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Protein Overview: Khc-PA

General Information:
Name(s) found: Khc-PA / FBpp0086328 [FlyBase]
Description(s) found:
Found 23 descriptions.
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  • The gene Kinesin heavy chain is referred to in FlyBase by the symbol Dmel\Khc (CG7765, FBgn0001308). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 2R:12154470..12159483. It has the cytological map location 53A3-53A4. There is experimental evidence that it has the molecular function</span>: microtubule motor activity; microtubule binding. There is experimental evidence that it is involved in the biological process</span>: cytoplasmic transport; mitochondrion transport along microtubule; microtubule-based movement; oocyte microtubule cytoskeleton polarization; mitochondrion distribution; regulation of pole plasm oskar mRNA localization; eye photoreceptor cell differentiation; pole plasm assembly; axon cargo transport; oocyte dorsal/ventral axis specification. 58 alleles are reported. The phenotypes of these alleles are annotated with: dendrite; neuromuscular junction; pole plasm; larval nervous system; oocyte nucleus; microtubule; mitochondrion; axon. It has one annotated transcript and one annotated polypeptide. [FlyBase]
    • Organism: Drosophila melanogaster
    Length: 975 amino acids

    Gene Ontology:
    Cellular Component: mitochondrion [IDA]
    kinesin complex [IDA][ISS][NAS]
    Biological Process: axon cargo transport [IMP]
    oocyte microtubule cytoskeleton polarization [IMP]
    oocyte dorsal/ventral axis specification [IMP]
    microtubule-based movement [IDA][ISS][NAS]
    pole plasm assembly [IMP]
    neurotransmitter secretion [NAS]
    cytoplasmic transport, nurse cell to oocyte [TAS]
    regulation of pole plasm oskar mRNA localization [IMP][TAS]
    eye photoreceptor cell differentiation [IGI]
    mitochondrion transport along microtubule [IMP]
    mitochondrion distribution [IMP]
    pole plasm oskar mRNA localization [NAS]
    cytoplasmic transport [IMP]
    neuronal action potential propagation [NAS]
    Molecular Function: ATP binding [IEA]
    microtubule motor activity [IDA][ISS][NAS]
    plus-end-directed microtubule motor activity [TAS]
    motor activity [NAS]
    microtubule binding [IDA][ISS]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSAEREIPAE DSIKVVCRFR PLNDSEEKAG SKFVVKFPNN VEENCISIAG KVYLFDKVFK  60
   61 PNASQEKVYN EAAKSIVTDV LAGYNGTIFA YGQTSSGKTH TMEGVIGDSV KQGIIPRIVN 120
  121 DIFNHIYAME VNLEFHIKVS YYEIYMDKIR DLLDVSKVNL SVHEDKNRVP YVKGATERFV 180
  181 SSPEDVFEVI EEGKSNRHIA VTNMNEHSSR SHSVFLINVK QENLENQKKL SGKLYLVDLA 240
  241 GSEKVSKTGA EGTVLDEAKN INKSLSALGN VISALADGNK THIPYRDSKL TRILQESLGG 300
  301 NARTTIVICC SPASFNESET KSTLDFGRRA KTVKNVVCVN EELTAEEWKR RYEKEKEKNA 360
  361 RLKGKVEKLE IELARWRAGE TVKAEEQINM EDLMEASTPN LEVEAAQTAA AEAALAAQRT 420
  421 ALANMSASVA VNEQARLATE CERLYQQLDD KDEEINQQSQ YAEQLKEQVM EQEELIANAR 480
  481 REYETLQSEM ARIQQENESA KEEVKEVLQA LEELAVNYDQ KSQEIDNKNK DIDALNEELQ 540
  541 QKQSVFNAAS TELQQLKDMS SHQKKRITEM LTNLLRDLGE VGQAIAPGES SIDLKMSALA 600
  601 GTDASKVEED FTMARLFISK MKTEAKNIAQ RCSNMETQQA DSNKKISEYE KDLGEYRLLI 660
  661 SQHEARMKSL QESMREAENK KRTLEEQIDS LREECAKLKA AEHVSAVNAE EKQRAEELRS 720
  721 MFDSQMDELR EAHTRQVSEL RDEIAAKQHE MDEMKDVHQK LLLAHQQMTA DYEKVRQEDA 780
  781 EKSSELQNII LTNERREQAR KDLKGLEDTV AKELQTLHNL RKLFVQDLQQ RIRKNVVNEE 840
  841 SEEDGGSLAQ KQKISFLENN LDQLTKVHKQ LVRDNADLRC ELPKLEKRLR CTMERVKALE 900
  901 TALKEAKEGA MRDRKRYQYE VDRIKEAVRQ KHLGRRGPQA QIAKPIRSGQ GAIAIRGGGA 960
  961 VGGPSPLAQV NPVNS

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..297] PSI-BLAST 87.522879 Kinesin
    2 View Details [298..382] PSI-BLAST 10.0 KINESIN (DIMERIC) FROM RATTUS NORVEGICUS
    3 View Details [383..665] FFAS03 2.84 Tropomyosin
    4 View Details [666..975] PSI-BLAST 5.30103 No description for 2i1jA was found.

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • microtubule motor activity
    		•  7.68336791348661 bayes_pls_golite062009
  • plus-end-directed microtubule motor activity
    		•  4.97507344344589 bayes_pls_golite062009
  • microfilament motor activity
    		•  4.176620576177 bayes_pls_golite062009
  • motor activity
    		•  4.04927796049806 bayes_pls_golite062009
  • nucleoside-triphosphatase activity
    		•  2.95079405147356 bayes_pls_golite062009
  • pyrophosphatase activity
    		•  2.87427509025394 bayes_pls_golite062009
  • hydrolase activity, acting on acid anhydrides
    		•  2.85499564954033 bayes_pls_golite062009
  • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides
    		•  2.85178667290149 bayes_pls_golite062009
  • actin-dependent ATPase activity
    		•  2.77140616759165 bayes_pls_golite062009
  • microtubule plus-end binding
    		•  2.71138928021716 bayes_pls_golite062009
  • tubulin binding
    		•  2.67743463093593 bayes_pls_golite062009
  • binding
    		•  2.64537357529343 bayes_pls_golite062009
  • microtubule binding
    		•  2.59155206524122 bayes_pls_golite062009
  • transporter activity
    		•  2.58140740499725 bayes_pls_golite062009
  • cytoskeletal protein binding
    		•  2.4101693596493 bayes_pls_golite062009
  • transmembrane transporter activity
    		•  2.39695871109024 bayes_pls_golite062009
  • ATPase activity
    		•  2.39535714892224 bayes_pls_golite062009
  • ATPase activity, coupled
    		•  2.18396165590908 bayes_pls_golite062009
  • ATP-dependent DNA helicase activity
    		•  2.07967285635739 bayes_pls_golite062009
  • actin binding
    		•  1.75397031486306 bayes_pls_golite062009
  • hydrolase activity
    		•  1.57549510726226 bayes_pls_golite062009
  • general RNA polymerase II transcription factor activity
    		•  1.40384549325664 bayes_pls_golite062009
  • helicase activity
    		•  1.33212695797068 bayes_pls_golite062009
  • substrate-specific transporter activity
    		•  1.29730375126024 bayes_pls_golite062009
  • protein binding
    		•  1.22129154759482 bayes_pls_golite062009
  • DNA-dependent ATPase activity
    		•  1.07479235523606 bayes_pls_golite062009
  • purine nucleotide binding
    		•  0.929901285538132 bayes_pls_golite062009
  • nucleotide binding
    		•  0.922442819194247 bayes_pls_golite062009
  • purine ribonucleotide binding
    		•  0.920987930180051 bayes_pls_golite062009
  • ribonucleotide binding
    		•  0.920926158369519 bayes_pls_golite062009
  • substrate-specific transmembrane transporter activity
    		•  0.906554174337376 bayes_pls_golite062009
  • nucleic acid binding
    		•  0.777787753097919 bayes_pls_golite062009
  • actin filament binding
    		•  0.728264616959762 bayes_pls_golite062009
  • structure-specific DNA binding
    		•  0.579644950922817 bayes_pls_golite062009
  • kinetochore binding
    		•  0.505370954958131 bayes_pls_golite062009
  • DNA binding
    		•  0.479412476059825 bayes_pls_golite062009
  • GTPase activity
    		•  0.437665353870877 bayes_pls_golite062009
  • active transmembrane transporter activity
    		•  0.434775387083003 bayes_pls_golite062009
  • ATP binding
    		•  0.41092997612902 bayes_pls_golite062009
  • adenyl ribonucleotide binding
    		•  0.385813421701492 bayes_pls_golite062009
  • adenyl nucleotide binding
    		•  0.377870145186619 bayes_pls_golite062009
  • ion transmembrane transporter activity
    		•  0.355466224802969 bayes_pls_golite062009
  • RNA helicase activity
    		•  0.34746349346164 bayes_pls_golite062009
  • histone acetyltransferase activity
    		•  0.328186246219424 bayes_pls_golite062009
  • lysine N-acetyltransferase activity
    		•  0.328186246219424 bayes_pls_golite062009
  • transcription regulator activity
    		•  0.312171320541728 bayes_pls_golite062009
  • ATP-dependent RNA helicase activity
    		•  0.30832907234141 bayes_pls_golite062009
  • RNA-dependent ATPase activity
    		•  0.29532978396745 bayes_pls_golite062009
  • primary active transmembrane transporter activity
    		•  0.294474570607914 bayes_pls_golite062009
  • P-P-bond-hydrolysis-driven transmembrane transporter activity
    		•  0.282352478532746 bayes_pls_golite062009
  • ATP-dependent helicase activity
    		•  0.25143870859482 bayes_pls_golite062009
  • purine NTP-dependent helicase activity
    		•  0.25143870859482 bayes_pls_golite062009
  • hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances
    		•  0.220608508617331 bayes_pls_golite062009
  • ATPase activity, coupled to transmembrane movement of substances
    		•  0.219533217661421 bayes_pls_golite062009
  • ATPase activity, coupled to movement of substances
    		•  0.219157471322311 bayes_pls_golite062009
  • protein transporter activity
    		•  0.178442534411253 bayes_pls_golite062009
  • DNA helicase activity
    		•  0.17029946873911 bayes_pls_golite062009
  • mismatched DNA binding
    		•  0.13866566261611 bayes_pls_golite062009
  • minus-end-directed microtubule motor activity
    		•  0.068779631341469 bayes_pls_golite062009
  • cation transmembrane transporter activity
    		•  0.0254369227200564 bayes_pls_golite062009
  • structural constituent of cytoskeleton
    		•  0.0111338193708552 bayes_pls_golite062009
  • RNA binding
    		•  0.00414926067713517 bayes_pls_golite062009
    2 No functions predicted.
    3 No functions predicted.
    4 No functions predicted.


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle