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Protein Overview: FBpp0308795, Drl...

General Information:
Name(s) found: FBpp0308795 [FlyBase]
Drl-2-PB / FBpp0086907 [FlyBase]
Description(s) found:
Found 26 descriptions.
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  • type=protein; loc=2R:complement(8945615..8945726,8945822..8946118,8946236..8946376,8946480..8946916,8954637..8954782,8954859..8955016,8955078..8955246,8955315..8955552,8955614..8955741,8960083..8960203); ID=FBpp0308795; name=Drl-2-PC; parent=FBgn0033791,FBtr0339747; dbxref=FlyBase:FBpp0308795,FlyBase_Annotation_IDs:CG3915-PC; MD5=1aa043a59bc76284deaef846c374fcef; length=648; release=r5.56; species=Dmel; [FlyBase]
  • The gene Derailed 2 is referred to in FlyBase by the symbol Dmel\Drl-2 (CG3915, FBgn0033791). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 2R:8944081..8967043. It has the cytological map location 49F1. Based on sequence similarity, it is predicted to have molecular function</span>: receptor signaling protein tyrosine kinase activity. There is experimental evidence that it is involved in the biological process</span>: salivary gland morphogenesis. 9 alleles are reported. The phenotype of these alleles is annotated with: embryonic salivary gland. It has one annotated transcript and one annotated polypeptide. [FlyBase]
    • Organism: Drosophila melanogaster
    Length: 648 amino acids

    Gene Ontology:
    Cellular Component: integral to plasma membrane [IEA]
    Biological Process: Wnt receptor signaling pathway [IEA]
    protein amino acid phosphorylation [IEA][NAS]
    salivary gland morphogenesis [IMP]
    Molecular Function: ATP binding [IEA]
    protein tyrosine kinase activity [NAS]
    transmembrane receptor protein tyrosine kinase activity [IEA]
    receptor signaling protein tyrosine kinase activity [ISS]
    Wnt-protein binding [IEA]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MELLPLKSPL PILLLCLTIS TSVSGYLNIF ISHHEVMKLM GLEADLFYVH EGAINTYAMH  60
   61 FTVPVPADVH ELEFSWQSLI AYPLPYAISI EYNNDQEALG TPTLSIPHKG LVPQEIESFL 120
  121 VYLPCTGNAS LQMPVNVNMV VRAPPRFNDT RLHFKRNKIC AKGISPEPNQ SPAPAHAPSQ 180
  181 GPALLSAAAC ALGLVLAVGL VASMMYVRAR KQLRQDSLHT SFTTAAYGSH QNVFIRLDPL 240
  241 GRPPSATGSY ATIASLNKYP ADSKKSCSIF DRFRSSPTPT PYATALLPMN LEQTAETIYS 300
  301 KPESICPSRI SYYASSQLTQ PCSLSTPKSI RSNGNGNCTS GSGSLSLFGG IPTGSTITMA 360
  361 SHGEKGNQRL RRITSVQPGA LSYEELVKEG TFGRIYAGKL GESCEALVKT VIDGASLTQV 420
  421 ACLLQDASLL IGVSHQHILA PLLANTELPG PPEIAYPHPS KGNLKMYLQK SRESSTALST 480
  481 RQLVEFGLHI TKGLAYLHSL GIVHKDIATR NCYLDEESYV KICDSALSRD LFPDDYDCLG 540
  541 DNENRPLKWL SLESLQKRVY ATQGDVWALG VTYWELVTLA QMPHEEVDIF ELTNYLAAGF 600
  601 RLEQPVNCPD EFFTVMNCCW HCEAKQRPTP SQLLSYLQDF HADLGMYI

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    SHOWING SINGLE HITS. [ Hide Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..162] PSI-BLAST 20.69897 No description for 2dtgE was found.
    2 View Details [163..648] PSI-BLAST 98.154902 No description for 2h8hA was found.

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • cytokine receptor activity
    		•  6.1064338595335 bayes_pls_golite062009
  • transmembrane receptor activity
    		•  4.81256300373074 bayes_pls_golite062009
  • receptor activity
    		•  4.66147271961356 bayes_pls_golite062009
  • prolactin receptor activity
    		•  4.60875985371574 bayes_pls_golite062009
  • cytokine binding
    		•  4.43581512268554 bayes_pls_golite062009
  • growth factor binding
    		•  4.06808996928726 bayes_pls_golite062009
  • molecular transducer activity
    		•  3.69234048247377 bayes_pls_golite062009
  • signal transducer activity
    		•  3.69234048247377 bayes_pls_golite062009
  • protein binding
    		•  3.24522318184038 bayes_pls_golite062009
  • binding
    		•  3.12471204223368 bayes_pls_golite062009
  • ciliary neurotrophic factor binding
    		•  2.91569341552992 bayes_pls_golite062009
  • interleukin-6 receptor activity
    		•  2.8106012499488 bayes_pls_golite062009
  • interleukin-6 binding
    		•  2.8106012499488 bayes_pls_golite062009
  • ciliary neurotrophic factor receptor activity
    		•  2.63544834801488 bayes_pls_golite062009
  • interleukin-11 binding
    		•  2.34894404420874 bayes_pls_golite062009
  • interleukin-11 receptor activity
    		•  2.34894404420874 bayes_pls_golite062009
  • peptide hormone binding
    		•  2.12033076929638 bayes_pls_golite062009
  • axon guidance receptor activity
    		•  2.01367445237355 bayes_pls_golite062009
  • polysaccharide binding
    		•  1.69642470905172 bayes_pls_golite062009
  • interleukin-2 binding
    		•  1.67132604890013 bayes_pls_golite062009
  • glycosaminoglycan binding
    		•  1.6158868405814 bayes_pls_golite062009
  • protein kinase activity
    		•  1.42856560840953 bayes_pls_golite062009
  • heparin binding
    		•  1.40418056272895 bayes_pls_golite062009
  • nucleic acid binding
    		•  1.32813363771214 bayes_pls_golite062009
  • receptor binding
    		•  1.31676259534833 bayes_pls_golite062009
  • transcription regulator activity
    		•  1.31663344632755 bayes_pls_golite062009
  • DNA binding
    		•  1.2006039770643 bayes_pls_golite062009
  • phosphotransferase activity, alcohol group as acceptor
    		•  1.15899955607967 bayes_pls_golite062009
  • transferase activity, transferring phosphorus-containing groups
    		•  1.12142142875217 bayes_pls_golite062009
  • kinase activity
    		•  1.11027658115625 bayes_pls_golite062009
  • cytokine receptor binding
    		•  1.09602077483848 bayes_pls_golite062009
  • cell surface binding
    		•  1.05599555585797 bayes_pls_golite062009
  • mercury ion binding
    		•  1.02618624913674 bayes_pls_golite062009
  • oncostatin-M receptor activity
    		•  0.979212281066169 bayes_pls_golite062009
  • leukemia inhibitory factor receptor activity
    		•  0.979212281066169 bayes_pls_golite062009
  • peptide binding
    		•  0.92031154055894 bayes_pls_golite062009
  • ciliary neurotrophic factor receptor binding
    		•  0.913376203169121 bayes_pls_golite062009
  • protein dimerization activity
    		•  0.86564366658585 bayes_pls_golite062009
  • actin filament binding
    		•  0.848221254225135 bayes_pls_golite062009
  • protein serine/threonine kinase activity
    		•  0.703490254739121 bayes_pls_golite062009
  • kinase binding
    		•  0.65927255037265 bayes_pls_golite062009
  • cytoskeletal protein binding
    		•  0.657804692814791 bayes_pls_golite062009
  • enzyme binding
    		•  0.60195860585095 bayes_pls_golite062009
  • identical protein binding
    		•  0.564711394496051 bayes_pls_golite062009
  • transcription factor activity
    		•  0.557290274937694 bayes_pls_golite062009
  • transmembrane receptor protein tyrosine kinase activity
    		•  0.554350228628563 bayes_pls_golite062009
  • hormone binding
    		•  0.49524185948356 bayes_pls_golite062009
  • transmembrane receptor protein kinase activity
    		•  0.46168925186147 bayes_pls_golite062009
  • transferase activity
    		•  0.432850266451294 bayes_pls_golite062009
  • structural constituent of muscle
    		•  0.412181409439388 bayes_pls_golite062009
  • protein kinase binding
    		•  0.405060010394646 bayes_pls_golite062009
  • phosphoinositide 3-kinase binding
    		•  0.302335010887221 bayes_pls_golite062009
  • peptidase activator activity
    		•  0.249363133780499 bayes_pls_golite062009
  • growth hormone receptor activity
    		•  0.179919001520689 bayes_pls_golite062009
  • pattern binding
    		•  0.16768253393396 bayes_pls_golite062009
  • protein heterodimerization activity
    		•  0.1430595594485 bayes_pls_golite062009
  • transcription activator activity
    		•  0.135753557343301 bayes_pls_golite062009
  • protein homodimerization activity
    		•  0.116391819218123 bayes_pls_golite062009
  • interleukin-2 receptor activity
    		•  0.115337814289139 bayes_pls_golite062009
  • transcription factor binding
    		•  0.075900818564989 bayes_pls_golite062009
  • growth factor activity
    		•  0.0477008672713168 bayes_pls_golite062009
    2
    Term Confidence Notes
  • protein kinase activity
    		•  5.4586557943719 bayes_pls_golite062009
  • phosphotransferase activity, alcohol group as acceptor
    		•  5.04467222534257 bayes_pls_golite062009
  • kinase activity
    		•  4.85903980916957 bayes_pls_golite062009
  • transferase activity, transferring phosphorus-containing groups
    		•  4.63692708178478 bayes_pls_golite062009
  • protein serine/threonine kinase activity
    		•  4.46381887831481 bayes_pls_golite062009
  • fibroblast growth factor 1 binding
    		•  4.09909681656699 bayes_pls_golite062009
  • transmembrane receptor protein tyrosine kinase activity
    		•  3.41480681854114 bayes_pls_golite062009
  • transmembrane receptor protein kinase activity
    		•  3.40140621607334 bayes_pls_golite062009
  • transferase activity
    		•  3.26787750561728 bayes_pls_golite062009
  • transmembrane receptor activity
    		•  3.1965684217331 bayes_pls_golite062009
  • epidermal growth factor receptor binding
    		•  2.9751846707539 bayes_pls_golite062009
  • receptor activity
    		•  2.96273889901429 bayes_pls_golite062009
  • signal transducer activity
    		•  2.85730457922199 bayes_pls_golite062009
  • molecular transducer activity
    		•  2.85730457922199 bayes_pls_golite062009
  • protein tyrosine kinase activity
    		•  2.8153155526437 bayes_pls_golite062009
  • binding
    		•  2.74863538127007 bayes_pls_golite062009
  • fibroblast growth factor receptor activity
    		•  2.70917101514973 bayes_pls_golite062009
  • growth factor binding
    		•  2.61235080252818 bayes_pls_golite062009
  • protein binding
    		•  2.276111749106 bayes_pls_golite062009
  • receptor signaling protein activity
    		•  2.10379226653669 bayes_pls_golite062009
  • ATP binding
    		•  1.97600611746091 bayes_pls_golite062009
  • adenyl ribonucleotide binding
    		•  1.93596671856664 bayes_pls_golite062009
  • adenyl nucleotide binding
    		•  1.90928021591891 bayes_pls_golite062009
  • fibroblast growth factor binding
    		•  1.9011085456623 bayes_pls_golite062009
  • phosphoinositide 3-kinase binding
    		•  1.82515074380651 bayes_pls_golite062009
  • receptor signaling protein serine/threonine kinase activity
    		•  1.81249386965144 bayes_pls_golite062009
  • molecular adaptor activity
    		•  1.81145713371725 bayes_pls_golite062009
  • non-membrane spanning protein tyrosine kinase activity
    		•  1.66669268613198 bayes_pls_golite062009
  • purine ribonucleotide binding
    		•  1.65732943334212 bayes_pls_golite062009
  • ribonucleotide binding
    		•  1.65726906484847 bayes_pls_golite062009
  • purine nucleotide binding
    		•  1.63763394711025 bayes_pls_golite062009
  • vinculin binding
    		•  1.63216315345235 bayes_pls_golite062009
  • nucleotide binding
    		•  1.63195828048121 bayes_pls_golite062009
  • SH3/SH2 adaptor activity
    		•  1.59474164216385 bayes_pls_golite062009
  • transforming growth factor beta receptor activity
    		•  1.51779793980227 bayes_pls_golite062009
  • transmembrane receptor protein serine/threonine kinase activity
    		•  1.51779793980227 bayes_pls_golite062009
  • kinase binding
    		•  1.26086833316556 bayes_pls_golite062009
  • catalytic activity
    		•  1.21655087018101 bayes_pls_golite062009
  • protein kinase binding
    		•  1.06030596516506 bayes_pls_golite062009
  • insulin receptor substrate binding
    		•  0.95914323793919 bayes_pls_golite062009
  • protein binding, bridging
    		•  0.83823250804321 bayes_pls_golite062009
  • MAP kinase activity
    		•  0.81943579965027 bayes_pls_golite062009
  • transporter activity
    		•  0.710766490066447 bayes_pls_golite062009
  • actin filament binding
    		•  0.66248865719696 bayes_pls_golite062009
  • nucleic acid binding
    		•  0.655396214040669 bayes_pls_golite062009
  • transcription regulator activity
    		•  0.631882811427766 bayes_pls_golite062009
  • MAP kinase kinase activity
    		•  0.610230065465794 bayes_pls_golite062009
  • transmembrane transporter activity
    		•  0.60324822483033 bayes_pls_golite062009
  • DNA binding
    		•  0.599969415455862 bayes_pls_golite062009
  • activin binding
    		•  0.510364757301021 bayes_pls_golite062009
  • cyclin-dependent protein kinase activity
    		•  0.499492353295369 bayes_pls_golite062009
  • enzyme binding
    		•  0.46284745266176 bayes_pls_golite062009
  • transcription factor activity
    		•  0.457173041568166 bayes_pls_golite062009
  • protein kinase C activity
    		•  0.41587987561486 bayes_pls_golite062009
  • magnesium ion binding
    		•  0.393328812780268 bayes_pls_golite062009
  • substrate-specific transporter activity
    		•  0.385603245903806 bayes_pls_golite062009
  • insulin receptor activity
    		•  0.359260732334699 bayes_pls_golite062009
  • JUN kinase kinase kinase kinase activity
    		•  0.349343975617553 bayes_pls_golite062009
  • glycosaminoglycan binding
    		•  0.294256794094724 bayes_pls_golite062009
  • transforming growth factor beta binding
    		•  0.287757704969289 bayes_pls_golite062009
  • protein complex binding
    		•  0.239339759110451 bayes_pls_golite062009
  • transforming growth factor beta receptor activity, type I
    		•  0.233896787419349 bayes_pls_golite062009
  • polysaccharide binding
    		•  0.229808864843639 bayes_pls_golite062009
  • cytokine binding
    		•  0.17817111033393 bayes_pls_golite062009
  • activin receptor activity
    		•  0.163693280420599 bayes_pls_golite062009
  • substrate-specific transmembrane transporter activity
    		•  0.152203945257581 bayes_pls_golite062009


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    [View Details]
    Source: Reynolds et al. 2008. Manuscript submitted Philius confidence legend
    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle