Protein Overview: SYUA_RAT

General Information:
Name(s) found:	SYUA_RAT [Swiss-Prot]
Description(s) found: SHOW ONLY BEST	gi\|9507125\|ref\|NP_062042.1\| synuclein, alpha (non A4 component of amyloid precursor) [Rattus norvegicus] [NCBI NR] gi\|586065\|sp\|P37377.1\|SYUA_RAT RecName: Full=Alpha-synuclein [NCBI NR] gi\|56388580\|gb\|AAH87682.1\| Synuclein, alpha (non A4 component of amyloid precursor) [Rattus norvegicus] [NCBI NR] gi\|45239326\|gb\|AAS55695.1\| alpha synuclein [Rattus norvegicus] [NCBI NR] gi\|45239324\|gb\|AAS55694.1\| alpha synuclein [Rattus norvegicus] [NCBI NR] gi\|2218254\|gb\|AAC16026.1\| synuclein 1 [Rattus norvegicus] [NCBI NR] gi\|149037059\|gb\|EDL91620.1\| synuclein, alpha, isoform CRA_a [Rattus norvegicus] [NCBI NR] gi\|149037057\|gb\|EDL91618.1\| synuclein, alpha, isoform CRA_a [Rattus norvegicus] [NCBI NR] gi\|149037056\|gb\|EDL91617.1\| synuclein, alpha, isoform CRA_a [Rattus norvegicus] [NCBI NR] Alpha-synuclein OS=Rattus norvegicus GN=Snca PE=1 SV=1 [Swiss-Prot] Ensembl_locations(Chr-bp):4-94082545 Splice isoform Syn1 of P37377 [hmr_yeast5_DM3-1_pombe.fasta] synuclein, alpha [HMR_022704-rand.fasta] synuclein, alpha [Rattus norvegicus]gi\|2218254\|gb\|AAC16026.1\| synuclein 1 [Rattus norvegicus]gi\|586065\|sp\|P37377\|SYUA_RAT Alpha-synucleingi\|45239326\|gb\|AAS55695.1\| alpha synuclein [Rattus norvegicus]gi\|45239324\|gb\|AAS55694.1\| alpha synuclein [Rattus n [nrdb_11152004_Chlamydomonas] Tax_Id=10116 Splice Isoform Syn1 of Alpha-synuclein [EBI-IPI_rat_3.17_05-10-2006_con_reversed.fasta] (NM_019169) synuclein, alpha [Rattus norvegicus] [NCBI-RefSeq_human-mouse-rat_na_10-18-2006_con_reversed.fasta] synuclein, alpha [Rattus norvegicus] [NCBI-RefSeq_multi-organisms_na_08-12-2008_con_reversed.fasta] Alpha-synuclein [NCBI-RefSeq_multi-organisms_na_08-12-2008_con_reversed.fasta] synuclein, alpha, isoform CRA_a [Rattus norvegicus] [NCBI-RefSeq_multi-organisms_na_08-12-2008_con_reversed.fasta] Synuclein, alpha [Rattus norvegicus] [NCBI-RefSeq_multi-organisms_na_08-12-2008_con_reversed.fasta] alpha synuclein [Rattus norvegicus] [NCBI-RefSeq_multi-organisms_na_08-12-2008_con_reversed.fasta] synuclein 1 [Rattus norvegicus] [NCBI-RefSeq_multi-organisms_na_08-12-2008_con_reversed.fasta] Tax_Id=10116 SPLICE ISOFORM 1 OF ALPHA-SYNUCLEIN [Xentr4_EBI-IPI_human_mouse_rat_Xenopus_tropicalis_laevis_con_reversed.fasta] synuclein, alpha (non A4 component of amyloid precursor) [Rattus norvegicus] [NCBI-RefSeq_human-rat_na_04-07-2009_con_reversed.fasta] Tax_Id=10116 Gene_Symbol=Snca Isoform Syn1 of Alpha-synuclein [rat-ipi-250309-contam.fasta] Isoform Syn1 of Alpha-synuclein OS=Rattus norvegicus GN=Snca [011711_HMR.fasta]
Organism:	Rattus norvegicus
Length:	140 amino acids
Gene Ontology:
Cellular Component:	synaptosome [UNKNOWN] platelet alpha granule membrane [UNKNOWN] synaptic vesicle [IDA] microsome [IDA] plasma membrane [UNKNOWN] axon terminus [IDA] fibril [UNKNOWN] membrane fraction [IDA] growth cone [UNKNOWN] nucleus [UNKNOWN] cytoplasmic vesicle membrane [IDA] soluble fraction [IDA] cytoskeleton [UNKNOWN] cytoplasm [UNKNOWN][IDA] terminal button [IDA] cell cortex [UNKNOWN] mitochondrion [IDA] actin cytoskeleton [UNKNOWN] cytosol [UNKNOWN][IDA] axon [UNKNOWN]
Biological Process:	dopamine biosynthetic process [UNKNOWN] dopamine metabolic process [UNKNOWN] positive regulation of endocytosis [UNKNOWN] negative regulation of dopamine metabolic process [IMP] adult locomotory behavior [UNKNOWN] phospholipid metabolic process [UNKNOWN] mitochondrial ATP synthesis coupled electron transport [UNKNOWN] negative regulation of exocytosis [UNKNOWN] neutral lipid metabolic process [UNKNOWN] negative regulation of monooxygenase activity [UNKNOWN] anti-apoptosis [UNKNOWN] synaptic vesicle transport [UNKNOWN] regulation of macrophage activation [UNKNOWN] regulation of long-term neuronal synaptic plasticity [UNKNOWN] negative regulation of caspase activity [UNKNOWN] regulation of neuronal synaptic plasticity [UNKNOWN] long-term synaptic potentiation [UNKNOWN] regulation of excitatory postsynaptic membrane potential [UNKNOWN] response to interferon-gamma [UNKNOWN] positive regulation of synaptic transmission [UNKNOWN] positive regulation of neurotransmitter secretion [UNKNOWN] response to interleukin-1 [UNKNOWN] cellular membrane organization [UNKNOWN] receptor internalization [UNKNOWN] negative regulation of serotonin uptake [UNKNOWN] regulation of glutamate secretion [UNKNOWN] response to cytokine stimulus [UNKNOWN] negative regulation of histone acetylation [UNKNOWN] [NOT]calcium ion homeostasis [UNKNOWN] regulation of locomotion [UNKNOWN] response to iron(II) ion [UNKNOWN] [NOT]regulation of neuron apoptosis [UNKNOWN] negative regulation of neuron apoptosis [UNKNOWN][IMP] negative regulation of dopamine uptake [UNKNOWN] synaptic transmission, dopaminergic [UNKNOWN] behavioral response to cocaine [IMP] positive regulation of receptor recycling [UNKNOWN] regulation of phospholipase activity [UNKNOWN] response to magnesium ion [UNKNOWN] regulation of acyl-CoA biosynthetic process [UNKNOWN] negative regulation of norepinephrine uptake [UNKNOWN] regulation of dopamine secretion [UNKNOWN][IEA] regulation of neurotransmitter secretion [UNKNOWN] positive regulation of release of sequestered calcium ion into cytosol [UNKNOWN] fatty acid metabolic process [UNKNOWN] positive regulation of inositol phosphate biosynthetic process [UNKNOWN] mitochondrial membrane organization [UNKNOWN] microglial cell activation [UNKNOWN] negative regulation of protein amino acid phosphorylation [IMP] response to drug [UNKNOWN] negative regulation of thrombin receptor signaling pathway [UNKNOWN] negative regulation of transporter activity [UNKNOWN] cellular response to oxidative stress [UNKNOWN] response to lipopolysaccharide [UNKNOWN] negative regulation of platelet-derived growth factor receptor signaling pathway [UNKNOWN]
Molecular Function:	zinc ion binding [UNKNOWN] protein domain specific binding [IPI] identical protein binding [UNKNOWN] ferrous iron binding [UNKNOWN] alpha-tubulin binding [UNKNOWN] phospholipid binding [IDA] [NOT]phospholipase D inhibitor activity [UNKNOWN] caspase inhibitor activity [UNKNOWN] dynein binding [UNKNOWN] magnesium ion binding [UNKNOWN] [NOT]fatty acid binding [UNKNOWN] protein binding [UNKNOWN][IPI] histone binding [UNKNOWN] calcium ion binding [UNKNOWN] phospholipase binding [UNKNOWN][IPI] protein N-terminus binding [IPI] tau protein binding [UNKNOWN] kinesin binding [UNKNOWN] arachidonic acid binding [UNKNOWN] Hsp70 protein binding [UNKNOWN]

Sequence:
Sequence: [PDR BLAST] [ProtParam]	1 11 21 31 41 51 \| \| \| \| \| \| 1 MDVFMKGLSK AKEGVVAAAE KTKQGVAEAA GKTKEGVLYV GSKTKEGVVH GVTTVAEKTK 60 61 EQVTNVGGAV VTGVTAVAQK TVEGAGNIAA ATGFVKKDQM GKGEEGYPQE GILEDMPVDP 120 121 SSEAYEMPSE EGYQDYEPEA

Protein Complex Data

No complex found for this protein.

Mass Spectrometry Data

No mass spectrometry results found for this protein.

Yeast Two-Hybrid Data

The following interactions contain this protein:

SHOWING SINGLE HITS. [ Hide Single Hits ]

[View our yeast two-hybrid interpretation guidelines.]

No yeast two-hybrid interactions found for this protein.

Microscopy / Localization Data

New Feature: Upload Your Own Microscopy Data

No microscopy data found in the PDR for this protein.

Protein Structure Data

[What does the above image mean?]
[View Top Sequence Alignments] [Show Ginzu Version Information]

Domains predicted:

#		Region(s)	Method	Confidence	Match Description
1	View Details	[1..140]	PSI-BLAST	36.09691	Human micelle-bound alpha-synuclein

Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

Philius Transmembrane Prediction:

Protein predicted to be:	GLOBULAR (No transmembrane regions or signal peptide)
Confidence of classification:	0.99

Source: Reynolds et al. (2008)

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle