Protein Overview: MLH1_RAT

General Information:
Name(s) found:	MLH1_RAT [Swiss-Prot]
Description(s) found: SHOW ONLY BEST	gi\|1724118\|gb\|AAB38506.1\| mismatch repair protein [Rattus norvegicus] [NCBI NR] gi\|13878571\|sp\|P97679.1\|MLH1_RAT RecName: Full=DNA mismatch repair protein Mlh1; AltName: Full=MutL protein homolog 1 [NCBI NR] gi\|13591989\|ref\|NP_112315.1\| mismatch repair protein 1 [Rattus norvegicus] [NCBI NR] DNA mismatch repair protein Mlh1 OS=Rattus norvegicus GN=Mlh1 PE=2 SV=1 [Swiss-Prot] Ensembl_locations(Chr-bp):8-119662133 DNA mismatch repair protein Mlh1 [hmr_yeast5_DM3-1_pombe.fasta] mismatch repair protein 1 [HMR_022704-rand.fasta] mismatch repair protein 1 [Rattus norvegicus]gi\|1724118\|gb\|AAB38506.1\| mismatch repair protein [Rattus norvegicus]gi\|13878571\|sp\|P97679\|MLH1_RAT DNA mismatch repair protein Mlh1 (MutL protein homolog 1) [nrdb_11152004_Chlamydomonas] Tax_Id=10116 DNA mismatch repair protein Mlh1 [EBI-IPI_rat_3.17_05-10-2006_con_reversed.fasta] (NM_031053) mismatch repair protein 1 [Rattus norvegicus] [NCBI-RefSeq_human-mouse-rat_na_10-18-2006_con_reversed.fasta] DNA mismatch repair protein Mlh1 (MutL protein homolog 1) [NCBI-RefSeq_multi-organisms_na_08-12-2008_con_reversed.fasta] mismatch repair protein 1 [Rattus norvegicus] [NCBI-RefSeq_multi-organisms_na_08-12-2008_con_reversed.fasta] mismatch repair protein [Rattus norvegicus] [NCBI-RefSeq_multi-organisms_na_08-12-2008_con_reversed.fasta] Tax_Id=10116 DNA MISMATCH REPAIR PROTEIN MLH1 [Xentr4_EBI-IPI_human_mouse_rat_Xenopus_tropicalis_laevis_con_reversed.fasta] DNA mismatch repair protein Mlh1 [Rattus norvegicus] [NCBI-RefSeq_Human_na_04-23-2010_reversed.fasta] DNA mismatch repair protein Mlh1 OS=Rattus norvegicus GN=Mlh1 [011711_HMR.fasta]
Organism:	Rattus norvegicus
Length:	757 amino acids
Gene Ontology:
Cellular Component:	condensed chromosome [UNKNOWN] chiasma [UNKNOWN] nucleus [IDA][IEA] MutLalpha complex [UNKNOWN] chromosome [UNKNOWN] synaptonemal complex [UNKNOWN][IDA] condensed nuclear chromosome [UNKNOWN] male germ cell nucleus [UNKNOWN]
Biological Process:	somatic recombination of immunoglobulin gene segments [UNKNOWN] DNA repair [UNKNOWN] reciprocal meiotic recombination [UNKNOWN] pachytene [UNKNOWN] resolution of meiotic recombination intermediates [UNKNOWN] double-strand break repair via nonhomologous end joining [UNKNOWN] response to toxin [IEP] response to hypoxia [IEP] meiotic chromosome segregation [UNKNOWN] isotype switching [UNKNOWN] male meiosis chromosome segregation [UNKNOWN] male meiosis [UNKNOWN] spermatogenesis [UNKNOWN][IEP] DNA damage response, signal transduction resulting in induction of apoptosis [UNKNOWN] mismatch repair [UNKNOWN][IEA] negative regulation of mitotic recombination [UNKNOWN] response to DNA damage stimulus [UNKNOWN] nuclear-transcribed mRNA poly(A) tail shortening [UNKNOWN] cell cycle [IEA] meiosis [UNKNOWN] meiotic metaphase I plate congression [UNKNOWN] spindle midzone assembly involved in meiosis [UNKNOWN] somatic recombination of immunoglobulin genes during immune response [UNKNOWN] oogenesis [UNKNOWN] response to drug [IEP] cellular response to organic cyclic substance [IEP] somatic hypermutation of immunoglobulin genes [UNKNOWN]
Molecular Function:	MutSalpha complex binding [UNKNOWN] ATP binding [IEA] protein binding [UNKNOWN] mismatched DNA binding [IEA] structure-specific DNA binding [UNKNOWN] molecular_function [ND] guanine/thymine mispair binding [UNKNOWN] single-stranded DNA binding [UNKNOWN]

Sequence:

Sequence:
[PDR BLAST]
[ProtParam]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSFVAGVIRR LDETVVNRIA AGEVIQRPAN AIKEMTENCL DAKSTNIQVI VREGGLKLIQ  60
   61 IQDNGTGIRK EDLDIVCERF TTSKLQTFED LAMISTYGFR GEALASISHV AHVTITTKTA 120
  121 DGKCAYRASY SDGKLQAPPK PCAGNQGTLI TVEDLFYNII TRKKALKNPS EEYGKILEVV 180
  181 GRYSIHNSGI SFSVKKQGET VSDVRTLPNA TTVDNIRSIF GNAVSRELIE VGCEDKTLAF 240
  241 KMNGYISNAN YSVKKCIFLL FINHRLVESA ALKKAIEAVY AAYLPKNTHP FLYLILEISP 300
  301 QNVDVNVHPT KHEVHFLHEE SILERVQQHI ESKLLGSNSS RMYFTQTLLP GLAGPSGEAV 360
  361 KSTTGIASSS TSGSGDKVHA YQMVRTDSRD QKLDAFMQPV SRRLPSQPQD PVPGNRTEGS 420
  421 PEKAMQKDQE ISELPAPMEA AADSASLERE SVIGASEVVA PQRHPSSPGS SRKRHPEDSD 480
  481 VEMMENDSRK EMTAACYPRR RIINLTSVLS LQEEINDRGH ETLREMLRNH TFVGCVNPQW 540
  541 ALAQHQTKLY LLNTTKLSEE LFYQILIYDF ANFGVLRLPE PAPLFDFAML ALDSPESGWT 600
  601 EEDGPKEGLA EYIVEFLKKK AKMLADYFSV EIDEEGNLIG LPLLIDSYVP PLEGLPIFIL 660
  661 RLATEVNWDE EECFESLSKE CAVFYSIRKQ YILEESALSG QQSDMPGSPS KPWKWTVEHI 720
  721 IYKAFRSHLL PPKHFTEDGN VLQLANLPDL CKVFERC

Protein Complex Data

No complex found for this protein.

Mass Spectrometry Data

No mass spectrometry results found for this protein.

Yeast Two-Hybrid Data

The following interactions contain this protein:

NOT SHOWING SINGLE HITS. [ Show Single Hits ]

[View our yeast two-hybrid interpretation guidelines.]

No yeast two-hybrid interactions found for this protein.

Protein predicted to be:	GLOBULAR (No transmembrane regions or signal peptide)
Confidence of classification:	0.99

Protein Overview: MLH1_RAT

Protein Complex Data

Mass Spectrometry Data

Yeast Two-Hybrid Data

Microscopy / Localization Data

Protein Structure Data

Philius Transmembrane Prediction: