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Protein Overview: ptc-PA

General Information:
Name(s) found: ptc-PA / FBpp0088443 [FlyBase]
Description(s) found:
Found 21 descriptions.
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  • The gene patched is referred to in FlyBase by the symbol Dmel\ptc (CG2411, FBgn0003892). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 2R:4537140..4552728. It has the cytological map location 44D5-44E1. There is experimental evidence that it has the molecular function</span>: protein binding; hedgehog receptor activity; lipoprotein receptor activity. There is experimental evidence for 11 unique biological process</span> terms, many of which group under: anatomical structure development; regulation of biological process; organ development; organ morphogenesis; chemical homeostasis; regulation of protein transport; reproductive process in a multicellular organism; regulation of cell cycle; post-embryonic morphogenesis; lipid homeostasis; cellular component movement; cell communication; negative regulation of smoothened signaling pathway; sensory organ development; determination of imaginal disc primordium; regulation of nucleocytoplasmic transport; multicellular organism reproduction. 175 alleles are reported. The phenotypes of these alleles are annotated with 85 unique terms, many of which group under: adult segment; organ system; adult mesothoracic segment; peripheral nervous system; embryonic nervous system; nervous system; abdominal ventral denticle belt; imaginal precursor; multi-cell-component structure; embryonic neuron; commissure. It has one annotated transcript and one annotated polypeptide. [FlyBase]
    • Organism: Drosophila melanogaster
    Length: 1286 amino acids

    Gene Ontology:
    Cellular Component: integral to plasma membrane [NAS][TAS]
    endocytic vesicle [IDA]
    perinuclear region of cytoplasm [IDA]
    cytoplasm [IDA]
    integral to membrane [IEA][TAS]
    fusome [IDA]
    plasma membrane [IDA]
    Biological Process: regulation of protein import into nucleus [IMP]
    embryonic pattern specification [TAS]
    lipid homeostasis [IMP]
    blastoderm segmentation [NAS]
    anterior/posterior pattern formation [NAS]
    imaginal disc-derived wing morphogenesis [IMP]
    smoothened signaling pathway [IGI][IMP][NAS][TAS]
    peripheral nervous system development [TAS]
    eye-antennal disc morphogenesis [IMP]
    germ-line stem cell division [TAS]
    axon guidance [IMP]
    negative regulation of smoothened signaling pathway [IGI][TAS]
    regulation of mitotic cell cycle [IMP]
    wing disc anterior/posterior pattern formation [TAS]
    anterior/posterior lineage restriction, imaginal disc [TAS]
    oogenesis [IMP]
    somatic stem cell division [TAS]
    Bolwig's organ morphogenesis [IMP]
    ovarian follicle cell development [TAS]
    proteolysis [TAS]
    dephosphorylation [TAS]
    determination of genital disc primordium [IMP]
    Molecular Function: lipoprotein receptor activity [IDA]
    transmembrane receptor activity [NAS]
    protein binding [IPI]
    hedgehog receptor activity [IMP][TAS]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MDRDSLPRVP DTHGDVVDEK LFSDLYIRTS WVDAQVALDQ IDKGKARGSR TAIYLRSVFQ  60
   61 SHLETLGSSV QKHAGKVLFV AILVLSTFCV GLKSAQIHSK VHQLWIQEGG RLEAELAYTQ 120
  121 KTIGEDESAT HQLLIQTTHD PNASVLHPQA LLAHLEVLVK ATAVKVHLYD TEWGLRDMCN 180
  181 MPSTPSFEGI YYIEQILRHL IPCSIITPLD CFWEGSQLLG PESAVVIPGL NQRLLWTTLN 240
  241 PASVMQYMKQ KMSEEKISFD FETVEQYMKR AAIGSGYMEK PCLNPLNPNC PDTAPNKNST 300
  301 QPPDVGAILS GGCYGYAAKH MHWPEELIVG GAKRNRSGHL RKAQALQSVV QLMTEKEMYD 360
  361 QWQDNYKVHH LGWTQEKAAE VLNAWQRNFS REVEQLLRKQ SRIATNYDIY VFSSAALDDI 420
  421 LAKFSHPSAL SIVIGVAVTV LYAFCTLLRW RDPVRGQSSV GVAGVLLMCF STAAGLGLSA 480
  481 LLGIVFNAAS TQVVPFLALG LGVDHIFMLT AAYAESNRRE QTKLILKKVG PSILFSACST 540
  541 AGSFFAAAFI PVPALKVFCL QAAIVMCSNL AAALLVFPAM ISLDLRRRTA GRADIFCCCF 600
  601 PVWKEQPKVA PPVLPLNNNN GRGARHPKSC NNNRVPLPAQ NPLLEQRADI PGSSHSLASF 660
  661 SLATFAFQHY TPFLMRSWVK FLTVMGFLAA LISSLYASTR LQDGLDIIDL VPKDSNEHKF 720
  721 LDAQTRLFGF YSMYAVTQGN FEYPTQQQLL RDYHDSFVRV PHVIKNDNGG LPDFWLLLFS 780
  781 EWLGNLQKIF DEEYRDGRLT KECWFPNASS DAILAYKLIV QTGHVDNPVD KELVLTNRLV 840
  841 NSDGIINQRA FYNYLSAWAT NDVFAYGASQ GKLYPEPRQY FHQPNEYDLK IPKSLPLVYA 900
  901 QMPFYLHGLT DTSQIKTLIG HIRDLSVKYE GFGLPNYPSG IPFIFWEQYM TLRSSLAMIL 960
  961 ACVLLAALVL VSLLLLSVWA AVLVILSVLA SLAQIFGAMT LLGIKLSAIP AVILILSVGM1020
 1021 MLCFNVLISL GFMTSVGNRQ RRVQLSMQMS LGPLVHGMLT SGVAVFMLST SPFEFVIRHF1080
 1081 CWLLLVVLCV GACNSLLVFP ILLSMVGPEA ELVPLEHPDR ISTPSPLPVR SSKRSGKSYV1140
 1141 VQGSRSSRGS CQKSHHHHHK DLNDPSLTTI TEEPQSWKSS NSSIQMPNDW TYQPREQRPA1200
 1201 SYAAPPPAYH KAAAQQHHQH QGPPTTPPPP FPTAYPPELQ SIVVQPEVTV ETTHSDSNTT1260
 1261 KVTATANIKV ELAMPGRAVR SYNFTS

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..1129] PSI-BLAST 1000.0 Multidrug efflux transporter AcrB pore domain; PN1, PN2, PC1 and PC2 subdomains; Multidrug efflux transporter AcrB TolC docking domain; DN and DC subdomains; Multidrug efflux transporter AcrB transmembrane domain
    2 View Details [1130..1286] FFAS03 0.983 Crystal structure of human fatty acid binding protein 1 (FABP1)

    Functions predicted (by domain):

    # Gene Ontology predictions
    1 No functions predicted.
    2
    Term Confidence Notes
  • binding
    		•  2.41587219066945 bayes_pls_golite062009
  • transporter activity
    		•  2.0790253220851 bayes_pls_golite062009
  • substrate-specific transporter activity
    		•  0.92165376847661 bayes_pls_golite062009
  • lipid binding
    		•  0.7017061461628 bayes_pls_golite062009
  • protein binding
    		•  0.213758754904511 bayes_pls_golite062009
  • transcription regulator activity
    		•  0.208634580746698 bayes_pls_golite062009


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    [View Details]
    Source: Reynolds et al. 2008. Manuscript submitted Philius confidence legend
    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle