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Protein Overview: UBE2B_RAT

General Information:
Name(s) found: UBE2B_RAT [Swiss-Prot]
Description(s) found:
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  • gi|745378|prf||2016220A ubiquitin-conjugating enzyme:ISOTYPE=E2-14k [NCBI NR]
  • gi|52783808|sp|P63149.1|UBE2B_RAT RecName: Full=Ubiquitin-conjugating enzyme E2 B; AltName: Full=Ubiquitin-protein ligase B; AltName: Full=Ubiquitin carrier protein B; AltName: Full=HR6B; AltName: Full=E2(14k) [NCBI NR]
  • gi|5019992|gb|AAD37966.1|AF144083_1 ubiquitin-conjugating enzyme [Rattus norvegicus] [NCBI NR]
  • gi|476117|gb|AAB60669.1| 14 kDa ubiquitin conjugating enzyme [Rattus norvegicus] [NCBI NR]
  • gi|47482130|gb|AAH70946.1| Ube2b protein [Rattus norvegicus] [NCBI NR]
  • pir||I51913 14 kDa ubiquitin conjugating enzyme - rat [NCBI NR]
  • gi|207555|gb|AAA21087.1| ubiquitin conjugating-protein [NCBI NR]
  • gi|149052522|gb|EDM04339.1| ubiquitin-conjugating enzyme E2B, RAD6 homolog (S. cerevisiae), isoform CRA_b [Rattus norvegicus] [NCBI NR]
  • gi|13592123|ref|NP_112400.1| ubiquitin-conjugating enzyme E2B [Rattus norvegicus] [NCBI NR]
  • Ubiquitin-conjugating enzyme E2 B OS=Rattus norvegicus GN=Ube2b PE=2 SV=1 [Swiss-Prot]
  • (P63149) Ubiquitin-conjugating enzyme E2 B (EC 6.3.2.19) (Ubiquitin-protein ligase B) (Ubiquitin carrier protein B) (HR6B) (E2(14k)) [Swiss-Prot]
  • Ensembl_locations(Chr-bp):10-35872439 Ubiquitin-conjugating enzyme E2 B [hmr_yeast5_DM3-1_pombe.fasta]
  • ubiquitin conjugating enzyme [HMR_022704-rand.fasta]
  • ubiquitin-conjugating enzyme E2B [Homo sapiens]gi|30582981|gb|AAP35734.1| ubiquitin-conjugating enzyme E2B (RAD6 homolog) [Homo sapiens]gi|13592123|ref|NP_112400.1| ubiquitin conjugating enzyme [Rattus norvegicus]gi|50755160|ref|XP_414633.1| PREDICTED: [nrdb_11152004_Chlamydomonas]
  • Tax_Id=10116 Ubiquitin-conjugating enzyme E2 B [EBI-IPI_rat_3.17_05-10-2006_con_reversed.fasta]
  • (NM_031138) ubiquitin conjugating enzyme [Rattus norvegicus] [NCBI-RefSeq_human-mouse-rat_na_10-18-2006_con_reversed.fasta]
  • Ubiquitin-conjugating enzyme E2 B (Ubiquitin-protein ligase B) (Ubiquitin carrier protein B) (HR6B) (E2(14k)) [NCBI-RefSeq_multi-organisms_na_08-12-2008_con_reversed.fasta]
  • Ube2b protein [Rattus norvegicus] [NCBI-RefSeq_multi-organisms_na_08-12-2008_con_reversed.fasta]
  • ubiquitin-conjugating enzyme E2B [Rattus norvegicus] [NCBI-RefSeq_multi-organisms_na_08-12-2008_con_reversed.fasta]
  • ubiquitin-conjugating enzyme E2B, RAD6 homolog (S. cerevisiae), isoform CRA_b [Rattus norvegicus] [NCBI-RefSeq_multi-organisms_na_08-12-2008_con_reversed.fasta]
  • 14 kDa ubiquitin conjugating enzyme [Rattus norvegicus] [NCBI-RefSeq_multi-organisms_na_08-12-2008_con_reversed.fasta]
  • ubiquitin-conjugating enzyme [Rattus norvegicus] [NCBI-RefSeq_multi-organisms_na_08-12-2008_con_reversed.fasta]
  • ubiquitin-conjugating enzyme:ISOTYPE=E2-14k [NCBI-RefSeq_multi-organisms_na_08-12-2008_con_reversed.fasta]
  • ubiquitin conjugating-protein [NCBI-RefSeq_multi-organisms_na_08-12-2008_con_reversed.fasta]
  • Tax_Id=10116 UBIQUITIN-CONJUGATING ENZYME E2 B [Xentr4_EBI-IPI_human_mouse_rat_Xenopus_tropicalis_laevis_con_reversed.fasta]
  • ubiquitin conjugating enzyme [Rattus norvegicus] [nr-271106-contam.fasta]
  • Tax_Id=10116 Gene_Symbol=Ube2b Ubiquitin-conjugating enzyme E2 B [rat-ipi-250309-contam.fasta]
  • Ubiquitin-conjugating enzyme E2 B OS=Rattus norvegicus GN=Ube2b [011711_HMR.fasta]
    • Organism: Rattus norvegicus
    Length: 152 amino acids

    Gene Ontology:
    Cellular Component: replication fork [UNKNOWN][IEA]
    XY body [UNKNOWN][IEA]
    nucleus [UNKNOWN][IEA]
    nuclear chromatin [UNKNOWN][IEA]
    cytoplasm [UNKNOWN][IEA]
    chromatin [UNKNOWN]
    cellular_component [ND]
    plasma membrane [IEA]
    Biological Process: DNA repair [UNKNOWN]
    maintenance of chromatin silencing [UNKNOWN][IEA]
    response to UV [UNKNOWN][IEA]
    post-translational protein modification [IEA]
    postreplication repair [UNKNOWN][IEA]
    cellular response to insulin stimulus [IEP]
    chiasma assembly [UNKNOWN][IEA]
    regulation of protein metabolic process [IEA]
    response to hypoxia [IEP]
    in utero embryonic development [UNKNOWN][IEA]
    Wnt receptor signaling pathway through beta-catenin [IEA]
    regulation of histone modification [UNKNOWN][IEA]
    protein autoubiquitination [UNKNOWN][IEA]
    protein polyubiquitination [UNKNOWN][IEA]
    spermatogenesis [UNKNOWN][IEA]
    sperm axoneme assembly [UNKNOWN][IEA]
    response to DNA damage stimulus [UNKNOWN]
    protein monoubiquitination [UNKNOWN][IEA]
    ubiquitin-dependent protein catabolic process [UNKNOWN][IEP]
    synaptonemal complex organization [UNKNOWN][IEA]
    positive regulation of reciprocal meiotic recombination [UNKNOWN][IEA]
    response to drug [UNKNOWN][IEA]
    negative regulation of apoptosis [UNKNOWN][IEA]
    histone lysine demethylation [UNKNOWN][IEA]
    histone H2A ubiquitination [UNKNOWN][IEA]
    protein stabilization [UNKNOWN][IEA]
    negative regulation of histone phosphorylation [UNKNOWN][IEA]
    protein ubiquitination [UNKNOWN]
    Molecular Function: nucleotide binding [IEA]
    ubiquitin-protein ligase activity [UNKNOWN][IEA]
    ATP binding [IEA]
    protein binding [UNKNOWN][IEA]
    ubiquitin protein ligase binding [UNKNOWN][IEA]
    molecular_function [ND]
    ligase activity [IEA]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSTPARRRLM RDFKRLQEDP PVGVSGAPSE NNIMQWNAVI FGPEGTPFED GTFKLVIEFS  60
   61 EEYPNKPPTV RFLSKMFHPN VYADGSICLD ILQNRWSPTY DVSSILTSIQ SLLDEPNPNS 120
  121 PANSQAAQLY QENKREYEKR VSAIVEQSWN DS

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..152] PSI-BLAST 47.30103 HsUbc2b

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • ubiquitin-protein ligase activity
    		•  11.3486134076304 bayes_pls_golite062009
  • small conjugating protein ligase activity
    		•  11.2964721480824 bayes_pls_golite062009
  • acid-amino acid ligase activity
    		•  10.2401422444624 bayes_pls_golite062009
  • ligase activity, forming carbon-nitrogen bonds
    		•  8.93602533934698 bayes_pls_golite062009
  • HLH domain binding
    		•  8.10904818707269 bayes_pls_golite062009
  • ligase activity
    		•  5.89730943108033 bayes_pls_golite062009
  • SUMO ligase activity
    		•  3.88357560284404 bayes_pls_golite062009
  • ISG15 ligase activity
    		•  3.37361650623694 bayes_pls_golite062009
  • transcription regulator activity
    		•  2.21355731489173 bayes_pls_golite062009
  • nucleic acid binding
    		•  2.13970605403492 bayes_pls_golite062009
  • DNA binding
    		•  1.95596447916631 bayes_pls_golite062009
  • protein binding
    		•  1.77678273247394 bayes_pls_golite062009
  • binding
    		•  1.75350658654805 bayes_pls_golite062009
  • transcription repressor activity
    		•  1.5236035191291 bayes_pls_golite062009
  • transcription activator activity
    		•  1.19240180311941 bayes_pls_golite062009
  • catalytic activity
    		•  0.891402822028799 bayes_pls_golite062009
  • NEDD8 ligase activity
    		•  0.715654744941217 bayes_pls_golite062009
  • phosphotransferase activity, alcohol group as acceptor
    		•  0.58835335751383 bayes_pls_golite062009
  • kinase activity
    		•  0.519703305315987 bayes_pls_golite062009
  • protein kinase activity
    		•  0.443948654247666 bayes_pls_golite062009
  • transferase activity, transferring phosphorus-containing groups
    		•  0.373779304908933 bayes_pls_golite062009
  • protein serine/threonine kinase activity
    		•  0.182854082413338 bayes_pls_golite062009
  • transcription corepressor activity
    		•  0.122859425935324 bayes_pls_golite062009
  • transferase activity
    		•  0.0984525836903841 bayes_pls_golite062009
  • transcription factor binding
    		•  0.0104967529560147 bayes_pls_golite062009


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle