YRC Logo
PROTEIN SEARCH:
Descriptions Names[Advanced Search]

The process by which immune receptor genes are diversified through recombination of the germline genetic elements within a single genetic locus. The process by which immunoglobulin gene segments are recombined within a single locus utilizing the conserved heptamer and nonomer recombination signal sequences (RSS). For immunoglobulin heavy chains V, D, and J gene segments are joined, and for immunoglobulin light chains V and J gene segments are joined. The addition of variable numbers of random nucleotides by terminal deoxytransferase in the N regions of heavy chain immunoglobulin genes. N regions are found at the V-D and D-J recombinational junctions. The process by which immunoglobulin genes are formed through recombination of the germline genetic elements, also known as immunoglobulin gene segments, within a single locus following the induction of an immune response. The process by which immunoglobulin genes are formed through recombination of the germline genetic elements, as known as immunoglobulin gene segments, within a single locus. Recombination occurring within or between DNA molecules in somatic cells. The process of replacing receptors on B cells, in which RAG gene expression allows continued light-chain gene rearrangement and expression of a new light change which combines with the previous heavy chain to form a new receptor. The somatic process by means of which sequence diversity of immunoglobulins is generated. The somatic process allowing for the production of immune receptors whose specificity is not encoded in the germline genomic sequences. The appearance of immunoglobulin due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels.

View Gene Ontology (GO) Term

GO TERM SUMMARY
Name: somatic recombination of immunoglobulin gene segments
Acc: GO:0016447
Aspect: Biological Process
Desc: The process by which immunoglobulin genes are formed through recombination of the germline genetic elements, as known as immunoglobulin gene segments, within a single locus.
Synonyms:
  • somatic recombination of antibody gene segments
Proteins in PDR annotated with:
   This term: 8 [Search]
   Term or descendants: 57 [Search]


[geneontology.org]
INTERACTIVE GO GRAPH

GO:0016447 - somatic recombination of immunoglobulin gene segments (interactive image map)
YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle