite062009
acid-amino acid ligase activity 8.99384576623969 bayes_pls_golite062009
ligase activity, forming carbon-nitrogen bonds 7.6988425139962 bayes_pls_golite062009
4.77196423114965 bayes_pls_golite062009
ligase activity 3.92677358871643 bayes_pls_golite062009
RNA binding 3.04658201081989 bayes_pls_golite062009
binding 2.78710909602478 bayes_pls_golite062009
transcription regulator activity 2.72498741013971 bayes_pls_golite062009
protein binding 2.64803540957326 bayes_pls_golite062009
SUMO polymer binding 2.43472107361379 bayes_pls_golite062009
nucleic acid binding 2.32387297115017 bayes_pls_golite062009
DNA binding 2.00904221080834 bayes_pls_golite062009
transcription repressor activity 1.98209395225978 bayes_pls_golite062009
ubiquitin-ubiquitin ligase activity 1.37401357060257 bayes_pls_golite062009
transcription factor activity 1.22579085356684 bayes_pls_golite062009
small conjugating protein-specific protease activity 1.2126425713931 bayes_pls_golite062009
transcription factor binding 1.11842175076436 bayes_pls_golite062009
ubiquitin-specific protease activity 1.03469202541773 bayes_pls_golite062009
general RNA polymerase II transcription factor activity 1.03166235240211 bayes_pls_golite062009
copper ion binding 0.649716953783871 bayes_pls_golite062009
hydrolase activity 0.52386813728704 bayes_pls_golite062009
cysteine-type peptidase activity 0.50197530717959 bayes_pls_golite062009
transcription corepressor activity 0.384990496120483 bayes_pls_golite062009
metal ion binding 0.27118370366296 bayes_pls_golite062009
cation binding 0.27118370366296 bayes_pls_golite062009
ubiquitin thiolesterase activity 0.265769062717221 bayes_pls_golite062009
ion binding 0.265633945008889 bayes_pls_golite062009
transcription cofactor activity 0.233838999434784 bayes_pls_golite062009
transition metal ion binding 0.219773564054437 bayes_pls_golite062009
catalytic activity 0.14112008370434 bayes_pls_golite062009
transcription activator activity 0.126093965701234 bayes_pls_golite062009
enzyme binding 0.104373352314595 bayes_pls_golite062009

Predicted Domain #2
Region A:
Residues: [66-166]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 PSATSIPATL KTMQDEWDAL MIHSFTQRQQ LQTTRQELSH ALYQHDAACR VIARLNKEVA  60
   61 AAREALATLK PQAGIANAPT AIPQPALASE AGGAAAHPME Q

[Run NCBI BLAST on this sequence.]

Detection Method: Pfam
Confidence: 38.619789
Match: PF08606.2
Description: No description for PF08606.2 was found.

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #3
Region A:
Residues: [167-505]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 AGMSAEVIQK LQDKATVLTQ ERKKRGRTVP EDLVTTDQVK NFLTVASHPG LHSASVPGIL  60
   61 ALDINSADHS KILTGGNDKN ATVFNKDTEQ MVAILKGHTK KITKVIYHPN EDTVITGSPD 120
  121 MNIRIWHVPT SQTQLLLRCH EGPVTGLSLH PTGDYLLSTS SDKHWAFSDI RTGRLLTKVI 180
  181 DTAEVGLTTA QFHPDGLIFG TGTVDSQVKI WDLKEQSNVA NFPGHTGPIS AISFSENGYY 240
  241 LATAADDACV KLWDLRKLKN FKTIQLDDGY EVKDLCFDQS GTYLAIAGSD VRVYLCKQWQ 300
  301 ELKVFNDHTA LATGVRFGKH AQYLASTSMD RTLKLYAIE

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 82.154902
Match: 2gnqA
Description: No description for 2gnqA was found.

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle