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Protein Overview: Pkn-PC

General Information:
Name(s) found: Pkn-PC / FBpp0087683 [FlyBase]
Description(s) found:
Found 20 descriptions.
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  • The gene Protein kinase related to protein kinase N is referred to in FlyBase by the symbol Dmel\Pkn (CG2049, FBgn0020621). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 2R:5139815..5172602. It has the cytological map location 45C1. There is experimental evidence that it has the molecular function</span>: protein kinase activity. There is experimental evidence that it is involved in the biological process</span>: dorsal closure. 44 alleles are reported. The phenotypes of these alleles are annotated with: dorsal closure embryo; anterior wing margin; wing margin bristle; posterior wing margin; wing; ommatidium; wing hair. It has 10 annotated transcripts and 10 annotated polypeptides. [FlyBase]
    • Organism: Drosophila melanogaster
    Length: 1407 amino acids

    Gene Ontology:
    Cellular Component: intracellular [IEA]
    Biological Process: dorsal closure [IMP][TAS]
    signal transduction [IEA]
    protein amino acid phosphorylation [ISS][NAS]
    Molecular Function: ATP binding [IEA]
    protein kinase activity [IDA]
    protein serine/threonine kinase activity [ISS][NAS]
    protein kinase C activity [ISS]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSDSYYQGEY IKHPVLYELS HKYGFTENLP ESCMSIRLEE IKEAIRREIR KELKIKEGAE  60
   61 KLREVAKDRR SLSDVAVLVK KSKSKLAELK SELQELESQI LLTSANTAVN SNGQESITAC 120
  121 IDPNGGFLVS GAVGGLGGGN TALEGGAPAT ANDKVLASLE KQLQIEMKVK TGAENMIQSL 180
  181 GIGCDKKLLA EAHQMLADSK AKIEFLRLRI IKVKQNREQA DRLKASRQMI DEHGQTIGGN 240
  241 NSSQPQSLET TLEERIEELR HRLRIEAAVV DGAKNVIRTL QTANRAPDKK ALQEAHGRLS 300
  301 ESSRKLDLLR YSLDLRRQEL PADSPAAQQL KTELQIVQLS TSPAPVTYTS LQSGQAGILG 360
  361 GKPYQSVSSL GRCASVTGKL EVRLLGCQDL LEDVPGRSRR DKDNNSSPGD LRSFVKGVTS 420
  421 RSSSKSYSVK DETSIEIMAV IKLDNITVGQ TSWKQCSQQA WDQRFSIDLD RSRELEIGVY 480
  481 WRDWRSLCAV KVLRLEEFID DVRHGMALQL EPQGLLFAEV KFLNPMISQK PKLRRQRMIF 540
  541 NRQQAKNISR AKQMNINVAT WGRLLKRNAP NHVHMGSAGS GSSLTGSSPM VVGGSRDSES 600
  601 PISRTPSSDA LVEPEPYTPG EQAQNLEFDP DAGINEHVET PGEYPDPAAS GLSGMRPLSM 660
  661 HMQGISVLPP ESPPVATGAA GRPNTLSLQM PGASKGQVIQ GGRTAAPTTA PPPPPVLKAT 720
  721 STTPILDQEL QDALHEFDFL SDLDSRPTTL RRLLKEQKMA LDAGALENLL LQQQQTEQQA 780
  781 LQQRQRQEQL RLQQFQEAQR QAILDLCVKQ REPAEQTSPT LANQTPTFPP LASNQIMPSL 840
  841 NARPCQSQSP NHNEFQLQPQ PPHPAQKPTN PEPPSAVEQQ LHRPVLILPP VVLLGGREED 900
  901 RSVPPSPLVE YPEDDDEYLY RGSNENLGTR LHSSHSSSAG DRFCVEVIPQ LGKLYVGSSQ 960
  961 QQYAQQSSPI IQEPATPTIY GNSAAAGAPQ FPQPAQRQEK QPPQQQPIYA NQYELNVAKA1020
 1021 AAAASVYSPS SSTTSNSNQQ QQQQRRNVAR GLQYRESGGL ETGRAGKQPP NAGMLSMDNF1080
 1081 RLLSVLGRGH FGKVILSQLR SNNQYYAIKA LKKGDIIARD EVESLLSEKR IFEVANAMRH1140
 1141 PFLVNLYSCF QTEQHVCFVM EYAAGGDLMM HIHTDVFLEP RAVFYAACVV LGLQYLHENK1200
 1201 IIYRDLKLDN LLLDTEGYVK IADFGLCKEG MGFGDRTGTF CGTPEFLAPE VLTETSYTRA1260
 1261 VDWWGLGVLI FEMLVGESPF PGDDEEEVFD SIVNDEVRYP RFLSLEAIAV MRRLLRKNPE1320
 1321 RRLGSSERDA EDVKKQAFFR SIVWDDLLLR KVKPPFVPTI NHLEDVSNFD EEFTSEKAQL1380
 1381 TPPKEPRHLT EEEQLLFQDF SYTAEWC

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..352] PSI-BLAST 24.045757 Heavy meromyosin subfragment
    2 View Details [353..578] FFAS03 2.9 Human protein kinase C, eta
    3 View Details [579..772] deduced N/A No confident structure predictions are available.
    4 View Details [773..1341] PSI-BLAST 55.0 No description for 2h8hA was found.
    5 View Details [1342..1407] PSI-BLAST 105.0 No description for 2jdoA was found.

    Functions predicted (by domain):

    # Gene Ontology predictions
    1 No functions predicted.
    2 No functions predicted.
    3 No functions predicted.
    4
    Term Confidence Notes
  • phosphotransferase activity, alcohol group as acceptor
    		•  5.49988294224815 bayes_pls_golite062009
  • protein kinase activity
    		•  5.4586557943719 bayes_pls_golite062009
  • kinase activity
    		•  5.3287080791198 bayes_pls_golite062009
  • cyclic nucleotide-dependent protein kinase activity
    		•  4.97855712164511 bayes_pls_golite062009
  • transferase activity, transferring phosphorus-containing groups
    		•  4.96052051118534 bayes_pls_golite062009
  • cAMP-dependent protein kinase activity
    		•  4.66277812893755 bayes_pls_golite062009
  • protein serine/threonine kinase activity
    		•  4.46381887831481 bayes_pls_golite062009
  • transferase activity
    		•  3.97138602499442 bayes_pls_golite062009
  • protein tyrosine kinase activity
    		•  2.8153155526437 bayes_pls_golite062009
  • binding
    		•  2.74863538127007 bayes_pls_golite062009
  • transmembrane receptor activity
    		•  2.59526003830791 bayes_pls_golite062009
  • transmembrane receptor protein kinase activity
    		•  2.54265774272269 bayes_pls_golite062009
  • molecular transducer activity
    		•  2.40586892801446 bayes_pls_golite062009
  • signal transducer activity
    		•  2.40586892801446 bayes_pls_golite062009
  • receptor activity
    		•  2.39311927684508 bayes_pls_golite062009
  • tubulin binding
    		•  2.18641675163967 bayes_pls_golite062009
  • transmembrane receptor protein tyrosine kinase activity
    		•  2.16831387024372 bayes_pls_golite062009
  • cytoskeletal protein binding
    		•  2.12615078788254 bayes_pls_golite062009
  • receptor signaling protein activity
    		•  2.10379226653669 bayes_pls_golite062009
  • ATP binding
    		•  1.97600611746091 bayes_pls_golite062009
  • adenyl ribonucleotide binding
    		•  1.93596671856664 bayes_pls_golite062009
  • adenyl nucleotide binding
    		•  1.90928021591891 bayes_pls_golite062009
  • microtubule binding
    		•  1.88110801192607 bayes_pls_golite062009
  • actin binding
    		•  1.87817875565699 bayes_pls_golite062009
  • acetylcholine receptor activator activity
    		•  1.83545227594542 bayes_pls_golite062009
  • phosphoinositide 3-kinase binding
    		•  1.82515074380651 bayes_pls_golite062009
  • receptor signaling protein serine/threonine kinase activity
    		•  1.81249386965144 bayes_pls_golite062009
  • molecular adaptor activity
    		•  1.81145713371725 bayes_pls_golite062009
  • purine ribonucleotide binding
    		•  1.65732943334212 bayes_pls_golite062009
  • ribonucleotide binding
    		•  1.65726906484847 bayes_pls_golite062009
  • purine nucleotide binding
    		•  1.63763394711025 bayes_pls_golite062009
  • nucleotide binding
    		•  1.63195828048121 bayes_pls_golite062009
  • insulin receptor substrate binding
    		•  1.62657794525303 bayes_pls_golite062009
  • SH3/SH2 adaptor activity
    		•  1.59474164216385 bayes_pls_golite062009
  • transcription regulator activity
    		•  1.56748951434625 bayes_pls_golite062009
  • DNA binding
    		•  1.35333135345112 bayes_pls_golite062009
  • kinase binding
    		•  1.26086833316556 bayes_pls_golite062009
  • ErbB-3 class receptor binding
    		•  1.25765701903393 bayes_pls_golite062009
  • protein binding
    		•  1.22565748038754 bayes_pls_golite062009
  • catalytic activity
    		•  1.21655087018101 bayes_pls_golite062009
  • nucleic acid binding
    		•  1.16049201286103 bayes_pls_golite062009
  • transporter activity
    		•  1.11833481501707 bayes_pls_golite062009
  • transcription factor activity
    		•  1.10928254946881 bayes_pls_golite062009
  • protein kinase binding
    		•  1.06030596516506 bayes_pls_golite062009
  • ErbB-2 class receptor binding
    		•  1.02996109010965 bayes_pls_golite062009
  • transmembrane transporter activity
    		•  0.97575992765505 bayes_pls_golite062009
  • cyclin-dependent protein kinase activity
    		•  0.959360414036299 bayes_pls_golite062009
  • growth factor binding
    		•  0.86076618871384 bayes_pls_golite062009
  • protein binding, bridging
    		•  0.83823250804321 bayes_pls_golite062009
  • MAP kinase activity
    		•  0.81943579965027 bayes_pls_golite062009
  • actin filament binding
    		•  0.794152600084 bayes_pls_golite062009
  • substrate-specific transporter activity
    		•  0.705905455086486 bayes_pls_golite062009
  • phosphoinositide 3-kinase regulator activity
    		•  0.688047400629641 bayes_pls_golite062009
  • vinculin binding
    		•  0.666656406096231 bayes_pls_golite062009
  • structural constituent of cytoskeleton
    		•  0.612883428421652 bayes_pls_golite062009
  • protein serine/threonine/tyrosine kinase activity
    		•  0.48345772948903 bayes_pls_golite062009
  • enzyme binding
    		•  0.46284745266176 bayes_pls_golite062009
  • substrate-specific transmembrane transporter activity
    		•  0.450699332958421 bayes_pls_golite062009
  • protein kinase C activity
    		•  0.41587987561486 bayes_pls_golite062009
  • magnesium ion binding
    		•  0.393328812780268 bayes_pls_golite062009
  • MAP kinase kinase kinase activity
    		•  0.37115026509016 bayes_pls_golite062009
  • MAP kinase kinase activity
    		•  0.35402045013148 bayes_pls_golite062009
  • phosphotyrosine binding
    		•  0.311079584914389 bayes_pls_golite062009
  • insulin receptor binding
    		•  0.266450215230107 bayes_pls_golite062009
  • protein complex binding
    		•  0.239339759110451 bayes_pls_golite062009
  • insulin receptor activity
    		•  0.237134032032089 bayes_pls_golite062009
  • SH2 domain binding
    		•  0.226760162354251 bayes_pls_golite062009
  • transforming growth factor beta receptor activity
    		•  0.20643152368029 bayes_pls_golite062009
  • transmembrane receptor protein serine/threonine kinase activity
    		•  0.20643152368029 bayes_pls_golite062009
  • receptor binding
    		•  0.197402253061255 bayes_pls_golite062009
  • ion transmembrane transporter activity
    		•  0.148194101970458 bayes_pls_golite062009
  • peptide binding
    		•  0.118578378753757 bayes_pls_golite062009
  • transforming growth factor beta receptor activity, type I
    		•  0.0506751594607393 bayes_pls_golite062009
  • general RNA polymerase II transcription factor activity
    		•  0.0405961152540697 bayes_pls_golite062009
  • nucleoside-triphosphatase activity
    		•  0.0040394359628233 bayes_pls_golite062009
    5 No functions predicted.


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.98

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle